Articles tagged with Breast Cancer
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.
Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.
Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.
Practical application of scientific knowledge and engineering principles to solve real-world problems and develop innovative technologies. Encompasses all engineering disciplines, technology development, computer science, artificial intelligence, environmental sciences, agriculture, materials applications, energy systems, and industrial innovation. Bridges theoretical research with tangible solutions for infrastructure, manufacturing, computing, communications, transportation, construction, sustainable development, and emerging technologies that advance human capabilities, improve quality of life, and address societal challenges through scientific innovation and technological progress.
Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.
Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.
Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
A case-control study found that injectable and oral contraceptives are associated with a transiently increased risk of breast and cervical cancer. Extended use, however, is linked to a reduced risk of ovarian and endometrial cancer in black South African women.
Two studies found that CYP2D6 genotypes associated with reduced enzyme activity do not predict clinical responsiveness to adjuvant tamoxifen therapy among postmenopausal women. This challenges the conventional hypothesis that poor metabolizers experience fewer side effects and may receive less benefit from tamoxifen.
A large clinical trial found radiation has little benefit for some older women with early stage, low-risk breast cancer, leading to changes in treatment guidelines. However, the use of radiation therapy among Medicare beneficiaries remained largely unchanged, suggesting minimal impact on clinician practice.
Scientists discover Plexin-B1 as a potential therapeutic target for ErbB-2-overexpressing breast cancers, which have high metastatic potential. Additionally, researchers find that blocking the ErbB-2/Plexin-B1 interaction may reduce the risk of metastasis in patients with this type of cancer. In another study, researchers identify a be...
Researchers have found that Plexin-B1 represents a new candidate therapeutic target to treat patients with breast cancer found to overexpress the molecule ErbB-2. Overexpression of ErbB-2 led to activation of Plexin-B1, promoting metastatic cell characteristics in human breast cancer cells and reducing prognosis in human patients.
Researchers find that loss of STAT1 protein leads to increased breast cancer development in mice, as the immune system loses ability to control tumors. This discovery suggests that STAT1 may play a crucial role in preventing unwanted cell division and tumor growth.
A recent study published in Cancer Epidemiology, Biomarkers, & Prevention suggests that stopping hormone therapy can lead to tumor regression and decline new breast cancer rates. Researchers analyzed data from over 741,000 woman-years, finding no correlation between screening mammography use and former hormone users
A study by Vall d'Hebron Institute of Oncology reveals a potential new strategy to boost efficacy and break down resistance in patients with HER2 positive breast cancer. The combination of two drugs shows promise as a third treatment option, offering hope for patients with advanced tumours.
A study published in the Journal of Clinical Oncology found that women who underwent chemotherapy with the CMF regimen between 1976 and 1995 scored slightly lower on cognitive tests compared to those without a history of cancer. The differences were subtle but statistically significant, affecting word learning, memory, and information ...
Scientists at UCSF found simultaneous targeting of two molecules can effectively shrink tumors, block invasion, and stop metastasis in mice. The approach may improve combination treatments, including drugs like Avastin, for various cancer types.
A survey of over 41,000 patients with various cancers found that women, young people, and ethnic minorities experience delayed recognition due to symptom characteristics. GPs are less likely to consider cancer in younger patients and those from different ethnic groups, leading to longer consultation times.
A recent study published in Radiology found that mammography-detected breast cancers in women between the ages of 40 and 49 have a significantly better prognosis compared to non-mammography detected cases. This is attributed to earlier detection and treatment, resulting in lower recurrence rates and mortality.
A new study has identified a mutation in the Abraxas gene as a potential contributor to breast cancer susceptibility. The Abraxas protein interacts with BRCA1 and its mutation impairs DNA repair, increasing cancer risk.
Researchers at Weill Cornell Medical College found that a single protein, versican, is key to reversing the process of cancer metastasis in breast cancer. When versican was stopped from functioning, breast cancer could not seed itself into the lungs and form secondary tumors.
The USP15 protein has been identified as a critical regulator of cancer progression and immune response, accelerating drug development against glioblastoma and other types of cancer. USP15 promotes tumor growth by activating the TGFβ pathway, but its inhibition can lead to decreased TGFβ activity and reduced tumor development.
Researchers found that breast cancers can hijack an embryonic program to promote tumor growth and survival. A new study details how this 'on-off' switch is flipped by a protein called SIX1, which allows doctors to delete the pathway when it promotes tumors.
A new study published in The Lancet Oncology shows that cognitive behavioural therapy (CBT) significantly reduces hot flushes and night sweats in women after breast cancer treatment. CBT improves symptoms by 46-52% compared to usual care, with sustained benefits at 26 weeks.
A new study found people with Lynch syndrome have an increased risk of developing several types of cancer, including bowel, uterus, ovarian, kidney, stomach, and bladder cancers. The study also revealed a moderately increased risk of breast and pancreatic cancer in those with the condition.
