Articles tagged with Breast Cancer
The Robert Wood Johnson Foundation announced the winners of its 2011 Community Health Leaders Award, recognizing 10 individuals who are improving the health and quality of life for disadvantaged communities. The recipients include Jamie Boyd, Naomi Cottoms, Lisanne Finston, Zane Gates, and others, who have overcome daunting odds to pro...
Researchers have discovered that connexin 36 protects mouse pancreatic beta-cells against immune molecules prevalent in type 1 diabetes. Additionally, a study found that PTHrP drives breast tumor initiation, progression, and metastasis in mice, suggesting it as a potential therapy target.
A review article reveals historically low breast reconstruction rates in Canada, with only 7.7% of Ontario patients undergoing the procedure in 1994/95. Factors such as age, socioeconomic status, and geography influence the use of breast reconstruction, with women living in urban areas more likely to undergo the procedure.
A review of 1,181 women from five countries found that many struggled with returning to work due to unrealistic expectations, lack of support, and physical appearance judgments. Employers must educate themselves and provide better support and policies to tackle the culture of ignorance.
A new study found that older women with breast cancer are not experiencing the same improvements in treatment and detection as younger women. The study, published in the Journal of Clinical Oncology, reveals a discrepancy between age groups when it comes to breast cancer outcomes.
Researchers discovered measles virus exits host via nectin-4, a biomarker for certain types of cancer. This finding opens up promising new approaches for targeted cancer therapy.
A new MU study reveals that depression affects breast cancer survivors, with single women and mothers experiencing higher rates of distress. The research also shows that depressed patients are less likely to adhere to medication regimens, potentially complicating treatment outcomes.
A large prospective cohort study found that low levels of alcohol consumption are associated with a small increase in breast cancer risk, and this association persists even after controlling for drinking patterns and age. Women who consumed at least 30 grams of alcohol daily had a significantly higher risk of breast cancer.
Researchers found that high levels of heat shock factor 1 (HSF1) in ER-positive breast cancer tissue are associated with poorer outcomes, including increased mortality. Elevated HSF1 levels also correlate with larger and more aggressive tumors.
A new international study found that women without genetic mutations but closely related to those who do have them are at an average risk of developing breast cancer. This contradicts previous claims that all women in such families share a high risk, according to Professor John Hopper from the University of Melbourne.
A population-based analysis found that close relatives of women with breast cancer who don't carry the BRCA mutation have a similar risk to the general population. The study suggests they may not need extra cancer screening and preventive measures.
A team of scientists at Tufts University is developing ultra-sensitive techniques to detect breast cancer earlier and treat it with greater precision. They aim to create a simple blood test for screening and diagnose the disease more accurately.
Researchers found that women related to a patient with a hereditary breast cancer mutation but without the mutation themselves have no increased risk. The study settles a controversy and supports current practice guidelines advising non-carriers on no additional risk attributable to their family-specific BRCA1 or BRCA2 mutation.
New research uses tumor-targeted magnetic nanoprobes and SQUID sensors to detect breast cancer, outperforming mammography in sensitivity and accuracy. This technology holds promise for refining treatment plans and improving patient survival by classifying tumors based on protein expression.
Researchers have identified a new potential cancer drug targeting EPHA7, a tumor suppressor protein associated with follicular lymphoma. The discovery demonstrates the power of functional genomics in translating genetic insights into therapies.
A new study by Georgetown researchers found that nipple sparing mastectomy is a safe and effective option for women with breast cancer. The procedure, which removes breast tissue while keeping the skin and nipple intact, showed no signs of cancer recurrence or development in 162 patients over 21 years.
A new fourth-generation oncolytic virus has shown greater effectiveness against human brain cancer, improving survival by 50% compared to previous versions. The virus is engineered to replicate in cells expressing nestin, a marker for neuronal stem cells and glioblastoma.
Researchers at Johns Hopkins Medicine have developed a new breast cancer therapy that delivers anticancer drugs directly into the breast ducts via the nipple. The treatment has shown no major side effects in human patients and has been effective in animal models, with some drugs even preventing tumors from forming.
Researchers are developing innovative technologies to improve hearing, including adaptive noise control and speech enhancement. Additionally, musical training has been shown to enhance speech perception, while artificial ears inspired by bats and ultrasounds are being explored for medical applications.
Exercise and cancer research have received a significant boost with Dr. Kerry Courneya's Canada Research Chair (CRC) renewal. Several large-scale trials are currently underway, including the CARE trial for breast cancer patients and the CHALLENGE trial for colon cancer survivors.
