Articles tagged with Breast Cancer
A multi-centre study found that specific lymph node radiotherapy is well-tolerated in early breast cancer patients after mastectomy or breast conserving surgery. The treatment showed no increased toxicity to the heart at three years follow-up, and estimated overall survival rates of 79%.
Researchers found that beta-blocker treatment reduced metastasis and improved survival in breast cancer patients, with a 71% reduced risk of death compared to other groups. The study suggests that beta-blockers may slow down tumour growth and target patients at high risk of secondary cancers.
A recent meta-analysis of 14 trials found that pregnancy after breast cancer diagnosis reduces the risk of death by 42%. The study suggests that hormonal changes during pregnancy may have an inhibitory effect on breast cancer cells, and that foetal antigens may also play a role in reducing the risk of recurrence. The findings support t...
Researchers identified CEP17 as a highly significant indicator of response to anthracycline treatment in breast cancer patients. Patients with CEP17 were approximately two-thirds more likely to survive and experience recurrence-free survival compared to those without the biomarker.
New research suggests that pregnant women with breast cancer can be treated with chemotherapy without endangering the health of their unborn baby. The study found that babies exposed to chemotherapy during pregnancy were born slightly lighter but otherwise had similar outcomes as those not exposed to chemotherapy.
A preclinical model of human prostate cancer mimics primary tumors' genetic behavior, offering a platform for biomarker and drug discovery. High expression levels of delta-like ligand 4 in breast cancer predict poor prognosis.
Women diagnosed with breast cancer after pregnancy are 48% more likely to die than others, but risk is similar if cancer is diagnosed during pregnancy. Further investigation is needed to understand the relationship between cumulative pregnancy effects and breast cancer prognosis.
Researchers found that women who have been diagnosed with breast cancer tend to overestimate their risk of developing cancer in the other breast. After counseling and a 12-month delay, most patients reconsidered and opted against prophylactic surgery.
Research suggests locoregional recurrence after long disease-free interval is associated with distant disease rather than cause. Patients with recurrence have four times higher risk of metastases and eight times higher risk of dying compared to those without recurrence.
Patients with metastatic breast cancer expect to prolong life by at least a year over current therapies, whereas doctors consider four to six months of additional survival significant. Thorough discussion of treatment goals is essential for both groups.
The largest European study on socioeconomic status and breast cancer survival found that women from poorer backgrounds had worse outcomes, even after adjusting for tumor size and stage. Women from the poorest backgrounds were a fifth more likely to die within ten years of diagnosis than those from the wealthiest backgrounds.
Young women with breast cancer are concerned about their fertility, with treatments like chemotherapy and hormonal therapy affecting egg production. Fertility preservation options, such as egg freezing or ovarian tissue transplantation, can help alleviate these concerns.
Researchers developed a strategy to overcome the issue, highlighting the importance of communication between healthcare providers. The study showed that changing drug therapy at an early stage can help patients get the full benefit of tamoxifen treatment, leading to improved breast cancer efficacy.
Researchers at Lombardi Comprehensive Cancer Center are working on a five-year $7.5 million grant to understand the role of the estrogen receptor in breast cells, aiming to develop more advanced and targeted therapies for ER+ breast cancer cases. The project involves collaborative research with Virginia Tech and Fox Chase Cancer Center.
African American patients with similar treatment settings as white counterparts show reduced mortality rates, highlighting the impact of institutional factors on cancer outcomes. The study suggests that where patients receive care may partly explain observed racial disparities.
Women with rare ATM gene mutations and radiation exposure may be at higher risk for a second breast cancer in the opposite breast. Researchers found a statistically significant increase in contralateral breast cancer among women with deleterious missense variants and radiation exposure.
Studies reveal significant health disparities among Asian Americans, Native Hawaiians, and Pacific Islanders, with culturally appropriate care shown to reduce cancer rates and heart disease. Immigrant women face high risk of death from breast cancer, while obesity and high blood pressure are major concerns for Native Hawaiians.
A content analysis found that media reports tend to focus on aggressive treatments and survival rates, neglecting discussions of death, palliative care, and adverse events. This study highlights the need for a more balanced approach in cancer news coverage.
A study found that case management in the National Breast and Cervical Cancer Early Detection Program reduced delays in diagnosis among low-income women by 45% between 1998 and 2007. Free treatment also showed no significant impact on diagnostic or treatment delays.
Researchers successfully froze breast cancer in patients who refused surgery, with no localized treatment recurrences seen for up to five years and no significant complications noted. The study used image-guided, multiprobe cryotherapy, which provided safe and effective breast conservation with minimal discomfort.
