Articles tagged with Breast Cancer
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Researchers found that radiation therapy significantly improved overall and breast cancer-specific survival rates for elderly women with early-stage ER-positive breast cancer. The study analyzed data from over 29,000 women and showed that radiation treatment increased median survival by nearly four years compared to surgery alone.
A recent study has found that non-Hispanic black women diagnosed with estrogen receptor-positive tumors have a significantly increased risk for breast cancer death, particularly within the first three years after diagnosis. This risk is more pronounced among black women compared to non-Hispanic white women.
A retrospective study found that patients with multifocal or multicentric breast cancer experienced higher rates of local recurrence compared to those with a single tumor. The researchers also noted that overall survival and distant recurrence rates were similar between the two groups.
Researchers have developed biodegradable iron-doped silica spheres to tag breast tumors, reducing the need for follow-up surgeries by up to 50%. The particles can be used to destroy tumor tissue with high-intensity focused ultrasound therapy, improving surgical precision and patient trauma.
A recent study published in Nature Cell Biology has identified Elf5, a protein necessary for lactation, as a key player in suppressing breast cancer tumors and metastasis. The research found that when Elf5 is absent or low, epithelial cells become more like stem cells, leading to cancer growth and spread.
A study found gene polymorphisms in hormone metabolism and growth factor pathways associated with breast density, which increases breast cancer risk. Variants in genes like PRL, TNF, and SULT1A1/2 were linked to breast density in both hormone therapy users and non-users.
Researchers developed a new technique using phase contrast tomography and EST algorithm to create high-quality 3D images of breast tissue, allowing for earlier and more accurate detection of breast tumors. The technique uses lower radiation doses than current CT scanners, enabling clearer images with sharper details.
Scientists have developed a method to produce 3D X-ray images of the breast with a radiation dose 25 times lower than current hospital scanners, enabling improved diagnosis and potentially reducing breast cancer mortality. The new technique combines high-energy X-rays, phase contrast imaging, and advanced mathematical algorithms.
Researchers discover that breast cancer cells' ability to spread is influenced by the tumor's protein-rich environment as much as genetic changes within the cells. The study reveals that a specific molecular signal in the protein meshwork can initiate metastasis to distant sites, while a healthy environment can even coax healthy cells ...
A study published in Journal of Clinical Oncology found that brachytherapy, a low-complication-rates treatment for early-stage breast cancer, actually results in more complications than whole-breast radiation one year after treatment. The use of brachytherapy was associated with a 16.9% higher rate of wound and skin complications.
Researchers found that green tea extract Polyphenon E inhibited vascular endothelial growth factor and hepatocyte growth factor, promoting tumor cell growth, migration, and invasion. Women taking the extract had a significant reduction in hepatocyte growth factor levels, but no long-term effects were observed.
A study found that blood hormone levels can predict postmenopausal breast cancer risk for up to 20 years. Women with elevated hormone levels had a higher risk of developing breast cancer, including aggressive forms.
A study at Columbia University's Mailman School of Public Health found that breastfeeding significantly reduces the risk of ER/PR-negative breast cancer. Women who breastfed their children had no increased risk of this aggressive tumor subtype.
A nested case-control study found increased concentrations of estradiol and progesterone during early pregnancy associated with a heightened risk for HR-negative breast cancer. The study, presented at the 11th Annual AACR International Conference on Frontiers in Cancer Prevention Research, included 223 cases and 417 controls.
Researchers found that elevated hormone levels, except for DHEAS, tracked closely with increased risk for HR-positive breast cancer. Women in the highest 25 percent of SHBG levels had a 30% lower risk for breast cancer compared to those in the lowest 25 percent.
Researchers have developed a novel compound from vegetable sources that demonstrates superior anticancer activities, particularly against triple-negative breast cancer. The orally active compounds could offer safer and more effective treatment options for patients.
Achieving and maintaining a healthy body weight, staying physically active, and following a healthy diet significantly reduced mortality in elderly female cancer survivors. Researchers found that adherence to lifestyle guidelines resulted in an almost 40% lower risk for death compared to those who did not follow these recommendations.
Researchers identified an epigenetic change associated with a higher risk of breast cancer in the sick twin before clinical diagnosis. The DOK7 gene showed pathological methylation gain, indicating potential as a novel biomarker for early detection.
The Robert Wood Johnson Foundation's 2012 Community Health Leaders Award recognizes individuals who have made significant contributions to improving health and healthcare in their communities. The recipients include Kay Branch, Fred Brason, Debbie Chatman Bryant, Beth Farmer, Amy Johnson, and Ifeanyi Anne Nwabukwu, who are addressing i...
