Articles tagged with Breast Cancer
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Researchers have identified a new biomarker that defines a subtype of aggressive breast cancer and offers potential for targeted therapy. The biomarker, associated with poorer outcomes, can be inhibited by a protein called Mesd, which has shown promise in slowing tumor growth and reducing side effects.
Aspiration is a fast and first approach for evaluating breast lumps without cancerous features. The procedure determines the type of lesion by removing fluid with a needle, which can be done in a doctor's office on women who do not have breast implants or are not on anticoagulants.
A recent multicenter cohort study reveals that magnetic resonance imaging (MRI) is substantially more accurate for early diagnosis of breast cancer than digital mammography or breast ultrasound. For young women at elevated risk, annual MRI is considered necessary and sufficient for screening.
A large population-based study found that contralateral prophylactic mastectomy (CPM) offers a survival benefit to a select group of breast cancer patients, primarily those under 50 years old and ER-negative. The procedure was associated with a 4.8% increased survival rate at five years for these patients.
A study found that contralateral prophylactic mastectomy is associated with improved 5-year breast cancer-specific survival rates for younger women with early-stage, estrogen-receptor negative tumors. However, the benefit is small and does not apply to most women with breast cancer.
A study by Collinge & Associates found that 14-minute massage sessions by family members significantly reduced stress and anxiety scores in advanced cancer patients. The research also showed improvements in fatigue, depression, and nausea, with effects comparable to professional massage therapy.
A research team led by Dr. Velusamy Rangasamy and Dr. Ajay Rana has identified a key protein that can serve as a target for estrogen-receptor positive breast cancer treatment. This finding could lead to the development of more targeted therapies to improve chemotherapy effectiveness.
A new study suggests that annual combined screening with both mammography and breast MRI can improve life expectancy in women with increased breast cancer risk. This approach detects early-stage cancers more effectively and provides the greatest relative mortality reduction.
Researchers at Saint Louis University have found that bitter melon extract significantly induces death in breast cancer cells and decreases their growth and spread. The study, published in Cancer Research, suggests that bitter melon extract may be a promising area of research for breast cancer treatment.
POSITIVE RESULTS is a comprehensive guidebook for those at high risk of breast and ovarian cancer, providing insights into genetics, diagnosis, and treatment options. The book offers a supportive approach to navigating complex decisions, covering genetic testing, screening, mastectomy, and more.
Researchers developed a new approach to track cancer by identifying personalized biomarkers from tumor DNA, using next-generation sequencing technology. The findings show that this method can provide accurate and specific monitoring of tumors, allowing for better assessment of treatment effectiveness.
The American Lymphedema Framework Project establishes a standard of care for breast cancer survivors with lymphedema, providing evidence-based treatment guidelines. Complete decongestive physiotherapy and compression garments are found to be effective methods in reducing swelling.
A University of Melbourne study reveals a genetic link between mammographic density and breast cancer, identifying two variants associated with increased risk. The findings confirm the long-suspected connection between higher mammographic density and breast cancer.
TGen Breast and Ovarian Cancer Research Unit making significant progress in three key areas of breast cancer research: genetic events, cellular mechanics, and genomic tests. The donations raised by Safeway will help find new treatments for breast cancer patients.
Researchers developed biological probes that can stick to and light up tumors in mice, allowing for more accurate tumor removal and improved survival rates. The probes enabled surgeons to visualize areas of tumors they wouldn't ordinarily see, reducing cancer cells by 90% on average.
A recent study published in Cancer journal by HealthCore confirms disparities in breast cancer treatment between African-American and white women. White women were more likely to receive anti-estrogen therapy compared to African-American women, despite both groups having similar cancer stages. The study highlights the need for improved...
A specific protein called Dab2 has been found to trigger the process of cancer cells spreading from the original tumor and developing into new tumors. The discovery could lead to the development of drugs to delay or halt this process, which is a major step in cancer progression.
The COMICE study found that adding MRI to conventional triple assessment for breast cancer diagnosis had no impact on reoperation rates. Despite this, the study suggests that routine use of MRI in this population may not reduce health outcomes or costs, but rather increase them. The results have implications for healthcare providers an...
A Michigan State University researcher is creating a support intervention to help women in treatment for breast cancer identify effective alternative therapies. The study found that 57% of women use complementary and alternative medicines, and those who are sicker are more likely to use multiple therapies.
A three-week course of accelerated hypofractionated whole-breast irradiation has been shown to be as safe and effective as the standard five-week regimen for women with early-stage breast cancer. The study, led by Dr. Tim Whelan, found that patients treated with this accelerated therapy had a low risk of side effects and recurrence of ...
