Articles tagged with Breast Cancer
A new study found that pregnant rats exposed to an obesity-linked hormone during pregnancy lost their reduced breast cancer risk after birth. Researchers believe this may be related to gene changes in healthy breast cells.
A study of 48 patients found higher coronary risks associated with left-sided radiation and supine body position. Targeting baseline cardiac risk factors may reduce radiotherapy-induced heart disease risks.
A new study found that women experiencing breast cancer often experience positive outcomes, including enhanced interpersonal relationships, increased appreciation for life, and greater spirituality. Increased social support was also linked to more post-traumatic growth in these women.
Researchers identified a link between rare RINT1 gene variants and increased risk of early onset breast cancer. The study found that these variants may also predispose individuals to other types of tumors, highlighting the potential for RINT1 to play a broader role in cancer susceptibility.
McGill University has made its online game Phylo available globally to connect thousands of scientists with hundreds of thousands of gamer-citizens scientists. Players have already contributed over 4,000 puzzle solutions based on genomic data.
Researchers used a genomic sequencing approach to evaluate all 24 genes implicated in breast cancer in women with normal BRCA genes. The study found that over 25% of these patients carried cancer-predisposing mutations in genes other than BRCA1 or BRCA2.
Researchers at the University of Twente in the Netherlands have developed a new imaging tool called the photoacoustic mammoscope, which uses a combination of infrared light and ultrasound to create a 3-D map of the breast. The device has shown promise in detecting breast cancer early, when it is most treatable.
Researchers have developed a new Trojan-horse approach using stealth nanoparticles to sneak into tumor cells, lower their defenses and attack them with drugs. The nanoparticles showed significantly enhanced therapeutic effects and shrunk tumors by 8-fold in mice, offering a potential strategy to treat aggressive breast cancer.
A simple blood test detecting epigenetic alterations may reveal the earliest signs of pancreatic cancer, a disease with nearly always fatal outcomes. The test's sensitivity and specificity are 97% and 85%, respectively, offering a promising step towards reducing mortality from this cancer.
A study by researchers from the Mount Sinai Hospital found that nearly 80% of women who contacted a patient assistance program had their needs met, compared to just 35% of those who did not. Most patients utilized programs for information about adjuvant therapies, psychosocial support, and overcoming practical/financial obstacles.
A phase I clinical trial of the investigational PARP inhibitor BMN 673 has demonstrated high objective and clinical benefit response rates in patients with BRCA-related breast and ovarian cancers. The treatment showed significant efficacy, with 44% of patients experiencing an objective response and 72% having clinical benefit.
Novartis' LEE011 has demonstrated robust antitumor activity in preclinical trials, particularly when combined with other targeted therapies. The small-molecule inhibitor of cyclin-dependent kinases (CDK) 4/6 shows promise in treating melanoma and breast cancer resistant to BRAF and PIK3CA inhibitors.
A study by UCL researchers found that abnormal levels of female hormones are a possible explanation for why women with BRCA1/2 mutations develop breast and ovarian cancer. The research suggests that targeting these hormones could lead to new ways of preventing cancers in high-risk women.
Researchers discovered 127 genes that appear to drive the development of a range of tumors in the body across 12 major cancer types. The study found common links among genes in different cancers, as well as mutations exclusive to particular cancer types.
A new optical imaging technique can accurately differentiate between breast cancer subtypes and detect responses to treatment as early as two days after therapy administration. The technique, known as optical metabolic imaging (OMI), measures the metabolic activity in cancer cells and generates distinct signatures for different types o...
Researchers at Thomas Jefferson University found that an HDL receptor in breast cancer cells may be responsible for the increased risk and aggressiveness of breast cancer. Blocking this receptor could help treat the disease, according to Dr. Philippe Frank.
A study of postmenopausal women found that taking multivitamin/mineral supplements reduced the risk of dying from invasive breast cancer by 30%. The association persisted even after controlling for other factors, suggesting a potential cause-and-effect relationship.
A major study has disproven the theory of a viral cause for breast cancer and glioblastoma, with over seven billion DNA sequences analyzed. The research found no genetic traces of viruses in these forms of cancer, contradicting previous theories suggesting Epstein-Barr virus and cytomegalovirus involvement.
A new diagnostic test for detecting BRCA1 and BRCA2 mutations has been developed using second-generation sequencing technology. The test is as sensitive as standard methodology but has the potential to improve efficiency and productivity in genetic testing laboratories.