Researchers identified tissue mechanisms that may increase a woman's risk of breast cancer after exposure to low-dose ionizing radiation. Gene expression profiles show women with specific gene expressions are more likely to survive breast cancer, while others are at higher risk.
Researchers found that genetic imbalances in most cases determine the evolution from noninvasive to invasive disease. The study identified patterns consistent with known aberration profiles for breast cancer, including the loss of tumor suppressor CDH1 and gain of oncogene MYC.
Researchers at Moffitt Cancer Center have discovered new components of the DNA damage response network, including proteins that could be targeted as sensitizers for chemotherapy. The study's findings may lead to the development of new therapeutic strategies and accelerated treatment for cancer.
A study published in The Lancet found that cancer resulted in the loss of nearly 170 million years of healthy life worldwide in 2008. This significant burden was largely attributed to colorectal, lung, breast, and prostate cancers, with men in eastern Europe facing the largest cancer burden.
A new study reveals that curcumin, a compound found in turmeric, can inhibit the formation of metastases in prostate cancer. Curcumin reduces inflammation and decreases the expression of proteins that promote metastasis, resulting in a decline in tumor cell growth.
Breast tumor cells interact with mesenchymal stem cells (MSCs) in the tumor microenvironment, triggering production of lysyl oxidase (LOX), a gene that enables cell migration and metastasis. This process, called epithelial-to-mesenchymal transition (EMT), allows cancer cells to spread to bones and other parts of the body.
A study from Lund University finds a strong link between neurotensin, a satiation hormone, and the risk of type 2 diabetes, cardiovascular disease, and breast cancer in women. Obesity is not the primary explanation for this connection.
Researchers at IDIBELL and ICO have developed new animal models for cancer research, including orthotopic implants of human tumor tissues in mice. These models mimic the growth of human tumors and response to chemotherapy, paving the way for personalized medicine against various cancers.
A study published in JAMA found that high plasma levels of proneurotensin are associated with an increased risk of developing diabetes, cardiovascular disease, and breast cancer in women. The study also found a significant interaction between sex and proneurotensin on the risk of cardiovascular disease.
Research reveals that Col6 protein's endotrophin alter tumor environment promoting growth and metastasis in mice. Reduced endotrophin expression linked to lower tumor burden and fewer metastases.
A study published in JNCI Journal of the National Cancer Institute found that HIV protease inhibitor Nelfinavir inhibits the growth of HER2-positive tumors in mice. The treatment uses a dosage regimen similar to that used for HIV patients, suggesting potential as an anticancer agent.
Researchers found that breast cancer survivors with higher self-efficacy scores were 10% more likely to be physically active six months after the intervention. Behavioral skills such as self-confidence and motivation can be taught, enabling women to overcome exercise-related barriers.
Professor Sidney Fu is studying small RNA biomarkers to develop a blood test for detecting early-stage breast cancer. His research aims to identify patients who will not benefit from aggressive treatments, saving them from unnecessary trauma and stress.
Army surgeons have presented two studies highlighting the potential of a cancer vaccine in improving survival rates. The first study showed that breast cancer survivors who received a HER2 peptide vaccine had a higher likelihood of surviving disease-free compared to those without the treatment. In contrast, patients with Crohn's Diseas...
Researchers found that a memory training program improved memory performance, while a computer-based program called Insight improved both memory and information processing speed. The study suggests these programs may help alleviate symptoms such as depression, anxiety, and fatigue in breast cancer survivors.
Research identifies NF1 as a driver in more than 25% of non-inheritable breast cancers, associated with increased Ras activity and decreased NF1 levels. This finding may guide clinicians to targeted treatments for patients with NF1 mutations.
A novel MRI technique using diffusion-weighted imaging (DWI) successfully characterizes 46% of non-malignant breast lesions as benign, reducing false-positive findings and preventable biopsies. DWI differentiates high-risk lesions requiring additional workup from other non-malignant subtypes.
Researchers at Wake Forest University have designed a targeted therapy that delivers a sneak attack on breast cancer cells, similar to a Trojan horse. The new platinum-based molecule has shown promising results in treating non-small cell lung cancer and pancreatic cancer, with potential applications for breast cancer treatment.
A new study from the Netherlands found that digital mammography improves breast cancer screening detection rates, particularly for high-grade lesions. While there was a slight increase in clinically insignificant disease diagnoses, the benefits of digital mammography outweighed the risks.
Researchers have found that one year of treatment with trastuzumab is as good as two years of treatment, improving outcomes and reducing the risk of disease recurrence. This conclusion comes from the HERA trial, which involved over 5100 women with early HER2-positive breast cancer.
A new study published in the Journal of American College of Surgeons found that needle biopsies can lead to improved treatment outcomes for women diagnosed with breast cancer. Patients who underwent needle biopsies were more likely to have adequate tumor excision and lymph node assessment compared to those who received open biopsies.
