Articles tagged with Breast Cancer
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Scientists have developed a new magnetic resonance imaging (MRI) method to evaluate the cellular proliferation of breast cancer tumor models. This non-invasive technique assesses water diffusion in tumor tissue, correlating it with growth rates.
Changes in progenitor cell populations in breast tissue may contribute to breast cancer development, according to new research. The study found that aging leads to a decrease in myoepithelial cells and an increase in multipotent progenitors, which can fuel malignant growth.
A preclinical study suggests that inhibiting mTORC1 with everolimus can suppress Myc-driven tumor initiation and growth. Everolimus caused tumor regression by inducing cellular senescence, rather than apoptosis.
Researchers discovered HER2-positive breast cancer stem cells in previously thought HER2-negative tumors, making these cells resistant to traditional treatments. The findings suggest that targeted therapies can effectively treat HER2-negative breast cancers, while also providing a new diagnostic tool.
A new hormone therapy combining conventional estrogen with a bone-protective SERM-like drug has shown promise in reducing menopausal symptoms and osteoporosis risk without increasing breast cancer risk. The treatment approach, termed TSEC, was tested in postmenopausal nonhuman primates over a 20-month period.
A large study finds that post-menopausal breast cancer survivors are more likely to develop diabetes, with a significant association observed after chemotherapy. The risk increases over time, suggesting the need for closer monitoring and screening of these patients.
A study published in Breast Cancer Research and Treatment found that delaying childbirth for at least 15 years after the first menstrual period can reduce the risk of triple-negative breast cancer by up to 60%. Breastfeeding is also associated with a protective effect against this aggressive form of breast cancer.
Researchers at Fox Chase Cancer Center developed a novel 3D culture system to mimic the environment surrounding IBC cells. The model showed that the tumor microenvironment promotes proliferation, growth and invasion of IBC tumors.
Scientists discovered blocking a specific protein makes tumors more vulnerable to treatment in mice, hinting at potential new therapies for humans. Researchers are now exploring inhibitors of the protein, which could boost cancer drugs' effectiveness.
A preclinical study published in Cancer Research found that obesity and overfeeding during menopause together drive aggressive tumor growth and progression. Obesity-related metabolic changes allowed breast tumors to accumulate glucose and promote proliferation.
Researchers found that Mesupron combined with Capecitabine significantly extended progression-free survival for patients with metastatic breast cancer to 8.3 months, nearly twice that of those taking Capecitabine alone. The study also showed improved results in previously treated patients.
A study by Vanderbilt-Ingram Cancer Center investigators found that most triple-negative breast cancer patients have multiple genetic mutations, despite treatment with chemotherapy. The research may provide targets for new therapies and shed light on the challenges of treating this form of cancer.
A Mayo Clinic study discovered 27 genes associated with a good outcome using concurrent trastuzumab and chemotherapy, while five genes linked to poor outcomes. The findings aim to develop a genetic test to select the best treatment for HER2-positive patients.
A phase III clinical trial compared eribulin mesylate to capecitabine in women with previously treated metastatic breast cancer, showing a trend towards improved overall survival. The median overall survival was 15.9 months for eribulin and 14.5 months for capecitabine.
Researchers found that some women with HER2 negative breast cancer may still benefit from anti-HER2 drugs due to undetected mutations. The study identified 25 patients with HER2 mutations without amplification, and most responded well to treatment. A phase II clinical trial is now underway to test the effectiveness of these treatments.
A pooled analysis of eight cohort studies found that women with higher circulating carotenoid levels had statistically significantly lower breast cancer risk. The inverse association was strongest for estrogen receptor-negative (ER-) breast cancers, highlighting carotenoids as a potential modifiable risk factor.
A study by TGen and US Oncology Research identified genetic mutations in 14 metastatic TNBC patients, including TP53 and ERBB4 tumor suppressor genes. The research offers potential drug targets for this aggressive form of breast cancer.
Research from Fox Chase Cancer Center finds that women are more likely to follow experts' advice on reducing risk of lymphedema after breast cancer surgery if they feel confident in their abilities and know how to manage stress. Women who feel empowered can modify their behavior to avoid the complication, whereas daily behavioral chang...
A groundbreaking clinical trial reveals that women with estrogen receptor-positive breast cancer who take tamoxifen for 10 years have a lower risk of recurrence and mortality rate compared to those taking the drug for 5 years. This new finding may prompt patients to reconsider their treatment options, particularly premenopausal women.
Researchers found that statin use improved progression-free survival and disease-specific survival in patients with stage III inflammatory breast cancer. Patients who took hydrophilic statins saw the greatest improvement in survival, with an average of 4.88 years.
