Articles tagged with Breast Cancer
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Physiologists and neuropathologists from the University of Zurich have identified the origin of metastasis formation in intestinal cancer cells. Cancer cells manipulate specific doorman receptors on blood vessel endothelium to enter other organs via bloodstream.
Researchers at Brigham and Women's Hospital have developed a new approach to cancer treatment using supramolecular nanochemistry. The innovative nanoparticles significantly enhanced antitumor activity while reducing toxicity in breast and ovarian cancer models.
A study found that women using fertility drugs had a reduced risk of breast cancer if they did not conceive a 10-plus week pregnancy, but an increased risk if they did. The study suggests that exposure to the drugs may raise risk by modifying breast tissue remodeling during pregnancy.
The Center for Cancer Support and Education in Arlington, Mass., will receive a $10,000 grant from ASTRO's Survivor Circle program to fund breast cancer, advanced cancer, and brain cancer support groups. The Center offers emotional support during treatment and recovery for patients and their family members.
A study by 23andMe identified seven single-nucleotide polymorphisms (SNPs) associated with breast size, including three linked to breast cancer. The analysis controlled for age, ancestry, and other factors, providing insight into the genetic factors underlying normal breast development.
A new study presents the largest number of preimplantation genetic diagnosis (PGD) treatments for BRCA1/2 in Europe, with a significant proportion of successful pregnancies. The results suggest that PGD offers an established option for couples seeking to avoid inherited BRCA mutations.
A BUSM in vitro study discovered a potent combination therapy for breast cancer, including triple-negative and hormone-refractory cases. The treatment re-expressed imprinted tumor suppressor genes, inhibiting cancer cell growth and promoting death.
A study published in The Journal of Nuclear Medicine found that imaging progesterone receptor (PR) status can identify responders and nonresponders to endocrine therapy in early stages. PR imaging with F-18-FFNP PET may help distinguish between patients who will benefit from hormone-based therapies.
Researchers at Georgetown University Medical Center discovered that glucose-regulated protein 78 (GRP78) is a major determinant of resistance to anti-estrogen therapy. Inhibiting GRP78 may provide a solution for tens of thousands of women who develop resistance to these drugs.
Researchers have developed a simple and cost-effective imaging device for breast tumor detection using a flexible wearable antenna system. The system shows promise of detecting breast cancer earlier than other methods by analyzing microwave signals from skin contact, reducing signal loss compared to traditional designs.
Preventive mammography rates in women aged 40-49 have dropped nearly 6 percent nationwide since the USPSTF recommended against routine mammograms. The decline is consistent with public resistance to the guidelines change and a modest effect seen in the first year after publication.
Georgetown University Medical Center will establish the Center of Excellence for Health Disparities, focusing on eliminating health disparities among minority populations in Washington, D.C. The center aims to reduce chronic diseases such as breast cancer and stroke through research, education, and community engagement.
Research finds that physical activity, regardless of intensity, may reduce breast cancer risk in women. Exercise before or after menopause can lower the risk, especially for hormone receptor-positive tumors.
A new analysis found that physical activity may reduce breast cancer risk by 30% in women, with moderate activity providing the greatest benefit. Exercise before or after menopause also shows promise in reducing breast cancer risk, particularly for hormone receptor-positive tumors.
The study discusses the biology of tumor-derived microvesicles and their clinical application as circulating biomarkers. Microvesicles released by tumor cells may provide a unique biosignature for individual cancers, enabling early detection and targeted therapies.
Researchers have discovered a new method to sub-typing GBM tumor lines using proteins expressed, which could lead to targeted drug treatments and more accurate patient prognoses. The study found that patients with the CNP subtype may live up to 10 years after diagnosis.
Researchers uncovered surprises in genes previously thought uninvolved in breast cancer, revealing the complex drivers of this leading cause of cancer death. The study found novel fusion gene MAGI1-AKT3, which acts as an oncogene and offers new therapy targets.
Researchers have discovered a new indicator for breast cancer relapse, directly associated with the activation of NF-kB signaling in tumour cells. The absence of the 14-3-3 protein sigma is not itself a prognosis factor, but its lack enables chronic NF-kB activity linked to tumour progression.
A major population study found that women who worked nights had a 30% higher risk of developing breast cancer compared to those who never worked nights. The study also suggested that women who worked at night prior to a first pregnancy may be more vulnerable to the increased risk.
Researchers identified significant variation in microRNA expression within single tumors, highlighting the importance of sampling multiple tumor zones. This finding may explain conflicting previous results and emphasizes the need for personalized medicine approaches.
