Articles tagged with Breast Cancer
A slowly progressive weightlifting regimen cut risk of developing lymphedema by 35 percent among breast cancer survivors. Women who had five or more lymph nodes removed during surgery saw a nearly 70 percent risk reduction, according to the study published in the Journal of the American Medical Association.
A weight lifting program did not increase the risk of arm swelling in breast cancer survivors, according to a new study. The study found that women who participated in a 1-year weight lifting intervention had a lower risk of developing lymphedema compared to those who did not exercise.
Women with ductal carcinoma in situ (DCIS) who undergo radiotherapy after surgery experience a significant reduction in local cancer recurrences and invasive disease, with the effect lasting long-term. Treatment with tamoxifen also reduces recurrence rates, particularly in the opposite breast.
Researchers suggest scheduling mammograms in the first week of a woman's menstrual cycle to improve accuracy in detecting breast cancer. The study found that mammography conducted at this time was more sensitive, but not necessarily specific, for finding breast cancers in pre-menopausal women.
Dr. George W. Sledge Jr is a pioneer in developing novel therapies for breast cancer. His work has improved the lives of countless cancer patients through anti-angiogenic therapy and molecular studies.
Researchers found decreased alpha-2 integrin expression predicts tumor dissemination and lower survival rates in breast and prostate cancer. Alpha-2 integrin suppression of metastasis was confirmed using a mouse model and human microarray databases.
A review of 134 studies on breast reconstruction found inconsistent reporting and a lack of standardization in outcome assessment. The authors highlight the need for non-clinical factors such as patient-reported outcomes to be incorporated into outcome assessment.
The Cone Beam Computed Tomography (CBCT) scanner provides high-quality images without compressing the breast tissue, making it a promising supporting role to conventional mammography. Preliminary research shows that breast coverage and radiation dose are comparable to mammography.
A Spanish Oncology study has established a new standard treatment for early-stage breast cancer, reducing the risk of recurrence by 32% in women with high-risk but node-negative disease. The treatment, which combines docetaxel with cyclophosphamide, was found to improve disease-free survival and overall quality of life.
Researchers in Rhode Island, led by Johns Hopkins Medicine, reduced central-line associated bloodstream infections to near zero using the widely-heralded Johns Hopkins checklist and other patient-safety tools. The intervention prevented 42 infections, saved 10 lives, and reduced ICU stays by 608 days.
Researchers discovered TXNL2 helps protect human breast cancer cells from high levels of reactive oxygen species (ROS), which can contribute to tumor development and progression. Enhanced TXNL2 expression correlated with cancer spread and decreased survival rates in primary breast cancer samples.
A study by the Radiological Society of North America found that annual mammography between ages 40 and 50 significantly reduces mastectomy rates. The researchers analyzed data from 971 women diagnosed with breast cancer and treated at a UK hospital, concluding that yearly screening improves breast conservation outcomes.
A study suggests that women with a personal history of breast cancer should consider annual MRI screening to detect cancers earlier. The research found higher cancer yields and lower false-positive rates in this group, supporting the consideration of MRI as an adjunct to mammography.
Research suggests that most women with small HER2-positive breast cancers could benefit from trastuzumab treatment due to the favorable prognosis and low risk of recurrence. The authors recommend discussing the benefits and risks of adjuvant trastuzumab with patients.
US women who stopped hormone therapy showed significant declines in ductal carcinoma in situ (DCIS) and invasive breast cancer. The study of over 2 million mammogram screenings found a direct link between reduced hormone therapy and decreased breast cancer incidence.
Breast cancers that arise sporadically likely start with defects of DNA repair mechanisms, allowing environmentally triggered mutations to accumulate. This deficiency could set the stage for cancer development, increasing risk with age as DNA damage accumulates.
Certain types of aggressive breast cancer cells bypass tumor suppression mechanisms due to the presence of Her2 proteins. The study found that protein Lip produced by these cells deactivates protective responses such as TGF-β and OIS, allowing them to grow uncontrolledly.
Researchers at Tufts University discovered that estrogen stimulates breast cancer stem cells through a pathway mirroring normal stem cell development. By disrupting this signaling mechanism, they were able to halt the expansion of breast cancer stem cells and prevent tumor growth.
A study published in the American Journal of Roentgenology found that targeted breast ultrasound was highly accurate in detecting breast cancer in women under 30. The study's high sensitivity and negative predictive value support its use as the primary imaging technique for young women with focal breast concerns.
A new study aims to discover the genetic and molecular underpinnings of small cell carcinoma of the ovary (SCCO), a rare and aggressive cancer affecting young women. Researchers will collect tumor and blood samples using advanced genomic approaches to understand the disease's origins and develop effective treatments.
