Articles tagged with Breast Cancer
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University of Missouri researchers say exercise is beneficial for breast cancer survivors and patients with lymphedema, outweighing risks. Patients at risk can exercise without increasing the risk of developing lymphedema, according to a new literature review.
The study reveals co-activating events in the MAPK and PI3K/AKT pathways, leading to targeted treatments with significant patient benefits. Physicians steered patients into tailored treatment plans based on sequencing data, resulting in improved outcomes.
Researchers have developed a new tumor-targeting compound called PU-H71 that can reveal the complete set of aberrant signaling pathways driving cancers in individual patients. This breakthrough method uses the compound to identify abnormal proteins bound to heat shock protein 90, which are crucial for cancer cell growth and survival.
Researchers at Thomas Jefferson University identified breast cancer cell mitochondria as a key target for therapy, showing that off-patent generic drug Metformin can prevent tumor growth and chemotherapy resistance. The study's findings suggest that targeting mitochondrial metabolism could be exploited in personalized cancer medicine.
A new study published at the Radiological Society of North America meeting found that women between 40-49 years old without a family history of breast cancer are equally likely to develop invasive breast cancer as those with a family history. Annual screening mammography is recommended for this age group.
A new study published in Cancer Discovery reveals that the 14-3-3σ gene plays a critical role in halting breast cancer initiation and progression. The research suggests that this gene is likely a major player in other types of cancer as well.
A new study shows that comparing a new biopsy of recurrent breast cancer with the original biopsy can dictate a change in treatment. The results suggest that patients may benefit from asking their physician if a second biopsy is needed to confirm their treatment therapy.
Experts from NYU Langone's Department of Radiology will present on various topics, including genitourinary evaluations and breast MRI outcomes. The department is a leader in advanced diagnostic imaging with over 100 board-certified radiologists.
Research found a significant link between women with lobular breast cancer and fathers with prostate cancer, with the risk of lobular cancer almost doubling when considering family history. The connection was independent of hormone receptor status.
A new study by Michigan State University researchers found that metformin prevents tumors from growing in human cultures, providing biological evidence for its potential to reduce the risk of diabetes-associated cancers. The research suggests that metformin may be used as a preventive drug for individuals with Type-2 diabetes.
Researchers at Moffitt Cancer Center found that men are less willing to be screened for cancer despite having higher mortality rates. The study suggests that better health and cancer screening promotion among men can improve existing practices.
The new guidelines recommend no routine mammography screening for women aged 40-49, and extend the screening interval to every 2-3 years for women aged 50-74. The task force also advises against routine clinical breast exams and breast self-exams in asymptomatic women.
Researchers at the University of Michigan Comprehensive Cancer Center discovered two cancer-spurring gene rearrangements that may trigger 5 to 7 percent of all breast cancers. These rearrangements, seen in the MAST kinase and Notch family genes, can give scientists targets for potential therapies.
A recent study found that women taking combination estrogen and progestin menopausal hormone therapy are at a greater risk of developing breast cancer if they experience new onset breast tenderness. In contrast, women on estrogen alone without breast tenderness did not have an increased risk of breast cancer.
Research reveals PBX1's role in breast cancer progression by modulating chromatin compaction and promoting ERα recruitment. The discovery holds promise for developing prognostic markers and therapeutic strategies to prevent breast cancer progression.
Despite widespread adoption, MRI's limited evidence supports its benefit only for high-risk women and no significant impact on treatment outcomes. MRI's increased sensitivity in detecting cancer has yet to translate into better patient selection or reduced surgical procedures.
Despite advancements in genetic profiling, breast cancer treatment remains non-personalized due to limited robust prognostic and predictive factors. Standard gene expression profiling has shown limitations in predicting chemotherapy benefit and prognosis for certain disease subsets.
A study published in Annals of Oncology found that nearly half of male breast cancer patients on tamoxifen experience significant side effects, including weight gain and sexual dysfunction. The research highlights the need for better understanding and awareness of treatment risks and benefits.
A large study found that 53% of male breast cancer patients experience tamoxifen-related side effects, leading to early discontinuation. The study suggests that these patients may be at increased risk of cancer recurrence.
Researchers identified a key interaction between BRCA1 and RHAMM proteins regulating epithelial cell polarity, found altered in some breast cancer patients. The discovery provides new insights into the molecular mechanisms driving breast cancer development.
