Articles tagged with Breast Cancer
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Researchers have identified a mechanism that explains how cancer cells change their appearance and progress from a solid state to a semiliquid mass. The study found that microRNA-200S inactivation leads to this transformation, allowing tumour cells to evade natural defences and invade neighbouring organs.
Researchers discovered that certain BRCA1 mutations causing hyper-recombination contribute to breast and ovarian cancers by disrupting genomic stability. Targeted therapies may be developed by disrupting ubiquitination to prevent hyper-recombination and kill cancer cells.
A study published in Nutrition and Cancer found that a diet rich in walnuts can significantly reduce the risk of breast cancer in mice. The researchers discovered that the walnut-containing diet changed the activity of multiple genes relevant to breast cancer, leading to fewer tumors and smaller tumor sizes.
Researchers found that low-risk patients aged 60 or older with small tumors and low-grade disease have mortality rates comparable to the general population. These patients may not benefit from adjuvant therapy, contradicting previous recommendations for almost all patients with hormone-responsive disease.
A new study reveals that millions of dollars are raised annually for breast cancer research and prevention programs through revenue-generating initiatives. States with higher breast cancer death rates are more likely to offer specialty license plates, which generate significant revenue.
A collaborative study of African-American women's breast cancer will investigate genetic and non-genetic risk factors using a large population of 11,000 participants. The researchers aim to discover prevention methods for this deadly disease.
A decline in hormone therapy use among women aged 50-64 is linked to lower mammogram rates, as doctors may not remind them about upcoming mammograms. The study suggests that the drop in HT use led to a decrease in mammography rates between 2000 and 2005.
Researchers found that longer AI use was associated with increased heart disease and bone fractures, but lower rates of blood clots and womb cancer. Use of AIs for 2-3 years after initial treatment may explain the lack of overall survival benefit despite improved breast cancer recurrence
A phase 2 trial found that olaparib reduced tumor size in 41% of patients with ovarian cancer and no BRCA gene mutations. The treatment was generally well-tolerated and offered new hope for ovarian cancer treatment targeting DNA repair mechanisms.
A study by Boston University's Slone Epidemiology Center found that high parity was associated with a 50% increase in the incidence of estrogen-receptor negative (ER-) breast cancer, but only among women who had not breastfed. Breastfeeding was also linked to a reduced risk of ER- breast cancer, particularly in African-American women.
Abnormalities in breast cancer stem cells found in some cancers can lead to tumor development and recurrence, according to a recent study published by OHSU Knight Cancer Institute researchers. The study suggests that these mutated cells are resistant to chemotherapy and radiation, allowing the disease to recur.
Researchers found that breast tumor cells can evade NK cell antitumor activity by promoting self-tolerance. The study suggests that restoring NK cell function could benefit individuals with breast cancer.
A new study from Northwestern University finds that Chicago's south and southwest sides suffer the most in terms of residents' health and access to basic health resources. The study highlights significant disparities in healthcare access, including limited mammogram screening and HIV testing sites.
A study in mice found that a genetic variation in the CDKAL1 gene leads to misreading of insulin-producing genes, causing decreased insulin production and impaired cell function. Meanwhile, researchers discovered that breast cancer cells evade the antitumor activity of NK cells by modifying their environment.
Researchers at Georgetown University Medical Center found that overproduction of aromatase in breast tissue is more dangerous than excess estrogen receptors. Aromatase inhibitors may prove to be a more potent choice for cancer prevention in postmenopausal women.
Researchers found that NSAIDs inhibit COX-2, reducing tumor growth and metastasis. However, the safety of these drugs during pregnancy remains uncertain due to the complex changes occurring in the body after childbirth.
Researchers at Thomas Jefferson University discovered that blocking a receptor of a key hormone in the renin-angiotensin system reduces cancer cell growth by activating the enzyme AMPK, which inhibits fatty acid synthase. This finding suggests a potential target for chemopreventive agents to fight pancreatic cancer.
Women should have open discussions with their doctors about individualized breast cancer screening timing, considering personal preferences, risk factors, and understanding of mammogram benefits and harms. This is particularly important for women under 50, who may be subjected to false positives and unnecessary procedures.
A study found that trastuzumab increases the risk of heart problems in elderly women with a history of heart disease or diabetes. The researchers recommend referring these patients to a cardiologist and monitoring for cardiac function.
A study published in Genes & Development reveals a specific RNA cluster, miR-17~92, plays a key role in the growth of retinoblastoma, a rare form of childhood eye cancer. The researchers found that overexpression of this microRNA cluster helps cells proliferate despite the loss of tumor-suppressing protein Rb.
