Articles tagged with Breast Cancer
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.
Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.
Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.
Practical application of scientific knowledge and engineering principles to solve real-world problems and develop innovative technologies. Encompasses all engineering disciplines, technology development, computer science, artificial intelligence, environmental sciences, agriculture, materials applications, energy systems, and industrial innovation. Bridges theoretical research with tangible solutions for infrastructure, manufacturing, computing, communications, transportation, construction, sustainable development, and emerging technologies that advance human capabilities, improve quality of life, and address societal challenges through scientific innovation and technological progress.
Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.
Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.
Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
The article discusses a new approach to breast cancer detection using microwave tomography, which is cheaper and less invasive than traditional X-ray mammography. The method uses mathematical models to reconstruct images of the breast based on electrical conductivity properties.
Two phase-2 trials demonstrate the efficacy of olaparib in treating advanced ovarian and breast cancer in patients with BRCA1 or BRCA2 mutations. The higher dose of olaparib showed better treatment response rates compared to the lower dose, with ORR of 33% and 41% respectively.
A new therapy called olaparib has shown promising results in slowing tumor growth in advanced breast cancer patients with a genetic mutation. The treatment was found to be effective in 85% of patients, with fewer side effects compared to traditional therapies.
A large-scale study involving over 7,700 participants found a positive association between DNA polymorphisms related to estrogen production and breast cancer development. The research suggests that combining multiple genetic markers can estimate breast cancer risk and may lead to the development of new prevention and treatment strategies.
Researchers found that virgin olive oil decreases oncogene p21Ras activity and stimulates tumour cell death, while also preventing DNA damage. This study provides new insights into the protective role of virgin olive oil against breast cancer.
Researchers at Ohio State University discovered how dietary supplement indole-3-carbinol (I3C) blocks cancer cell growth by destroying the Cdc25A molecule. I3C reduced tumor size by up to 65% in breast cancer models, offering potential health benefits and a new strategy for cancer treatment.
The authors propose a new paradigm for breast cancer screening, shifting focus from mammography to more effective early detection methods. Behavioral interventions appear to have limited impact on repeat screening rates, and media attention highlights the flaws of current technologies.
A new study found that nearly 49% of women with early-stage breast cancer did not complete their full hormone therapy regimen. Younger women were more likely to discontinue treatment. The study highlights the need for better understanding and interventions to reduce treatment non-compliance.
A four-year clinical trial will investigate the effects of weight loss and increased physical activity on quality of life and co-existing medical conditions in overweight breast cancer survivors. The study aims to reduce breast cancer recurrence risk and improve psychosocial problems.
African-American women have more advanced breast cancer at diagnosis and poorer survival outcomes compared to non-Hispanic whites. Despite similar surgical care and adjuvant therapy, African-Americans experience lower overall and breast cancer-specific survival rates due to socio-demographic factors.
Menopausal hormone therapy may offer significant benefits to some women, particularly those starting treatment a short time after menopause. The Endocrine Society's new statement suggests that MHT can lead to a 30-40% decrease in mortality and a 90% reduction of menopausal symptoms.
A recent study found that women taking tamoxifen for early-stage breast cancer are more likely to carry a gene mutation for clotting if they develop blood clots. The Factor V Leiden genetic mutation is associated with increased thrombosis risk in these patients.
A study published in the Journal of Advanced Nursing found that specially trained nurse practitioners detected the same breast abnormalities as consultant surgeons in 92% of cases. The research aimed to test the theory that trained nurse practitioners can perform an important role in assessing new patients with symptomatic breast cancer.
Researchers have discovered that peach and plum extracts induce the death of breast cancer cells without harming normal cells. The compounds chlorogenic and neochlorogenic were found to be responsible for this differential effect.
A study published in The Lancet Oncology found that zoledronic acid reduced the number of tumor cells in bone marrow at surgery and improved bone density in women with stage II or III breast cancer. The treatment may also help fight certain types of breast tumors directly.
Researchers at the University of Pennsylvania School of Medicine have made significant progress in treating metastatic breast cancer, using a targeted immunotherapy approach that boosts the effectiveness of a therapeutic vaccine. The treatment has shown rapid and marked loss of Tregs without toxicity, resulting in stabilization of dise...
Cancer patients can benefit from moderate-intensity aerobic exercise, tailored to individual needs, to improve quality of life, muscular strength, and reduce the risk of recurrence for breast cancer patients. Exercise also helps maintain lean body mass, contributing to increased well-being.
A large UK study found that genetic variations associated with an increased risk of breast cancer do not interact with environmental factors such as hormone replacement therapy, age at first birth, or obesity. The study's authors conclude that genetic and environmental risks for breast cancer are independent.
