Articles tagged with Breast Cancer
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Post-menopausal women with high hormone levels, including estrogen and testosterone, have a higher risk of breast cancer. Researchers found that each additional elevated hormone level increases risk by 16%. The study suggests that models assessing breast cancer risk could be improved by considering multiple hormone levels.
Andrew J. Dannenberg, M.D., is recognized for his seminal contributions to understanding the inflammation-cancer connection and developing strategies to prevent breast cancer. His work has provided key insights into the role of prostaglandin biology in cancer prevention.
Researchers discovered a complex cell mechanism that makes breast cancer cells resistant to radiation treatment. The mechanism is activated by the protein HOXB9, which accelerates DNA repair and increases radiation resistance.
A large study of over 10,000 breast cancer patients found that radiotherapy significantly reduces the risk of cancer recurrence and mortality. The study found that radiotherapy almost halves the 10-year-risk of recurrence and reduces the 15-year-risk of mortality by a sixth
A Michigan State University researcher is working on a $450,000 grant to better understand breast cancer's genetic complexity and heterogeneity. The study aims to create more accurate models to study human cases, potentially leading to tailored therapies and improved patient outcomes.
A recent study published in Nutrición Hospitalaria found that obese women, particularly those with morbid obesity, develop breast cancer at a significantly earlier age. The researchers discovered that the age at first menstruation is a key factor in determining the development and diagnosis of breast cancer.
Researchers studied mammography registries to compare cumulative probability of false-positive results after 10 years of annual or biennial screening. Biennial screening reduced false-positive recalls by one-third, but associated with a small increase in late-stage cancer diagnosis. Digital mammography was found to be equally effective...
A new study identifies SIRT2 as a key tumor suppressor linked to gender-specific tumor development in mice. The research suggests the existence of a rare family of tumor suppressors, and its findings have implications for understanding the biological processes underlying cancer and aging.
Researchers discovered a gene has opposite effects in prostate and breast cancers, promoting growth when 'on' or 'off'. This finding suggests treating prostate and breast cancers requires distinct strategies, with blocking AR effective for prostate cancer but supporting AR production for breast cancer.
A new study found that over half of cancer-free women will experience false-positive results from annual mammograms, leading to unnecessary testing and anxiety. Shifting screening to every other year can lower the risk by a third.
A recent study identified a protein called estrogen-related receptor alpha (ERRα) that fuels the growth of aggressive breast tumors. Researchers found that targeting this protein with an experimental drug can inhibit tumor growth in cellular models, offering a potential new approach for treating estrogen-receptor negative cancers.
NextBio's web-based tools aid in assessing potential drug efficacy and adverse effects by analyzing publicly available genomic data, identifying correlations with gene expression changes and cancer profiles.
Post-menopausal women experiencing new onset breast tenderness after starting combination hormone therapy may have an increased risk of breast cancer compared to those without breast tenderness. Higher breast density is associated with a higher risk of breast cancer, with extremely dense breasts posing a four to six times higher risk.
A study published in the Journal of the American College of Surgeons found that Hispanic women are more likely to develop phyllodes tumors, a rare and unpredictable breast malignancy. The study also revealed higher-grade tumors in Hispanic patients and larger tumor sizes compared to other racial groups.
A new study has found that zoledronic acid can prevent and treat bone loss in postmenopausal breast cancer patients taking aromatase inhibitors. The five-year study showed significant increases in bone density when the drug was administered upfront, but also found that initiating treatment even after bone loss developed was beneficial.
Researchers developed a mouse model to track bone marrow cell migration to tumors and found that these cells can slow tumor growth. The study suggests that targeting bone marrow cells may lead to more effective cancer treatments.
A Rutgers-affiliated company has received a $207,000 grant from the National Institutes of Health to develop a technology that analyzes tissue from breast cancer biopsies to predict how aggressive the disease is likely to be. This technology could help physicians and patients plan effective therapies with minimal side effects.
A study published in Journal of Interferon & Cytokine Research found that Tyk2 protein helps suppress breast tumor growth and metastasis. Mice with normal Tyk2 expression were less susceptible to breast cancer, suggesting boosting Tyk2 activity may be beneficial for treating the disease.
People with disabilities continue to face difficulties meeting major social needs, including accessing health care facilities and services. Iezzoni's analysis highlights barriers that restrict their access to health services, including lower rates of mammography and Pap tests. She argues that healthcare professionals need to understand...
A study by UCLA's Jonsson Comprehensive Cancer Center found that a combination of chemotherapy and Herceptin significantly increases survival in patients with HER-2 positive breast cancer. The regimen without Adriamycin was comparable to the standard therapy, reducing heart toxicity and acute side effects.
