Articles tagged with Breast Cancer
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A phase III clinical trial will recruit 4,000 women with low to intermediate Oncotype DX recurrence scores to determine whether a gene expression test can spare thousands of women from unnecessary chemotherapy. The RxPONDER trial aims to identify an optimal recurrence score cutpoint for these patients.
Research at the University at Buffalo found that early life air pollution exposure and motherhood may alter DNA, increasing premenopausal breast cancer risk. Decreased E-cadherin promoter methylation was associated with higher birth exposure, while increased p16 methylation linked to first child birth in higher-pollution areas.
Researchers will test a novel antibody against TGFβ to enhance radiation therapy's effectiveness in metastatic breast cancer patients. The goal is to induce an immune response against tumor sites outside the radiation field.
Two studies published in JAMA describe the first clinical applications of whole-genome sequencing in patients with cancer, enabling targeted therapies based on genetic mutations. The technology is becoming increasingly affordable, with costs expected to drop below $10,000 within five years.
A biophysicist is developing a drug that targets Interleukin-6 (IL-6) to combat breast and prostate cancer. By blocking the protein's signaling pathway, researchers aim to prevent cellular inflammation and tumor growth.
A study by UCLA researchers found that ACE inhibitors may increase the risk of breast cancer recurrence in women who have had early-stage breast cancer. In contrast, beta blockers appeared to have a protective effect, and when used together with ACE inhibitors, may help mitigate this risk.
Researchers at the University of Calgary developed a new digital tool using fractal dimension analysis to assess breast cancer tumours. The method provides an objective and reproducible measure of tissue abnormality and aggressiveness, promising more accurate risk assessment and therapeutic decisions.
Researchers found that healthy breast cells secrete interleukin 25 to actively kill nearby breast cancer cells without harming normal cells. This discovery suggests IL25 receptor signaling as a new therapeutic target for treating breast cancer.
The sentinel node procedure has evolved to limit surgical overtreatment, but isolated tumor cells and micrometastases have led to increased surgeries. Current studies examine the role of radiotherapy, pathologic protocols, and prognostic impact of these findings on breast cancer patients.
A clinical study suggests that a specific combination of nutritional ingredients, including indole-3 carbinol and vitamin D, may increase the mean urinary concentration of 2-OHE in pre- and post-menopausal women by 110% and 88%, respectively. The supplement was well-tolerated with no adverse side effects.
New research from the University of Oregon found that breast cancer awareness campaigns have reduced fluctuations in diagnoses, with most cases now linked to routine screenings. The study suggests that increased awareness and advocacy efforts have led to better screening rates among American women.
Researchers found that fish oil increases expression of genes related to cellular specialization, differentiation, and immune defenses against tumors. However, it also triggers counterproductive immune responses like inflammation and allergic reactions.
A recent study suggests that breast cancer patients experiencing persistent fatigue may have an imbalance in their autonomic nervous system, leading to accelerated aging. Researchers found that fatigued patients showed higher levels of stress hormones and lower parasympathetic activity compared to non-fatigued patients.
A study in the American Journal of Preventive Medicine found that US women were confused by recent mammography screening recommendations, with 30% more confused than helped. The majority of media coverage was unsupportive, and women aged 40-49 years were most likely to be confused.
An observational study found that women with poor physical health scores had a 27% increased risk of cancer recurrence or new breast cancer. Physical health also impacted survival, with a 65% greater risk of death among those with poorer health scores.
Breast cancer survivors who experience large weight gain (10% or more over pre-diagnosis weight) are 14% more likely to experience a cancer recurrence compared to women whose weight remains stable. Researchers found that moderate weight gain does not affect breast cancer outcomes.
A recent study published by the American Association for Cancer Research found that consuming soy food did not increase the risk of cancer recurrence or death among breast cancer survivors. In fact, women who consumed more soy isoflavones had a reduced risk of mortality and cancer recurrence compared to those with lower intake levels.
A recent study suggests that estrogen-only hormone therapy may decrease the risk of breast cancer in women who have had a hysterectomy. However, experts caution against long-term use due to unknown consequences and conflicting evidence from previous studies.
Breast cancer survivors who experience extreme weight gain have an increased risk of death and cancer recurrence. Moderate weight gain did not affect breast cancer outcomes, according to a study presented at the AACR 102nd Annual Meeting.
Researchers at the University of Pennsylvania School of Medicine have found a novel drug combination that successfully treats advanced cancer patients. The temsirolimus-hydroxychloroquine combination was shown to halt tumor growth in two-thirds of patients, including those with melanoma, colorectal, and head and neck cancers.