Contralateral prophylactic mastectomy (CPM) may not significantly increase life expectancy for women with early-stage breast cancer in one breast. A new decision-making model helps women weigh the benefits of CPM against its risks and potential impact on survival.
A Mayo Clinic-led study found that a less-invasive procedure called sentinel lymph node surgery successfully identified whether cancer remained in lymph nodes in 91% of patients with node-positive breast cancer who received chemotherapy before their surgery. The procedure removed only a few lymph nodes, reducing surgical complications.
Researchers have developed a technique for injecting therapeutics into the nipple to target breast cancer in its most common origin. This method could reduce side effects and enhance effective drug levels, making it a promising treatment option.
A new study links moderate physical activity to lower breast cancer risk in postmenopausal women. Women who engaged in regular activities such as walking had a 14% lower risk and those with higher activity levels had a 25% lower risk compared to inactive women.
A study published in Cancer Epidemiology, Biomarkers & Prevention found that walking for at least seven hours a week reduced breast cancer risk by 14% in postmenopausal women. Women who engaged in vigorous physical activity daily had a 25% lower risk of breast cancer.
A study published in Cancer Cell identified a previously unknown vulnerability in triple-negative breast cancers, which can be effectively treated with an FDA-approved drug. The researcher found that targeting the cystine transporter xCT significantly inhibited tumor growth in mice and cell culture.
A massive data analysis has implicated dozens of mutations in breast and prostate cancer development, focusing on non-coding DNA elements. The study provides new insights into the causes and treatment of cancer.
Researchers have identified potential genetic variants in non-coding DNA regions that drive the development of various cancers. The new approach prioritizes these variants based on their predicted impact on human disease, offering a promising tool for finding disease-causing genetic mutations.
Group Health Research Institute received two PCORI awards to study the effectiveness of breast MRI compared to mammography for breast cancer surveillance. The institute also provides assistance to a new national data network, enhancing the nation's ability to conduct patient-centered comparative effectiveness research.
Losartan opens up collapsed tumor blood vessels, improving chemotherapy delivery and oxygenation. Combining losartan with standard treatments delays tumor growth and extends survival in animal models.
A conservative approach to removing lymph nodes during breast cancer surgery is associated with less harm and similar results to more radical procedures. The study found that avoiding axillary surgery can reduce complications and morbidity in patients.
Research by the University of California, San Diego reveals that Mexican women with more children and those who breastfeed for extended periods are at a higher risk of developing triple negative breast cancer. This contradictory finding challenges existing knowledge about breastfeeding's benefits in reducing breast cancer risk.
Researchers conducted a 15-year follow-up study of the GAZEL cohort to investigate the link between depression and cancer. The results found no significant association between experiencing symptoms of depression and contracting specific types of cancer, including prostate, breast, colon, and leukemia.
A $5.9 million Department of Defense grant enables the development of drugs that target androgen receptors as a driver of breast cancer. The treatment shows promising results in preclinical work and may offer new options for patients with previously limited therapy.
A new analysis by American Cancer Society researchers found that breast cancer incidence rates are converging between white and African-American women. Incidence rates increased among African Americans from 2006 to 2010, bringing their rates closer to those of white women, particularly among women aged 50-59 years.
Researchers have developed a new blood test that can detect cancer metastasis in dogs by analyzing cell-free DNA in blood plasma. The test has shown promising results in detecting minimal residual disease and tracking tumor progression, with potential implications for human cancer treatment.
Researchers estimated that approximately 0.60 Gray of the daily radiotherapy dose is 'wasted' due to overnight and weekend tumor growth, suggesting shorter treatment schedules may be more effective against breast cancer recurrence. This finding supports current trends to deliver shorter radiotherapy schedules.
A new study has found that treating chest lymph nodes in early breast cancer patients improves overall survival without increasing side effects. The research involved 4004 patients from 43 centres and found that irradiating the IM-MS lymph nodes gave a better patient outcome than radiation therapy to the breast/thoracic wall alone.
A meta-analysis found that diabetic patients have an increased risk of developing both breast and colon cancer. The study also showed that diabetic patients are at a higher risk of dying from these cancers, with a 23% increased risk for breast cancer and a 38% increased risk for colon cancer compared to non-diabetic patients.
Research finds that increased government spending on health care is associated with decreased cancer mortality rates in Europe. Eastern European countries tend to have higher mortality rates, while Western Europe has better outcomes due to effective screening programs and treatments.
Researchers at Brigham Young University have developed a new breast cancer screening technique using sodium MRI that produces five-times more accurate images than previous methods. The device aims to reduce false positives and unnecessary biopsies by scanning for sodium levels in the breast.