Perinatal exposure to BPA may alter long-term hormone response and increase predisposition to breast cancer. Researchers found that BPA-exposed female mice had an increased response to progesterone and a higher cell number in their milk ducts.
The American Cancer Society reports a decline in breast cancer death rates among women in affluent areas, shifting the burden to poor women who have lower screening rates. The study highlights disparities in access to prevention and treatment services.
Researchers found that free radical peroxynitrite is produced by myeloid cells in tumors and interferes with the immune system's ability to kill cancer cells. This mechanism may explain why some cancer immunotherapies fail to work, allowing tumors to evade immune detection.
Researchers discovered that resveratrol blocks the growth of breast cancer cells by reducing estrogen receptor levels. This finding has significant implications for treating women with breast cancer whose tumors develop resistance to hormonal therapy. Resveratrol may serve as a potential tool to combat hormone-resistant breast cancer.
Dr. Giuliano was awarded the Brinker Award for Scientific Distinction for his pioneering findings on lymph node removal and his contributions to less invasive breast surgery. His research has led to improved quality of life for women with breast cancer and reduced side effects from breast surgery.
According to a recent poll, nearly 9-in-10 women reported that having regular mammograms gave them control over their own healthcare. The poll also showed that 90% of women considered mammograms important to their health and well-being.
Researchers at Karolinska Institutet have found that treating common Cytomegalovirus (CMV) can reduce tumour growth and size. CMV is found in 70-75% of adults and plays a central role in brain tumours, breast cancer, colon cancer, and prostate cancer.
Researchers at Wake Forest Baptist Medical Center have identified 16 genes involved in iron metabolism that provide better prognostic information than conventional markers. These genes, known as the Iron Regulatory Gene Signature, convey valuable information about breast cancer outcomes.
A new trial suggests that zoledronic acid may extend survival in postmenopausal breast cancer patients by boosting disease-free survival rates. However, the drug's effects on younger women are less clear-cut, with some studies indicating a possible adverse impact on recurrence rates outside bone.
A University of Melbourne study found that women with a strong family history of breast cancer but no genetic link are not consistently utilizing breast cancer services. They often struggle to interpret their risk and manage it effectively, leading to inadequate access to screenings and interventions.
A significant benefit of zoledronic acid was found for post-menopausal women with stage II/III breast cancer, with an overall survival rate of 85%. The drug may alter the balance of substances in the bone marrow micro-environment, potentially preventing cancer cells from spreading.
A 12-year update of the Breast International Group 1-98 trial shows that letrozole reduces the risk of breast cancer relapse by 18% and death by 21% compared to tamoxifen after surgery. The study provides long-term reassurance on the efficacy of aromatase inhibitors in preventing breast cancer recurrence.
A phase III clinical trial has shown that combining everolimus and exemestane significantly improves progression-free survival for women with advanced breast cancer resistant to hormonal therapy. The combination treatment resulted in an improved survival of nearly seven months compared to women treated with only exemestane.
Research reveals breast cancer tumors alter hormonal status and marker stability during relapse, impacting treatment decisions. Regular biopsies may be crucial in ensuring correct treatment and detecting other cancers or benign lesions.
A Phase II study showed that trastuzumab emtansine (T-DM1) significantly delayed breast cancer progression, improving patients' lives with fewer side effects. The treatment improved time to disease worsening by 41% compared to standard docetaxel chemotherapy plus trastuzumab.
A major UK trial found that giving radiotherapy between or during chemotherapy cycles significantly reduces the risk of breast cancer recurring in the breast or chest wall. The treatment, known as synchronous chemoradiation, has minimal adverse side-effects and no detrimental effect on quality of life.
A multi-institute team led by TGen will study triple-negative breast cancer, a highly aggressive form of the disease that disproportionately affects African-Americans. The research aims to uncover new ways of treating this aggressive form of breast cancer by understanding molecular makeup of breast cancer stem cells.
A study found that elderly breast cancer patients are more likely to die from age-related conditions rather than the disease itself, highlighting shortcomings in patient care. Researchers argue that these patients are being under-treated due to a false perception of their prognosis.
Researchers found that Adeno-associated virus type 2 (AAV2) targets all different grades of breast cancer by activating death pathways. The virus causes 100% of cancer cell destruction within seven days, with majority of cell death proteins activated on the fifth day.
Breast cancer researchers identify FGFR3 as a key protein responsible for tumor growth and resistance to hormone therapies. This discovery may lead to the development of novel drugs targeting this protein to treat recurrent breast cancers.
