Articles tagged with Breast Cancer
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A new study found that despite publication of treatment guidelines, only 55% of older high-risk breast cancer patients received recommended radiation treatment after mastectomy. The lack of improvement in radiation use suggests guidelines may not be effectively improving care for breast cancer patients.
A new breast cancer risk model quantifies the impact of modifiable lifestyle factors on absolute breast cancer risk. The study predicts a 1.6% to 4.1% reduction in absolute risk among women aged 65, with higher reductions seen among those with positive family history or more non-modifiable risk factors.
Research published in BioMed Central's Breast Cancer Research journal found that two-thirds of women with breast cancer died from other causes, with cardiovascular disease being the leading cause of death. Women over 50 with co-existing health conditions were most likely to die from non-cancer related causes.
The American Cancer Society's latest report finds a steady decline in overall cancer death rates since the early 1990s, with about 898,000 deaths avoided between 1990 and 2007. However, progress has not benefited all segments of the population equally, with cancer death rates among less-educated individuals being more than twice those ...
A new roadmap has been published to understand estrogen signaling in breast cancer cells, which could lead to better treatments and therapies. The model aims to capture the molecular events controlling cell growth, proliferation, damage responses, and programmed cell death in mathematical form.
A new combination of a breast cancer chemotherapy agent and an artificial antibody has been tested in clinical trials, showing promising results in targeting colon cancer cells. The treatment, which combines lapatinib with monoclonal antibodies, has the potential to provide hope for patients with treatment-resistant cancers.
A study by Rosalia C. M. Simmen found that blueberry powder improved indicators of rat mammary gland health, including branching and biochemical markers like PTEN. The effects have not been shown in humans and may aid breast cancer research.
Research in mice reveals a link between pregnancy and tumor dissemination, with decreased NK cell activity and myeloid-derived suppressor cells contributing to metastasis. The study suggests that these immune cells may represent a shared mechanism of immune suppression during pregnancy and tumor growth.
Researchers found that Bim is required for anti-cancer therapies targeting tumor blood vessels to be effective. The discovery could lead to new treatments by attacking both the tumor and its blood supply.
A new imaging agent called 18F FPPRGD2 targets breast tumor development by detecting angiogenesis, a process that forms new blood vessels in tissues. This allows for better clinical decisions and earlier identification of patients who are ideal candidates for aggressive therapies.
Researchers from NYU Cancer Institute presented studies on the association between MC1R variants, ultraviolet light exposure, and melanoma risk. They also identified serum-based microRNAs as biomarkers for melanoma recurrence. These findings suggest that naturally occurring genetic variations in MC1R may increase an individual's predis...
A study found that gamma imaging outperformed ultrasound in detecting breast cancer, especially in women with dense breast tissue. Gamma imaging provided 100% sensitivity and 82% specificity, leading to a better prognosis for breast cancer patients.
Researchers found that myeloid-derived suppressor cells mediate immune suppression during pregnancy, allowing tumors to spread more easily. This mechanism may also be relevant to lung cancer patients with poor prognosis.
A hormone test measuring anti-Mullerian hormone (AMH) levels can predict a woman's ovarian function after chemotherapy for breast cancer. Women with low AMH levels before treatment are more likely to experience infertility due to chemotherapy-induced damage.
A Mayo Clinic study found that flaxseed does not significantly reduce hot flashes in breast cancer patients and postmenopausal women. The researchers suggest alternative uses for flaxseed, such as managing constipation.
Women with obesity before and after diagnosis have a higher risk of dying from breast cancer. Obesity is strongly linked to death due to breast cancer, particularly in estrogen receptor-positive cases.
Researchers identified phytochemicals in mushrooms that block aromatase enzyme activity, potentially reducing estrogen levels and killing hormone-dependent breast cancers. Early-stage studies show promise in preventing breast cancer recurrence and treating lung cancer.
University at Buffalo researchers and hundreds of Western New York women participated in a phase III clinical trial evaluating exemestane, which reduces breast cancer risk by 65% in postmenopausal women at increased risk. The study found no serious toxicities and minimal changes in quality of life.
A new study found that adding radiation therapy to breast-conserving surgery improves disease-free survival and reduces cancer recurrence in women with early breast cancer. The treatment significantly lowered the rate of recurrences in the breast and lymph nodes, as well as in other parts of the body.
Women with early-stage hormone receptor-sensitive breast cancer who received zoledronic acid alongside standard hormone therapy had a significantly lower risk of cancer returning (32%) compared to those on hormone therapy alone. The treatment's anticancer benefit persisted even after stopping treatment for over two years.
