Articles tagged with Breast Cancer
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A study found that Mexican-American women with breast cancer experienced an earlier onset of menopause, potentially reducing their risk due to shorter estrogen exposure. Weight gain during adulthood also reduced breast cancer risk, regardless of menopausal status.
Duke University researchers identified a possible biomarker to measure breast cancer chemoprevention trial progress, allowing for smaller trials with fewer patients. This biomarker could indicate increased risk of breast cancer and be prevented by drugs targeting specific molecular signals.
A large prospective cohort study found that smoking significantly increased the risk of breast cancer progression and overall death among multiethnic women. Current or past smokers had a 39% higher rate of dying from breast cancer.
A study found that high soy isoflavone intake was associated with a 30% decreased risk of invasive breast tumors and a 60% decreased risk of grade 1 tumors. In premenopausal women, the highest isoflavone intake reduced the risk of stage I disease, tumor size, and stage 2 breast cancer by significant margins.
A study by Roman Perez-Fernandez and colleagues found that high levels of Pit-1 expression in breast tumors with lymph node involvement are associated with tumor spread to distant sites. This discovery may help predict patient outcomes for those with lymph node-positive breast cancer.
A new study published in Cancer found that women with silicone implants after a double mastectomy reported higher satisfaction levels compared to those with saline implants. Radiation therapy and time also negatively impacted breast satisfaction in both groups.
Researchers have identified markers associated with breast cancer outcomes and found a protein linked to tumor spread. Additionally, a new therapeutic target for tumor suppression has been discovered, while gene therapy shows promise for improving wound healing in diabetic patients.
Researchers have developed an algorithm to predict breast cancer patients with little risk of disease recurrence, potentially eliminating unnecessary chemotherapy. The tool uses gene expression signatures and achieves 87-100 percent accuracy in different patient groups.
Researchers at Georgetown University Medical Center found no conclusive evidence linking joint complaints to inflammatory arthritis or autoimmune disease in women taking aromatase inhibitors. However, they suggest encouraging women to continue taking the medication despite joint pain.
Researchers at Washington University School of Medicine identified a gene linked to eye melanoma metastasis. BAP1 mutations were found in 84% of metastatic tumors but rare in non-metastatic ones. The discovery may lead to more effective treatments and insights into cancer cell evolution.
Lasofoxifene statistically reduced the overall risk of breast cancer and ER positive invasive breast cancer in postmenopausal women with low bone density. The study found a significant reduction in coronary events, strokes, vertebral fractures, and non-vertebral fractures.
A study of 503 breast cancer survivors who underwent lumpectomy and radiation found that 30% rated their post-treatment breast appearance as 'fair' or 'poor'. The study highlights the need for additional patient education about potential cosmetic complications and encourages patients to take an active role in managing their health afte...
A study by the American College of Radiology found that nearly all US community facilities performing breast MRI exams meet ACRIN and EUSOBI technical requirements. The Breast Cancer Surveillance Consortium data revealed excellent adherence to equipment recommendations, with 94% of scanners using a dedicated breast coil.
Researchers found that younger women (under 35) are more likely to have cancer invade lymph nodes, while a posterior axillary boost reduces regional recurrence rates. The study suggests patients at higher risk may benefit from additional radiation therapy under the armpit.
Women with dense breasts and no lobular involution are at a higher risk for developing breast cancer. A study of 2666 women found that mammographic breast density and extent of lobular involution are independent risk factors for breast cancer.
A team of scientists at Beth Israel Deaconess Medical Center discovered that the Rictor protein plays a key role in destroying a close cousin of the AKT oncogene, SGK1. This finding suggests that faulty regulation of Rictor may play a part in some forms of cancer and could offer new targets for treating the disease.
A recent study published in PLoS Genetics has identified genetic variants that may modify the risk of breast cancer in women with BRCA2 mutations. The research found that variants near the ZNF365 gene decreased breast cancer risk by approximately 25 percent, while other variants like FGFR2 increased risk.
A large-scale study published in BMC's Breast Cancer Research journal found no overall association between green tea intake and the risk of breast cancer. The study assessed over 54,000 Japanese women and found that drinking green tea had no protective effect against breast cancer regardless of tea type or quantity.
The Program in Women's Oncology at Women & Infants Hospital will receive a $5,000 donation from Pink Heals Rhode Island to support the Patient Advocate Program. The program helps eliminate obstacles and stresses for women battling breast cancer by arranging transportation, financial assistance, and other services.