The Damon Runyon Cancer Research Foundation awarded $3.3 million to eight promising young clinical investigators, focusing on breast cancer and brain tumors.
A preclinical study found that normal p53, a tumor suppressor gene, makes breast cancer chemotherapy with doxorubicin less effective. Senescent cells produced by non-mutated p53 fueled the relapse of tumors. The research challenges the existing paradigm and is another step closer to personalized cancer medicine.
A study suggests that women can reduce their breast cancer risk by avoiding unnecessary medical imaging. According to the UCSF analysis of IOM report, radiation exposure from medical imaging is a known risk factor for breast cancer.
Dr. Rowan Chlebowski, a leading breast cancer researcher at LA BioMed, has been recognized for his significant contributions to cancer prevention and control through the ASCO-American Cancer Society Award and Lecture. His work on clinical trials and lifestyle interventions has reduced breast cancer recurrence and incidence.
A Vanderbilt-led study identified a gene expression pattern linked to resistance to breast cancer chemotherapy. The researchers found that tumors with low concentrations of the dual specificity protein phosphatase 4 (DUSP4) were more resistant to chemotherapy, suggesting new therapy options for patients with specific subtypes of breast...
Researchers identified distinct cancer signatures linked to treatment response in breast tumors, which could help personalize treatment for patients. The study found mutations in genes like TP53 and MAP3K1 associated with good response to aromatase inhibitors, while others like MALAT1 predicted poor outcomes.
A new blood test discovered circulating tumour cells can predict progression-free survival and overall survival in early-stage breast cancer patients. The presence of CTCs is associated with worse survival rates, but the correlation increases when concentrations are higher.
A study found that women treated with chest radiation for childhood cancer have a high risk of developing breast cancer comparable to those with BRCA1/2 mutations. The study analyzed data from over 1,200 female survivors and found a 24% breast cancer incidence by age 50.
Researchers have identified changes in adult stem cells and tumor suppressors that contribute to age-related breast cancer vulnerability. The 'HMEC Aging Resource' provides a valuable resource for studying cellular aging, allowing researchers to explore potential preventative measures.
A Mayo Clinic-led study found that high doses of American ginseng reduced cancer-related fatigue in patients more effectively than a placebo. The herb showed significant improvement in general exhaustion at eight weeks, with no apparent side effects.
A new breast cancer treatment, trastuzumab emtansine (T-DM1), has shown significant improvements over standard therapy in keeping advanced tumors from progressing, with fewer and less harsh side effects.
Researchers have identified androgen receptors as a key target for treating breast cancer, leading to the development of enzalutamide as a potential new therapy. The study suggests that blocking these receptors can inhibit cancer growth, offering new hope for patients with hormone-dependent breast cancers.
Researchers identified a genetic marker, microRNA, that differs in expression between African American and Caucasian women with breast cancer. The study found that African American patients overexpressed only six microRNAs, while Caucasian patients expressed 20 microRNAs, suggesting potential connections to treatment outcomes.
A study found that combining lapatinib and pazopanib did not improve outcomes for patients with inflammatory breast cancer, despite increased side effects. Lapatinib was shown to be an effective treatment option for women with this disease.
The US Food and Drug Administration (FDA) is issuing recommendations for breast cancer trials that would substantially accelerate patient access to new medications. The new regulatory guidelines are based in part on groundbreaking, national breast cancer research led by UCSF.
The global cancer burden is projected to rise by over 75% by 2030, driven by demographic changes and Westernized lifestyle factors. Countries with low Human Development Index (HDI) are expected to experience a significant surge in cancer cases, particularly those associated with infection.
The CNRCS has awarded three students for their work on prostate cancer, including Jayantha Tennakoon, who aims to identify molecules that provoke cancer cell growth. Undergraduate Hannah Do is maintaining a drug library to isolate new therapeutic targets for advanced prostate cancer. Eylem Aydogdu became the first Ph.D. graduate at the...
Researchers found that Skp2 E3 ligase promotes Herceptin resistance in breast cancer by activating the Akt kinase, which also regulates glucose metabolism. The study suggests that blocking Skp2 could inhibit glycolysis and provide a new approach to cancer treatment.
A study by Duke University Medical Center found that breast cancer patients have significantly impaired cardio-pulmonary function that can persist for years after treatment. Higher cardio fitness levels were linked to longer median survival among women with advanced breast cancer, suggesting exercise may be a useful intervention.
A new study shows that Breast MRI provides an indication of a breast tumor's response to pre-surgical chemotherapy significantly earlier than possible through clinical examination. MRI size measurements were superior to clinical examination at all time points, predicting both complete tumor response and residual cancer burden.