The study identified biologically relevant targets in breast cancer using mRNA sequencing, revealing novel and unannotated transcripts. The GW research team discovered common and differentially expressing transcripts between three types of breast cancer, shedding light on the disease's underlying mechanisms.
A study published in the American Journal of Physical Medicine and Rehabilitation found that breast cancer patients undergo increased activation of neck and shoulder muscles during upper limb tasks, potentially leading to chronic pain.
Researchers at UCLA's Jonsson Comprehensive Cancer Center found that radiation treatment converts normal breast cancer cells into treatment-resistant stem cells. These induced breast cancer stem cells have a 30-fold increased ability to form tumors, undermining the effectiveness of radiation therapy.
Researchers at Stanford University have identified a sequential treatment regimen that enhances the effectiveness of trastuzumab in xenotransplant models of breast cancer. Trastuzumab activates natural killer cells to kill HER2-overexpressing tumor cells.
A prospective study links Lynch syndrome with significantly increased risks of breast and pancreatic cancers, while relatives without genetic mutations have no increased risk. The study provides clearer estimates of cancer risks associated with Lynch syndrome and may inform screening and early detection strategies.
A study found that children born to mothers who received chemotherapy during pregnancy have normal cognitive development and no significant differences in behavior, health, or hearing compared to the general population. However, premature birth was associated with lower cognitive scores.
Breast cancer in pregnant women is common and treatable with surgery or chemotherapy. A normal-length pregnancy should be the aim to avoid premature birth. Chemotherapy can be given as per standard guidelines, but radiation therapy is not advised due to fetal shielding concerns.
Researchers at Wake Forest Baptist Medical Center have developed a nanotube therapy that kills breast cancer stem cells by generating heat using laser treatment. The approach has shown promise in eliminating both differentiated cells and cancer stem cells, offering new hope for a cure.
Increasing age is associated with a higher risk of death from breast cancer in postmenopausal women, particularly those over 75 years old. The study found that disease-specific mortality increases with age, even after accounting for other factors, suggesting possible undertreatment as an underlying mechanism.
Researchers found striking similarities between genetic signatures of human breast cancer and those of stem cells in mouse embryos, revealing a new way to predict and personalize cancer therapies. The discovery could lead to the development of targeted treatments for aggressive forms of triple-negative breast cancer.
Researchers at Kimmel Cancer Center found that cyclin D1 overexpression associates with chromosomal instability in luminal B breast cancer. Elevated levels of cyclin D1 promote genetic breakdown known as chromosomal instability, which correlates with this subtype.
A new study reveals that women born to older mothers and taller, thinner girls before puberty are more likely to develop breast cancer. The research suggests that accumulated exposure to hormones during early life influences breast tissue composition and tumour development.
Researchers use molecular imaging to improve diagnosis and treatment decisions for estrogen-receptor positive breast cancer patients, detecting bone metastases and predicting therapy response. PET imaging with 18F-FES and 18F-FDG improves diagnostic information and prompts changes in treatment for 88% and 48% of subjects respectively.
Research by Sheila Collins and colleagues found that cardiac natriuretic peptides cause white fat cells to take on characteristics of brown fat cells, increasing energy usage. In another study, Anne Müller's team identified a cellular mechanism by which Helicobacter pylori protects against asthma by modulating immune cells.
A study found exemestane significantly worsens age-related decreases in bone mineral density by three times, even with adequate calcium and vitamin D intake.
Researchers have uncovered new genetic evidence supporting the hypothesis that acral melanoma is a distinct subtype with UV-damage signatures. Whole-exome sequencing of pancreatic cancer cell lines revealed a significant correlation between loss of MLH1 gene and indel mutation rates, disrupting several well-known cancer genes.
A new study reveals substantial differences in follow-up surgeries for women with breast cancer, affecting cancer recurrence and overall survival rates. The research highlights the need for quality measures to compare breast cancer surgical outcomes among surgeons and hospitals.
A new study reveals substantial differences in follow-up surgeries for women with breast cancer after partial mastectomy, which cannot be explained by medical or treatment history. The variation affects both cancer recurrence and overall survival rates, highlighting the need for increased accountability and transparency in healthcare.
A study of 64,659 women found that only 173 received recommended breast screening MRI despite being at high enough risk. The researchers aim to understand the disconnect and assess the value, feasibility, and implementation of breast MRI screening.
Researchers found significant variation in reexcision rates among surgeons and institutions, with some hospitals performing up to 70% more reexcisions than others. The study highlights the need for increased accountability and transparency in healthcare outcomes.
Researchers report that a short course of vaccination with an anti-HER2 dendritic cell vaccine eradicates tumors in nearly 20% of women with ductal carcinoma in situ. The treatment triggers strong, lasting immune responses in over 85% of patients, potentially reducing the risk of invasive cancer.