Women who inherit BRCA1 or BRCA2 gene mutations from their father are at increased risk of breast and ovarian cancer, yet this risk is often overlooked. A study found that patients with a paternal family history of cancer were 5 times more likely to be referred for genetic testing than those with a maternal family history.
A new study published in the Journal of General Internal Medicine found that patient navigation services significantly improved biennial mammography screening rates among inner city women. The study showed a significant increase in adherence rates to 87% in those who received patient navigation, compared to 76% in the non-navigated group.
Research by the University of Missouri School of Health Professions reveals that women's environments and support systems significantly impact their quality of life after chemotherapy. Those with limited social support, including therapy, report lower quality of life and higher depression rates.
Mount Sinai researchers discovered a hormone receptor linked to several malignant tumor types, suggesting a new diagnostic or therapeutic target. The receptor's presence may be used to improve cancer detection and develop imaging agents that can visualize early tumors.
A new Women's Health Initiative report shows hormone therapy is associated with a higher incidence of invasive breast cancer and increased risk of death from breast cancer. The study found that postmenopausal women taking estrogen plus progestin had more advanced cancers with lymph node involvement, leading to poorer prognosis
Researchers found FSH receptor present in all cancer tumour samples, regardless of type or stage. The discovery highlights the potential of this receptor as a target for anti-cancer drugs and imaging procedures.
A study published in the JAMA Network found that hormone therapy use by postmenopausal women is associated with an increased incidence of invasive breast cancers, particularly those with positive lymph nodes. The study also showed a higher risk of deaths attributable to breast cancer among women who received combined hormone therapy.
A study of post-menopausal women with hormone-sensitive breast cancers found that consuming high amounts of soy isoflavones lowered the risk of recurrence. The research, published in CMAJ, involved 524 women who were followed for five to six years.
Researchers have identified a potential therapeutic target for basal-like ER-negative breast cancer. High levels of the protein NOS2 are associated with poor survival in these patients. Selective NOS2 inhibitors may offer new treatment options for this aggressive subtype.
A study found that removing 2mm around invasive breast cancer tumors reduces residual disease in 98% of patients, according to a research published in the International Journal of Clinical Practice. The study also showed that patients with non-invasive cancer have higher rates of residual disease.
A genetic test predicting early menopause risk could help UK women in their 30s plan families. Researchers identified four genes associated with early menopause and found they combined to have a larger impact on the condition.
African American women with higher vegetable intake have a lower risk of developing estrogen receptor-negative breast cancer. High cruciferous and carrot consumption may play a role in reducing breast cancer risk through their effects on estrogen metabolism and antioxidant properties.
A significant proportion of patients with advanced cancer receive common cancer screenings, despite the limited benefit. Screening rates are higher among those with a recent history of screening and in those with higher socioeconomic status and married status.
A study of postmenopausal women found that engaging in a healthy lifestyle reduces breast cancer risk for those with and without a family history. Women who adhered to regular physical activity, maintained a healthy weight, and drank less alcohol had lower rates of invasive breast cancer.
Researchers at Fox Chase Cancer Center found that the loss of protein Nedd9 initially slows cancer formation but then makes tumors more aggressive. A class of drugs already used in clinics can make these aggressive tumors more sensitive to treatment.
Regular physical activity, maintaining a healthy weight, and reducing alcohol consumption lower breast cancer risk for women with and without a family history of the disease. A study of over 85,000 postmenopausal women found that these behaviors significantly reduce breast cancer risk.
Researchers found that targeting epidermal growth factor receptor (EGFR) provides substantial clinical benefit for women with hard-to-treat triple-negative breast cancer. Adding cetuximab to chemotherapy doubled response rate and time to progression compared to chemotherapy alone.
The AACR will honor two leading breast cancer researchers, Klaus Pantel and Alan Ashworth, for their groundbreaking work on detection and treatment of breast cancer. Pantel will receive the Outstanding Investigator Award for his pioneering research on minimal residual disease, while Ashworth will deliver the Distinguished Lectureship f...
A study published in Cancer found that racial disparities in breast cancer care persist, even after accounting for patients' insurance and socioeconomic status. Black and Hispanic women are less likely to receive recommended treatments compared to white women.
The final phase-II results show that iniparib plus chemotherapy significantly improves overall survival from 7.7 to 12.3 months, offering a promising new treatment option for metastatic triple-negative breast cancer patients. Over half of patients experience clinical benefit, and there is little increase in adverse events.
A new meta-analysis shows that continuing chemotherapy after bringing cancer under control can increase survival time and reduce disease progression in metastatic breast cancer patients. The analysis found a 34% reduction in disease progression and a 9% reduction in death rates for patients who received longer chemotherapy durations.
