Articles tagged with Breast Cancer
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Scientists at Queen's University Belfast have developed a gene delivery system that targets and kills breast cancer cells using an innovative nanoparticle transport system. The iNOS gene forces cancer cells to produce poisonous nitric oxide, leading to cell death or increased vulnerability to chemotherapy and radiotherapy.
A long-term study confirms trastuzumab's benefit for women with early-stage HER2-positive breast cancer, showing a significant reduction in disease-free survival and no increase in mortality risk. The treatment also improves outcomes in patients who cross over to trastuzumab therapy.
A Michigan State University study is investigating the effectiveness of acupressure on persistent fatigue in breast cancer survivors. The research aims to alleviate symptoms that decrease quality of life and are associated with depression, poor sleep quality, and decreased well-being.
Scientists at the University of California, San Diego are creating a new technique for identifying critical lymph nodes in breast cancer patients. By injecting fluorescent microbubbles into the tumor and imaging them with ultrasound, doctors can pinpoint the sentinel lymph node without surgery.
Researchers have developed a new DNA microarray technology that can measure the unique genetic changes in breast cancer patients. This technology has the potential to identify new biomarkers for various types of cancer and serve as a universal cancer biomarker.
Women with a history of breast cancer have double the cancer rates as those without, according to a comprehensive study. Annual mammography screening detects second breast cancers early, but may not be as effective in detecting invasive breast cancer.
The study found that radiologists who interpreted more mammograms had clinically and statistically significantly fewer false-positive findings without missing more cancers. Increasing annual screening volume requirements could lower the number of American women with false-positive workups by over 70,000 per year.
Researchers identify thymic stromal lymphopoietin (TSLP) as a key driver of Th2 inflammation in human breast and pancreatic tumors. TSLP from cancer cells or fibroblasts fuels Th2 inflammation, promoting tumor growth.
A study published in Annals of Epidemiology analyzed breast cancer mortality data from 1975 to 2005 in Spanish provinces. The research found that geographical differences in death rates began to level out due to the uniform distribution of early prevention programs, reproductive therapy, and lifestyle factors.
Research at University of California, San Diego School of Medicine identifies regulatory T cells as primary source of RANKL protein, accelerating breast cancer spread. Interfering with RANKL interaction with cancer cells may block tumor progression, offering potential target for drug therapy.
Researchers at UT MD Anderson Cancer Center discovered that overproduction of the EZH2 protein promotes growth of breast cancer stem cells. The team also identified two drugs that block the molecular events leading to breast tumor-initiating cell formation, which drives cancer progression.
A new study found that MRI screening in women with a history of chest irradiation can detect invasive cancers missed on mammography. The addition of MRI to the screening process resulted in a 4.4% incremental cancer detection rate.
Researchers found that oestrogen can reduce the proportion of breast cancer stem cells, explaining a better prognosis for tumours expressing the oestrogen receptor. This study presents new insights into oestrogen's effect on cancer stem cells and opens doors to developing tools for preventing breast cancer.
Researchers at Cleveland Clinic's Lerner Research Institute found that combining resveratrol with rapamycin suppresses tumor growth in breast cancer cells. Resveratrol, a compound in red wine, mitigates rapamycin-induced resistance and promotes anti-tumor activity.
Researchers identify Hunk as a key protein required for HER2/neu-induced mammary tumorigenesis, potentially leading to new treatments for aggressive breast cancer. A new compound, ABT-737, sensitizes human cancer cells to apoptosis in hypoxic regions, offering a potential combination therapy for solid tumors.
A study found that protein Hunk plays a key role in the formation of HER2-driven tumors, suggesting it as a potential target for treatment. Inhibiting Hunk may provide a new approach to treating HER2-positive breast cancer.
A survey of hundreds of cancer survivors confirms that more than forty percent want medical attention for their sexual health needs. The researchers found that younger women and those who had been out of treatment for over a year were more likely to want medical care, highlighting the need for better support.
A study found that female rats given folic acid supplements before conception and during pregnancy had higher rates of breast cancer, with twice as many tumours and faster-growing tumours. The researchers stress the need for more research to determine whether this applies to humans.
A study found that removing only the first lymph node (sentinel lymph node dissection) did not impact overall survival for women with early-stage breast cancer. The use of this method resulted in fewer complications compared to more extensive axillary lymph node dissection.
Cancer rates are expected to nearly double globally by 2030 due to demographic changes and adoption of unhealthy lifestyles. Preventive measures must be widely applied to mitigate the impact.
