Articles tagged with Breast Cancer
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High levels of kisspeptins in aggressive breast cancers increase tumor grade and metastatic potential, according to Western University research. The study suggests that estrogen receptor status may play a role in kisspeptin's unusual behavior, making it a potential diagnostic biomarker for more aggressive breast cancer.
The study found that women with more advanced breast cancer at diagnosis, higher body mass index, and more positive lymph nodes were at increased risk of developing lymphedema. Genetic markers associated with the development of lymphedema in breast cancer survivors were also identified.
Researchers at UCLA have developed a potentially more effective treatment for triple-negative breast cancer (TNBC) using nanoscale, diamond-like particles called nanodiamonds. The new compound has been shown to decrease tumor growth and eliminate side effects of cancer treatment in mice.
The American College of Physicians recommends high-risk women receive preventive drug therapy to reduce risk of primary breast cancer. CT scans can also be used to screen for osteoporosis at lower costs without additional radiation exposure. However, using computer-aided detection in mammography increases diagnosis of early stage cance...
Researchers at Massachusetts General Hospital identified a genetic signature associated with the risk of tumor recurrence or spread in men surgically treated for prostate cancer. The 32-gene index proved to be the most accurate method, predicting actual incidence of tumor recurrence (47%) and metastasis (14%) among high-risk patients.
Researchers at IRCM identified the DOCK1 protein as a key regulator of metastasis in breast cancer. The study found that eliminating DOCK1 in mice resulted in a significant decrease in lung metastases and tumor growth.
Tomosynthesis surpasses 2D mammography in detecting infiltrating ductal carcinoma, particularly in women at increased risk of breast cancer. The study found that tomosynthesis improved visibility in 41% of cases and identified cancers only visible on tomosynthesis.
A new breast imaging algorithm is being implemented in Uganda to diagnose and treat women with palpable breast masses. The program combines a unique diagnostic algorithm with targeted community outreach to combat myths surrounding cancer, aiming for early diagnosis and effective care.
Gabriel Hortobagyi, a renowned breast cancer researcher, is being recognized for his contributions to advancing minority investigators in cancer research. He has developed groundbreaking therapies and treatment regimens that have become standard practices for managing breast cancer.
Breast cancers with high androgen receptor (AR) levels are more likely to relapse after estrogen-targeting therapies. Anti-androgen therapy shows promising responses in cell lines and preclinical models, offering a new potential target for breast cancer treatment.
Researchers found that omega-3 fatty acids and their metabolites slow or stop the proliferation of triple-negative breast cancer cells, reducing growth by up to 90 percent. The effect was stronger in triple-negative cell lines, with reduced motility and apoptosis rates.
A new study found that one-quarter of women who need hormone-blocking therapies as part of their breast cancer treatment either do not start or do not complete the five-year course. Side effects were cited as the most common reason for skipping treatment.
A new study by Fox Chase researchers finds that heterogeneity is prevalent even in early-stage ductal carcinoma in situ (DCIS) breast cancer, making it challenging for pathologists to accurately diagnose and treat the disease. The results suggest that a multiple-target approach may be necessary to effectively combat breast cancer.
Researchers found that excess estrogen levels during pregnancy can silence the BRCA1 tumor suppressor gene, increasing breast cancer risk in daughters. Additionally, molecular abnormalities in the unfolded protein response pathway were also found to contribute to breast cancer risk.
Scientists at Fox Chase Cancer Center have identified several dozen transcripts known as lincRNAs that are dysregulated in breast cancer. The study found that these lincRNAs are differentially regulated within breast cancer cell lines, indicating their potential role in tumorigenesis or regulation of other cancers.
A study at Capital Breast Cancer Center (CBCC) found that low-income and minority women screened for breast cancer had a high rate of medical follow-up after a positive mammogram. The researchers credit CBCC patient navigators with playing a key role in ensuring the high follow-up rates.
A new study published in the Journal of Clinical Oncology found that alcohol consumption before and after diagnosis has no impact on breast cancer survival. However, moderate drinkers may have a reduced risk of dying from cardiovascular disease, with moderate wine consumption associated with a lower risk.
A study found that only 53% of newly diagnosed breast cancer patients who were at high risk of carrying a BRCA 1 or BRCA 2 mutation received a recommendation for genetic testing. Women who were older, had lower income, and were employed were less likely to receive the recommendation.
Research shows that inhibiting autophagy in breast cancers dependent on it may be enough alone to kill the disease. Chloroquine, an anti-malaria drug, has been found to inhibit autophagy and is being tested as a potential treatment for certain breast cancer subtypes.