Researchers have identified new genetic markers for patients at high risk for bone metastasis, which may provide additional targets for preventing and treating the disease. A novel vaccine for HER2+ breast cancer is also being developed to address a particularly aggressive form of the disease.
Researchers present novel approaches to breast cancer treatment, including reconstituted cholesterol as a drug delivery model and heat-activated peptide therapy. These methods aim to improve patient outcomes by reducing side effects and increasing targeted treatments.
Research presented at the Era of Hope conference explores genes that contribute to breast cancer risk in African Americans and the possibility of mitigating it through vitamin D intake. Additionally, studies examine how daughters of BRCA mutation carriers manage their own risk of breast cancer.
A study found that a diet rich in omega 3 fatty acids and methyl nutrients may reduce the risk of breast cancer in female offspring. Researchers also discovered that supplementing a mother's diet with lipotropic nutrients during pregnancy may induce epigenetic changes, altering gene expression permanently.
Researchers found familial breast cancer patients have significantly shorter telomeres, suggesting a genetic mechanism contributing to disease progression. The study also demonstrated genetic anticipation in affected daughters, with decreased telomere length relative to their mothers.
Researchers at Lawson Health Research Institute have found that introducing maspin protein into the nucleus of cancer cells can significantly limit tumor growth and spread. This discovery may lead to new targets for drug development and improved understanding of cancer prognosis.
A UT Southwestern men's support group has published a book to reach out to husbands and partners of women with cancer. The book shares stories of five men who know firsthand what it's like to love and care for a cancer patient, offering emotional support and practical advice.
Using a 'systems biology' approach, researchers identified proteins in the blood that change in abundance long before aggressive breast cancer is clinically detectable. The study found that host tissues respond to and amplify signals from tumor cells, leading to changes in blood-protein levels.
Tamoxifen therapy for 5 years improves survival by about a third in women with hormone-sensitive breast cancer, according to an analysis of over 20,000 patients. The treatment reduces the risk of breast cancer recurrence and death in ER-positive disease, regardless of chemotherapy use.
A large UC Davis study analyzed 1.6 million mammograms and found that computer-aided detection (CAD) technology is not effective in finding breast tumors, leading to increased false-positive results and unnecessary recalls for further testing.
Scientists identify two genetic sequences that control how a breast cancer gene responds to estrogen, leading to tamoxifen resistance. The discovery may help guide the search for new therapeutic targets in breast cancer.
A study found that computer-aided detection (CAD) software used in analyzing three out of four mammograms does not improve detection rates or cancer outcomes. CAD was associated with more false positives, but did not detect smaller or less aggressive cancers.
A new study published in Journal of the American Medical Association found that removing lymph nodes due to microscopic cancer cells has no impact on survival outcomes for women with early-stage breast cancer. The study, conducted by Cedars-Sinai Medical Center, challenged the common approach to treating early-stage breast cancer.
Scientists have developed a novel protein called HER2-Affitoxin that targets HER2-positive cancer cells without interfering with the signaling pathway. The protein has shown promising results in killing tumor cells and is warranting clinical trials.
High-dose vitamin D significantly reduces musculoskeletal pain and improves quality of life for breast cancer patients on aromatase inhibitors. The study found that high-dose vitamin D may also help maintain bone density, providing a potential tool to enhance treatment tolerability.
A study found that many physicians do not follow guidelines for breast and ovarian cancer counseling and testing, affecting high-risk women who may miss out on life-saving interventions. Physicians were more likely to follow guidelines when accurately estimating patients' ovarian cancer risks.
Research found that taller individuals are at higher risk of various cancers, including breast, ovary, and bowel cancers. The study suggests that increases in population height may explain changes in cancer incidence over time.
A new drug targeting the PI3K gene has shown significant shrinkage of tumors in two patients with advanced breast and cervical cancers. The drug, GDC-0941, is being tested in an early phase I study conducted by TGen and Virginia G. Piper Cancer Center.
Researchers found that temporarily suppressing ovarian function with triptorelin reduced the occurrence of early menopause induced by chemotherapy among premenopausal women with breast cancer. The treatment resulted in a 17% lower rate of early menopause compared to chemotherapy alone.
Researchers at Whitehead Institute have identified a protein called phosphoglycerate dehydrogenase (PHGDH) that is crucial for the growth of estrogen receptor-negative breast cancer cells. PHGDH is overexpressed in approximately 70% of ER-negative breast cancer patients, making it a promising target for drug development.