Researchers at the University of Georgia have discovered a key enzyme that regulates the early growth of breast cancer cells, which can delay tumor onset and spread by blocking GnT-V activity. The study found that eliminating this enzyme reduces breast cancer stem cells, potentially leading to new drug targets and treatment options.
Researchers have found that cough suppressant syrup can be used as a probe to predict how well individual breast cancer patients metabolize tamoxifen, leading to more effective and targeted treatment. The study's results suggest that this method could improve patient outcomes by identifying those with altered metabolism.
A study found that yearly mammogram screening in women under 50 with a family history of breast cancer can lead to smaller, less aggressive tumors and improved survival rates. The research suggests that this approach could prevent up to two deaths from breast cancer per 10,000 screens.
A new study by Radiological Society of North America suggests that routine mammography screening in women over 40 has a very low risk of radiation-induced breast cancer. The study found that annual or biennial screening would result in few cancers and fatalities, but numerous lives saved through early detection.
Researchers found that compounds disrupting EGFR signalling reduced TNBC cell growth by up to 91%. Inhibiting ADAMs may be a promising therapeutic option for TNBC and other cancers with EGFR activity.
Researchers found that using erythropoietis-stimulating drugs with Herceptin resulted in reduced effectiveness of the cancer treatment. The study suggests that these drugs may activate similar downstream pathways as trastuzumab, causing antagonism between the two treatments.
A new inhalable dry powder treatment for lung cancer has been shown to significantly increase survival rates, with over 80% of mice surviving for more than 90 days. The treatment method is also less invasive than traditional options, reducing the risk of side effects and improving overall patient outcomes.
The Seattle Cancer Consortium Breast SPORE initiative aims to improve breast cancer prevention, detection, and treatment through four scientific projects. These projects focus on developing targeted therapies for drug-resistant tumors, with the goal of providing unique treatment options that are developed from cutting-edge science.
A new risk factor for developing breast cancer has been identified as a DNA methylation modification to the BRCA1 gene, which inactivates its protective function. This epimutation is present in the blood of some women with breast cancer and appears not to be inherited.
Researchers found that women treated with aromatase inhibitors experience a wide range of side effects, including hot flashes, fatigue, and breast sensitivity. The study suggests that addressing these side effects is crucial for improving treatment adherence and patient outcomes.
The National Cancer Institute has awarded nearly $4 million to the University of New Mexico Cancer Center and Sandia National Laboratories for a five-year partnership and training center. The award aims to advance new nanotechnology discoveries and develop cancer-relevant applications in clinical practice.
A new study combines digital breast tomosynthesis and diffuse optical tomography to improve breast cancer diagnosis accuracy. The combined imaging system can distinguish between malignant and benign lesions, reducing unnecessary biopsies.
A study found that Mexican-American women with breast cancer experienced an earlier onset of menopause, potentially reducing their risk due to shorter estrogen exposure. Weight gain during adulthood also reduced breast cancer risk, regardless of menopausal status.
Duke University researchers identified a possible biomarker to measure breast cancer chemoprevention trial progress, allowing for smaller trials with fewer patients. This biomarker could indicate increased risk of breast cancer and be prevented by drugs targeting specific molecular signals.
A large prospective cohort study found that smoking significantly increased the risk of breast cancer progression and overall death among multiethnic women. Current or past smokers had a 39% higher rate of dying from breast cancer.
A study found that high soy isoflavone intake was associated with a 30% decreased risk of invasive breast tumors and a 60% decreased risk of grade 1 tumors. In premenopausal women, the highest isoflavone intake reduced the risk of stage I disease, tumor size, and stage 2 breast cancer by significant margins.
A study by Roman Perez-Fernandez and colleagues found that high levels of Pit-1 expression in breast tumors with lymph node involvement are associated with tumor spread to distant sites. This discovery may help predict patient outcomes for those with lymph node-positive breast cancer.
A new study published in Cancer found that women with silicone implants after a double mastectomy reported higher satisfaction levels compared to those with saline implants. Radiation therapy and time also negatively impacted breast satisfaction in both groups.
Researchers have identified markers associated with breast cancer outcomes and found a protein linked to tumor spread. Additionally, a new therapeutic target for tumor suppression has been discovered, while gene therapy shows promise for improving wound healing in diabetic patients.
Researchers have developed an algorithm to predict breast cancer patients with little risk of disease recurrence, potentially eliminating unnecessary chemotherapy. The tool uses gene expression signatures and achieves 87-100 percent accuracy in different patient groups.