A new clinical trial is testing a combination of fulvestrant and ganetespib, an HSP90 inhibitor, to treat recurrent or metastatic estrogen receptor-positive breast cancer. The goal is to make tumor cells more susceptible to hormonal therapies.
Researchers have identified a new genetic signature associated with basal-like breast cancer, which is more prevalent in African Americans. The discovery suggests that combination therapy targeting multiple pathways could be an effective treatment strategy for this aggressive subtype.
A decade after the Women's Health Initiative stopped a widely used hormone therapy, experts have reassessed its benefits and risks. The new research supports the use of hormone therapy near menopause to alleviate symptoms and reduce the risk of heart disease and fractures for most women.
Researchers discovered a novel mechanism regulating breast cancer bone metastases and found that heparin-like compounds can inhibit bone destruction and tumor growth in bone. A promising heparin-like compound has reduced anticoagulant activity, improving its applicability as a potential cancer therapeutic agent.
A team of scientists has developed a new strategy to reactivate genes that cause cancer tumors to shrink and die. The researchers found that inhibiting the PAD4 enzyme can effectively target unhealthy, cancerous tissue without damaging healthy tissues.
A randomized clinical trial found that moderate weight loss can significantly reduce levels of circulating estrogens associated with an increased risk of breast cancer. The study, published by Fred Hutchinson Cancer Research Center, showed that losing just 5% of one's total body weight had a beneficial impact on hormone levels.
Researchers from NUS have discovered how a drug-lead compound named BPTES can deprive cancer cells of energy and stop them from growing into a tumour. Building on these findings, they also derived positive results for a novel dual-drug treatment regime that kills kidney and breast cancer cells more effectively.
A new study published in Breast Cancer Research found that panobinostat selectively targets and destroys triple negative breast cancer cells. The HDAC inhibitor also reduces tumor growth in mice and partially reverses the morphological changes in cells to a more epithelial type.
A team of researchers at the Wellcome Trust Sanger Institute sequenced the genomes of 21 breast cancers, revealing new mutation processes that drive their development. The study found that these mutations accumulate over time, creating a complex landscape of genetic changes in the cancer cells.
A hybrid vaccine has demonstrated a 43% reduction in risk of recurrence, with an estimated rate of 10.3% compared to 18% in control group, in patients with varying levels of HER2 expression.
A study published in Science Translational Medicine found that daclizumab improved the survival of breast cancer patients taking a cancer vaccine by 30%, compared to those not taking daclizumab. The drug depletes regulatory T cells, allowing immune cells to fight tumors more effectively.
Researchers will investigate Cu-64, a biomolecule that selectively seeks out a prostate tumor biomarker, to stage prostate cancers and detect recurrent disease accurately. The new technique involves PET scans and could significantly reduce the number of confirmation biopsies.
Researchers investigated whether preoperative imaging differed between black and white women with breast cancer. They found no disparity in the use of imaging, contrary to some earlier studies. However, they did note that women from more educated areas were more likely to receive certain types of imaging.
Researchers identify nine new genes that drive breast cancer development, highlighting the genetic diversity of the disease. The study provides insights into the consequences of this diversity and its implications for treatment.
A collaborative study is exploring the proteome of triple negative breast cancers to identify new drug therapies and diagnostic tools. The researchers aim to understand how cancer cells operate and find proteins that could suggest treatment options.
Researchers at the University of Missouri discovered that apigenin slows breast cancer cell growth by inducing cell death, inhibiting proliferation, and reducing gene expression. Apigenin-treated mice showed smaller tumors and restricted nutrient flow to cancer cells.
Researchers identified a cell surface protein ganglioside GD2 that flags breast cancer stem cells as potent tumor-generating cells. A small molecule drug triptolide inhibits GD3 synthase, essential to GD2 production, and stymies cancer growth in preclinical tests.
Research reveals a link between Glyoxylase 1 and increased anxiety in mice, with implications for potential therapeutic targets. Additionally, studies provide hope for new treatments for the rare disease Beare-Stevens syndrome and graft versus host disease.
A multicenter study found that the Breast Imaging and Reporting Data Systems (BI-RADS) terminology used by radiologists is useful in predicting malignancy in breast lesions detected with MRI. Features such as irregular shape, spiculated margins, and marked enhancement are most predictive of cancer.
A cancer vaccine targeting MUC1 glycoprotein significantly increased survival when combined with the drug letrozole in mice. The findings suggest a promising new approach to combating cancer using immunotherapy.