A new study conducted by Mayo Clinic reveals that sentinel lymph node surgery can accurately identify residual breast cancer in lymph nodes after chemotherapy, with a success rate of 91%. The procedure removed only a few lymph nodes, reducing surgical complications, and found complete eradication of cancer in 40% of patients.
Researchers found that continuing tamoxifen treatment beyond 5 years further reduced breast cancer recurrence and mortality rates. The additional benefits took some years to emerge, with risks of recurrence decreasing from 21.4% at year 15 in those who continued treatment compared to 25.1% in controls.
African American women with early-stage invasive breast cancer were 12% less likely to receive the minimally invasive axillary sentinel lymph node biopsy compared to Caucasian women. The study found higher rates of lymphedema among African American women who underwent the older, more invasive procedure.
Researchers at the UNM Cancer Center are studying GPER, a novel estrogen receptor, to develop potential therapies for breast cancer. By understanding how GPER influences tumor growth and metastasis, they aim to create more effective treatments that can reduce resistance to existing drugs.
A series of studies by Intermountain Healthcare's Oncology Clinical Program shows that improving care across a large hospital system is possible through standardized care. Key findings include reduced mastectomies and lymph node removals in breast cancer patients, indicating a more consistent approach to treatment.
A new genetic test can accurately identify the presence of breast cancer tumors and predict the progression of tumor development. This breakthrough technology analyzes genetic switches to detect cancer growth, enabling earlier diagnosis and more effective treatment plans.
A study at Thomas Jefferson University found that meditation paired with art therapy significantly reduced stress and anxiety in women with breast cancer. The treatment altered brain activity, increasing emotional centers associated with positive emotions, stress regulation, and reward system function.
Women with advanced breast cancer who wait over 60 days for treatment face significantly higher risks of dying. Early detection and timely treatment can increase five-year survival rates to as high as 98 percent.
Kornelia Polyak and Mina J. Bissell will receive the AACR Outstanding Investigator Award for Breast Cancer Research and Distinguished Lectureship, respectively. The symposium presents a balance of clinical, translational, and basic research on breast cancer.
A study found that DCIS patients with combined RB and PTEN loss are at high risk of progressing to invasive breast cancer. Women lacking both genes are over 5 times more likely to develop invasive breast cancer.
Several studies presented at the 2012 Quality Care Symposium provide insight into improving quality of cancer care. Researchers found that increasing awareness among physicians and patients can reduce the overuse of diagnostic imaging in young adult cancer survivors, resulting in decreased anxiety and unnecessary radiation exposure.
A survey of women with dense breasts found that many would pursue additional screening if notified of their breast density. The study highlights the need for patient education regarding breast density and available alternative technologies to aid in screening.
A new study found a four-fold increase in breast cancer incidence among women with neurofibromatosis-1, prompting recommendations for earlier screening. The researchers suggest annual manual breast exams and mammograms beginning at age 40 for this high-risk population.
Two studies presented at RSNA 2012 found that revised guidelines for screening mammography may lead to a decline in screening, potentially resulting in missed cancers. The new recommendations, issued by the USPSTF, recommend routine screening every two years for women 50-74 years old.
The American Society of Clinical Oncology's Quality Care Symposium reveals important advances in cancer care quality measurement, physician adherence to quality standards, and end-of-life care. The studies also highlight the overuse of contralateral prophylactic mastectomy.
A study of 250,000 women found that repeated CT and nuclear imaging increased breast cancer risk, especially in younger patients. The risk was highest among young women who received multiple scans, with estimates suggesting a 20% increase in 10-year breast cancer risk.
A recent study found that 70% of women with breast cancer have both breasts removed despite a very low risk of recurrence in the healthy breast. The study suggests that concern about recurrence drives the decision, but this procedure is often associated with higher morbidity and unnecessary complications.
Dr. Debra Auguste aims to develop targeted treatments for four metastatic breast cancer populations using engineered liposomes that deliver short interfering RNA to inhibit tumor progression and metastasis. The goal is to enhance cooperative binding, reduce cell migration, and improve treatment efficacy.
Johns Hopkins researchers identified a protein called JMJD2C that helps breast cancer cells spread by unlocking genes. The discovery confirms the protein's role in breast cancer progression and offers a potential target for anti-cancer therapy.
A new breast imaging technology, tomosynthesis, significantly improves radiologists' diagnostic accuracy and reduces false positive recall rates when combined with standard digital mammography. The study found a 10.7% increase in diagnostic sensitivity and a 38.6% reduction in absolute recall rates.