Researchers at Georgetown University Medical Center found no conclusive evidence linking joint complaints to inflammatory arthritis or autoimmune disease in women taking aromatase inhibitors. However, they suggest encouraging women to continue taking the medication despite joint pain.
Researchers at Washington University School of Medicine identified a gene linked to eye melanoma metastasis. BAP1 mutations were found in 84% of metastatic tumors but rare in non-metastatic ones. The discovery may lead to more effective treatments and insights into cancer cell evolution.
Lasofoxifene statistically reduced the overall risk of breast cancer and ER positive invasive breast cancer in postmenopausal women with low bone density. The study found a significant reduction in coronary events, strokes, vertebral fractures, and non-vertebral fractures.
A study of 503 breast cancer survivors who underwent lumpectomy and radiation found that 30% rated their post-treatment breast appearance as 'fair' or 'poor'. The study highlights the need for additional patient education about potential cosmetic complications and encourages patients to take an active role in managing their health afte...
A study by the American College of Radiology found that nearly all US community facilities performing breast MRI exams meet ACRIN and EUSOBI technical requirements. The Breast Cancer Surveillance Consortium data revealed excellent adherence to equipment recommendations, with 94% of scanners using a dedicated breast coil.
Researchers found that younger women (under 35) are more likely to have cancer invade lymph nodes, while a posterior axillary boost reduces regional recurrence rates. The study suggests patients at higher risk may benefit from additional radiation therapy under the armpit.
Women with dense breasts and no lobular involution are at a higher risk for developing breast cancer. A study of 2666 women found that mammographic breast density and extent of lobular involution are independent risk factors for breast cancer.
A team of scientists at Beth Israel Deaconess Medical Center discovered that the Rictor protein plays a key role in destroying a close cousin of the AKT oncogene, SGK1. This finding suggests that faulty regulation of Rictor may play a part in some forms of cancer and could offer new targets for treating the disease.
A recent study published in PLoS Genetics has identified genetic variants that may modify the risk of breast cancer in women with BRCA2 mutations. The research found that variants near the ZNF365 gene decreased breast cancer risk by approximately 25 percent, while other variants like FGFR2 increased risk.
A large-scale study published in BMC's Breast Cancer Research journal found no overall association between green tea intake and the risk of breast cancer. The study assessed over 54,000 Japanese women and found that drinking green tea had no protective effect against breast cancer regardless of tea type or quantity.
The Program in Women's Oncology at Women & Infants Hospital will receive a $5,000 donation from Pink Heals Rhode Island to support the Patient Advocate Program. The program helps eliminate obstacles and stresses for women battling breast cancer by arranging transportation, financial assistance, and other services.
Women who inherit BRCA1 or BRCA2 gene mutations from their father are at increased risk of breast and ovarian cancer, yet this risk is often overlooked. A study found that patients with a paternal family history of cancer were 5 times more likely to be referred for genetic testing than those with a maternal family history.
A new study published in the Journal of General Internal Medicine found that patient navigation services significantly improved biennial mammography screening rates among inner city women. The study showed a significant increase in adherence rates to 87% in those who received patient navigation, compared to 76% in the non-navigated group.
Research by the University of Missouri School of Health Professions reveals that women's environments and support systems significantly impact their quality of life after chemotherapy. Those with limited social support, including therapy, report lower quality of life and higher depression rates.
Mount Sinai researchers discovered a hormone receptor linked to several malignant tumor types, suggesting a new diagnostic or therapeutic target. The receptor's presence may be used to improve cancer detection and develop imaging agents that can visualize early tumors.
A new Women's Health Initiative report shows hormone therapy is associated with a higher incidence of invasive breast cancer and increased risk of death from breast cancer. The study found that postmenopausal women taking estrogen plus progestin had more advanced cancers with lymph node involvement, leading to poorer prognosis
Researchers found FSH receptor present in all cancer tumour samples, regardless of type or stage. The discovery highlights the potential of this receptor as a target for anti-cancer drugs and imaging procedures.
A study published in the JAMA Network found that hormone therapy use by postmenopausal women is associated with an increased incidence of invasive breast cancers, particularly those with positive lymph nodes. The study also showed a higher risk of deaths attributable to breast cancer among women who received combined hormone therapy.
A study of post-menopausal women with hormone-sensitive breast cancers found that consuming high amounts of soy isoflavones lowered the risk of recurrence. The research, published in CMAJ, involved 524 women who were followed for five to six years.
Researchers have identified a potential therapeutic target for basal-like ER-negative breast cancer. High levels of the protein NOS2 are associated with poor survival in these patients. Selective NOS2 inhibitors may offer new treatment options for this aggressive subtype.