Researchers at Fox Chase Cancer Center have discovered a gene expression pattern in breast tissue that differs between post-menopausal women who had children and those who did not. This genomic signature may help scientists understand why pregnancy reduces breast cancer risk and develop chemopreventive strategies.
A longer-term follow-up of postmenopausal women who used estrogen therapy for 6 years found that the increased risk of stroke during treatment had dissipated, while the decreased risk of breast cancer persisted. The risk of hip fracture was not maintained during the postintervention phase.
Researchers found that vitamin D significantly reduced estrogen receptor-positive (ER+) breast cancer in both lean and obese mice, but had no effect on estrogen receptor-negative (ER-) cancer. Vitamin D also reversed insulin resistance in obese mice, while having no benefit in lean mice.
Researchers found that social isolation combined with a high-fat diet increases levels of a brain neurotransmitter called neuropeptide Y, promoting obesity, insulin resistance, and breast cancer risk in mice. The study's findings suggest a link between human social isolation and elevated cancer risk.
Researchers have developed a method to assess breast cancer risk using epithelial cells found in breast milk. The study showed that average RASSF1 methylation levels were higher in biopsied breasts compared to non-biopsied breasts, suggesting a potential correlation between epigenetic signals and breast cancer risk.
A new study suggests that the soy-based compound Natural S-equol does not increase the risk of estrogen-sensitive breast cancer. Supplements containing SE5-OH have reduced menopause symptoms in postmenopausal women, and the study's findings enhance our understanding of Natural S-equol's safety profile.
A new study confirms that genetic differences exist in breast tissue across racial groups, which may explain disparities in breast cancer morbidity and mortality. The research found varying levels of genes related to the DNA repair pathway, a known mechanism in cancer.
Researchers at Queen's University Belfast have developed a new drug that prevents tumor growth by cutting off their blood supply, showing promise for treating prostate and breast cancers. The treatment targets tumor angiogenesis using an entirely different pathway than existing therapies.
A team of University of Cincinnati researchers is sequencing individual glioblastoma genomes and tracking abnormalities in the bloodstream to establish personalized biomarkers. The study aims to guide treatment efforts and identify new therapeutic targets for this aggressive brain tumor.
Researchers found that macrophage and T-cell levels can predict recurrence and survival in breast cancer. A new therapy targeting macrophages shows promising results in preclinical studies.
A new study found that young women with breast cancer have limited knowledge about fertility issues, causing confusion and conflict when planning for a family. The researchers suggest providing targeted fertility information may reduce uncertainty and increase informed decision-making.
A UCSF research team has made a breakthrough in predicting breast cancer survival by analyzing the immune profile of tumors. By identifying specific patterns of immune cells, they were able to develop a treatment strategy that slows tumor growth and improves patient outcomes.
A recent study published in the American Association for Cancer Research found that smoking did not affect breast cancer risk among obese postmenopausal women. In contrast, non-obese women with a history of smoking had a significantly higher risk for breast cancer.
Researchers sequenced whole genomes of tumors from 50 breast cancer patients and compared them to healthy cells, finding over 1,700 unique mutations. The study highlights the complexity of cancer genomes and offers new insights into personalized medicine.
Researchers sequenced whole genomes of tumors from 50 breast cancer patients and compared them to healthy cells, finding over 1,700 unique mutations. The study identified three significant mutations that may be common in ER-positive breast cancers, offering new avenues for personalized treatment.
The American Association for Cancer Research is prioritizing clinical trials to advance cancer treatment and prevention. Researchers presented findings on basal cell cancer and lung cancer, highlighting the potential of biomarkers and hedgehog pathway inhibitors. New discoveries aim to improve patient outcomes and reduce side effects.
In developing countries, breast cancer mortality rates are high due to inadequate diagnosis, treatment, and awareness. The Lancet Oncology review highlights the need for resource-appropriate solutions to improve outcomes.
The Breast Health Global Initiative has published a landmark publication offering diverse but not insurmountable barriers to breast cancer screening and treatment in developing nations. Key findings include the need for public awareness, pathology services, and supportive care services to improve breast health care programs.
A new pilot study aims to fill the research gap for young women with Triple Negative Breast Cancer, a rare and aggressive form of breast cancer that affects mostly African-American or Hispanic women. The two-year study will survey up to 60 women recently diagnosed with this type of breast cancer.
Researchers found low Rho GDI-alpha protein levels in tamoxifen-resistant breast cancer tumors, predicting recurrence. MTA2 protein levels rose with declining Rho GDI-alpha, combining to predict tumor progression.