Researchers are examining genetic variations that may predispose Hispanic women to greater breast cancer risk. Additionally, they're assessing the impact of obesity on breast cancer incidence rates among different ethnic groups.
A new study finds that both dense and non-dense fat tissue are independently associated with an increased risk of breast cancer. The research used sophisticated computer software to analyze mammograms of postmenopausal women with breast cancer, comparing them to controls without cancer.
A new genome sequencing method has identified mutations in 12 genes linked to inherited ovarian and related cancers. The test, called BROCA, could become a single test for screening broad range of cancers.
Researchers have discovered a panel of proteins shed by breast cancer that can distinguish between real cancer and benign lumps. The biomarker panel outperforms mammograms and single biomarkers in distinguishing between breast cancer and benign lumps, with some panels ranking above 0.95.
A new study finds that women who undergo advanced post-mastectomy breast reconstruction experience significant gains in psychological, social, and sexual wellbeing just three weeks after surgery. However, physical wellbeing at the abdominal location may not improve until later.
Rural women are more likely to be diagnosed with late-stage breast cancer due to limited access to healthcare facilities and high costs. To address this issue, researchers recommend improving the accessibility of free breast cancer screening programs in rural areas.
A new model estimates that the probability of a woman with screen-detected breast cancer surviving is likely below 10%, contradicting previous claims. The study's findings suggest that the benefit of screening mammography may be lower than previously thought.
Researchers at Huntsman Cancer Institute have discovered a new way to model human breast cancer that could lead to predicting which breast cancers will spread. The model was created using tumor tissue grafted into mouse mammary glands and found that it accurately predicted the behavior of human breast cancers.
Researchers found that most molecular markers associated with breast cancer in animals or cell cultures have little predictive value in humans, questioning their validity. The study highlights the need for a better understanding of the connection between experimental models and human biology.
The BIG 1-98 study found that letrozole monotherapy reduced the risk of relapse and death by at least a fifth compared to tamoxifen treatment alone. Long-term follow-up showed significant survival benefits, with women given letrozole having a 20% lower risk of breast cancer recurrence.
Post-menopausal women with high hormone levels, including estrogen and testosterone, have a higher risk of breast cancer. Researchers found that each additional elevated hormone level increases risk by 16%. The study suggests that models assessing breast cancer risk could be improved by considering multiple hormone levels.
Andrew J. Dannenberg, M.D., is recognized for his seminal contributions to understanding the inflammation-cancer connection and developing strategies to prevent breast cancer. His work has provided key insights into the role of prostaglandin biology in cancer prevention.
Researchers discovered a complex cell mechanism that makes breast cancer cells resistant to radiation treatment. The mechanism is activated by the protein HOXB9, which accelerates DNA repair and increases radiation resistance.
A large study of over 10,000 breast cancer patients found that radiotherapy significantly reduces the risk of cancer recurrence and mortality. The study found that radiotherapy almost halves the 10-year-risk of recurrence and reduces the 15-year-risk of mortality by a sixth
A Michigan State University researcher is working on a $450,000 grant to better understand breast cancer's genetic complexity and heterogeneity. The study aims to create more accurate models to study human cases, potentially leading to tailored therapies and improved patient outcomes.
A recent study published in Nutrición Hospitalaria found that obese women, particularly those with morbid obesity, develop breast cancer at a significantly earlier age. The researchers discovered that the age at first menstruation is a key factor in determining the development and diagnosis of breast cancer.
Researchers studied mammography registries to compare cumulative probability of false-positive results after 10 years of annual or biennial screening. Biennial screening reduced false-positive recalls by one-third, but associated with a small increase in late-stage cancer diagnosis. Digital mammography was found to be equally effective...
A new study identifies SIRT2 as a key tumor suppressor linked to gender-specific tumor development in mice. The research suggests the existence of a rare family of tumor suppressors, and its findings have implications for understanding the biological processes underlying cancer and aging.
Researchers discovered a gene has opposite effects in prostate and breast cancers, promoting growth when 'on' or 'off'. This finding suggests treating prostate and breast cancers requires distinct strategies, with blocking AR effective for prostate cancer but supporting AR production for breast cancer.
A new study found that over half of cancer-free women will experience false-positive results from annual mammograms, leading to unnecessary testing and anxiety. Shifting screening to every other year can lower the risk by a third.