Researchers found that the HSPPC-96 vaccine for recurrent glioblastoma (GBM) extended median survival to 11 months, compared to the current three to five month survival rate. The vaccine showed a favorable safety profile and evoked a significant innate immune response in patients.
A large study by Mayo Clinic and NCCTG found that PTEN status has no significant impact on disease-free survival when Herceptin is added to chemotherapy. Patients with HER2-positive breast cancer did equally well regardless of PTEN activity levels.
Researchers are testing a new treatment for triple-negative breast cancer using the experimental drug entinostat, which aims to reprogram tumor cells to respond to hormone therapy. The clinical trial is evaluating the effectiveness of combining entinostat with an aromatase inhibitor in postmenopausal patients.
Researchers are conducting a clinical trial called MANTICORE to detect and treat cardiovascular disease in breast cancer patients before treatment begins. The study aims to use special blood tests and imaging scans to identify potential cardiac risk factors.
Researchers found that increasing CRP levels resulted in increasingly poor prognosis, with a five-year survival rate decreasing from 90% to 74% and deaths from breast cancer increasing from 11% to 20%. Elevated CRP at diagnosis remained predictive of overall survival rates even after excluding patients with suspected bacterial infections.
Researchers identified a key role for hedgehog in breast cancer cellular cross-talk, finding that silencing the molecule slows tumour growth and spread. The discovery applies to all breast cancers, particularly basal breast cancer, which has no current targeted therapy.
Researchers found that women with estrogen receptor negative cancers who did not receive radiation were 91% more likely to die from breast cancer. There is a corresponding increase in the use of radioactive implants for these patients.
New research finds that women with BRCA1/2 mutations who undergo prophylactic oophorectomy and take short-term HRT have a decreased risk of developing breast cancer. However, the procedure also increases the risk of early menopause and related quality-of-life issues.
Researchers identified PKC-delta as a critical regulator of cisplatin-mediated kidney toxicity, and inhibiting it protected the kidneys without blocking chemotherapy efficacy in mouse models. Additionally, studies divided breast cancers into subtypes to identify effective therapies for triple-negative breast cancer patients.
Researchers at Dana-Farber Cancer Institute have identified an overactive network of growth-spurring genes that drive stem-like breast cancer cells enriched in triple-negative breast tumors. The Jak2/Stat3 pathway was found to be elevated in these cells, and a drug specifically aimed at blocking this pathway halted tumor growth in mice.
A recent study by Oregon State University researchers found that breast cancer survivors used online forums to share their personal experiences and challenge scientific authority. The women's reactions were intensified by their online connection to others who shared similar experiences, leading to a shift in the balance of power betwee...
A protein activated by diabetes drugs may slow cancer spread in breast tumors, and removing it increases cancer risk. Women exposed to environmental pollutants or poor diets are more likely to develop aggressive breast cancers.
Researchers found that cancer cells induce oxidative stress in normal connective tissue to extract vital nutrients, accelerating aging and inflammation. This process can identify breast cancer patients at risk of metastasis and offers a potential therapeutic target via antioxidant and anti-inflammatory drugs.
A UNC laboratory study shows that Tacrolimus, a commonly used organ transplant rejection medication, inhibits breast cancer growth by over 70 percent in pre-clinical studies. The drug works by blocking new blood vessel growth to tumors, a therapeutic strategy to inhibit tumor growth.
A new study suggests that lipofilling is a safe procedure for women with breast cancer, with no significant difference in local recurrence rates between the treatment group and controls. However, longer follow-up and more research are needed to confirm these findings.
Researchers have discovered a link between a variant of the fat mass and obesity associated gene (FTO) and an increased incidence of breast cancer. The study, published in BMC Medical Genetics, found that people with this genetic variant have a 30% higher chance of developing breast cancer.
Scientists have discovered a protein involved in drug resistance in breast cancer, which could be targeted for new treatments. Blocking the production of this protein in human cells made them more responsive to anti-oestrogen drugs.
Research suggests that doctors should tailor treatment to specific qualities of second tumor, regardless of whether it's old or new. Studies found that 89% of recurring tumors differed in at least one characteristic compared to the original tumor.
Researchers at Thomas Jefferson University discovered a biomarker Stat5 in breast cancer that predicts patient response to anti-estrogen therapy tamoxifen. Women with active Stat5 have an increased likelihood of responding to the treatment, while those without it are at a higher risk of dying from breast cancer.
Researchers have discovered a new mechanism of action for Herceptin, revealing its ability to stimulate interferons and activate lymphocytes. Combining Herceptin with lymphocyte-stimulating therapies greatly increases efficacy in animals, paving the way for targeted therapies.