Research reveals genetic variations that affect estrogen levels and inflammation, leading to joint pain in breast cancer survivors on aromatase inhibitors. The study identifies personalized strategies to boost compliance and offers new treatment options for this debilitating side effect.
Women who have had a bilateral oophorectomy tend to have smaller tumors and have their tumors detected by mammography rather than physical exam. However, hormone therapy after surgery wipes out any difference in tumor size or detection method.
Researchers at Yale University found that prenatal exposure to BPA and DES can increase an offspring's risk of breast cancer. The chemicals, known as endocrine disruptors, alter gene expression in the breast throughout life, leading to a higher risk of breast cancer in adults.
Researchers found that inflammasome activation increases muscle damage in muscular dystrophy, while galectin-7 expression levels are associated with metastasis in breast cancer. These findings provide new insights into disease mechanisms and potential therapeutic targets.
A study of 2.5 million screening mammograms found improved detection of breast cancer from non-cancerous lesions over nine years, with increased recall rates and sensitivity rates. The increase in cancer detection outweighed false-positive test results, leading to a positive net effect.
A new study found that genome-wide association studies (GWA) have identified several genetic risk factors for common cancers, but their predictive power is limited by small effect sizes. The study suggests that performing GWA studies using larger sample sizes would yield more genetic loci with smaller or very small effects.
A study of over 10,000 breast cancer cases reveals the long-term prognosis for ER-negative disease subtypes is better than previously thought. The research also identifies two sub-types within triple negative tumors with differing outcomes.
A DNA-vaccine targeting DLL4 inhibits the formation of new blood vessels in tumours, leading to reduced tumour growth. The vaccine was shown to be effective in mice with breast cancer, causing a tightly packed network of non-functional blood vessels and poor blood supply.
A study in mice suggests that prenatal exposure to BPA or DES may program a fetus for life, increasing the risk of breast cancer in adulthood. Higher EZH2 levels are associated with an increased risk of breast cancer in humans, highlighting the potential need for monitoring women exposed to these chemicals.
Researchers have developed silica cages that can package anti-cancer antibodies, which significantly slow the growth of tumors and prolong the lives of mice. The treatment also reduces side effects compared to traditional intravenous drips.
A nationwide study confirms the benefit of estrogen-lowering drugs before surgery for breast cancer patients. The treatment increased the likelihood that women could undergo breast-conservation surgery instead of mastectomy. After 16-week aromatase inhibitor therapy, 82% of women had successful breast-conservation surgery.
Peregrine's PS-targeting antibody bavituximab reactivates the immune system to attack and destroy cancer cells, potentially working synergistically with multiple therapies. The company plans to initiate two new Phase II trials in refractory and front-line lung cancer patients by mid-year.
Researchers at Henry Ford Hospital found that exercise programs like ExCITE improve quality of life and reduce fatigue in breast and prostate cancer patients. The study, which followed patients for one year after treatment completion, also showed benefits in physical and psychological well-being.
Researchers found that minor adjustments to estrogen receptor alpha and p53 genes can lead to precancerous changes in breast tissue. Testing healthy women for these gene variations may help predict future breast cancer risk.
Researchers at Beth Israel Deaconess Medical Center have identified palladin as a critical regulator of cell motility and migration in breast cancer. By inhibiting these processes, palladin helps suppress breast cancer invasion and metastasis.
Researchers from Georgetown University Medical Center identify a potential new combination therapy to increase or 'rescue' sensitivity to fulvestrant in ER+ breast cancers. The study found that the cytokine IFNγ appears to increase IRF1 expression, leading to increased apoptosis of cancer cells.
Researchers found that PDE5 inhibitors increase blood-brain barrier permeability to Herceptin, boosting effectiveness against lung and breast cancer brain metastases. The combination of vardenafil plus Herceptin improved survival by 20% in mouse models.
A new study found that the number of circulating tumor cells in a patient's blood directly correlates with their survival time in metastatic breast cancer. The research suggests that monitoring these cells could improve personalized therapy for patients.
A powerful new technique for analyzing tumor cells has been developed, allowing scientists to study the biology of how tumors develop. An international team discovered molecular evidence that may explain why some women with HER2 over-expressing breast cancer do not respond to anti-HER therapies.
A recent study presented at the ARRS Annual Meeting found that whole body MRI is highly accurate in detecting breast cancer metastases. The test identified bone metastases in 47 out of 99 patients with known breast cancer, while a chest X-ray only detected them in 24 patients.
Carla Finkielstein, a Virginia Tech Assistant Professor, has received the Minority Scholar Award in Cancer Research from the American Association for Cancer Research. The award recognizes her contributions to advancing cancer research and increasing diversity in the field.