A recent study identified a protein called estrogen-related receptor alpha (ERRα) that fuels the growth of aggressive breast tumors. Researchers found that targeting this protein with an experimental drug can inhibit tumor growth in cellular models, offering a potential new approach for treating estrogen-receptor negative cancers.
NextBio's web-based tools aid in assessing potential drug efficacy and adverse effects by analyzing publicly available genomic data, identifying correlations with gene expression changes and cancer profiles.
Post-menopausal women experiencing new onset breast tenderness after starting combination hormone therapy may have an increased risk of breast cancer compared to those without breast tenderness. Higher breast density is associated with a higher risk of breast cancer, with extremely dense breasts posing a four to six times higher risk.
A study published in the Journal of the American College of Surgeons found that Hispanic women are more likely to develop phyllodes tumors, a rare and unpredictable breast malignancy. The study also revealed higher-grade tumors in Hispanic patients and larger tumor sizes compared to other racial groups.
A new study has found that zoledronic acid can prevent and treat bone loss in postmenopausal breast cancer patients taking aromatase inhibitors. The five-year study showed significant increases in bone density when the drug was administered upfront, but also found that initiating treatment even after bone loss developed was beneficial.
Researchers developed a mouse model to track bone marrow cell migration to tumors and found that these cells can slow tumor growth. The study suggests that targeting bone marrow cells may lead to more effective cancer treatments.
A Rutgers-affiliated company has received a $207,000 grant from the National Institutes of Health to develop a technology that analyzes tissue from breast cancer biopsies to predict how aggressive the disease is likely to be. This technology could help physicians and patients plan effective therapies with minimal side effects.
A study published in Journal of Interferon & Cytokine Research found that Tyk2 protein helps suppress breast tumor growth and metastasis. Mice with normal Tyk2 expression were less susceptible to breast cancer, suggesting boosting Tyk2 activity may be beneficial for treating the disease.
People with disabilities continue to face difficulties meeting major social needs, including accessing health care facilities and services. Iezzoni's analysis highlights barriers that restrict their access to health services, including lower rates of mammography and Pap tests. She argues that healthcare professionals need to understand...
A study by UCLA's Jonsson Comprehensive Cancer Center found that a combination of chemotherapy and Herceptin significantly increases survival in patients with HER-2 positive breast cancer. The regimen without Adriamycin was comparable to the standard therapy, reducing heart toxicity and acute side effects.
Perinatal exposure to BPA may alter long-term hormone response and increase predisposition to breast cancer. Researchers found that BPA-exposed female mice had an increased response to progesterone and a higher cell number in their milk ducts.
The American Cancer Society reports a decline in breast cancer death rates among women in affluent areas, shifting the burden to poor women who have lower screening rates. The study highlights disparities in access to prevention and treatment services.
Researchers found that free radical peroxynitrite is produced by myeloid cells in tumors and interferes with the immune system's ability to kill cancer cells. This mechanism may explain why some cancer immunotherapies fail to work, allowing tumors to evade immune detection.
Researchers discovered that resveratrol blocks the growth of breast cancer cells by reducing estrogen receptor levels. This finding has significant implications for treating women with breast cancer whose tumors develop resistance to hormonal therapy. Resveratrol may serve as a potential tool to combat hormone-resistant breast cancer.
Dr. Giuliano was awarded the Brinker Award for Scientific Distinction for his pioneering findings on lymph node removal and his contributions to less invasive breast surgery. His research has led to improved quality of life for women with breast cancer and reduced side effects from breast surgery.
According to a recent poll, nearly 9-in-10 women reported that having regular mammograms gave them control over their own healthcare. The poll also showed that 90% of women considered mammograms important to their health and well-being.
Researchers at Karolinska Institutet have found that treating common Cytomegalovirus (CMV) can reduce tumour growth and size. CMV is found in 70-75% of adults and plays a central role in brain tumours, breast cancer, colon cancer, and prostate cancer.
Researchers at Wake Forest Baptist Medical Center have identified 16 genes involved in iron metabolism that provide better prognostic information than conventional markers. These genes, known as the Iron Regulatory Gene Signature, convey valuable information about breast cancer outcomes.
A new trial suggests that zoledronic acid may extend survival in postmenopausal breast cancer patients by boosting disease-free survival rates. However, the drug's effects on younger women are less clear-cut, with some studies indicating a possible adverse impact on recurrence rates outside bone.
A University of Melbourne study found that women with a strong family history of breast cancer but no genetic link are not consistently utilizing breast cancer services. They often struggle to interpret their risk and manage it effectively, leading to inadequate access to screenings and interventions.