Researchers discovered that precancerous cells in high-risk African-American women consume high amounts of glucose and have activated insulin signaling pathways. Conditions like obesity and gestational diabetes can stimulate these cells, but exercise, weight loss, and metformin may help prevent aggressive breast cancer.
A study found that MRI screenings detected more breast cancer cases than mammography in high-risk, underserved women. The use of MRI also increased patient compliance with follow-up care. Lowering the cost of MRI may make this screening method more accessible to underinsured populations.
Three European medical oncologists, Johann de Bono, Rafael Rosell, and Hans Jörg Senn, have been recognized by ESMO for their groundbreaking work in prostate cancer management, lung cancer treatment, and breast cancer care. The awards celebrate their commitment to improving cancer research and clinical practice.
Researchers have identified a neurotransmitter released in response to stress that stimulates the growth and migration of breast cancer cells. The study found that this neurotransmitter, norepinephrine, and its receptor NPY play a key role in the progression of breast cancer.
Research reveals a strong association between stress and tumor aggressiveness in black and Hispanic breast cancer patients, compared to white patients. The study found that higher levels of psychosocial stress were linked to more aggressive tumors, suggesting potential impact on treatment outcomes.
Black women are more likely to develop a second breast cancer, even if they were not previously diagnosed with the disease. The average age for this development is significantly lower in black women compared to white women.
Researchers discovered that genes interact with each other in complex pathways, which can help breast cancer progress. Targeting multiple pathways may lead to more effective combination therapies against the disease. A diuretic used to treat hypertension also showed promise in stopping cancer cell progression.
A Spanish research establishes factors associated with tiredness in cancer survivors to improve their quality of life and rehabilitation. More than 66% of breast cancer survivors suffer from fatigue following recovery, caused directly by the disease, physical deterioration or treatment received.
A protein discovered by Dr. Suresh Alahari's laboratory can inhibit breast cancer cell growth and reduce tumor progression. The research found that Nischarin, a novel protein regulating breast cancer cell migration, acts as a tumor suppressor in breast cancer.
The study estimates 1.6 million new breast cancer cases and 425,000 new cervical cancer cases worldwide in 2010. Most cases occurred in developing countries, with a significant increase in women of reproductive age diagnosed with the diseases.
Breast and cervical cancer cases are rising globally, with more women dying at younger ages in developing countries. The study reveals stark differences in trends between high- and low-income countries, highlighting the need for increased cancer screening and treatment programs in poor nations.
Researchers at Helmholtz Association find that phytoestrogens, particularly lignans and their metabolite enterolactone, may help reduce breast cancer mortality. Enterolactone levels are linked to clinical disease progression and mortality risk, with higher levels associated with lower risk.
A study published in Food and Chemical Toxicology found that a soy-based natural S-equol supplement did not increase the risk of estrogen-sensitive breast cancer. The supplement, SE5-OH containing Natural S-equol, was previously shown to reduce menopause symptoms in postmenopausal women.
A web-based tool called WISE has been developed to help breast cancer survivors manage their symptoms and improve employment outcomes. The tool provides customized information and decision support tools to identify ergonomic workplace problems and implement changes.
Researchers developed a gene therapy that targets breast cancer stem cells, eliminating them and increasing chemotherapy effectiveness. The therapy, VISA-claudin4-BikDD, was shown to reduce tumor volume by 75% and extend survival in mice.
A new analysis found that women who inherit BRCA gene mutations develop breast and ovarian cancers at significantly younger ages than their female relatives in the previous generation. The study suggests that early age of diagnosis is crucial for providing effective counseling, screening, and treatment services.
A new study estimates that 27.6% of people will develop COPD by age 35, making it a significant public health concern. The risk is higher in men and those with lower socioeconomic status, emphasizing the need for increased awareness and funding to combat this chronic disease.
Researchers used computer-aided design to create accurate moulds and patient-specific physical scaffolds for breast tissue reconstruction. This technology holds promise for reducing scars, blood loss, and anaesthesia time, while improving surgical outcomes.
The Translational Genomics Research Institute (TGen) has been awarded $50,000 by the Inflammatory Breast Cancer Research Foundation to discover the genetic origins of Inflammatory Breast Cancer (IBC), a rare and aggressive form of breast cancer that rapidly progresses without warning.
A University of Maryland study found that young women with early-stage breast cancer who undergo lumpectomy and radiation have similar survival rates as those who undergo mastectomy. The analysis of nearly 15,000 patients showed no difference in overall or breast cancer-specific survival between the two groups.