A new study found a significant association between adolescent alcohol consumption and increased risk of benign breast disease among girls with a family history of breast cancer. Consuming more alcohol was linked to a higher risk, particularly in those with rapid height growth spurts.
A new study from Washington University School of Medicine finds that adolescent girls with a family history of breast disease have a higher risk of developing benign breast disease as young women, and this risk rises with increasing alcohol consumption. The researchers suggest limiting alcohol intake to lower risk or avoid increasing it.
A study published in Archives of Neurology found that breast cancer survivors who received chemotherapy demonstrated reduced activation in key brain areas and poorer executive function. The researchers also discovered that negative effects of chemotherapy may be exacerbated by factors such as age and educational level.
Researchers at George Mason University have identified a key driver in inflammatory breast cancer, allowing for the development of new treatments. The study found that nearly all samples had high activation of the protein anaplastic lymphoma kinase (ALK), paving the way for targeted therapy.
Researchers identified ALK amplification in up to 86% of inflammatory breast cancer patients, a potentially targeted therapy approach. Inhibiting ALK with a small-molecule inhibitor resulted in tumor cell death, paving the way for clinical trials.
UCSF researchers have discovered the molecular basis for tamoxifen resistance and found a potential way to defeat it. They showed that cells can develop resistance through epigenetic modification, specifically by elevating expression of the 'survival' gene AKT.
A combination of REGN910 and aflibercept has been shown to inhibit tumor growth more effectively than single-agent therapies, with significant improvements in antitumor effects observed in animal models. The treatment also induced increased tumor hypoxia, leading to rapid cell death and dramatic regression in colorectal tumors.
Researchers found that introducing a novel histone deacetylase inhibitor can reverse tumor's survival strategy and stop resistance, leading to higher cell death rates. This approach may prevent hormone therapy resistance in patients with estrogen receptor-positive breast cancer.
Researchers at McGill University Health Centre have identified parathyroid hormone-related protein (PTHrP) as a key player in breast cancer progression and metastasis. The study found that blocking PTHrP production can reduce tumor growth by 80-90% and prevent its spread to other organs.
A Stanford team developed a machine-learning-based method called Computational Pathologist (C-Path) to analyze breast cancer microscopic images, outperforming human evaluations. The model assesses 6,642 cellular factors and identifies structural features that matter in predicting patient survival.
The Robert Wood Johnson Foundation announced the winners of its 2011 Community Health Leaders Award, recognizing 10 individuals who are improving the health and quality of life for disadvantaged communities. The recipients include Jamie Boyd, Naomi Cottoms, Lisanne Finston, Zane Gates, and others, who have overcome daunting odds to pro...
Researchers have discovered that connexin 36 protects mouse pancreatic beta-cells against immune molecules prevalent in type 1 diabetes. Additionally, a study found that PTHrP drives breast tumor initiation, progression, and metastasis in mice, suggesting it as a potential therapy target.
A review article reveals historically low breast reconstruction rates in Canada, with only 7.7% of Ontario patients undergoing the procedure in 1994/95. Factors such as age, socioeconomic status, and geography influence the use of breast reconstruction, with women living in urban areas more likely to undergo the procedure.
A review of 1,181 women from five countries found that many struggled with returning to work due to unrealistic expectations, lack of support, and physical appearance judgments. Employers must educate themselves and provide better support and policies to tackle the culture of ignorance.
A new study found that older women with breast cancer are not experiencing the same improvements in treatment and detection as younger women. The study, published in the Journal of Clinical Oncology, reveals a discrepancy between age groups when it comes to breast cancer outcomes.
Researchers discovered measles virus exits host via nectin-4, a biomarker for certain types of cancer. This finding opens up promising new approaches for targeted cancer therapy.
A new MU study reveals that depression affects breast cancer survivors, with single women and mothers experiencing higher rates of distress. The research also shows that depressed patients are less likely to adhere to medication regimens, potentially complicating treatment outcomes.
A large prospective cohort study found that low levels of alcohol consumption are associated with a small increase in breast cancer risk, and this association persists even after controlling for drinking patterns and age. Women who consumed at least 30 grams of alcohol daily had a significantly higher risk of breast cancer.
Researchers found that high levels of heat shock factor 1 (HSF1) in ER-positive breast cancer tissue are associated with poorer outcomes, including increased mortality. Elevated HSF1 levels also correlate with larger and more aggressive tumors.