A subset of breast cancer patients with HER-2 positive tumors may benefit from a combination of targeted treatments that avoid chemotherapy. The study, published in the Journal of Clinical Oncology, shows high efficacy in eradicating tumors and offers a groundbreaking approach to treatment without significant side effects.
Researchers at Moffitt Cancer Center found that microRNA-155 overexpression promotes new blood vessel growth, tumor inflammation, and metastasis in breast cancer. Controlling miR-155 expression could inhibit malignant growth, providing a new avenue of treatment.
The CTC-iChip system rapidly produces a purified solution of tumor cells for pathological and molecular analysis. This technology enables the analysis of single metastatic cells, providing insights into cancer evolution and metastasis.
Researchers at Princess Margaret Cancer Centre identify Notch signalling pathway as key driver of resistance to hormone therapies in ER-positive breast cancer cells. A companion prognostic test is proposed to predict tumour response to new therapy.
A study published in the Journal of the National Cancer Institute found that estrogen plus progestin use is associated with an increased risk of breast cancer incidence. However, survival after diagnosis did not differ between users and non-users, suggesting higher mortality rates among hormone therapy users.
A recent study published in the Journal of the National Cancer Institute found that estrogen plus progestin use is associated with an increased risk of breast cancer. The study suggests that mortality from breast cancer may be higher for women using this combined hormonal therapy.
An international study has identified up to 80 new regions of the genome associated with increased susceptibility to breast, prostate, and ovarian cancers. Researchers have also discovered a total of 41 new genes or regions that may contribute to the development of breast cancer.
Researchers at Mayo Clinic Cancer Center have identified new DNA sequences linked to an increased risk of developing breast and ovarian cancers. The findings, published in three studies, will help improve risk models and support new prevention strategies for these diseases.
Researchers identified a specific cell membrane protein blocking cell death in hormone-therapy-related breast cancers, which could be targeted by new therapies. Progestin, a synthetic hormone used in hormone replacement therapy, affects the protein's activity and increases cancer risk.
A large-scale research study has identified over 80 genetic 'spelling mistakes' linked to an increased risk of breast, prostate, and ovarian cancers. The study found that these alterations can be described as single nucleotide polymorphisms (SNPs), which are common in the DNA of patients with cancer.
A Quebec researcher has identified 49 new genetic variations linked to breast cancer, almost tripling the known number of risk factors. The discovery was made as part of a massive international study involving over 200,000 participants and will help predict breast cancer risk with greater accuracy.
A review of 21 National Comprehensive Cancer Network member institutions found that only four provided nutritional guidelines, while many linked to external sites with inconsistent information. The analysis highlights the need for evidence-based, standardized guidelines on dietary recommendations for cancer patients.
Researchers at Moffitt Cancer Center have developed a small molecule, S31-1757, that inhibits the ability of STAT3 to cause malignancy. This development could impact the treatment of several tumor types, including breast, lung, prostate and others that depend on STAT3 for survival.
Researchers from Scripps Research Institute have identified a class of compounds that can modify cell signaling activity, including anti-inflammatory effects, which could lead to innovative treatments for breast cancer. The study focuses on compounds interacting with the estrogen receptor-α, a key target in breast cancer treatment.
The study found that many young black women with BRCA mutations do not receive genetic counseling or testing, despite meeting national guidelines. This may represent a missed clinical opportunity to reduce breast cancer incidence and mortality.
A new imaging dye has been shown to effectively detect and map cancers in lymph nodes, improving staging accuracy. The radioactive dye successfully identified cancerous lymph nodes, detecting 94% of malignancies compared to the standard blue dye's 76%.
Researchers identified a set of genes associated with lipid metabolism that may help identify women at risk for hormone receptor-negative breast cancer. These genes were found to be overexpressed in the unaffected breasts of women with estrogen receptor-negative disease.
A new study involving over 900,000 women found that biennial mammograms are as effective as yearly exams in detecting breast cancer and reducing false positives. For women with dense breasts, screening every two years decreases the risk of false-positive results by about a third.
Researchers have discovered a set of genes that can predict which women are at high risk for estrogen-sensitive breast cancer, making it possible to identify potential beneficiaries of preventive drugs. The study identifies 13 genes associated with lipid or fat metabolism in women with hormone receptor-negative breast cancer.
A new study published in JAMA Internal Medicine found that biennial mammography screening for women aged 50-74 does not increase the risk of advanced breast cancer, but rather reduces the risk of false-positive results. For women under 50 with extremely dense breasts, annual screening may be necessary to decrease the risk of advanced d...
A recent study published in the Journal of Family Planning and Reproductive Health Care analyzed data from three major studies on hormone replacement therapy (HRT) and found no clear evidence linking its decline to a decrease in breast cancer rates. The authors point out methodological flaws in the original studies, including detection...
