Articles tagged with Breast Cancer
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A relative utility curve is a simple method to evaluate risk prediction in medical decision-making frameworks. The author illustrates its application in analyzing previously published data involving breast density and risk prediction models for invasive breast cancer.
A combination of estrogen and a selective estrogen receptor modulator (SERM) may relieve menopause symptoms and lower breast cancer risk without the progestin side effects. Researchers treated breast and endometrial cell lines with the hormone mix, finding that it blocked cell growth and prevented proliferation.
A $4 million NCI grant will fund comparative effectiveness research on cancer at the Southwest Oncology Group. The Center for Comparative Effectiveness Research in Cancer Genomics will evaluate emerging genomics technologies to identify promising treatments.
Breast cancer patients can reduce their risk of lymphedema by seeking physical therapy services before, during, and after treatment. A study published in the journal Cancer found that pre-operative assessments by physical therapists enable early diagnosis and management of the condition, leading to more conservative treatment options.
Researchers at Georgetown University Medical Center discovered that a gene associated with immunological disorders plays a crucial role in preventing breast cancer. The study suggests that drugs targeting this gene may inadvertently promote breast cancer development.
A study of nearly 2,000 women with breast cancer found that 75.4% received breast-conserving surgery as initial therapy, while 23% underwent mastectomy. The results suggest that most surgeons recommend local therapy options and that patient preferences play a role in shaping treatment choices.
A study found that breast-conserving surgery was offered to the majority of patients, with surgeons' recommendations and patient preferences playing key roles. The study suggests that increased patient involvement in breast surgery decisions is associated with greater probability of mastectomy.
A new study found that socio-economic disparities in breast cancer survival are linked to stage at diagnosis, treatment, and race. Women from low-income areas were more likely to receive late-stage cancer diagnoses and less access to first-course treatment.
A recent UCLA study found that women developing new-onset breast tenderness after starting estrogen plus progestin hormone replacement therapy are at a significantly higher risk of developing breast cancer. The research analyzed data from over 16,000 participants in the Women's Health Initiative clinical trial.
A new study found significant socioeconomic disparities in the use of breast-conserving surgery (BCS) for older women with nonmetastatic invasive breast cancer. BCS was more widely used in younger patients, areas with high education levels, and metropolitan regions.
A new study found that elevated levels of Müllerian inhibiting substance in women may increase their risk for breast cancer. Researchers discovered an association between higher MIS serum concentrations and increased breast cancer risk in a population of participants.
A recent study published in Molecular Cell reveals that the KEAP1 tumor suppressor binds to and degrades the cancer-promoting protein IKKß, which is involved in several types of cancer. The research suggests that underexpression of KEAP1 is associated with poor survival rates among breast cancer patients.
A study of over 2,000 women with stage II and III breast cancer found that achieving pathological complete response after treatment was not related to race. Despite racial disparities in breast cancer incidence and mortality rates, Hispanic women had better outcomes than white women.
A new study finds that women with a deleterious BRCA gene mutation are diagnosed with breast cancer six years earlier than their relatives who also had the disease and/or ovarian cancer. The findings could impact how women at highest risk for breast cancer are counseled and screened in the future.
A study of 166 breast cancer patients found nearly 70% had low vitamin D levels, increasing fracture risk. High-dose supplements improved levels and boosted bone mass, helping mitigate disease symptoms.
The American Association for Cancer Research is honoring two leading breast cancer researchers, Robert Weinberg and Charles Perou, at the 32nd annual CTRC-AACR San Antonio Breast Cancer Symposium. The symposium will feature research on metastasis, genetic technology, and molecular subtypes of breast cancer.
Researchers have created a new technology that analyzes tiny blood and breast tissue samples to detect increased estrogen levels, which may indicate breast cancer. This breakthrough could lead to faster screening for high-risk populations and improved diagnosis.
Surgeons agree that percutaneous needle biopsy is the best practice for initial diagnosis of breast abnormalities, offering equivalent accuracy and reduced risk of scarring. The procedure has been shown to provide detailed information about tumor characteristics, aiding in therapeutic decision-making before surgical intervention.
The debut edition of Science Translational Medicine describes a microfluidics device for detecting tiny amounts of estrogen, which could improve breast cancer screening. Researchers have also identified a novel mechanism to protect patients from graft-versus-host disease after bone marrow transplants.
A study found that genetic variation of the CYP2D6 enzyme is associated with clinical outcomes for women treated with tamoxifen. Women with reduced or absent CYP2D6 function had higher breast cancer event rates and poorer survival rates compared to those with extensive metabolism.
