Articles tagged with Breast Cancer
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A QUT study found that extensive breast cancer surgery is linked to an increased risk of developing arm lymphoedema. The study revealed one in five women may be diagnosed with the condition, which can cause anxiety, depression, and emotional distress.
Researchers at UCLA's Jonsson Comprehensive Cancer Center have successfully combined cellular therapy and gene therapy in a mouse-model system to develop a viable treatment strategy for breast cancer that has spread to the brain. The approach shows significant promise in reducing metastatic brain tumor size, providing new hope for pati...
A population-based study found that current use of calcium-channel blockers for 10 or more years was associated with a higher risk of ductal and lobular breast cancer. The relationship did not vary based on the type of calcium-channel blockers used, with other antihypertensive medications showing no increased risk.
A new study by Fred Hutchinson Cancer Research Center scientists found that long-term use of calcium-channel blockers increases the risk of invasive ductal and lobular cancers. The study suggests alternative options for managing hypertension may be beneficial for reducing breast cancer risk.
HudsonAlpha and UAB researchers aim to identify optimal treatments for ER+ breast cancer using tumor genomics. By analyzing genetic data from patients who responded or didn't respond to treatment, they hope to develop targeted therapies.
The lack of investment in tumor biomarker research, inconsistent regulatory rules, and inadequate payment have created a vicious cycle preventing the development and testing of reliable biomarker tests. Experts recommend reforms to break this cycle and increase the value of tumor biomarker tests.
A new study published in Radiology found that digital tomosynthesis reduces the recall rate in breast cancer screening, particularly in younger women and those with dense breast tissue. The addition of tomosynthesis resulted in a 30 percent reduction in overall recall rate, compared to conventional mammography alone.
Researchers developed statistical models that predict individual women's risk of each cancer based on commonly known risk factors. The models were able to accurately calculate risk ranges from 0.5% to 29.5% over the next 20 years, providing a valuable tool for clinical decision-making.
Researchers at the University of Kentucky Markey Cancer Center have made significant discoveries about the Par-4 gene and its role in cancer recurrence. The study found that low levels of Par-4 protein may predict breast cancer relapse, while high levels can eliminate cancer cells through apoptosis.
Researchers at Lund University found that lymph nodes provide a more accurate picture of breast cancer prognosis than breast tissue alone. Analyzing the proliferation, hormone receptor status, and HER2 status of lymph nodes showed significantly improved results in predicting metastases and disease recurrence.
Singapore scientists have identified genes that are potential targets for therapeutic drugs against aggressive breast cancer. UBASH3B is a protein tyrosine phosphatase that promotes tumor growth and metastasis in triple-negative breast cancer patients.
Undergraduate students at University of Houston are conducting research on Alzheimer's diagnostics, breast cancer treatment, and fruit fly courtship patterns. Their projects aim to develop new diagnostic methods and treatments, while exploring adaptations to environmental changes.
A large study of 23,000 people in Italy and Switzerland found a strong link between family history of cancer and increased risk of developing different types of cancer. The study revealed associations between specific cancers, such as oral and pharyngeal cancer, ovarian cancer, and prostate cancer, with a range of risk increases
Scientists at Ohio State University have identified two regions on the HER1/EGFR receptor as potential targets for peptide-based cancer vaccines and therapeutic agents. These peptides show promise in inhibiting tumor growth in breast and lung cancer models.
A study of 5-year survival rates among black and white women with breast cancer found that black women continued to have a lower rate of survival. The difference was largely attributed to factors such as poorer health at diagnosis and more advanced disease, rather than treatment differences.
Researchers have discovered a novel approach to combat hormone-resistant breast cancer, exploiting the epigenetic 'silencing' of the BCL-2 gene. This process may be detectable in blood samples, offering a diagnostic marker for resistant tumors.
Researchers have found that elevated levels of a receptor protein called Ret are associated with lower survival rates in breast cancer patients. Inhibiting this protein may be a promising approach to treating the disease.
Women who survive cancer have more frequent, severe, and troubling hot flashes than other women with menopausal symptoms. However, the study also found that the cancer survivors reported better psychological and social well-being, similar levels of sexual activity and function compared to women without cancer.
A pilot study by TGen and Scottsdale Healthcare shows that personalized cancer treatment based on molecular profiling improves clinical benefits, with 52% of advanced breast cancer patients experiencing disease control. The study demonstrates feasibility of personalized cancer treatment and sets the stage for a larger study.
A new study published in the Journal of the National Cancer Institute found that epoetin alfa can help alleviate anemia in high-risk breast cancer patients while maintaining overall and relapse-free survival rates. However, the treatment may increase the risk of thrombotic events.