Using biological markers can increase the success rate of new breast cancer drugs. A study found that the use of biomarkers such as HER2 resulted in a 23% success rate, compared to 15%, with significant cost savings.
Researchers explored AMP-activated protein kinase's role in Drosophila energy homeostasis and tissue-specific gene expression in Arabidopsis. Cellular memory of stress resistance was also studied in Saccharomyces cerevisiae, revealing a multifaceted response mechanism.
Researchers are developing a simple blood test to detect early signs of breast cancer, which could improve treatment and detection rates. The study aims to identify DNA markers consistent with cancer in blood samples from women attending breast screening clinics.
Researchers have discovered a new vaccinia virus that targets triple-negative breast cancer cells, achieving over 90% cell kill and extensive tumor destruction. The virus also inhibits tumor blood vessel growth, offering a potential targeted therapy for this deadly form of breast cancer.
A large-scale trial has successfully tested whole-genome cancer testing to identify targeted therapies for patients with metastatic breast cancer. The study found that around 20% of patients had rare and unexpected genomic alterations, highlighting the need for whole-genome approaches.
New research reveals that women with HER2 positive breast cancer that is also hormone (estrogen and progesterone) receptor negative have an increased risk of early death and less likely to recur in bone compared to those with hormone-sensitive cancer. The study suggests HR status defines two different subsets of HER2 positive cancers.
Studies presented at ESMO 2012 Congress reveal that a large proportion of people overestimate the cancer risk attributable to genetics and underestimate the risks associated with obesity, alcohol, and sunlight exposure. Increasing awareness of primary cancer prevention is crucial to reduce incidence rates.
Research reveals activation of PI3K-Akt signaling pathway induces mammary gland cells to produce prolactin, triggering Stat5 activation and milk production. Prolactin's role in human breast cancer is reevaluated, with potential implications for treatment.
A new study suggests that not enough women with breast cancer are being offered the chance to undergo treatments that may conserve their breasts. Despite high response rates to neoadjuvant therapy, only around 40% of patients receive breast-conserving surgery. The studies call for a clear consensus on the role of breast conserving surg...
A new optical imaging technology, developed at Tufts University School of Engineering, uses near infrared light to scan breast tissue and can identify water, fats, and oxygen-rich and oxygen-poor tissue. This non-invasive technique could complement standard mammography, particularly for women with dense breast tissue.
A blood test developed by Kansas State University researchers can accurately detect the beginning stages of breast and non-small cell lung cancer. The test works by detecting increased enzyme activity in the body, with a 95% success rate in detecting cancer in participants.
A study of Jewish women who lived under Nazi control during World War Two found that those with severe hunger were five times more likely to develop breast cancer. Women aged seven or younger at the time had a three times higher risk of developing breast cancer than their older counterparts.
Near-infrared (NIR) spectral imaging has been shown to be highly predictive of flap outcome in breast reconstruction, detecting circulatory complications early on. This non-invasive method can provide real-time feedback to surgeons during surgery and post-operative period, improving patient outcomes.
A retrospective study found that regular mammography screening can help eliminate the disparity in breast cancer mortality between black and white women. Women screened regularly were more likely to have hormone receptor-positive breast cancers, suggesting early detection can blunt negative prognostic biological characteristics.
A new program aims to improve the quality of breast cancer treatment decisions by studying how patients and doctors make choices. The researchers will develop an online decision tool to help patients weigh options and risks, with the goal of reducing unnecessary side effects and improving patient outcomes.
The Cancer Genome Atlas study identifies four main breast cancer subtypes defined by PAM50, with diverse genetic and epigenetic alterations converging into these phenotypes. The study's findings advance understanding of breast cancer biology and support the use of PAM50 as a gold standard for categorizing breast cancer by subtype.
Researchers developed a new nanotechnology that detects micrometastases in mouse models of breast cancer, marking them for early diagnosis and treatment. The technology uses nanochains to target cancer cells with integrins, allowing doctors to guide surgery or deliver cancer-killing drugs directly to the cells before a tumor forms.
A team of researchers identified genetic causes of the most common form of breast cancer, Estrogen-Receptor positive Luminal A subtype, providing clues for new therapeutic targets. They also found a molecular similarity between basal-like breast cancers and high-grade serous ovarian tumors.
A study by NIH/National Cancer Institute reveals shared genomic features between high-grade serous ovarian cancer and one subtype of breast cancer. This similarity suggests that the two cancers share a common molecular origin, facilitating comparison of therapeutic data.
A recent study reveals that basal-like breast tumors and ovarian tumors have similar genetic origins, suggesting potential for shared treatments. The research found unique genetic signatures within each subtype, highlighting the need for personalized cancer therapies.