Articles tagged with Breast Cancer
A team of University of Cincinnati researchers is sequencing individual glioblastoma genomes and tracking abnormalities in the bloodstream to establish personalized biomarkers. The study aims to guide treatment efforts and identify new therapeutic targets for this aggressive brain tumor.
Researchers found that macrophage and T-cell levels can predict recurrence and survival in breast cancer. A new therapy targeting macrophages shows promising results in preclinical studies.
A new study found that young women with breast cancer have limited knowledge about fertility issues, causing confusion and conflict when planning for a family. The researchers suggest providing targeted fertility information may reduce uncertainty and increase informed decision-making.
A UCSF research team has made a breakthrough in predicting breast cancer survival by analyzing the immune profile of tumors. By identifying specific patterns of immune cells, they were able to develop a treatment strategy that slows tumor growth and improves patient outcomes.
A recent study published in the American Association for Cancer Research found that smoking did not affect breast cancer risk among obese postmenopausal women. In contrast, non-obese women with a history of smoking had a significantly higher risk for breast cancer.
Researchers sequenced whole genomes of tumors from 50 breast cancer patients and compared them to healthy cells, finding over 1,700 unique mutations. The study highlights the complexity of cancer genomes and offers new insights into personalized medicine.
Researchers sequenced whole genomes of tumors from 50 breast cancer patients and compared them to healthy cells, finding over 1,700 unique mutations. The study identified three significant mutations that may be common in ER-positive breast cancers, offering new avenues for personalized treatment.
The American Association for Cancer Research is prioritizing clinical trials to advance cancer treatment and prevention. Researchers presented findings on basal cell cancer and lung cancer, highlighting the potential of biomarkers and hedgehog pathway inhibitors. New discoveries aim to improve patient outcomes and reduce side effects.
In developing countries, breast cancer mortality rates are high due to inadequate diagnosis, treatment, and awareness. The Lancet Oncology review highlights the need for resource-appropriate solutions to improve outcomes.
The Breast Health Global Initiative has published a landmark publication offering diverse but not insurmountable barriers to breast cancer screening and treatment in developing nations. Key findings include the need for public awareness, pathology services, and supportive care services to improve breast health care programs.
A new pilot study aims to fill the research gap for young women with Triple Negative Breast Cancer, a rare and aggressive form of breast cancer that affects mostly African-American or Hispanic women. The two-year study will survey up to 60 women recently diagnosed with this type of breast cancer.
Researchers found low Rho GDI-alpha protein levels in tamoxifen-resistant breast cancer tumors, predicting recurrence. MTA2 protein levels rose with declining Rho GDI-alpha, combining to predict tumor progression.
Researchers develop innovative strategy to target tumor metabolism, block energy production required for malignant cancer growth, delaying tumor volume and spread. The treatment combines ultrasound-guided intra-tumoral delivery of a potent drug with imaging guidance to minimize healthy tissue exposure.
A new study found that certain women with early-stage breast cancer experience excessive worrying about cancer recurrence, affecting medical care and quality of life. The research identified factors associated with high levels of worry, including younger age, employment, pain, fatigue, and radiation treatment.
A new U-M study finds that nearly half of Latinas who speak little English express a great deal of worry about breast cancer recurrence. The study highlights the need for culturally sensitive counseling to help women understand their risk and manage anxiety.
Carey Anders will receive a $181,000 grant to test the effectiveness of PARP-inhibitors and nanoparticle agents in treating triple-negative breast cancer brain metastases. The research aims to improve survival rates for women with this aggressive form of breast cancer.
A long-term study found that consuming three or more drinks a day is associated with an increased risk of pancreatic cancer death in both men and women. Heavy drinking, specifically liquor consumption, also shows a significant association with pancreatic cancer mortality, particularly among never smokers.
Researchers developed two peptide inhibitors targeting HER-2 and VEGF pathways, showing additive benefits in reducing tumor burdens with minimal side effects. The strategy aims to overcome acquired resistance and provide clinical benefit in several types of cancer.
A study published in Cancer suggests that tamoxifen can significantly reduce breast cancer risk in post-menopausal women under 55 with a high risk of developing the disease. The medication not only saves lives but also reduces medical costs, preventing 29 breast cancer cases and 9 deaths per 1,000 treated women.
A new analysis method by CSHL team suggests tumors grow through 'punctuated, clonal expansions,' providing insights into tumor growth and metastasis. By analyzing single cells from breast cancer samples, the researchers inferred three distinct subpopulations of tumor cells, each with highly similar genomic profiles.