A study found that a walnut-enriched diet reduced prostate cancer formation by 18% and slowed tumor growth. The results suggest that using walnuts on a regular basis may be beneficial in deferring or preventing certain types of cancer, including breast cancer.
Cardiovascular screening is crucial for cancer patients who received chest radiation, especially those at high risk of developing radiation-induced heart disease (RIHD). The European Society of Cardiology recommends regular screenings to detect cardiac abnormalities and reduce the risk of death from coronary artery disease.
Researchers at the University of Minnesota have discovered that APOBEC3B, a human antiviral enzyme, causes DNA mutations that lead to several types of cancer. The enzyme was found to be significantly elevated in six types of cancer and produced a unique mutational signature that matches the actual mutation pattern in these cancers.
A recent study found that the protein Tissue Factor promotes the growth of both metastatic pancreatic cancer and primary breast cancer. Researchers identified a novel monoclonal antibody targeting this protein, which showed promise in stopping tumor growth in animal models.
The GammaPod uses tens of thousands of beams of radiation to focus on tumors with pinpoint accuracy, minimizing damage to surrounding healthy tissue. Clinical trials are underway to test the device's effectiveness as an alternative to invasive surgery and traditional radiation therapies.
A study of 601 women with breast cancer found that African-American women were more likely to experience delay in treatment due to type of treatment received or younger age. White women experienced delay if they underwent immediate breast reconstruction following mastectomy.
A large Dutch nationwide cohort study found that women giving birth to multiples after IVF treatment have a higher risk of breast cancer. The study suggests a link between high embryo implantation potential and breast cancer risk, with increased levels of VEGF possibly playing a role.
Researchers at the Walter and Eliza Hall Institute have discovered that BH3-mimetics, currently in clinical trials for leukaemia, could offer hope for treating aggressive oestrogen receptor-positive (ER-positive) breast cancers. The compounds were effective when combined with tamoxifen in preclinical models, improving treatment outcomes.
Research by a University of North Carolina-led team shows that inhibiting MerTK signaling in macrophages can activate the immune system to kill cancer cells, slowing tumor growth and metastasis. The study's findings suggest combining this approach with existing therapies may offer a new avenue for activating anti-tumor immunity.
Removing MerTK from immune cells decreases tumor growth and metastasis in breast, melanoma, and colon cancers. Inhibition of MerTK may stimulate anti-tumor responses and have clinical benefits.
Researchers found that macrophages are essential for embryo implantation in the uterus. The absence of these cells leads to reduced hormone levels, causing embryos to fail to implant. Restoration of macrophage function or hormone replacement therapy can revive pregnancy, shedding new light on a potential cause of infertility.
Researchers have identified microRNA-22 as a driver of both cancer onset and metastasis, particularly in breast cancer and blood cancers. The study suggests that inhibiting miR-22 through a 'decoy' method could offer a novel therapeutic option for treating these diseases.
The UNC team developed biomarkers for challenging molecular subtypes of human breast cancer using genetically engineered mouse models. They found that these models accurately predicted human response to chemotherapy drugs, providing valuable insights into breast cancer treatment.
Seventy percent of US plastic surgeons use fat grafting techniques for breast operations, with 88% using it for breast reconstruction. However, issues like mammography interference and unpredictable results are noted as potential obstacles.
A recent study has found a significant link between long-term night shifts and an increased risk of breast cancer. Women who worked night shifts for 30 or more years were twice as likely to develop the disease, highlighting the importance of workplace policy.
A high HOXB13/IL17BR ratio in tumor tissue indicates increased risk of recurrence after tamoxifen therapy, but drops significantly if a patient receives letrozole. This biomarker can help identify patients who may benefit from extended treatment with letrozole.
A team of Johns Hopkins graduate students has designed a device to inspect breast tissue in real-time, reducing the need for follow-up surgeries. The device applies an adhesive film to the tissue, preventing damage and allowing pathologists to quickly review samples within 20 minutes.
Researchers have developed a targeted viral therapy that selectively kills breast cancer stem cells and induces apoptosis without affecting normal stem cells. The therapy, which uses the mda-7/IL-24 gene, was shown to be effective in both cell culture and animal models, with no toxic effects on healthy cells.
A recent study by Mayo Clinic and others reveals that rural women with breast cancer are less likely to receive guideline-recommended radiation therapy after a lumpectomy. The researchers found that rural women were also more likely to choose mastectomy over lumpectomy, leading to potential gaps in care.