Researchers at VCU Massey Cancer Center have found a new biomarker related to the immune system that can predict breast cancer recurrence. The five-gene signature shows over 85% accuracy in predicting relapse-free survival.
Researchers discovered that breast cancer cells can thrive under starvation conditions by using fatty acids as an alternative energy source. The protein CPT1C plays a key role in this adaptation, and its expression is increased under conditions of metabolic stress.
Researchers discovered a new way breast cancer cells adapt to starvation conditions by turning to fatty acids for energy. This adaptation highlights the resilience of cancer cells and could lead to targeted therapies that block their ability to survive.
A recent study published in Breast Cancer Research found that coffee consumption is associated with a lower incidence of ER-negative breast cancer. The research, which adjusted for other lifestyle factors, suggests that moderate coffee consumption may offer protective effects against this type of breast cancer.
A new genomic test has shown promise as a predictor of chemotherapy response and survival benefit in women with invasive breast cancer. The test combines multiple signatures, including estrogen receptor status, endocrine therapy response, chemotherapy resistance and sensitivity, to predict treatment outcomes.
A new predictive test developed from gene expression microarrays identified patients with a high probability of survival following chemotherapy for breast cancer. The test had a positive predictive value of 56 percent and showed significant association between predicted sensitivity to treatment and improved distant relapse-free survival.
Researchers found that apigenin in parsley and celery can delay and reduce breast cancer tumor formation by blocking blood vessel growth. The study suggests incorporating these plant-based compounds into daily diets may help prevent breast cancer progression in women taking hormone replacement therapies.
Researchers found that estrogen-lowering drugs can shrink tumors and reduce mastectomy rates for patients with stage 2 or 3 breast cancer. Aromatase inhibitors, which block the production of estrogen, were shown to be effective in reducing tumor size and improving surgical outcomes.
Chronic diseases are a major concern in Brazil, driven by increasing prevalence of risk factors such as obesity, hypertension, and diabetes. The country has made significant progress in combating non-communicable diseases (NCDs), with age-standardised mortality rates declining by 1.8% per year since 1996.
French researchers have reported the strongest proof yet that circulating tumor cells found in patient blood are linked to poor outcomes. The study suggests using a threshold of 1 CTC for defining high-risk patients, supporting its use in non-metastatic breast cancer patients.
Researchers at UNC Chapel Hill School of Medicine isolated normal stem cells with aggressive breast cancer properties and identified a genetic intersection that contributes to metastasis. The study suggests a new target for treating triple negative breast cancer.
Researchers used Foerster resonance energy transfer (FRET) imaging to measure protein interactions on breast cancer cells, revealing a 'signature' representing functional molecular biology. This signature may help predict patient outcome in terms of likelihood of recurrence and response to treatment like lapatinib.
Researchers have identified sFRP1 as a molecular marker that correlates with chemotherapy sensitivity in triple-negative breast cancers. The study found that sFRP1 expression levels in individual tumors predict response to chemotherapy, and knocking down the gene in cell culture decreased sensitivity to certain chemotherapies.
Researchers found that celecoxib induced an anti-tumor response at the molecular level, affecting genes involved in cell proliferation, apoptosis, and extracellular matrix biology. The study suggests that celecoxib may be efficient as a cancer treatment for people with primary invasive breast cancer.
Two widely used multi-gene tests produce broadly similar results for high- and low-risk breast cancer patients, but differ for those at intermediate risk. The study's findings suggest that these tests can provide additional independent prognostic information to help clinicians make informed treatment decisions.
A new study finds that breast shields can significantly reduce skin entrance radiation dose to the breast by up to 38% without increasing overall radiation dose. This technique is considered the best method for protecting women from radiation exposure during chest CT examinations.
Two new studies show a significant drop in mammograms performed in women aged 40-49, leading to decreased benefits of early detection. Researchers found that cancers detected earlier through screening mammography presented at an earlier stage than those not screened, resulting in lower survival rates if guidelines are followed.
A new study found that annual mammograms are as effective as interval post-treatment mammograms in detecting breast cancer recurrences. The research suggests eliminating the interval mammogram would save healthcare costs without negatively impacting patient outcomes, decreasing unnecessary biopsies and stress.
A study found that Medicare reimbursement policy significantly affects the use of costly breast cancer therapy, including intensity-modulated radiation therapy (IMRT). The analysis showed a sharp increase in IMRT usage and costs between 2001 and 2005, with billing rates varying by region and treatment setting.
Scientists have developed a new imaging agent using tantalum oxide nanoparticles, which stays in the body long enough to image multiple organs. The material is inexpensive and has shown promising results in laboratory tests, potentially overcoming limitations of existing imaging agents.