A new international study found that women without genetic mutations but closely related to those who do have them are at an average risk of developing breast cancer. This contradicts previous claims that all women in such families share a high risk, according to Professor John Hopper from the University of Melbourne.
A population-based analysis found that close relatives of women with breast cancer who don't carry the BRCA mutation have a similar risk to the general population. The study suggests they may not need extra cancer screening and preventive measures.
A team of scientists at Tufts University is developing ultra-sensitive techniques to detect breast cancer earlier and treat it with greater precision. They aim to create a simple blood test for screening and diagnose the disease more accurately.
Researchers found that women related to a patient with a hereditary breast cancer mutation but without the mutation themselves have no increased risk. The study settles a controversy and supports current practice guidelines advising non-carriers on no additional risk attributable to their family-specific BRCA1 or BRCA2 mutation.
New research uses tumor-targeted magnetic nanoprobes and SQUID sensors to detect breast cancer, outperforming mammography in sensitivity and accuracy. This technology holds promise for refining treatment plans and improving patient survival by classifying tumors based on protein expression.
Researchers have identified a new potential cancer drug targeting EPHA7, a tumor suppressor protein associated with follicular lymphoma. The discovery demonstrates the power of functional genomics in translating genetic insights into therapies.
A new study by Georgetown researchers found that nipple sparing mastectomy is a safe and effective option for women with breast cancer. The procedure, which removes breast tissue while keeping the skin and nipple intact, showed no signs of cancer recurrence or development in 162 patients over 21 years.
A new fourth-generation oncolytic virus has shown greater effectiveness against human brain cancer, improving survival by 50% compared to previous versions. The virus is engineered to replicate in cells expressing nestin, a marker for neuronal stem cells and glioblastoma.
Researchers at Johns Hopkins Medicine have developed a new breast cancer therapy that delivers anticancer drugs directly into the breast ducts via the nipple. The treatment has shown no major side effects in human patients and has been effective in animal models, with some drugs even preventing tumors from forming.
Researchers are developing innovative technologies to improve hearing, including adaptive noise control and speech enhancement. Additionally, musical training has been shown to enhance speech perception, while artificial ears inspired by bats and ultrasounds are being explored for medical applications.
Exercise and cancer research have received a significant boost with Dr. Kerry Courneya's Canada Research Chair (CRC) renewal. Several large-scale trials are currently underway, including the CARE trial for breast cancer patients and the CHALLENGE trial for colon cancer survivors.
Researchers are examining genetic variations that may predispose Hispanic women to greater breast cancer risk. Additionally, they're assessing the impact of obesity on breast cancer incidence rates among different ethnic groups.
A new study finds that both dense and non-dense fat tissue are independently associated with an increased risk of breast cancer. The research used sophisticated computer software to analyze mammograms of postmenopausal women with breast cancer, comparing them to controls without cancer.
A new genome sequencing method has identified mutations in 12 genes linked to inherited ovarian and related cancers. The test, called BROCA, could become a single test for screening broad range of cancers.
Researchers have discovered a panel of proteins shed by breast cancer that can distinguish between real cancer and benign lumps. The biomarker panel outperforms mammograms and single biomarkers in distinguishing between breast cancer and benign lumps, with some panels ranking above 0.95.
A new study finds that women who undergo advanced post-mastectomy breast reconstruction experience significant gains in psychological, social, and sexual wellbeing just three weeks after surgery. However, physical wellbeing at the abdominal location may not improve until later.
Rural women are more likely to be diagnosed with late-stage breast cancer due to limited access to healthcare facilities and high costs. To address this issue, researchers recommend improving the accessibility of free breast cancer screening programs in rural areas.
A new model estimates that the probability of a woman with screen-detected breast cancer surviving is likely below 10%, contradicting previous claims. The study's findings suggest that the benefit of screening mammography may be lower than previously thought.
Researchers at Huntsman Cancer Institute have discovered a new way to model human breast cancer that could lead to predicting which breast cancers will spread. The model was created using tumor tissue grafted into mouse mammary glands and found that it accurately predicted the behavior of human breast cancers.
Researchers found that most molecular markers associated with breast cancer in animals or cell cultures have little predictive value in humans, questioning their validity. The study highlights the need for a better understanding of the connection between experimental models and human biology.
The BIG 1-98 study found that letrozole monotherapy reduced the risk of relapse and death by at least a fifth compared to tamoxifen treatment alone. Long-term follow-up showed significant survival benefits, with women given letrozole having a 20% lower risk of breast cancer recurrence.