A new phase 2 trial is underway to evaluate the efficacy of HER-2 targeted regimens in elderly patients with HER-2 positive metastatic breast cancer. The study aims to delay or avoid conventional chemotherapy while maintaining tumor control.
CNIO researchers describe molecular bases of resistance to PARP inhibitor drugs in familial breast and ovarian cancers. Secondary mutations in genes like 53BP1 or PTIP can compensate for BRCA1/2 mutations, rendering drugs ineffective.
Research suggests that social stress can lead to increased metabolism in breast fat cells, which in turn stimulates nearby pre-cancerous cells to proliferate more rapidly. This local effect of fat cells in the breast may contribute to the development of triple-negative breast cancer.
Researchers have discovered a crucial signaling network between EGFR and MCM7 proteins, which plays a key role in DNA replication and cell growth. In breast cancer patients, high expression of Lyn and MCM7 is associated with reduced survival rates, highlighting a potential new target for cancer therapy.
Researchers found that medical specialists can identify abnormality in breast and cervical cancer images with high accuracy, outperforming random guessing. However, localizing the issue proves challenging even for experts.
Harvard researchers have identified the SALL4 gene as a key player in tumor formation, and have demonstrated that blocking its activity can halt cancer growth. The study provides new hope for treating aggressive forms of leukemia and other cancers.
Researchers identified a new molecular pathway involving the gene ZNF365 that may predict worse outcomes for patients with breast cancer. Abnormalities in this pathway can lead to genomic instability and an increased risk of developing tumors.
Researchers identified genetic variations associated with breast cancer risk among women on tamoxifen and raloxifene therapy. Women with favorable variations of the ZNF423 and CTSO genes are more likely to respond to prevention therapy, while those with unfavorable variations face a five-fold increased risk of developing breast cancer.
A study by University of Pennsylvania researchers found that the tumor suppressor protein Par-4 plays a crucial role in preventing breast cancer recurrence. Low Par-4 expression is associated with an increased risk of recurrence and poor response to chemotherapy, highlighting potential new therapeutic strategies.
Researchers at Case Western Reserve University found that gene HEXIM1 enhances heart health by increasing blood vessel growth, making hearts healthier and more efficient. HEXIM1 also suppresses breast cancer metastasis.
Researchers identified two gene variants that can predict which women are most likely to benefit from breast cancer prevention treatment and which should avoid it. The study found that women with the beneficial version of the two SNPs were 5.71 times less likely to develop breast cancer while taking preventive drugs.
A new study published in Cancer Discovery identified two genetic variations associated with breast cancer risk in women receiving preventive therapy. Women with favorable variations were more likely to respond to the therapy, while those with unfavorable variations had a five-fold increased risk of developing breast cancer.
A subgroup analysis from a phase III clinical trial found that eribulin demonstrated a greater potential benefit in overall survival compared to capecitabine for women with previously treated metastatic breast cancer. Specifically, patients with multiple organs involved, those who had not received chemotherapy for six months or longer,...
New research published by the University of Oxford found that breast cancer screening programs do not reduce mortality rates, contradicting previous findings. The study analyzed data from England over nearly 40 years and concluded that there is no evidence of a benefit from mammographic screening on breast cancer mortality.
Researchers found that none of the 169 cancer clinical practice guidelines met all eight criteria set by the Institute of Medicine. However, some guidelines were rated as 'good,' highlighting the need for a balance between ideal standards and practical implementation.
Researchers used parallel PET/MR imaging to map chemotherapy distribution before surgery, improving risk stratification and patient management. This study suggests simultaneous PET/MR imaging can benefit patients by predicting cancer recurrence and avoiding unnecessary chemotherapy.
A new study reveals low uptake of genetic testing for cancer-causing mutations in affected families in France. Despite steady increase in tests for BRCA1/2, MMR mutation testing remains under-used, putting whole families at risk.
A new study released by George Mason University researchers has shown success in pinpointing individualized treatment for women with metastatic breast cancer. The pilot study combined proteomic and genomic research, achieving a 30% increase in progression-free survival for nearly half of the patients.
Scientists have created a model to study breast cancer biology, confirming that primary tissue from patients behaves similarly to those derived from long-term cultured cell lines. This breakthrough advances the development of targeted therapies for advanced cancer treatments.
A University of Missouri researcher studied how stories influence patients' decision-making when behavior change is not the desired outcome. The study found that including patient stories in decision aids can make them more trustworthy and emotional, but may not affect treatment choice.
African-American women with breast cancer are more likely to carry inherited genetic mutations that increase their risk for breast cancer. Genetic testing can help identify at-risk family members and provide personalized strategies for early detection and prevention.