A recent study published in the Journal of the National Cancer Institute found that consuming high-fat dairy products following breast cancer diagnosis increases the risk of dying from the disease. The study tracked over 1,800 women and found an association between high-fat dairy intake and poorer breast cancer survival.
Research published in Occupational and Environmental Medicine found that night shift workers have a higher risk of developing ovarian cancer. Women who identified as 'owls' had a lower risk compared to those who were 'larks'. The study, based on data from over 1,100 women, suggests that melatonin may play a role in the increased risk.
A study published in the Journal of the National Cancer Institute found that Medicare spending for advanced cancer patients does not correlate with survival rates. Despite significant regional differences in spending, researchers discovered a strong link between higher spending and more frequent hospital visits.
The EPSRC is investing £12.2 million in 15 research projects that aim to improve the diagnosis and treatment of serious illnesses, including Alzheimer's and cancer, as well as enhance patient outcomes and quality of life for severely disabled individuals.
Researchers found African-Americans have a 1.4-fold greater risk for heart failure compared to their white counterparts after breast cancer treatment. The study also highlights the importance of closer monitoring and pretreatment with cardioprotective drugs.
Researchers at Vall d'Hebron Institute of Oncology have successfully eliminated mouse lung tumors by inhibiting the Myc protein, a key regulator of gene expression and cell growth. The study confirms that Myc-targeted therapy is a safe and effective option for treating various types of cancer, with no signs of resistance or side effects.
The Endocrine Society issues a position statement on estradiol measurement, highlighting the need for accurate testing to diagnose conditions like breast cancer, osteoporosis, and infertility. The organization calls for a universally recognized estradiol standard and new methods capable of measuring small concentrations.
A large US study has found that living in high-poverty areas or being uninsured significantly increase the risk of being diagnosed with breast cancer at a later stage. The study's findings highlight the importance of addressing health insurance coverage and poverty levels as key predictors of late-stage breast cancer diagnosis.
The UK's pace of decline in premature mortality has fallen behind the average of other European countries and EU15+ nations over the past 20 years. The country struggles with disabling conditions such as back and neck pain, depression, and drug use, leading to more chronic disability than ever before.
A study of over 1,100 women found that nearly a quarter developed post-traumatic stress disorder (PTSD) symptoms within two to three months after breast cancer diagnosis. Younger women and those from Asian and black backgrounds were at higher risk.
A study published in Plastic and Reconstructive Surgery finds that round and shaped silicone implants have similar patient-reported outcomes in breast reconstruction, with few significant differences in quality of life. The researchers evaluated 65 women receiving round implants and 63 receiving shaped implants, finding average scores ...
Swedish scientists developed theranostic nanoparticles that can deliver chemotherapy to breast cancer cells while being detectable in MR scanners. The particles are biodegradable and show no toxicity, making them a potential tool against cancer.
A groundbreaking UK study found that aggressive triple-negative breast cancer cells lack the enzyme FBP1, leading to a glucose anabolic pathway that 'feeds' the cancer. This metabolic switch enables tumor cells to survive in low-oxygen environments, making it a promising target for new treatments.
A recent study found a small but statistically significant increase in the incidence of advanced breast cancer among young women aged 25-39 years, without a corresponding increase in older women. This trend is concerning due to the poor prognosis and lower survival rates associated with younger patients.
Women with Lynch Syndrome have a 50-60% lifetime risk of developing colorectal cancer, but an 11% risk of breast cancer, 11% risk of kidney cancer, and 9% risk of bladder cancer. This study expands the spectrum of cancers associated with Lynch Syndrome.
A new University of Michigan study found that the protein HER2 plays a role even in breast cancers traditionally classified as HER2-negative. The research suggests that the drug Herceptin may have a greater impact on treating breast cancer and preventing its spread, particularly when given early to prevent tumor recurrence.
A new study found that 75% of women who had arm node removal surgery worried about getting lymphedema, despite only 19% developing it. Most patients adopted multiple risk-reducing behaviors, which were not supported by data.
A UNC-led team has identified four molecular classes of head and neck squamous cell carcinoma (HNSCC), a disease with limited information on its molecular profile. The study confirms the presence of these subtypes and demonstrates their clinical relevance, paving the way for targeted therapies.
A study published in The Journal of Nutritional Biochemistry found that a lifelong diet rich in omega-3 fatty acids can inhibit the growth of breast cancer tumours. Mice producing omega-3s developed only two-thirds as many tumours and had 30-per-cent smaller tumours compared to control mice.
A new study found that a commonly used breast cancer risk prediction model developed for African Americans tends to underestimate risk in certain subgroups, particularly those who first gave birth at an older age. The researchers conclude that a better risk model is needed for estrogen receptor-negative breast cancer, a subtype disprop...