Articles tagged with Breast Cancer
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A study found that body fat distribution is associated with an increased risk of ER-negative breast cancer. Abdominal adiposity was more strongly linked to ER-negative breast cancer than ER-positive breast cancer, suggesting sex hormone-independent pathways may be involved.
Researchers at Kimmel Cancer Center have found that breast inflammation promotes the development and progression of breast cancer. By selectively blocking inflammation in the breast, they were able to prevent tumor formation and reduce cancer stem cells.
Researchers found that p53 mutations can allow cancer cells to acquire stem cell-like characteristics, leading to increased tumor heterogeneity and aggressiveness. The study suggests that p53 plays a critical role in preventing the emergence of more aggressive cancer cells.
A study found that higher co-payments increase the chance of early discontinuation and inadequate use of breast cancer therapy, particularly among older women. Co-payments above $90 were associated with a higher risk of discontinuation in both younger and older age groups.
Researchers identified significant effects of different treatment options on infant outcomes, including higher rates of congenital malformations in premature deliveries. The study suggests that pregnant women with breast cancer should continue their pregnancy and receive standard treatment recommendations.
A higher prescription co-payment is associated with early discontinuation and incomplete use of adjuvant aromatase inhibitor therapy in hormone-sensitive early stage breast cancer. Women over 50 years old are more likely to discontinue medication or not take it as prescribed if co-payments exceed $30.
Researchers developed a new imaging technique that uses single photon emission computed tomography (SPECT) with computerized tomography (CT) scans to pinpoint critical lymph nodes under the arm. This allows physicians to block these nodes from X-ray beams, reducing radiation and subsequent lymphedema in breast cancer patients.
Researchers found that a depression drug, duloxetine, reduced joint and muscle pain in women taking aromatase inhibitors for breast cancer treatment by at least 30%. The study suggests that duloxetine may be an effective treatment option for this type of pain, with only mild additional side effects.
HER2 test results can vary in up to 10% of patients when multiple tumor blocks are analyzed, according to Mayo Clinic researchers. This variability has significant implications for patient treatment and highlights the need for additional testing.
A new study by researchers at MD Anderson Cancer Center found that metastatic breast cancer patients with circulating tumor cells (CTCs) before or after treatment have shorter survival periods. Patients with higher percentages of epithelial cells or specific cellular transitions had higher chances for relapse. The study suggests that u...
Researchers have tested a cocktail of three drugs that targets gene regulation and cancer cell growth in triple negative breast cancers. The combination therapy halted tumor growth in laboratory-cultured cells and rejuvenated RARbeta expression in mice engrafted with breast tumor cells.
Researchers found that CTCs in blood before chemotherapy and after transplant are associated with reduced survival and faster recurrence. The study adds insights into how hematopoietic progenitor cells recruit CTCs from bone marrow, which may be responsible for cancer recurrence.
A Phase II study found that the combination of pertuzumab and trastuzumab had superior antitumor activity, eradicating 46% of tumors in patients with early HER2-positive breast cancer. The treatment also showed promise in eliminating tumors without chemotherapy in 17% of cases.
Researchers found that overexpression of HOXB7 gene leads to tamoxifen resistance by interacting with estrogen-activated genes and proteins, including HER2. Knocking out HOXB7 gene increased responsiveness to tamoxifen in breast cancer cells.
A study published by the American Association for Cancer Research found that circulating tumor cells (CTCs) in the blood of early-stage breast cancer patients are associated with an increased risk of relapse and death. The presence of CTCs is predicted to be a significant predictor for disease-free and overall survival.
Denosumab was found to delay the time to first skeletal-related event by 18% and the time to first and subsequent event by 22%, while overall survival and disease progression were similar between groups. The treatment also showed a lower rate of jaw osteonecrosis compared to zoledronic acid.
A Phase III study compared the efficacy of neoadjuvant therapy with lapatinib or trastuzumab in combination with chemotherapy for patients with early breast cancer. The study, conducted at 85 centers in Germany, included 2,500 patients and found similar results between the two treatment groups.
Researchers developed a simple fingertip test to evaluate the risk of developing carpal tunnel syndrome in postmenopausal women taking aromatase inhibitor drugs. The two-point discrimination score worsened significantly among overweight women, indicating a potential way to measure risk for CTS.
A study found that high circulating tumor cells (CTCs) are an independent prognostic marker for poor overall survival in metastatic breast cancer patients undergoing first-line chemotherapy. Persistence of high CTC levels during therapy was also an early marker of poor outcome.
Researchers investigating bevacizumab's efficacy in early breast cancer report promising results, with a higher pathological complete response rate compared to chemotherapy alone. The study, which included over 1,900 patients, will provide valuable insights into the effectiveness of bevacizumab as an adjuvant treatment.