A new study reveals that BRCA1 mutations regulate cell fate in breast tissue, leading to the formation of aggressive basal-like tumors. Cells with mutant BRCA1 exhibit elevated Slug levels and remain immature, stalled in a premature state of development.
A Princeton University research team has unraveled the mystery of how breast cancer tumors take root in the bone. The discovery highlights a specific protein called Jagged1 that sends destructive signals to cells, disrupting normal bone growth and paving the way for potential drug therapies.
Researchers found that breast cancer treatment contributes to weakened bones in middle-aged women, leading to hip fractures. Six breast cancer survivors were studied over a year, showing difficulty with daily activities despite not having osteoporosis.
Researchers at Thomas Jefferson University developed a new real-time tumor tracking technique that minimizes radiation delivery to surrounding healthy tissue by up to 50%. This approach enables radiation oncologists to administer more radiation and faster to tumors, potentially decreasing side effects.
A new study found that repeat MRI screenings for breast cancer result in fewer false-positive results, with a cancer detection rate nearly twice as high as baseline exams. This improved detection rate reassures high-risk patients about the effectiveness of annual MRI screening.
Using microbubbles and ultrasound can help determine treatment for early breast cancer patients, reducing the need for additional surgeries. The study found that microbubble contrast-enhanced ultrasound accurately identified sentinel lymph nodes in 89% of patients.
Researchers discovered that breast cancer cells release heat shock protein 27 (Hsp27), which renders immune cells unresponsive and fuels tumor growth. This finding provides a new treatment target in the fight against breast cancer.
The report finds progress in reducing cancer death rates for lung and prostate cancers among African American men. However, disparities remain, with higher mortality rates from breast, colorectal, and lung cancers in women. The study highlights the critical role of socioeconomic status in cancer disparities.
A study by Kaiser Permanente Center for Health Research found that obese women are more likely to report pain with mammograms, while women under 60 may avoid the test due to being too busy. The study also identified other barriers to breast cancer screening, including lower household income and shorter health insurance coverage.
A large cohort study found that hormone therapy started at menopause increases breast cancer risk, particularly among women who start therapy before or soon after menopause. The study's results support previous findings and provide new insights into the relationship between timing of hormone therapy and breast cancer risk.
Researchers at McGill University Health Centre solved two cold cases using genetic studies, identifying a gene responsible for rare cancer and thyroid disease. The findings provided answers for families affected by the diseases, including information on screening tests and risk for future generations.
A new study questions US Task Force recommendations for breast cancer screening, finding that starting at a younger age and screening more frequently saves more lives. The research found that women who undergo yearly mammograms between ages 40-49 have a 40% reduction in breast cancer deaths.
Researchers identified a gene signature that can accurately assess which breast cancer patients are at risk of relapse. The test has the potential to identify low-risk patients who may not require aggressive treatments, balancing risks against benefits.
A deficiency in a protein that fends off aging-related cellular damage may set the stage for estrogen and progesterone receptor-positive breast tumors to develop. Researchers have identified a link between this protein and increased levels of reactive oxygen species, providing a potential biomarker for these tumors.
Women experiencing hot flushes and menopausal symptoms may have a 50 percent lower risk of developing invasive ductal and invasive lobular carcinoma. The protective effect increases with the number and severity of symptoms.
Researchers found that N-acetylcysteine can decrease the size of von Willebrand factor multimers in mice, potentially treating life-threatening blood disorder thrombotic thrombocytopenic purpura (TTP). However, chronic use of drugs targeting Notch1 raises concerns due to its link to vascular tumors and lethal hemorrhage in mice.
A study by Elisabetta Rapiti found that women taking tamoxifen had 87% fewer lung cancer deaths than the general population. The research supports a hormonal influence on lung cancer and estrogen's role in patients' prognosis.
Researchers at Purdue University have developed a tiny slide-sized model of the female breast, dubbed 'breast on-a-chip,' to test nanomedical approaches for detecting and treating breast cancer. The model mimics the branching mammary duct system where most cancers begin.
Breast cancer patients with a strong social support system in the first year after diagnosis have a lower risk of dying or having a cancer recurrence. Emotional support was found to be the strongest predictor of cancer recurrence, reducing the risk by 43% for women with favorable interpersonal relationships.
A study by German Cancer Research Center found that hormone replacement therapy and a lack of physical activity significantly increase breast cancer risk. Behavioral changes in these areas could prevent nearly 30% of postmenopausal breast cancers.
Postmenopausal women receiving hormone replacement therapy with estrogen plus progestin are at increased risk of breast cancer due to the interaction between estrogen, progesterone, and amphiregulin. The discovery may lead to new treatment methods targeting hormone-dependent breast cancers.