Researchers at Northwestern University discovered a potent new chemotherapy cocktail that inhibits breast cancer cell invasion by half. The mix of dasatinib and doxorubicin targets the Src kinase enzyme, believed to play a key role in breast cancer metastasis.
Fernandez-Valle's research aims to identify proteins that could deliver cancer-fighting drugs to NF2 tumors, potentially improving lifestyles and extending patients' lives. She has established nationally affiliated clinics in Florida, bringing together physicians with expertise in treating the disease.
Mayo Clinic researchers found that certain structural features within breast tissue can indicate a woman's individual cancer risk. The percentage of acini present per lobule at a given age indicates cancer risk. This method is more accurate in predicting risk for an individual than the Gail model.
A study from the University of Michigan Comprehensive Cancer Center found that less-acculturated Latinas were less likely to undergo breast reconstruction surgery after a mastectomy for breast cancer. Despite having a desire for reconstruction, these women faced barriers such as lack of information and limited access to plastic surgeons.
Researchers at Fred Hutchinson Cancer Center and local institutions receive $16 million in federal stimulus funding to conduct comparative-effectiveness research on cancer diagnostics, genetic tests, and breast imaging. The projects aim to determine the optimal choices for balancing benefits and harms.
Researchers identified KLF17 as a key gene involved in breast cancer metastasis. The study found that expression of KLF17 together with Id1 accurately predicts whether the disease will spread to the lymph nodes.
Researchers found that NEDD9 protein is required for aggressive breast cancer growth, and its absence limits the appearance of metastatic breast cancer. The study suggests that NEDD9 could serve as a biomarker for aggressive forms of breast cancer.
A new molecular imaging technique using PET imaging shows promising results in evaluating and predicting the course of endometrial carcinoma. The technique combines estrogen receptor expression imaging with 18F-FDG PET to improve diagnostic accuracy, potentially saving women from unnecessary operations and biopsies.
Researchers found that post-menopausal women who engage in moderate to vigorous exercise for over 7 hours per week have a 16% lower risk of developing breast cancer. However, no link was observed between physical activity and breast cancer risk in younger women.
Researchers found that social isolation caused increased tumor growth and altered gene expression in mouse mammary glands, suggesting potential molecular biomarkers and targets for preventive intervention in human breast cancer. The study also supports previous epidemiologic studies linking social isolation to chronic disease mortality.
The University of California's ATHENA Breast Health Network is a groundbreaking statewide collaboration aimed at improving breast cancer care. The project will involve 150,000 women across California and generate rich data on breast cancer treatment, potentially leading to breakthroughs in personalized medicine.
A study published in Cancer Prevention Research found that isolated mice developed significantly larger mammary gland tumors compared to group-housed mice, suggesting a link between social environment and cancer growth. The researchers also identified potential molecular biomarkers for breast cancer prevention.
Research identifies women who entered menopause recently may be at higher risk of joint pain caused by breast cancer drugs. Electro-acupuncture proves helpful for alleviating symptoms, improving fatigue and anxiety.
A new study finds that the number of women opting for prophylactic mastectomies is rising, particularly among those with cancer in one breast. Despite limited information available, the surgery appears to be increasing, but its benefits and risks should be carefully considered.
Researchers from Boston University School of Medicine recommend that women on hormone therapy continue their treatment before annual mammogram screenings. The increase in breast density due to hormone therapy is unlikely to mask early cancer detection, making it unnecessary to stop treatment prior to screening.
A study estimates that excess body weight causes 124,050 new cancers in 2008 across European countries. The proportion of cases attributable to a BMI of 25kg/m2 or more is highest among women and in central European countries.
A study published in International Journal of Andrology reveals a significant difference in environmental chemicals found in breast milk between Denmark and Finland. High levels of EDCs were associated with male reproductive problems, including testicular cancer, in Denmark, while Finland had lower exposure levels.
A large randomized trial has found that sorafenib plus capecitabine improves the time women live without disease worsening by 74% compared to chemotherapy alone. The treatment was well-tolerated and manageable, with no new side effects observed.
A new study found that targeted heat therapy significantly improves overall survival and reduces cancer recurrence in patients with locally advanced soft tissue sarcomas. The treatment, which involves heating the tumor to kill cancer cells, also makes chemotherapy more effective and improves blood flow.
A large study on adjuvant endocrine treatment for postmenopausal, hormone-positive breast cancer found that patients who continued to take exemestane or tamoxifen had significantly better outcomes than those who stopped taking the medication. Non-compliance was higher in countries with less stringent guidelines.