A combination of lapatinib, trastuzumab, and paclitaxel significantly improved tumor response rates compared to single-agent treatments in patients with HER2-positive breast cancers, according to early data from the NeoALTTO Trial. The study suggests that dual blockade against HER2 is an efficient way to target HER2-positive tumors.
A study of over 12 million women found that only half received annual mammograms, with rates varying by age group. The low rate has sparked theories on reasons behind non-compliance, including discomfort and lack of available screening centers.
A retrospective study found that obese women with estrogen receptor-positive/HER2-negative breast cancer experienced significantly worse disease-free and overall survival rates compared to non-obese patients. Obesity was not associated with poorer outcomes in HER2-positive or triple-negative breast cancer subtypes.
A meta-analysis reveals that postmenopausal women with breast cancer who use aromatase inhibitors are at a higher risk of developing cardiovascular disease. The study suggests that these women should be monitored for shorter durations of treatment to minimize this risk.
Researchers found exemestane to be comparable to anastrozole in preventing recurrent breast cancer and overall survival. However, exemestane showed lower cholesterol levels and fewer reports of osteoporosis, while anastrozole had more side effects on blood tests and mood changes.
The AZURE trial, involving 3,360 patients, explores the effects of zoledronic acid on disease-free survival and secondary outcomes in Stage II/III breast cancer. The results will provide valuable insights into the benefits of combining zoledronic acid with adjuvant endocrine therapy.
Fox Chase researchers have discovered several tumor characteristics that increase the risk of brain metastases in breast cancer patients. These include high-grade tumors, negative progesterone receptor status, and inflammatory breast cancer. The study aims to identify women at risk for brain metastases, potentially leading to preventiv...
A study published at the 33rd Annual CTRC-AACR San Antonio Breast Cancer Symposium found that hormone replacement therapy (HRT) with estrogen alone can reduce breast cancer risk in certain women. The analysis of data from the Women's Health Initiative (WHI) trials showed a significantly reduced breast cancer incidence in subsets of wom...
A slowly progressive weightlifting regimen cut risk of developing lymphedema by 35 percent among breast cancer survivors. Women who had five or more lymph nodes removed during surgery saw a nearly 70 percent risk reduction, according to the study published in the Journal of the American Medical Association.
A weight lifting program did not increase the risk of arm swelling in breast cancer survivors, according to a new study. The study found that women who participated in a 1-year weight lifting intervention had a lower risk of developing lymphedema compared to those who did not exercise.
Women with ductal carcinoma in situ (DCIS) who undergo radiotherapy after surgery experience a significant reduction in local cancer recurrences and invasive disease, with the effect lasting long-term. Treatment with tamoxifen also reduces recurrence rates, particularly in the opposite breast.
Researchers suggest scheduling mammograms in the first week of a woman's menstrual cycle to improve accuracy in detecting breast cancer. The study found that mammography conducted at this time was more sensitive, but not necessarily specific, for finding breast cancers in pre-menopausal women.
Dr. George W. Sledge Jr is a pioneer in developing novel therapies for breast cancer. His work has improved the lives of countless cancer patients through anti-angiogenic therapy and molecular studies.
Researchers found decreased alpha-2 integrin expression predicts tumor dissemination and lower survival rates in breast and prostate cancer. Alpha-2 integrin suppression of metastasis was confirmed using a mouse model and human microarray databases.
A review of 134 studies on breast reconstruction found inconsistent reporting and a lack of standardization in outcome assessment. The authors highlight the need for non-clinical factors such as patient-reported outcomes to be incorporated into outcome assessment.
The Cone Beam Computed Tomography (CBCT) scanner provides high-quality images without compressing the breast tissue, making it a promising supporting role to conventional mammography. Preliminary research shows that breast coverage and radiation dose are comparable to mammography.
A Spanish Oncology study has established a new standard treatment for early-stage breast cancer, reducing the risk of recurrence by 32% in women with high-risk but node-negative disease. The treatment, which combines docetaxel with cyclophosphamide, was found to improve disease-free survival and overall quality of life.
Researchers in Rhode Island, led by Johns Hopkins Medicine, reduced central-line associated bloodstream infections to near zero using the widely-heralded Johns Hopkins checklist and other patient-safety tools. The intervention prevented 42 infections, saved 10 lives, and reduced ICU stays by 608 days.
Researchers discovered TXNL2 helps protect human breast cancer cells from high levels of reactive oxygen species (ROS), which can contribute to tumor development and progression. Enhanced TXNL2 expression correlated with cancer spread and decreased survival rates in primary breast cancer samples.