A Northwestern University research team found that binding chemotherapy drugs to nanodiamonds significantly improves the effectiveness of cancer treatment, particularly in cases where tumors are resistant to conventional therapies. The discovery holds promise for treating aggressive cancers with fewer toxic side effects.
A novel clinical trial is exploring a new method to potentially prevent recurrence of early stage, aggressive breast cancer. The study is recruiting patients with HER-2 neu+ breast cancer and aims to identify high-risk patients who may benefit from an additional cancer-targeting drug.
Researchers have shown how laminin influences genetic information inside a cell's nucleus, while its destruction plays a detrimental role in tumor development. The study also identifies laminin-111 as the regulator of nuclear actin, a key mediator of epithelial cell quiescence.
Researchers found that upregulation of HER3 receptor limits effectiveness of targeted therapies in HER2-positive breast cancers. Targeting both HER2 and HER3 together with these agents improves clinical utility. Combination therapy also shows potential in treating other cancers.
Postmenopausal breast cancer survivors are more likely to fall than their peers, according to a new study in the Archives of Physical Medicine and Rehabilitation. The research suggests that balance disturbances caused by treatment may contribute to falls in these patients.
Using genomic analysis, researchers have discovered a key role for E2F2 gene activation in increasing the risk of breast cancer relapse. The study also found that removing this gene can significantly decrease tumor growth and improve treatment outcomes.
A recent study published in JNCI found that shift work may be associated with a reduced risk of skin cancer in women. The researchers analyzed data from the Nurses' Health Study and discovered that rotating night shifts were linked to a lower risk of skin cancer, particularly melanoma. Darker-haired women had the lowest risk.
A study published in the Journal of Consumer Affairs found that rural Appalachian women are more likely to perform breast health self-examinations and seek medical attention when their caregiving responsibilities are recognized. The research suggests that appealing to their strength as caretakers encourages them to take care of themsel...
A study published in The Lancet found that eribulin monotherapy extends the lives of breast cancer patients with extensive treatment by a median 2.5 months compared to physician's choice treatment. The drug targets microtubules, leading to cell death and improved survival rates.
Scientists have identified a potential target to treat an aggressive type of prostate cancer, known as SPINK1. A 'blocking' antibody to SPINK1 reduced tumor growth by up to 74% in mice. The study suggests that targeting SPINK1 may be effective in treating SPINK1-positive tumors.
Breast cancer is a significant global health issue, with most deaths occurring in low- and middle-income countries. A Personal View published in The Lancet Oncology suggests that population-based mammography screening is not practical or cost-effective in these countries.
A new peptide has demonstrated efficacy against triple negative breast cancer, extending average survival time by 80% compared to chemotherapy. The leptin receptor antagonist peptide targets a protein that promotes cancer development in obese individuals.
Scientists at Queen's University Belfast have developed a gene delivery system that targets and kills breast cancer cells using an innovative nanoparticle transport system. The iNOS gene forces cancer cells to produce poisonous nitric oxide, leading to cell death or increased vulnerability to chemotherapy and radiotherapy.
A long-term study confirms trastuzumab's benefit for women with early-stage HER2-positive breast cancer, showing a significant reduction in disease-free survival and no increase in mortality risk. The treatment also improves outcomes in patients who cross over to trastuzumab therapy.
A Michigan State University study is investigating the effectiveness of acupressure on persistent fatigue in breast cancer survivors. The research aims to alleviate symptoms that decrease quality of life and are associated with depression, poor sleep quality, and decreased well-being.
Scientists at the University of California, San Diego are creating a new technique for identifying critical lymph nodes in breast cancer patients. By injecting fluorescent microbubbles into the tumor and imaging them with ultrasound, doctors can pinpoint the sentinel lymph node without surgery.
Researchers have developed a new DNA microarray technology that can measure the unique genetic changes in breast cancer patients. This technology has the potential to identify new biomarkers for various types of cancer and serve as a universal cancer biomarker.
Women with a history of breast cancer have double the cancer rates as those without, according to a comprehensive study. Annual mammography screening detects second breast cancers early, but may not be as effective in detecting invasive breast cancer.
The study found that radiologists who interpreted more mammograms had clinically and statistically significantly fewer false-positive findings without missing more cancers. Increasing annual screening volume requirements could lower the number of American women with false-positive workups by over 70,000 per year.
Researchers identify thymic stromal lymphopoietin (TSLP) as a key driver of Th2 inflammation in human breast and pancreatic tumors. TSLP from cancer cells or fibroblasts fuels Th2 inflammation, promoting tumor growth.
