Articles tagged with Breast Cancer
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A new technique called Deep Inspiration Breath Hold (DIBH) helps deliver the correct dose to the right place, sparing healthy tissue. The study found that treating patients during DIBH reduced the heart mean dose by 68% and lung radiation by 20-30%, offering a clinical benefit for breast cancer patients.
A randomized trial found that highly targeted irradiation had equally good results as whole breast radiotherapy in early stage cancer, with a lower risk of adverse effects. The treatment reduced the rate of local recurrence by 0.8% and improved cosmetic outcomes by 18%, making it a potential game-changer for breast cancer patients.
Researchers developed gene expression signatures to predict breast cancer patient responses to chemotherapy. The signatures, based on TOP2A and β-tubulin, accurately predicted complete response rates and combined indices improved accuracy.
A study of 163 patients with cervical cancer found that 3D image-guided adaptive brachytherapy (IGABT) achieved high rates of tumor control and low side effects, making hysterectomies unnecessary for most women. The technique was effective in controlling the return and spread of the disease, and overall survival was 84% after three years.
A recent study published in the Journal of the National Cancer Institute found that physical activity is associated with reduced mortality in breast and colon cancer patients. The research suggests that exercise may provide benefits such as improved insulin levels, reduced inflammation, and enhanced immunity for cancer survivors.
A new Stanford study reveals that the cells sloughed off from a cancerous tumor into the bloodstream are genetically diverse and may require different treatments. The research found that these cells can express genes that predict their response to therapy, highlighting the need for personalized treatment approaches.
Research reveals that commonly occurring large chromosomal deletions contain areas with multiple functionally linked genes whose loss confers a survival advantage on tumors. The study validated the presence of these linked genes in mouse models of human liver cancer and demonstrated their cooperative action.
Researchers developed a new imaging device that uses photoacoustics to detect breast tumors, revealing high-contrast images of malignant tissue. The technology combines light-based system with ultrasound, providing superior targeting ability and potentially clinically useful for making breast cancer diagnoses.
A new study found that preoperative MRI exams are equally effective in detecting additional malignancies and high-risk lesions in both dense and non-dense breasts. The study suggests that breast density should not influence the decision to perform a preoperative MRI.
Heidelberg University Hospital's Breast Center reports excellent treatment results for breast cancer patients in Germany. Eighty-six percent of patients survived the first five years after onset of treatment and 80% remained disease-free during this period.
Research reveals breast cancer in young women is often diagnosed at an advanced stage, with a significantly higher risk of relapse independent of other factors. Genomic analysis identified age-related biological processes and potential targets for treatment, including the phosphoinositide 3-kinase molecular pathway and RANKL.
A new study conducted at Elizabeth Wende Breast Care in Rochester, NY found that women aged 40-49 with no family history of breast cancer are still at a high risk of developing invasive disease. The study included 211 women who underwent screening mammography and found that 64% had invasive disease.
Researchers identified a group of patients with high immune response gene expression who are more likely to have their tumors completely eradicated by pre-operative chemotherapy. Patients with HER2-positive and ER-negative/HER2-negative subtypes showed better treatment outcomes.
A new study reveals that automated breast ultrasound can detect additional clinically significant breast cancers missed by mammography, in just three minutes of physician time. This technology is a game-changer for women with dense breasts, who are at higher risk of missing cancer diagnoses.
Researchers have found that measuring progesterone receptor expression can improve hormone-receptor-positive breast cancer management. The study identifies a subpopulation of patients with high survival rates when treated with endocrine therapy alone, and could lead to a more personalized medicine approach in breast cancer.
Researchers have made significant breakthroughs in understanding the biological differences between individual breast cancers, highlighting the importance of biomarkers in identifying new targets for therapy. Studies also explored the mechanisms behind endocrine resistance and proposed a new approach to predicting response to treatment.
A new study found that women with benign breast biopsies do not require close surveillance at six or twelve months, and may not need follow-up care at all. The study suggests an annual mammogram could replace the need for follow-up examinations.
Scientists at UCSF used a pioneering imaging technique to study the interaction between breast cancer and the immune system in mice. They found that activated immune cells are headed off at the pass by healthy cells forming a 'thin red line' around tumors.
A study from the University of Texas M.D. Anderson Cancer Center found that Accelerated Partial Breast Irradiation (APBI) is associated with a higher risk of later mastectomy, increased radiation-related toxicities and post-operative complications compared to traditional whole breast irradiation.
Researchers estimate that screening mammography for women aged 40-49 with a twofold increased risk level of breast cancer has similar benefits and harms as average-risk women who start biennial screening at age 50. Factors such as family history and dense breasts increase risk by twofold.