M.D. Anderson researchers discover that low-molecular-weight (LMW-E) forms of cyclin E render aromatase inhibitor letrozole ineffective in women with estrogen-receptor-positive breast cancers. A CDK2 inhibitor can reverse letrozole resistance, offering a potential treatment option for patients.
Advanced breast cancer diagnosis among black women is 30-90% higher than among white women between 1992 and 2004. The disparity in advanced colorectal cancer also widens over time. Black women are more likely to be diagnosed with aggressive, hormone-receptor-negative breast cancers that are difficult to detect and treat.
A study published in The Lancet Oncology found that hypofractionated radiotherapy schedules do not increase adverse symptoms or worsen body image compared to the international standard treatment. Patients reported moderate or striking concerns about body image, but these did not differ between radiotherapy schedules.
Researchers at Loyola University Chicago Stritch School of Medicine have identified a regulatory protein that binds to RSK, keeping its activity in check. This discovery could lead to new treatments for breast cancer, prostate cancer, and heart enlargement, as well as Carney complex.
Researchers found that prolactin reduces levels of BCL6, an oncogene linked to poorly differentiated breast cancer. Prolactin's role is mediated by Stat5a, which may lead to better diagnostic tests and new treatment options for aggressive breast cancers.
A recent study published in Journal of the American Geriatrics Society found that older married women who survived cancer had more health problems than their non-cancer counterparts. The study, which matched women for age, ethnicity, and race, revealed higher levels of fatigue, physical limitations, and depression among cancer survivors.
Researchers found that Herceptin significantly improved event-free survival in patients with HER2-positive locally advanced or inflammatory breast cancer, with a 3-year event-free survival rate of 71% compared to 56%. The treatment was well-tolerated, with only two patients experiencing symptomatic cardiac failure.
Case Western Reserve University School of Medicine has received six Department of Defense grants totaling $2.8 million to advance breast cancer research. The grants will support innovative medical research in the field of breast cancer, including studies on novel oncogenes and antitumor T-Cell responses.
Researchers from Cytori Therapeutics published a study demonstrating that cell-enriched autologous fat grafts have significantly higher quality and improved blood vessel density compared to traditional grafts. The results show a two-fold increase in long-term retention of cell-enriched grafts.
The study found that disrupting TGFβ signaling leads to the re-expression of silenced genes, reversing tumorigenic properties and putting brakes on cancer progression. This discovery may pave the way for new therapeutic strategies targeting the Smad signaling pathway.
Researchers at Dana-Farber Cancer Institute discovered a gene activity signature predicting high cancer recurrence risk in breast tumors treated with chemotherapy drugs. The study suggests that these tumors may still be vulnerable to other types of chemotherapy agents.
Researchers at University of Florida have developed a tiny new sensor that can detect glucose levels in the breath and pH levels, offering a potential solution for non-invasive diagnosis and treatment. The sensor is made from widely used technology already in cell phones and other devices, making it inexpensive to produce.
A study by researchers at Tufts University School of Medicine identifies two populations of progenitor cells that propose a new model for breast cell differentiation. One population appears to be the cell of origin for luminal-like breast cancer, which is sensitive to hormones and tends to grow more slowly.
Researchers at OU Health Sciences Center have developed a new treatment that kills large breast cancer tumors and reduces the need for mastectomies by almost 90 percent. The treatment, called Focused Microwave Thermotherapy, uses microwave technology to kill cancer cells, allowing women to save their breast tissue.
Researchers found that tumor-associated macrophages produce high levels of proteases cathepsin B and S, enhancing tumor growth and invasion. Interleukin-4 stimulation by tumors stimulates increased Cts B and S activity, providing a potential therapeutic target.
A new report investigates the cognitive biases that lead people to misidentify common objects, such as guns or tumors. The researchers suggest retraining individuals in these professions through simulated searches to improve their accuracy.
Researchers found a significant correlation between mammography center availability and breast cancer mortality rates, with lower rates in counties with more facilities. Mammography availability was linked to a decrease in breast cancer mortality rates, suggesting that increasing access to these services can lead to better outcomes.
A new 21-gene test is helping doctors and patients make informed treatment decisions by predicting whether chemotherapy is necessary for early-stage breast cancer. The test, which examines tumor gene activity, has led to changes in treatment recommendations in 31.5% of cases, with most changes favoring avoidance of chemotherapy.
Researchers block COUP-TFII to suppress tumor blood vessel growth and tumor formation. This discovery identifies a new pathway for fighting tumors and offers hope for developing new treatments, including antagonists that can intervene to halt tumor growth.
A new study from the University of Michigan Comprehensive Cancer Center found that most breast cancer surgeons' practices do not meet quality care standards. Only about one-third of surgeons reported offering patient education resources and connecting patients with peers.