Researchers found that Avastin and Sutent, anti-angiogenesis drugs, increase cancer stem cells in breast tumors, fueling growth and spread. The study suggests combining these drugs with cancer stem cell inhibitors may enhance treatment effectiveness.
Researchers discovered 13 new gene regions associated with menopause onset, providing insights into reproductive lifespan and conditions like breast cancer and heart disease. Early menopause is linked to increased risk of these diseases, while later menopause may provide protection.
A study published in the Journal of the National Cancer Institute found that younger breast cancer patients experience more severe mental health issues and physical impairments than older women. Researchers recommend educating these patients about potential post-treatment effects to reduce anxiety and improve quality of life.
A commonly used medication for enlarged prostates may also slow the progression of early-stage prostate cancer, according to a new study. The treatment, dutasteride, was found to delay disease progression and reduce anxiety related to the disease in patients undergoing active surveillance.
A study published in the Journal of the National Cancer Institute found that younger women with breast cancer experience decreased health-related quality of life, including increased psychological distress, weight gain, and early onset menopause. Personalized treatment approaches are crucial to mitigate these side effects.
Statins, cholesterol-lowering medications, have been shown to inhibit the growth of breast cancer cells with mutant p53 genes. By targeting a specific pathway involved in cell proliferation, statins may be effective in treating these types of tumors.
A new imaging platform has been developed by Lawson researchers to study the moment when cancer cells turn deadly. The approach uses a shell-less chick embryo model implanted with human cancer cells, allowing scientists to modulate and monitor protein effects in real-time.
A world-first study conducted by QUT and CSIRO found that temperature-related deaths in Brisbane account for 6,572 years of life lost annually. Improving housing conditions through better insulation can help mitigate this issue.
Researchers identified a biochemical chain of events leading to activation of a protein-cleaving enzyme called hepsin on the surface of breast tumor cells. Hepsin breaks down basement membrane proteins, allowing tumor cells to escape and invade surrounding tissues.
A new study finds that pericytes, a group of cells in the tumor microenvironment, play a crucial role in preventing cancer progression and metastasis. Researchers discovered that inhibiting these cells can inadvertently make tumors more aggressive and likely to spread.
Researchers found that combining lapatinib and trastuzumab improved pathologic complete response rates in early-stage HER2-positive breast cancer patients compared to single-agent treatment. The study suggests dual HER2 blockade as a more effective approach for patients with early, non-metastatic HER2 breast cancer.
A study has identified a protein called hepsin that may trigger the spread of breast cancer in certain cases. Hepsin, a protease enzyme, was found to free tumor cells from their native tissue matrix, allowing them to invade other tissues and grow into aggressive tumors.
New studies published in The Lancet Oncology and The Lancet show that combining lapatinib with trastuzumab is almost twice as effective as single-agent therapy, but causes more side effects. Lapatinib is less beneficial than trastuzumab for single-agent therapy.
A possible receptor for the key breast cancer regulator Tumor Differentiating Factor (TDF) has been identified by researchers at Clarkson University. The receptor, labeled TDF-R, is found exclusively in breast cancer cells and shows specificity, suggesting its potential as a target for new therapies.
Researchers have developed targeted, fluorescent molecular imaging probes that can non-invasively detect breast cancer lymph node metastases, improving breast cancer staging and prognosis. CAIX and CAXII cell surface markers are highly expressed in breast cancer lymph node metastases.
Research finds that ISG15 pathway disrupts cytoskeletal architecture in breast cancer cells, promoting cell migration and invasion. The study suggests that targeting the ISG15 pathway could provide a therapeutic advantage for patients with metastatic tumors.
Research found parabens in breast tissue of all study participants, regardless of underarm product use, indicating alternative sources. The study detected five common paraben esters in 60% of samples and high levels of n-propylparaben near the armpit.
A study found that early-stage breast cancer patients often lacked knowledge about their disease and were not meaningfully involved in treatment discussions. This can lead to treatments not aligning with patient preferences, highlighting the need for improvements in the surgical decision-making process.
A new study found that most parents who get tested for breast cancer genes share their results with their children, even if they are very young. The majority of parents shared their results with at least one child, with older children more likely to be informed than younger ones.
A malignancy-risk gene signature developed for breast cancer has been found to have predictive and prognostic value for patients with early stage non-small cell lung cancer. The signature was able to distinguish between low and high malignancy risk groups, correlating with good or poor overall survival rates.
A prospective surveillance model for breast cancer treatment has been shown to significantly reduce costs and improve outcomes. The model, which involves early identification and intervention of lymphedema-related impairment, has been associated with direct treatment costs of $636.19 per year compared to traditional care at $3,124.92.