Researchers found that half of Medicare patients waited at least 32 days after their first doctor visit to undergo breast cancer surgery. Wait times varied by demographics and procedure type, but overall outcomes do not appear to be affected.
A Canadian case-control study found that women in jobs with high exposures to carcinogens and endocrine disrupters had an elevated breast cancer risk. The study highlights the importance of occupational studies in identifying environmental risk factors.
A study by George Washington University researchers estimates that over 1 million low-income women could get mammograms and Pap tests for breast and cervical cancer. The Affordable Care Act could lead to major gains in screening and early detection, resulting in faster treatment and better outcomes for women across the nation.
The Marilyn B. Gula Mountains of Hope Foundation raised $100,000 for groundbreaking breast cancer research at TGen through its annual 'Cookin' for a Cure at Eddie's House.' The funds will focus on primary Luminal B breast cancer, one of the most difficult-to-treat subtypes, to determine genetic variables driving this type of cancer.
Researchers have developed a new computer algorithm that analyzes thermal images of breasts to enhance breast cancer detection. The approach improved accuracy from 90% to 96% in tests on 28 patients, paving the way for future studies with larger patient groups.
Sanford-Burnham researchers found that different brain tumor cell types respond to distinct treatments due to varying growth factor regulation. This discovery offers potential for more effective and less harmful treatments tailored to individual tumors.
A new digital mammography technique has been shown to improve the accuracy of breast cancer screening, reducing both false positive findings and recalls. The stereoscopic method uses a unique workstation and polarizing lenses to identify lesions at different depths within the breast volume.
Researchers found that inhibiting PI3-kinase can convert BRCA-proficient triple-negative breast cancers into BRCA-deficient ones, making them sensitive to PARP inhibitors. This combination treatment showed promising results in preclinical studies and is now being tested in a clinical trial.
A new statistical image analysis method can assist in grading breast cancer by automatically segmenting tumour regions and detecting dividing cells. The method, developed at the University of Warwick, promises to bring objectivity and automation to the cancer grading process.
A new study by the University of Cambridge reveals substantial inequalities in cancer stage at diagnosis, which can impact survival. The research highlights the importance of awareness campaigns to improve early diagnosis for specific patient groups, including those living in poorer neighborhoods or with different tumour sub-types.
Women with large social networks and high levels of support had better breast cancer survival rates. The study found that small social networks were associated with higher mortality from all causes, while community relationships mattered when family ties were less supportive.
PARP inhibitor olaparib traps PARP proteins at DNA damage sites, leading to cell toxicity. Researchers identify genetic mutations that sensitize cells to trapped PARP complexes, suggesting new therapeutic targets.
A new study reports that endoscopic mastoscopic axillary lymph node dissection (MALND) reduces blood loss, pain, and swelling compared to conventional surgery. MALND also shows promise in reducing distant metastasis rates and improving aesthetic outcomes.
Researchers have identified a specific cellular mechanism that may help overcome endocrine therapy-resistance in patients with estrogen-positive breast cancers. A novel molecular 'crosstalk' point between estrogen and HER2 signaling pathways has been found to drive tamoxifen resistance, according to new findings.
A phase 2 study reports that the combination of lapatinib and capecitabine reduces brain tumour size by at least 50% in two-thirds of women with advanced HER2-positive breast cancer. This treatment delays radiotherapy, which can impair cognitive function, offering a potential advance for patients.
Researchers at George Mason University are conducting three trials to target breast cancer using a malarial drug called chloroquine. The trials aim to prevent the development of breast cancer in its early stages, reducing the risk of invasive cancer.
Researchers developed a new optical imaging technique that uses tissue-penetrating laser light to analyze ultra-thin collagen fibers in breast tumor tissue samples. The study found that women with denser fiber patterns were more likely to need lymph node biopsy and removal, reducing the risk of unnecessary surgeries.
A combination of an anti-HER2 drug and an angiogenesis inhibitor significantly improves survival in a mouse model of brain metastatic breast cancer. The treatment extends patient survival by slowing the growth of brain tumors, making it a promising approach for patients with HER2-positive breast cancer who develop brain metastases.
A team from the University of Manchester has identified a molecular biomarker that can predict which breast cancer patients are most likely to respond to tamoxifen treatment. The discovery could lead to more effective treatment options for patients who have not responded to traditional therapies.
A recent study found that over one-third of cancer survivors in the US experience physical and mental health problems after treatment. The study identified groups at higher risk for long-term quality-of-life issues, with those with certain types of cancer facing significant challenges.