A study of Italian women with breast cancer found that most cases were diagnosed in people over 50 and had not spread to lymph nodes. The disease was hormone-receptor positive and HER2-negative, indicating a classical endocrine-responsive type. Treatment choices were influenced by tumor stage rather than biological factors.
A study by Dr. Hatem Azim found that breastfeeding is safe for women after breast cancer treatment, contrary to common advice. Successful long-term breastfeeding was associated with type of breast surgery and post-delivery lactation counseling.
Scientists at the University of Illinois Chicago have found a gene expression mechanism that contributes to drug resistance in aggressive ER-positive breast tumors. The study reveals how estrogen and inflammatory proteins work together to drive cancer progression.
A new Montreal study suggests a link between air pollution from traffic and an increased risk of post-menopausal breast cancer. The study found that women living in areas with high levels of nitrogen dioxide, a by-product of vehicular traffic, were more likely to develop breast cancer.
A retrospective cohort study of 983 women found that non-Hispanic black and Hispanic women experienced significantly longer diagnostic delays than white women, regardless of insurance status. Diagnostic delay times ranged from 11.9 to 70.8 days, with uninsured black women facing the longest waits.
Researchers found that Puerto Rican women with triple-negative breast cancer had a higher risk of death from breast cancer, even after adjusting for age and cancer stage. Women under 50 years old with regional/distant disease were also more likely to die from their breast cancer.
A study found that Mexican women who are exposed to environmental tobacco smoke are at a higher risk of developing breast cancer, with a threefold increased risk compared to those who do not smoke. The link between passive smoking and breast cancer remained regardless of menopausal status.
Computer-aided detection (CAD) software highlighted abnormal areas on mammographic images, used in 74% of screening exams and 50% of diagnostic exams by 2008. The technology is becoming standard practice despite controversy over its efficacy.
A study published by the American Association for Cancer Research found that vigorous exercise of more than two hours per week can significantly reduce the risk of developing breast cancer in postmenopausal African-American women. Women who engaged in such exercise had a 64% reduced risk compared to those who did not.
A group-based, holistic mind-body intervention was found to be equally effective in treating persistent fatigue and improving quality of life for breast cancer survivors across different racial groups. The program combined relaxation techniques, nutrition optimization, physical activity, and cognitive behavioral therapy.
A landmark study found that annual mammography screenings for women aged 40-49 reduces breast cancer deaths by nearly 30%. The results confirm that age 50 as a screening threshold is unfounded, and women should begin getting annual mammograms at age 40.
A study by the University of Melbourne found that close relatives of women diagnosed with breast cancer before age 35 have a higher risk of developing other cancers. These include prostate, lung, brain, and urinary tract cancers, with increased risks ranging from 2 to 8 times higher than expected.
A team of researchers led by Ellen Velie aims to identify risk factors for breast cancer in young women, particularly black women younger than 50. The five-year study will investigate the impact of early life growth patterns, physical activity, diet, and body size on tumor characteristics.
Seth Field, a UC San Diego researcher, has been awarded $3.86 million to study GOLPH3's role in breast cancer. His project aims to understand the mechanism by which GOLPH3 contributes to cancer and develop new therapy targets.
Researchers at Indiana University School of Medicine found gray matter changes in breast cancer patients' brains during and after chemotherapy treatment. Memory and executive functions were most affected, with some women experiencing subtle and others severe cognitive impairments.
Researchers identified insulin-like growth factor 1 receptor (IGF-1R) overexpression in 25% of triple-negative breast cancers, correlated with gene amplification. IGF-1R blockade has been successful in sarcomas, and targeting this receptor may offer new therapeutic options for triple-negative breast cancer.
Researchers have identified a single biomarker that may predict resistance to tivozanib in patients with kidney and breast cancer. The biomarker reflects the presence of white blood cells inside tumors and is associated with clinical activity.
A new disposable device based on microfluidics can efficiently capture cancer cells overexpressing HER2, enabling therapy with trastuzumab. The device offers a non-invasive alternative to current methodologies and has shown promising results in early studies.
Researchers found that circulating tumor cells (CTCs) can provide real-time information on patient's current disease state through biomarker assessments. The technology has potential for non-invasive detection and analysis of cancer biomarkers.
A new analysis reveals that male partners of women with breast cancer are at a significantly higher risk of developing severe mood disorders requiring hospitalization. The study found a 39% increased risk of being hospitalized with an affective disorder among men whose partners had breast cancer, compared to those without.