Researchers found that most African-American breast cancer survivors were satisfied with their treatment but lacked access to critical information about treatment options, support services, and clinical trials. Only 62% of women received information about support services, while nearly half said they wanted such services.
Two new studies published in Annals of Internal Medicine found that younger women at increased risk for breast cancer may benefit from biennial mammography screening beginning at age 40. The data suggest that this approach has more benefits than harms for women with a two-fold increased risk. Meanwhile, hospital management strategies h...
A new analysis suggests that every-other-year mammography screening offers a better balance of benefits and harms for women aged 40 to 49 with an increased risk of developing breast cancer. Digital mammography screening resulted in greater false-positive results and harm compared to film mammography.
Researchers found that automated breast volume sonography (ABVS) detected suspicious lesions and uncovered additional cases compared to hand-held ultrasound. ABVS helped identify new breast cancers in mammographically negative cases, improving breast cancer detection rates.
A Moffitt researcher has received a $100,000 grant from General Electric to develop a genetic tool that can identify an individual's predisposition to developing or resisting breast cancer metastasis. The study aims to evaluate inherited changes in DNA predictive of and identify risk for developing or resisting breast cancer metastasis.
A new study found that only 6% of breast cancer survivors experience persistent and debilitating fatigue a year after treatment, contradicting previous reports. The researchers suggest that factors unrelated to the cancer or its treatment may have contributed to the high rates of reported fatigue.
A study published in American Journal of Roentgenology found that routine screening mammography benefits women between 40-49 years by detecting smaller tumors and high-risk lesions at earlier stages. This practice can lead to improved survival rates and reduced need for chemotherapy or extensive surgery.
Researchers at the University of Illinois Chicago are developing a community-based weight loss program for African American breast cancer survivors. The program aims to improve diet and physical activity habits, as well as reduce body mass index and weight-related health risks.
The study found that overactivation of RANK signalling pathway promotes tumour stem cells, increasing tumour growth and metastasis in human breast epithelial cells. High levels of RANK protein are associated with poor prognosis tumours and basal type tumours.
A study by Concordia University found that breast cancer survivors who can redefined their goals show an overall improvement in well-being. The researchers measured the capacity to adjust goals and found a positive association with more physical activity, emotional well-being, and fewer physical symptoms.
A study found a potential link between alcohol consumption and breast cancer, suggesting that the protein CYP2E1 plays a direct role in explaining the long-established risk factor. Women who naturally express higher levels of CYP2E1 and consume alcohol may be at a greater risk for developing breast cancer.
A study found high levels of TRAIL protein in human milk, which may contribute to its anticancer properties. Researchers detected 400- and 100-fold higher levels of TRAIL in colostrum and mature breast milk than in blood.
A recent study by Maggie Louie reveals that prolonged exposure to cadmium can cause breast cancer cells to become more aggressive and develop malignant characteristics. The researchers found that even small concentrations of cadmium at chronic exposures can contribute to the progression of breast cancer.
Researchers at IBN discover engineered human stem cells can target and inhibit tumor growth, prolonging survival in mice with breast tumors. This finding paves the way for innovative stem cell-based therapies, offering a promising alternative to conventional cancer treatment.
Researchers discover Perp, a protein involved in cellular 'glue', plays dual role in preventing breast cancer. Abnormal levels of Perp linked to enhanced inflammatory response and tumor development.
New research from Lund University identifies a potential cancer treatment by targeting a protein involved in cell division. The study found that blocking this protein could kill cancer cells while sparing healthy ones.
Researchers found that two-thirds of breast cancer survivors experience moderate-level cancer worry three years after treatment, with fatigue and risk perception being significant factors. The study aimed to identify characteristics associated with cancer worry, which can impact health behaviors.
Researchers at Moffitt Cancer Center found that breast cancer survivors who underwent chemotherapy and/or radiation therapy performed worse on cognitive tests than those who did not have cancer. The study's findings suggest long-term cognitive effects of these therapies need further investigation.
Researchers have reclassified breast cancer into 10 subtypes based on genetic features, allowing doctors to predict tumor behavior and tailor treatment. The study also discovered several completely new genes linked to breast cancer, which could lead to the development of new drugs and treatments.
A recent study published in PNAS contradicts the prevailing belief that basal-like cells are responsible for invasive tumors. Luminal-like cells, previously thought to lack stem cell properties, have been found to be highly tumorigenic and capable of generating larger tumors than their basal-like counterparts.