The TH3RESA trial shows that T-DM1 significantly improves progression-free survival in women with advanced HER2 positive breast cancer, with a nearly three-month increase from 3.3 months to 6.2 months. The treatment also demonstrates a more favorable safety profile compared to standard therapy.
A study of Stage T1aN0 breast cancer patients found no significant increase in deaths from cardiac disease or secondary malignancies among those receiving external beam radiation therapy (XRT). Women who received XRT had better survival rates and fewer deaths from all causes compared to non-XRT groups.
The American College of Physicians recommends treating obstructive sleep apnea with weight loss and continuous positive airway pressure (CPAP) therapy as initial treatment. For patients who do not tolerate or comply with CPAP, a mandibular advancement device (MAD) is an alternative therapy option.
A new study published in CANCER journal found that many newly diagnosed older breast cancer patients experience difficulty with daily tasks. The research suggests that therapy to improve physical function could benefit these patients, particularly African-American women who are four times more likely to have functional disability.
Researchers have found that immune cells known as macrophages may help make the breast more susceptible to cancer at certain stages of the menstrual cycle. Hormonal fluctuations around menstruation may impact immune defenses in breast tissue, increasing risk of breast cancer.
Scientists at WashU Medicine have created human breast tumor models in mice, which maintain genetic errors and can help identify drivers of tumor growth. The models allow researchers to study specific patient tumors with detailed information on treatment regimens and consent.
Researchers cataloged interactions between breast cancer cells and normal cells in their environment, finding that most signals promoted cancer. Blocking multiple signals simultaneously inhibited tumor growth more effectively than blocking individual signals.
Research finds high levels of Fragile X Mental Retardation Protein (FMRP) in human breast tissue correlate with increased risk and spread of breast cancer. FMRP acts as a master regulator controlling aggressive cancer progression.
A MU researcher found that certain types of stories in patient decision-aids can inform patients' decisions without influencing their choices. Process narratives helped women search for information, while experience narratives improved their ability to envision treatment outcomes and evaluate their decisions more favorably.
Researchers found that a 3-week radiotherapy course is comparable to the traditional 5-week treatment in terms of tumour control rates. The study also revealed reduced damage to healthy tissue and fewer hospital visits with the shorter treatment schedule.
Lymphedema is a disease with no cure and little hope for sufferers, where the body fails to circulate lymphatic fluid leading to swelling and permanent tissue remodeling. A new engineering approach may lead to new technologies to test and treat lymphatic disease.
A study published in Genome Medicine has identified a specific subtype of pancreatic cancer that expresses high levels of the HER2 gene, which could be treated with existing breast and gastric cancer therapies. The research suggests using personalized medicine strategies to target this subtype, potentially improving patient outcomes.
A survey of young women with breast cancer found many overestimate the benefits of prophylactic mastectomy, despite knowing it has little impact on survival rates. The study suggests that improving risk communication and addressing anxiety are crucial to helping patients make informed decisions.
The study, conducted by UC Davis and EWC researchers, found that starting mammography screening biennially at age 50 is strongly supported by the model results. This approach aims to maximize impact on reducing breast cancer deaths while working within limited program funding.
A survey of young breast cancer patients found that nearly all chose prophylactic mastectomy to reduce risk of contralateral breast cancer, despite knowing it doesn't improve survival rates. The study highlights the need for better risk communication strategies to help patients make informed decisions.
The EORTC will present various cancer research studies, including a phase III trial on breast cancer radiation therapy and a study on the use of data warehouses for response measurements. The organization will also showcase its clinical trials and discuss regulatory issues.
The SHIVA trial is the first randomised trial to look at patient outcomes after treatments were chosen according to individual molecular profiles. Preliminary results show that this approach works, paving the way for personalized treatment and a potential major change in cancer drug development.
Researchers found that high levels of miR-200 expression boost survival rates for patients with lung, ovarian, renal, and triple-negative breast cancers. MicroRNAs regulate gene activation and expression, and targeting IL-8 and CXCL1 can inhibit angiogenesis and cancer progression.
A new gene-expression-based biomarker, the Breast Cancer Index (BCI), accurately identifies patients at continued risk of breast cancer recurrence after five years of treatment. The BCI distinguishes between high and low-risk patients, enabling prolonged treatment for those who remain at risk and avoiding unnecessary side effects.
Exposure to ionizing radiation during puberty increases the risk of developing aggressive ER negative breast cancers later in life. Researchers discovered that self-renewal of stem cells is the primary mechanism behind this increased risk.