Researchers at the University of Nottingham successfully reactivated tumour suppressor genes in breast cancer cells by treating them with Axolotl oocyte extract, stopping cancerous growth after 60 days. This breakthrough discovery holds promise for developing a powerful new technology platform for the treatment of various cancers.
U-M researchers found that breast cancer stem cells are regulated by mesenchymal stem cells from the bone marrow, creating a 'niche' for the cancer cells to replicate. By blocking signals from this niche, researchers hope to target and kill breast cancer stem cells using existing medications.
The TEAM study found that sequential treatment of tamoxifen followed by exemestane yields a comparable disease-free survival rate to exemestane alone, yet with distinct side effect profiles. This implies the need to tailor treatment regimens for specific patient groups.
Researchers at Ohio State University have identified a link between PI3K/AKT signaling and epigenetic silencing in breast cancer. Combining an agent that inhibits PI3K with a drug that reverses gene silencing significantly slows tumor growth, suggesting a new approach for treating the disease.
A study found that women with false-positive mammograms reported significant anxiety and reduced quality of life, particularly if they were prone to anxiety. The effects lasted at least a year, with more diagnostic procedures required for a final diagnosis.
A new ultrasound technique, elastography, can accurately predict cancer in patients with BI-RADS category 4 masses by measuring tissue softness. The study found an 79% accuracy rate in identifying cancer, suggesting that this method could reduce unnecessary breast biopsies.
The estimated total cost of cancer care in the US is expected to reach $158 billion in 2020, driven by an aging population and increasing prevalence of cancer. Breast and prostate cancers are projected to experience significant increases in costs, with breast cancer projected to be the highest-cost cancer at $20.5 billion.
A study found that preoperative Breast MRI detected occult cancer in nearly 1 in 8 patients, resulting in an added cancer yield of 12%. The use of preoperative Breast MRI is a relatively new indication for the test, with benefits seen in detecting otherwise hidden additional disease.
Nationwide Children's Hospital has been awarded a $11.5 million contract extension to continue its role as a Biospecimen Core Resource for The Cancer Genome Atlas (TCGA). This award will enable the hospital to analyze tumor specimens, extract DNA and RNA, and distribute these samples to researchers nationwide.
A new study has identified over 30 breast cancer gene targets involved in drug resistance to chemotherapy, including several novel genes. The findings may aid in the development of a more personalized approach to therapy and early screening for those who may become resistant to treatment.
Quality of life measures are most useful in breast cancer clinical trials using non-biomedical interventions. The authors recommend including QOL measures as secondary endpoints in adjuvant therapy trials for vulnerable populations or when minimal survival difference is expected.
A study published in The American Journal of Pathology found that mice fed a Western-style diet with high fat and cholesterol developed larger, faster-growing tumors and metastasized more easily. The researchers suggest that measuring blood cholesterol levels may be an effective method of screening cancer development.
Researchers discovered that the peptide angiotensin-(1-7) inhibits both the growth of human breast tumors and the growth of cancer-associated fibroblasts, reducing tumor size by 40% and fibrosis by 64-75%. This finding offers a potential new treatment option for breast cancer.
The study reveals KILLIN as a novel predisposition gene for Cowden syndrome and Cowden-like syndrome, allowing for earlier diagnosis of tumors. Individuals with classic Cowden syndrome should be offered PTEN testing first, followed by screening for the inactivated KILLIN gene.
Researchers at the University of Pennsylvania School of Medicine have identified P-Rex1 as a crucial protein in signal transmission from ErbB receptors, driving breast cancer growth and metastasis. The study suggests that targeting this pathway could improve responses to existing therapies.
Researchers identified a genetic alteration that predisposes individuals to Cowden syndrome, a rare disorder with high risks of breast, thyroid, and other cancers. The study found KILLIN as a predisposition gene, associated with increased risk of breast and kidney cancer.
Survival rates for breast, ovarian, colorectal, and lung cancer are higher in Australia, Canada, and Sweden compared to the UK and Denmark. International differences narrowed for breast cancer, but significant disparities remain in other cancers.
A new genetic biomarker indicates an increased risk for developing breast cancer is present in an individual's non-coding DNA, particularly in a repetitive microsatellite sequence. The study found that patients with more than 13 copies of this repeat have a cancer susceptibility rate three times higher than those without.
Researchers at Arizona State University have identified a broad panel of 28 early predictors, or biomarkers, that may aid in the early diagnosis of breast cancer. The biomarkers were specific to breast cancer patients and not found in healthy women or those with benign breast disease.