Researchers at Case Western Reserve University have developed a magnetic nanochain delivery system that explodes chemotherapy drugs inside tumors, killing cancer cells more efficiently. The technology reduced tumor growth by up to 90% and increased survival rates in rats with triple-negative breast cancer.
The Prospective Surveillance Model is a novel approach to managing pathological conditions resulting from cancer treatment by promoting early identification and treatment of known side effects. The goal of the model is to identify impairment at the earliest onset, alleviate impairment, or prevent it from progressing.
Researchers at Mayo Clinic have discovered a new class of molecular mutation in various forms of breast cancer, which may shed light on the development and growth of different types of breast tumors. Fusion transcripts, the mutated forms of RNA, could provide a way to identify tumor subtypes and offer new strategies for treatment.
A recent study found that men who reported the highest levels of stress in relation to their wives' breast cancer were at the highest risk for physical symptoms and weaker immune responses. The researchers suggest that clinicians caring for breast cancer patients could help their patients by considering the caregivers' health as well.
A web-based intervention tool called Guide to Decide helped post-menopausal women understand their breast cancer options and feel comfortable with their choice, leading to less uncertainty and increased decision-making. The study found that tailored information reduced anxiety and improved decision outcomes for high-risk women.
A University of Miami study shows that physically active women with non-metastatic breast cancer experience reduced depression and fatigue, as well as improved quality of life. Women who engaged in regular physical activity reported less debilitating fatigue and an enhanced ability to perform daily activities.
A team from UNC Health Care has developed a broad-based test to measure the activation of protein kinases, enabling the measurement of drug resistance in cancer. The test can identify combinations of drugs that block resistance, offering personalized therapies for breast cancer.
Researchers from the University of Hull have identified a family of proteins associated with chemotherapy resistance in breast cancer patients. The 14-3-3 protein family was found to be twice as prevalent in resistant patients, suggesting its potential use as a predictive test for clinical decision-making.
Research suggests stress can cause cognitive decline in women with breast cancer, regardless of treatment status. Women with passive coping strategies and high stress levels experience impaired memory and attention. Effective coping strategies are essential to maintaining cognitive function.
A new breast cancer rehabilitation model proposes a prospective surveillance approach to address physical issues, promoting reduced impairment, improved function, and increased exercise participation. The model aims to integrate disease treatment with rehabilitation and exercise interventions for better survivorship care.
Combining antiangiogenesis drugs with smaller nanomedicines may enhance treatment effectiveness for certain cancers. Vascular normalization temporarily decreases tumor blood vessel diameter, improving drug penetration of smaller particles but not larger molecules.
A new study finds that more than 60% of breast cancer survivors experience treatment-related complications even six years after their diagnosis. The study provides a comprehensive snapshot of the physical late effects of breast cancer treatment and outlines a model for monitoring and preventing these conditions.
Scientists have identified bimodal genes acting as molecular switches in ovarian cancer, providing potential targets for clinical prognostic and diagnostic testing. These gene expressions are associated with different tumor subtypes and patient survival outcomes.
A new study by Rush University Medical Center found that lung cancer screening with low-dose spiral CT scans can detect early-stage disease and reduce cancer-related deaths. The study estimates that commercial insurers should consider providing this benefit to high-risk individuals, which could lead to significant cost savings.
A study found that women with false-positive mammography results have a statistically significant higher risk of developing breast cancer compared to those who test negative. The long-term excess risk underscores the need for regular screenings despite potential anxiety from false-positive experiences.
A McGill University team has developed a new microarray technology that can accurately measure multiple proteins in a droplet of blood to detect breast cancer. The test, which uses a 'fingerprint' approach, showed promise in classifying patients with estrogen receptor-positive breast cancer.
Researchers at Fox Chase Cancer Center have developed a new cell and animal model of inflammatory breast cancer, which may provide a better understanding of the disease and help with developing effective interventions. The model recapitulates aggressive metastasis and cancer stem cell activity associated with poor outcomes in patients.
A new study has found a link between injectable contraceptives and increased breast cancer risk in young women, particularly those who have recently used the birth control method. Recent DMPA use for over a year was associated with a 2.2-fold increased risk of invasive breast cancer, which dissipates after discontinuation.
A large-scale genetic study reveals that triple negative breast cancer tumours exhibit a continuum of different types, making them difficult to treat. The discovery highlights the importance of tailoring cancer drug treatment to individual tumour profiles.
African American women are more likely to have estrogen receptor (ER) negative breast cancer due to genetic variations in the vitamin D receptor. Vitamin D deficiency is also common among these women, but those with specific genetic variations may have reduced risk.