Researchers discovered a new class of anti-cancer agent, BH3 mimetics, that target Bcl-2 proteins in cancer cells. Combining these agents with chemotherapy shows improved tumour response and survival rates for aggressive breast cancers.
A study published in Clinical Cancer Research found that trastuzumab, chemotherapy, and surgery significantly improved overall survival in HER2-positive breast and brain cancer patients. Treatment with these therapies led to improved survival rates of up to 20 months for those with central nervous system metastases.
Scientists have developed a tiny fiber-optic biosensor to detect elevated PSA levels in cases of breast cancer. The biosensor's sensitivity and specificity are comparable to those found in current screening methods for breast cancer.
A study found that changes in family history of cancer can significantly alter screening recommendations, particularly for colorectal, breast, and prostate cancers. For patients aged 30-50, the risk of increased cancer risk more than tripled for colorectal cancer and increased by 60% for breast cancer.
Research found substantial changes in cancer family history between ages 30-50, leading to recommendations for earlier or more intense screening. Updates to family history should occur every 5-10 years to inform risk assessments and screening guidelines.
The World Health Organization has stated that alcohol is carcinogenic in both animals and humans. Several studies have linked alcohol consumption to an increased risk of cancers in the mouth, throat, esophagus, liver, colon-rectum, and breast cancers. New international guidelines are needed to address this issue.
Research published in BMJ Open found a strong association between contact allergies and reduced rates of breast, non-melanoma skin, and brain cancers. However, higher rates of bladder cancer were detected among those with contact allergies.
Companies that use pink ribbons and support breast cancer research but permit the use of carcinogenic chemicals are committing a form of social injustice, argue authors. The practice of pinkwashing increases profits while potentially contributing to higher cancer rates.
A University of Michigan study found that breast cancer patients may be underreported for radiation treatment after breast-conserving surgery, with discrepancies in the SEER database affecting up to 1 in 5 cases. The study highlights the need for improved data accuracy to inform clinical decision-making and policy.
A new study published in Annals of Internal Medicine finds that massage therapy is more effective than usual medical interventions for improving pain and function in patients with chronic low back pain. The researchers also suggest that relaxation massage may have a slight advantage over structural massage due to its wider availability.
Researchers found clinical and personal barriers hinder mammography screening among African-American women. Interventions can be effective by educating providers to build trust, offer culturally appropriate health education, and make referrals.
A team of researchers at CSHL identified the PTPN23 enzyme as a significant regulator of breast cancer development. Suppressing its expression in human mammary cells led to a cascade of effects, including cell scattering, invasion through extracellular matrix, and metastasis.
A study of 64,034 women found that those with heart problems, chronic lung disease, and diabetes had lower overall survival rates. Researchers conclude that managing both cancer and comorbidities is crucial for improving patient outcomes.
A large-scale Swedish trial shows that regular mammography screening reduces breast cancer mortality by 30% over seven years. The study's findings confirm the long-term benefits of mammography screening and provide new insights into its impact on breast cancer deaths.
A recent study shows that regular breast screening with mammography significantly reduces the number of deaths from breast cancer. Over 130,000 women were monitored for nearly three decades, and results indicate that 30% fewer women in the screening group died of breast cancer.
A study led by St. Jude Children's Research Hospital found that about 10% of adult childhood cancer survivors develop new tumors unrelated to their original cancers. Regular cancer screenings are crucial for this growing population.
A team of researchers has identified a new breast cancer tumor suppressor called Runx3, which regulates gene expression and targets the estrogen receptor alpha. The study found that Runx3 suppressed breast cancer cell growth and inhibited tumor formation in mice, offering potential benefits for early detection and treatment.
A new study from UT MD Anderson Cancer Center found that nearly half of women with advanced breast cancer in the US are not receiving life-saving post-mastectomy radiation therapy (PMRT), despite evidence-based guidelines outlining its benefits. The study suggests that better strategies, such as requiring compliance for accreditation a...
Researchers identified six distinct subtypes of triple-negative breast cancer, each responding differently to chemotherapies. The study provides molecular targets for drug discovery and development efforts, offering hope for personalized therapy.
Research at Yale University reveals 10-20% of breast cancers classified as ER negative are actually positive, leading to under-treatment and missed opportunities for effective therapies. A new method for standardizing Estrogen Receptor measurement has been developed, which detects the receptor with higher sensitivity and reproducibility.