Researchers have developed an assay to distinguish between harmful and harmless BRCA1 mutations, providing a way to identify women with increased breast cancer risk. This breakthrough has immense clinical potential for early prevention and treatment strategies.
A new study found that switching post-menopausal women with early breast cancer to exemestane after two or three years of tamoxifen improves disease-free survival and overall survival. The study involved 4,724 postmenopausal women who were followed for an average of 91 months.
Researchers have identified a potential link between B cells and spinal cord injury, suggesting that therapies targeting these immune cells may improve recovery outcomes. In a separate study, scientists developed an assay to distinguish harmful from harmless BRCA1 mutations, which could help identify patients at risk of breast cancer.
Three medications effective in reducing breast cancer risk also have serious side effects, according to a new study. Tamoxifen, raloxifene, and tibolone reduce invasive breast cancer incidence but vary in their adverse effect profiles.
A new Tel Aviv University drug carrier delivers existing life-saving therapies directly to cancer tumors, reversing growth and inhibiting tumor growth by 50%. The innovative formulation targets tumors without affecting normal healthy cells, offering a potential solution for various forms of cancers and diseases.
A study published in Journal of Cancer Survivorship reveals that chemotherapy-induced cognitive impairment, known as chemobrain, significantly diminishes women's quality of life. Women experience memory loss, difficulty concentrating, and reduced independence, affecting their work and social lives.
The report finds Hispanic/Latino Americans have a unique cancer risk profile, with lower incidence rates for all cancers combined, but higher rates of stomach, cervix, liver, and gallbladder cancers. They also experience later stage diagnoses for many cancers, including breast and melanoma.
A Loyola University Health System study found that breast cancer patients can prevent bone loss by correcting secondary causes, such as vitamin D deficiency, and using bisphosphonate osteoporosis drugs. After one year, patients with secondary causes showed stable bone mineral density.
Researchers validated a simple blood test to assess treatment effectiveness in metastatic breast cancer patients, correlating CTC count with disease response. The study supports the use of CTC enumeration as an adjunct to standard clinical and radiographic methods.
A study found increased risks of breast cancer in women from the most exposed zone and an excess of lymphatic and hematopoietic tissue neoplasms in all but the least exposed zone. Researchers analyzed medical records of over 36,000 individuals exposed to dioxin after a 1976 industrial accident.
A study by American Cancer Society found that many breast cancer patients are not receiving targeted therapies due to lack of testing. Inaccurate HER2 test results also affect treatment choices, highlighting the need for better testing practices.
Researchers at Harvard Medical School have discovered a diabetes drug that selectively targets and kills cancer stem cells in mice, leading to faster tumor reduction and prolonged remission. The findings support the potential use of metformin as a first-line treatment in breast cancer patients.
Researchers found a diabetes drug, metformin, selectively targets and kills cancer stem cells in mice, reducing tumor growth and prolonging remission. The compound's effectiveness is attributed to its ability to work independently of insulin sensitivity improvements.
Researchers found that tamoxifen citrate, raloxifene, and tibolone reduce the risk of invasive breast cancer, but increase the risk for adverse events. Particle beam radiation therapy may be more effective in treating cancer while minimizing damage to surrounding healthy tissue.
Researchers have discovered that Fanconi anemia and breast cancer proteins are controlled by replication at DNA damage sites. This finding highlights a new paradigm for understanding the repair of DNA crosslinks in both FA and BRCA cancer proteins.
A study by Fred Hutchinson Cancer Center researchers found that obesity, alcohol use, and smoking significantly increase the risk of second breast cancer in survivors. The study suggests reducing weight, quitting smoking, and drinking in moderation to lower this risk.
Researchers discover that overexpression of 14-3-3ζ launches a molecular cascade that removes bonds holding premalignant cells together, converting them to highly mobile mesenchymal-like cells. This process is recognized as a crucial step in metastasis and can be identified using biomarkers.
A team of researchers has identified a molecular signature that can predict which patients with aggressive cancers, such as pancreatic and breast cancer, are likely to respond to therapy with the anti-cancer drug dasatinib. The discovery could lead to personalized treatment approaches for solid tumors currently resistant to therapies.
Duke University researchers create a mouse model to study tumor diversity, enabling rapid trial studies and more effective cancer treatment. The study examines genetic pathways and sensitivity to drugs, shedding light on the importance of matching therapies with individual patient characteristics.
Researchers at the University of New South Wales found high-risk HPV strains in 39% of ductal carcinoma in situ and 21% of invasive ductal carcinoma breast cancer specimens. The study suggests a causal role for HPV in many breast cancers, establishing the possibility of preventing some breast cancers by vaccination against HPV.