Scientists at the University of Nottingham have discovered that genetic rogue elements in 'junk DNA' are more common in breast cancer cells. The elements, produced by DNA sequences called LINE-1, can sabotage normal cell function and may play a role in cancer progression.
A U-M study reveals that a specific receptor, CXCR1, triggers growth of breast cancer stem cells in response to inflammation and tissue damage. Researchers found that blocking this receptor using an existing anti-inflammatory drug repertaxin kills breast cancer stem cells and prevents metastasis in mice.
A recent study identifies CXCR1 as a crucial protein in targeting human breast cancer stem cells. Inhibiting this protein selectively depletes the cancer stem cell population, leading to reduced tumor growth and metastasis. The findings suggest that strategies targeting CXCR1 may offer a promising approach for treating breast cancer.
The new SBI and ACR recommendations suggest that breast cancer screening should begin at age 40, with annual screening recommended for average-risk patients. High-risk patients may start screening as early as age 30. The guidelines aim to reduce mortality rates from breast cancer through earlier detection.
A study published in the Journal of Oncology found that acupuncture is as effective as drug therapy in reducing hot flashes and improving energy and clarity of thought in breast cancer patients. Acupuncture also showed benefits for sex drive and overall sense of well-being, with minimal side effects.
A new study reveals that self-seeding allows circulating tumor cells to return to their primary tumor and promote local growth while increasing potential for distant metastases. The research identifies key genes responsible for this process, which may lead to targeted therapies to slow or prevent tumor progression.
Researchers characterised genomic rearrangements in 24 breast cancers, revealing diverse patterns of disruption and defective DNA repair mechanisms. These findings have significant implications for tumour classification and the development of targeted therapies.
A study found that only 51.6% of eligible women completed a screening MRI, with claustrophobia as the primary reason for nonparticipation. Alternative methods like ultrasound may be considered for high-risk women who cannot undergo MRI screening.
Research links BRCA1 gene mutations to lower ovarian response rates in women undergoing fertility preservation treatments for breast cancer. Women carrying the mutated gene are more likely to experience infertility due to decreased egg production.
Scientists have discovered a possible way to identify malignant breast tumors without invasive biopsies, using an agent called 64Cu-TP3805 that targets a specific biomarker called VPAC1. This method has the potential to significantly contribute to breast cancer management.
The Scripps Research Institute has been awarded $1.2 million to develop high-throughput screening tests that will help identify potential small molecule therapies for breast cancer and cardiovascular disease. The project aims to modulate the activity of the LRH-1 receptor, which plays a crucial role in hormone-driven breast cancer.
A new study found that DC-SCRIPT has prognostic value in breast cancer, regulating nuclear receptor activity and affecting tumor behavior. Lower DC-SCRIPT expression levels were associated with poorer outcomes in ER- and/or PR-positive tumors.
A new study by the University of Texas M. D. Anderson Cancer Center reveals racial disparities in radiation therapy rates for early stage breast cancer patients, with black women less likely to receive standard treatment. The study examined over 37,000 patients and found significant variations in radiation rates across different regions.
Using Herceptin with chemotherapy reduces the risk of cancer recurrence by 25% compared to using it after chemotherapy. This new standard of care may benefit up to 10,000 women worldwide each year.
A new hybrid agent, T-DM1, has shown promising results in a Phase 2 clinical trial for metastatic HER2-positive breast cancer. The compound shrunk tumors by 30% or more in 40% of women with confirmed HER2-positive cancers, and had a total clinical benefit rate of approximately 53%.
Researchers at M. D. Anderson Cancer Center identified an association between mucinous carcinoma and multiple undetected tumors, contrary to its long-considered favorable prognosis. The study suggests that these patients may need more treatment and additional screening.
A study presented at the CTRC-AACR San Antonio Breast Cancer Symposium found that anti-estrogen therapy for breast cancer patients reduced their risk of dying from lung cancer. The research involved 6,715 women diagnosed with breast cancer between 1980 and 2003.
A recent study found that black women with hormone receptor-positive breast cancer have worse disease-free and overall survival rates than women of other races. This disparity persists even after controlling for other factors such as medical care and comorbidities.
A new study presents a promising approach to re-sensitize breast cancer to standard therapy after it becomes resistant. The treatment combination of an aromatase inhibitor and sorafenib shows encouraging responses in 20% of post-menopausal women with metastatic breast cancer, offering a potential new treatment option.
Researchers found that combining targeted therapies lapatinib and trastuzumab significantly extends survival in HER2-positive breast cancer patients, with a median overall survival of 60.7 weeks compared to 41.4 weeks alone.