Researchers developed a simple genetic test using three genes to classify breast cancer into sub-types, highlighting the importance of molecular classification in treatment outcomes. The study's findings suggest that these models are robust and can aid clinicians in making therapeutic decisions.
Research finds that estrogen receptor status in HER2+ breast cancer is correlated with response to anti-HER therapies. Patients with ER+/HER2+ cancers may benefit more from PI3K/AKT inhibitors, while ER-/HER2+ patients may see worse outcomes with hormonal therapy alone.
A study found that sulforaphane from broccoli limits breast cancer stem cells in mice and cell cultures, preventing tumor growth. Researchers believe eliminating these cells is key to controlling cancer, suggesting a potential new treatment approach.
A new study suggests that indeterminate breast lesions found in high-risk patients should be evaluated more aggressively to exclude a possible malignancy. The research found that 22% of these lesions were proven positive for cancer on follow-up and subsequent biopsy, highlighting the need for earlier evaluation.
The Fred Hutchinson Cancer Center has been awarded $10.24 million from the NIH to investigate breast cancer disparities among Hispanic women. The research aims to understand and prevent breast cancer in this population, with a focus on improving mammography screening rates and exploring the interplay of risk factors and biology.
A new study published in the Journal of the American College of Surgeons found that more than 90% of breast cancer patients had their expectations met or exceeded with regard to dates of service. The study highlights the importance of balancing timeliness with safety, effectiveness and equity in patient satisfaction.
A study suggests that breast magnetic resonance imaging (MRI) can detect breast lesions missed on mammography and ultrasound, influencing surgical management choices. Breast MRI positively impacts patient management decisions, potentially reducing the need for re-intervention by accurately assessing tumor extent.
Researchers found that tumor-secreted exosomes increase myeloid-derived suppressor cells, inhibiting immune activation and accelerating tumor metastasis. The study identified the role of MyD88 in this process, suggesting potential strategies to develop immune-stimulating tumor vaccines.
Dr. William Muller's research reveals how a particular gene regulates epithelial cells, leading to the loss of polarity and contributing to breast tumor formation. Reintroducing the gene into tumors shows promise in restoring polarity, suggesting new avenues for cancer treatment.
A review of available breast cancer risk assessment tools reveals their limitations, particularly in assessing individual risks. The models rely heavily on known risk factors, with up to 60% of breast cancers arising without them.
A new method has been developed to predict which women with DCIS are at high risk of developing more invasive tumors. The study found that two factors - the method of detection and biomarker expression - can identify patients who are most likely to develop invasive cancer within eight years.
A new study found that breast cancer risk factors differ significantly among Hispanic and non-Hispanic white women. In Hispanic women, known breast cancer risk factors were associated with only 7-36% of cases, compared to 62-75% in non-Hispanic whites.
A new study reveals that even slight reductions in PTEN expression can significantly increase cancer susceptibility in specific tissues, implying that environmental factors like diet and carcinogens may drive tumor development. This finding has implications for the development of diagnostic tests targeted to these gene alterations.
Molecular biologist Alan Ashworth will receive a $50,000 grant from the Samuel Waxman Cancer Research Foundation to study PARP inhibitors in BRCA-mutated cancers. His research aims to develop novel treatments for triple-negative breast cancer and other related cancers.
A recent study by the Oregon Health & Science University Knight Cancer Institute found that up to 49% of physicians interpreting screening mammograms could benefit from additional training. The study identified criteria for low-performance measures, targeting ranges of accuracy and potential overuse of tests.
A recent review found that approximately 25% of breast cancers and 60% of prostate cancers detected by screening tests may not be destined to cause symptoms or death due to overdiagnosis. This phenomenon leads to unnecessary treatment and other harms, emphasizing the need for strategies to address it.
Researchers have identified a new breast and ovarian cancer susceptibility gene, RAD51C, in a German study. The gene is associated with a high risk of breast and ovarian cancer, particularly in familial cases.
Researchers from Georgetown University Medical Center are studying multiple ways to address treatment-resistant breast cancers. A third approach involves triggering vulnerable cells to respond to existing treatments, while another study focuses on targeting orphan nuclear receptors to prevent resistance.
A new WHI analysis found an association between breast density changes and increased breast cancer risk in women taking estrogen plus progestin therapy. Researchers used mammograms from over 150,000 women, including those with invasive breast cancer, to determine that a decline in mammographic density was linked to lower cancer risk.
Researchers found that women with a breast density of 75% or higher have a four-to-five-fold increased risk of breast cancer. Decreases in breast density over time may be associated with lower breast cancer risk.
Researchers found a 28% reduced risk of developing breast cancer in women whose breasts decreased in density over time. The study suggests that measures of breast density may provide additional information for assessing breast cancer risk.