A study published in Annals of Epidemiology analyzed breast cancer mortality data from 1975 to 2005 in Spanish provinces. The research found that geographical differences in death rates began to level out due to the uniform distribution of early prevention programs, reproductive therapy, and lifestyle factors.
Research at University of California, San Diego School of Medicine identifies regulatory T cells as primary source of RANKL protein, accelerating breast cancer spread. Interfering with RANKL interaction with cancer cells may block tumor progression, offering potential target for drug therapy.
Researchers at UT MD Anderson Cancer Center discovered that overproduction of the EZH2 protein promotes growth of breast cancer stem cells. The team also identified two drugs that block the molecular events leading to breast tumor-initiating cell formation, which drives cancer progression.
A new study found that MRI screening in women with a history of chest irradiation can detect invasive cancers missed on mammography. The addition of MRI to the screening process resulted in a 4.4% incremental cancer detection rate.
Researchers found that oestrogen can reduce the proportion of breast cancer stem cells, explaining a better prognosis for tumours expressing the oestrogen receptor. This study presents new insights into oestrogen's effect on cancer stem cells and opens doors to developing tools for preventing breast cancer.
Researchers at Cleveland Clinic's Lerner Research Institute found that combining resveratrol with rapamycin suppresses tumor growth in breast cancer cells. Resveratrol, a compound in red wine, mitigates rapamycin-induced resistance and promotes anti-tumor activity.
Researchers identify Hunk as a key protein required for HER2/neu-induced mammary tumorigenesis, potentially leading to new treatments for aggressive breast cancer. A new compound, ABT-737, sensitizes human cancer cells to apoptosis in hypoxic regions, offering a potential combination therapy for solid tumors.
A study found that protein Hunk plays a key role in the formation of HER2-driven tumors, suggesting it as a potential target for treatment. Inhibiting Hunk may provide a new approach to treating HER2-positive breast cancer.
A survey of hundreds of cancer survivors confirms that more than forty percent want medical attention for their sexual health needs. The researchers found that younger women and those who had been out of treatment for over a year were more likely to want medical care, highlighting the need for better support.
A study found that female rats given folic acid supplements before conception and during pregnancy had higher rates of breast cancer, with twice as many tumours and faster-growing tumours. The researchers stress the need for more research to determine whether this applies to humans.
A study found that removing only the first lymph node (sentinel lymph node dissection) did not impact overall survival for women with early-stage breast cancer. The use of this method resulted in fewer complications compared to more extensive axillary lymph node dissection.
Cancer rates are expected to nearly double globally by 2030 due to demographic changes and adoption of unhealthy lifestyles. Preventive measures must be widely applied to mitigate the impact.
A new study reveals that BRCA1 mutations regulate cell fate in breast tissue, leading to the formation of aggressive basal-like tumors. Cells with mutant BRCA1 exhibit elevated Slug levels and remain immature, stalled in a premature state of development.
A Princeton University research team has unraveled the mystery of how breast cancer tumors take root in the bone. The discovery highlights a specific protein called Jagged1 that sends destructive signals to cells, disrupting normal bone growth and paving the way for potential drug therapies.
Researchers found that breast cancer treatment contributes to weakened bones in middle-aged women, leading to hip fractures. Six breast cancer survivors were studied over a year, showing difficulty with daily activities despite not having osteoporosis.
Researchers at Thomas Jefferson University developed a new real-time tumor tracking technique that minimizes radiation delivery to surrounding healthy tissue by up to 50%. This approach enables radiation oncologists to administer more radiation and faster to tumors, potentially decreasing side effects.
A new study found that repeat MRI screenings for breast cancer result in fewer false-positive results, with a cancer detection rate nearly twice as high as baseline exams. This improved detection rate reassures high-risk patients about the effectiveness of annual MRI screening.
Using microbubbles and ultrasound can help determine treatment for early breast cancer patients, reducing the need for additional surgeries. The study found that microbubble contrast-enhanced ultrasound accurately identified sentinel lymph nodes in 89% of patients.
Researchers discovered that breast cancer cells release heat shock protein 27 (Hsp27), which renders immune cells unresponsive and fuels tumor growth. This finding provides a new treatment target in the fight against breast cancer.
The report finds progress in reducing cancer death rates for lung and prostate cancers among African American men. However, disparities remain, with higher mortality rates from breast, colorectal, and lung cancers in women. The study highlights the critical role of socioeconomic status in cancer disparities.