A new study found that breast cancers detected through palpable lumps, not mammography, were more common in women who didn't undergo annual screening. The researchers also found that clinical breast examination and breast self-examination played a crucial role in detecting breast cancer.
A new clinical trial at the Virginia G. Piper Cancer Center uses molecular profiling to identify specific treatments for refractory breast cancer. The trial aims to keep cancer under control for longer periods and potentially shrink tumors.
A recent study has found that breast cancer is affecting premenopausal women in Iraq, with a significant proportion presenting with advanced stage cancer. The study also highlights the importance of early detection and treatment, as only 32% of women detected a lump on self-examination sought medical advice within the first month.
Researcher Dolores Takemoto found a correlation between protein Coonexin46 and hypoxia, leading to potential treatments for retinoblastoma and breast cancer. Her study suggests that siRNA medication could prevent tumor growth by suppressing Cx46.
Postmenopausal women, especially those over 70, have a higher prevalence of cancer detected in the undiagnosed breast with MRI compared to premenopausal women. Detecting and treating both breasts at the same time may save costs and reduce patient stress.
A new study found that one in three early-stage breast cancer patients felt they didn't fully understand their genomic test result discussions, while a quarter experienced distress. The study suggests there is room for improvement in communicating cancer recurrence risks and treatment decisions with patients.
Breast cancer patients with early-stage disease and one lymph node metastasis have a low risk of recurrence without post-mastectomy radiation. Researchers found no significant difference in the 10-year risk of recurrence between women with lymph node spread and those without, highlighting the need for individualized treatment approaches.
A study of over 18,000 women aged 65 and older with breast cancer found that delaying radiation treatment after surgery increased local recurrence risk. The risk rose incrementally by day, with a 19% increase at longer intervals.
A combination of Herceptin and Tykerb significantly inhibits tumor growth in gastric cancers with HER2 amplification, providing a new treatment option for tens of thousands of patients worldwide.
A large study of nearly 6,000 Wisconsin women found that bisphosphonate drug use for more than two years was associated with a nearly 40% reduction in breast cancer risk. The protective effect was observed only among non-obese women.
A new study from Michigan Medicine found that freezing breast tumors using cryoablation kills the cancer and generates an immune response that helps stop its spread, leading to improved survival rates. The rapid freezing technique appears to be more effective than slower techniques in killing metastases and improving survival.
A new imaging technique combines ultrasound and specially modified contrast agents to detect cancer at the molecular level, allowing for early detection and potentially saving lives. The technique uses microbubbles paired with a peptide that binds to tumor vessel cells, enabling visualization of tumor activity.
Researchers have identified a new biomarker that defines a subtype of aggressive breast cancer and offers potential for targeted therapy. The biomarker, associated with poorer outcomes, can be inhibited by a protein called Mesd, which has shown promise in slowing tumor growth and reducing side effects.
Aspiration is a fast and first approach for evaluating breast lumps without cancerous features. The procedure determines the type of lesion by removing fluid with a needle, which can be done in a doctor's office on women who do not have breast implants or are not on anticoagulants.
A recent multicenter cohort study reveals that magnetic resonance imaging (MRI) is substantially more accurate for early diagnosis of breast cancer than digital mammography or breast ultrasound. For young women at elevated risk, annual MRI is considered necessary and sufficient for screening.
A large population-based study found that contralateral prophylactic mastectomy (CPM) offers a survival benefit to a select group of breast cancer patients, primarily those under 50 years old and ER-negative. The procedure was associated with a 4.8% increased survival rate at five years for these patients.
A study found that contralateral prophylactic mastectomy is associated with improved 5-year breast cancer-specific survival rates for younger women with early-stage, estrogen-receptor negative tumors. However, the benefit is small and does not apply to most women with breast cancer.
A study by Collinge & Associates found that 14-minute massage sessions by family members significantly reduced stress and anxiety scores in advanced cancer patients. The research also showed improvements in fatigue, depression, and nausea, with effects comparable to professional massage therapy.
A research team led by Dr. Velusamy Rangasamy and Dr. Ajay Rana has identified a key protein that can serve as a target for estrogen-receptor positive breast cancer treatment. This finding could lead to the development of more targeted therapies to improve chemotherapy effectiveness.
A new study suggests that annual combined screening with both mammography and breast MRI can improve life expectancy in women with increased breast cancer risk. This approach detects early-stage cancers more effectively and provides the greatest relative mortality reduction.
Researchers at Saint Louis University have found that bitter melon extract significantly induces death in breast cancer cells and decreases their growth and spread. The study, published in Cancer Research, suggests that bitter melon extract may be a promising area of research for breast cancer treatment.