A study by the Radiological Society of North America found that annual mammography between ages 40 and 50 significantly reduces mastectomy rates. The researchers analyzed data from 971 women diagnosed with breast cancer and treated at a UK hospital, concluding that yearly screening improves breast conservation outcomes.
A study suggests that women with a personal history of breast cancer should consider annual MRI screening to detect cancers earlier. The research found higher cancer yields and lower false-positive rates in this group, supporting the consideration of MRI as an adjunct to mammography.
Research suggests that most women with small HER2-positive breast cancers could benefit from trastuzumab treatment due to the favorable prognosis and low risk of recurrence. The authors recommend discussing the benefits and risks of adjuvant trastuzumab with patients.
US women who stopped hormone therapy showed significant declines in ductal carcinoma in situ (DCIS) and invasive breast cancer. The study of over 2 million mammogram screenings found a direct link between reduced hormone therapy and decreased breast cancer incidence.
Breast cancers that arise sporadically likely start with defects of DNA repair mechanisms, allowing environmentally triggered mutations to accumulate. This deficiency could set the stage for cancer development, increasing risk with age as DNA damage accumulates.
Certain types of aggressive breast cancer cells bypass tumor suppression mechanisms due to the presence of Her2 proteins. The study found that protein Lip produced by these cells deactivates protective responses such as TGF-β and OIS, allowing them to grow uncontrolledly.
Researchers at Tufts University discovered that estrogen stimulates breast cancer stem cells through a pathway mirroring normal stem cell development. By disrupting this signaling mechanism, they were able to halt the expansion of breast cancer stem cells and prevent tumor growth.
A study published in the American Journal of Roentgenology found that targeted breast ultrasound was highly accurate in detecting breast cancer in women under 30. The study's high sensitivity and negative predictive value support its use as the primary imaging technique for young women with focal breast concerns.
A new study aims to discover the genetic and molecular underpinnings of small cell carcinoma of the ovary (SCCO), a rare and aggressive cancer affecting young women. Researchers will collect tumor and blood samples using advanced genomic approaches to understand the disease's origins and develop effective treatments.
Researchers at the University of Georgia have discovered a key enzyme that regulates the early growth of breast cancer cells, which can delay tumor onset and spread by blocking GnT-V activity. The study found that eliminating this enzyme reduces breast cancer stem cells, potentially leading to new drug targets and treatment options.
Researchers have found that cough suppressant syrup can be used as a probe to predict how well individual breast cancer patients metabolize tamoxifen, leading to more effective and targeted treatment. The study's results suggest that this method could improve patient outcomes by identifying those with altered metabolism.
A study found that yearly mammogram screening in women under 50 with a family history of breast cancer can lead to smaller, less aggressive tumors and improved survival rates. The research suggests that this approach could prevent up to two deaths from breast cancer per 10,000 screens.
A new study by Radiological Society of North America suggests that routine mammography screening in women over 40 has a very low risk of radiation-induced breast cancer. The study found that annual or biennial screening would result in few cancers and fatalities, but numerous lives saved through early detection.
Researchers found that compounds disrupting EGFR signalling reduced TNBC cell growth by up to 91%. Inhibiting ADAMs may be a promising therapeutic option for TNBC and other cancers with EGFR activity.
Researchers found that using erythropoietis-stimulating drugs with Herceptin resulted in reduced effectiveness of the cancer treatment. The study suggests that these drugs may activate similar downstream pathways as trastuzumab, causing antagonism between the two treatments.
A new inhalable dry powder treatment for lung cancer has been shown to significantly increase survival rates, with over 80% of mice surviving for more than 90 days. The treatment method is also less invasive than traditional options, reducing the risk of side effects and improving overall patient outcomes.
The Seattle Cancer Consortium Breast SPORE initiative aims to improve breast cancer prevention, detection, and treatment through four scientific projects. These projects focus on developing targeted therapies for drug-resistant tumors, with the goal of providing unique treatment options that are developed from cutting-edge science.
A new risk factor for developing breast cancer has been identified as a DNA methylation modification to the BRCA1 gene, which inactivates its protective function. This epimutation is present in the blood of some women with breast cancer and appears not to be inherited.
Researchers found that women treated with aromatase inhibitors experience a wide range of side effects, including hot flashes, fatigue, and breast sensitivity. The study suggests that addressing these side effects is crucial for improving treatment adherence and patient outcomes.
The National Cancer Institute has awarded nearly $4 million to the University of New Mexico Cancer Center and Sandia National Laboratories for a five-year partnership and training center. The award aims to advance new nanotechnology discoveries and develop cancer-relevant applications in clinical practice.
A new study combines digital breast tomosynthesis and diffuse optical tomography to improve breast cancer diagnosis accuracy. The combined imaging system can distinguish between malignant and benign lesions, reducing unnecessary biopsies.