Researchers develop innovative strategy to target tumor metabolism, block energy production required for malignant cancer growth, delaying tumor volume and spread. The treatment combines ultrasound-guided intra-tumoral delivery of a potent drug with imaging guidance to minimize healthy tissue exposure.
A new study found that certain women with early-stage breast cancer experience excessive worrying about cancer recurrence, affecting medical care and quality of life. The research identified factors associated with high levels of worry, including younger age, employment, pain, fatigue, and radiation treatment.
A new U-M study finds that nearly half of Latinas who speak little English express a great deal of worry about breast cancer recurrence. The study highlights the need for culturally sensitive counseling to help women understand their risk and manage anxiety.
Carey Anders will receive a $181,000 grant to test the effectiveness of PARP-inhibitors and nanoparticle agents in treating triple-negative breast cancer brain metastases. The research aims to improve survival rates for women with this aggressive form of breast cancer.
A long-term study found that consuming three or more drinks a day is associated with an increased risk of pancreatic cancer death in both men and women. Heavy drinking, specifically liquor consumption, also shows a significant association with pancreatic cancer mortality, particularly among never smokers.
Researchers developed two peptide inhibitors targeting HER-2 and VEGF pathways, showing additive benefits in reducing tumor burdens with minimal side effects. The strategy aims to overcome acquired resistance and provide clinical benefit in several types of cancer.
A study published in Cancer suggests that tamoxifen can significantly reduce breast cancer risk in post-menopausal women under 55 with a high risk of developing the disease. The medication not only saves lives but also reduces medical costs, preventing 29 breast cancer cases and 9 deaths per 1,000 treated women.
A new analysis method by CSHL team suggests tumors grow through 'punctuated, clonal expansions,' providing insights into tumor growth and metastasis. By analyzing single cells from breast cancer samples, the researchers inferred three distinct subpopulations of tumor cells, each with highly similar genomic profiles.
A Northwestern University research team found that binding chemotherapy drugs to nanodiamonds significantly improves the effectiveness of cancer treatment, particularly in cases where tumors are resistant to conventional therapies. The discovery holds promise for treating aggressive cancers with fewer toxic side effects.
A novel clinical trial is exploring a new method to potentially prevent recurrence of early stage, aggressive breast cancer. The study is recruiting patients with HER-2 neu+ breast cancer and aims to identify high-risk patients who may benefit from an additional cancer-targeting drug.
Researchers have shown how laminin influences genetic information inside a cell's nucleus, while its destruction plays a detrimental role in tumor development. The study also identifies laminin-111 as the regulator of nuclear actin, a key mediator of epithelial cell quiescence.
Researchers found that upregulation of HER3 receptor limits effectiveness of targeted therapies in HER2-positive breast cancers. Targeting both HER2 and HER3 together with these agents improves clinical utility. Combination therapy also shows potential in treating other cancers.
Postmenopausal breast cancer survivors are more likely to fall than their peers, according to a new study in the Archives of Physical Medicine and Rehabilitation. The research suggests that balance disturbances caused by treatment may contribute to falls in these patients.
Using genomic analysis, researchers have discovered a key role for E2F2 gene activation in increasing the risk of breast cancer relapse. The study also found that removing this gene can significantly decrease tumor growth and improve treatment outcomes.
A recent study published in JNCI found that shift work may be associated with a reduced risk of skin cancer in women. The researchers analyzed data from the Nurses' Health Study and discovered that rotating night shifts were linked to a lower risk of skin cancer, particularly melanoma. Darker-haired women had the lowest risk.
A study published in the Journal of Consumer Affairs found that rural Appalachian women are more likely to perform breast health self-examinations and seek medical attention when their caregiving responsibilities are recognized. The research suggests that appealing to their strength as caretakers encourages them to take care of themsel...
A study published in The Lancet found that eribulin monotherapy extends the lives of breast cancer patients with extensive treatment by a median 2.5 months compared to physician's choice treatment. The drug targets microtubules, leading to cell death and improved survival rates.
Scientists have identified a potential target to treat an aggressive type of prostate cancer, known as SPINK1. A 'blocking' antibody to SPINK1 reduced tumor growth by up to 74% in mice. The study suggests that targeting SPINK1 may be effective in treating SPINK1-positive tumors.
Breast cancer is a significant global health issue, with most deaths occurring in low- and middle-income countries. A Personal View published in The Lancet Oncology suggests that population-based mammography screening is not practical or cost-effective in these countries.
A new peptide has demonstrated efficacy against triple negative breast cancer, extending average survival time by 80% compared to chemotherapy. The leptin receptor antagonist peptide targets a protein that promotes cancer development in obese individuals.