POSITIVE RESULTS is a comprehensive guidebook for those at high risk of breast and ovarian cancer, providing insights into genetics, diagnosis, and treatment options. The book offers a supportive approach to navigating complex decisions, covering genetic testing, screening, mastectomy, and more.
Researchers developed a new approach to track cancer by identifying personalized biomarkers from tumor DNA, using next-generation sequencing technology. The findings show that this method can provide accurate and specific monitoring of tumors, allowing for better assessment of treatment effectiveness.
The American Lymphedema Framework Project establishes a standard of care for breast cancer survivors with lymphedema, providing evidence-based treatment guidelines. Complete decongestive physiotherapy and compression garments are found to be effective methods in reducing swelling.
A University of Melbourne study reveals a genetic link between mammographic density and breast cancer, identifying two variants associated with increased risk. The findings confirm the long-suspected connection between higher mammographic density and breast cancer.
TGen Breast and Ovarian Cancer Research Unit making significant progress in three key areas of breast cancer research: genetic events, cellular mechanics, and genomic tests. The donations raised by Safeway will help find new treatments for breast cancer patients.
Researchers developed biological probes that can stick to and light up tumors in mice, allowing for more accurate tumor removal and improved survival rates. The probes enabled surgeons to visualize areas of tumors they wouldn't ordinarily see, reducing cancer cells by 90% on average.
A recent study published in Cancer journal by HealthCore confirms disparities in breast cancer treatment between African-American and white women. White women were more likely to receive anti-estrogen therapy compared to African-American women, despite both groups having similar cancer stages. The study highlights the need for improved...
A specific protein called Dab2 has been found to trigger the process of cancer cells spreading from the original tumor and developing into new tumors. The discovery could lead to the development of drugs to delay or halt this process, which is a major step in cancer progression.
The COMICE study found that adding MRI to conventional triple assessment for breast cancer diagnosis had no impact on reoperation rates. Despite this, the study suggests that routine use of MRI in this population may not reduce health outcomes or costs, but rather increase them. The results have implications for healthcare providers an...
A Michigan State University researcher is creating a support intervention to help women in treatment for breast cancer identify effective alternative therapies. The study found that 57% of women use complementary and alternative medicines, and those who are sicker are more likely to use multiple therapies.
A three-week course of accelerated hypofractionated whole-breast irradiation has been shown to be as safe and effective as the standard five-week regimen for women with early-stage breast cancer. The study, led by Dr. Tim Whelan, found that patients treated with this accelerated therapy had a low risk of side effects and recurrence of ...
M.D. Anderson researchers discover that low-molecular-weight (LMW-E) forms of cyclin E render aromatase inhibitor letrozole ineffective in women with estrogen-receptor-positive breast cancers. A CDK2 inhibitor can reverse letrozole resistance, offering a potential treatment option for patients.
Advanced breast cancer diagnosis among black women is 30-90% higher than among white women between 1992 and 2004. The disparity in advanced colorectal cancer also widens over time. Black women are more likely to be diagnosed with aggressive, hormone-receptor-negative breast cancers that are difficult to detect and treat.
A study published in The Lancet Oncology found that hypofractionated radiotherapy schedules do not increase adverse symptoms or worsen body image compared to the international standard treatment. Patients reported moderate or striking concerns about body image, but these did not differ between radiotherapy schedules.
Researchers at Loyola University Chicago Stritch School of Medicine have identified a regulatory protein that binds to RSK, keeping its activity in check. This discovery could lead to new treatments for breast cancer, prostate cancer, and heart enlargement, as well as Carney complex.
Researchers found that prolactin reduces levels of BCL6, an oncogene linked to poorly differentiated breast cancer. Prolactin's role is mediated by Stat5a, which may lead to better diagnostic tests and new treatment options for aggressive breast cancers.
A recent study published in Journal of the American Geriatrics Society found that older married women who survived cancer had more health problems than their non-cancer counterparts. The study, which matched women for age, ethnicity, and race, revealed higher levels of fatigue, physical limitations, and depression among cancer survivors.
Researchers found that Herceptin significantly improved event-free survival in patients with HER2-positive locally advanced or inflammatory breast cancer, with a 3-year event-free survival rate of 71% compared to 56%. The treatment was well-tolerated, with only two patients experiencing symptomatic cardiac failure.
Case Western Reserve University School of Medicine has received six Department of Defense grants totaling $2.8 million to advance breast cancer research. The grants will support innovative medical research in the field of breast cancer, including studies on novel oncogenes and antitumor T-Cell responses.