Articles tagged with Breast Cancer
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Research by the University of California, San Diego reveals that Mexican women with more children and those who breastfeed for extended periods are at a higher risk of developing triple negative breast cancer. This contradictory finding challenges existing knowledge about breastfeeding's benefits in reducing breast cancer risk.
Researchers conducted a 15-year follow-up study of the GAZEL cohort to investigate the link between depression and cancer. The results found no significant association between experiencing symptoms of depression and contracting specific types of cancer, including prostate, breast, colon, and leukemia.
A $5.9 million Department of Defense grant enables the development of drugs that target androgen receptors as a driver of breast cancer. The treatment shows promising results in preclinical work and may offer new options for patients with previously limited therapy.
A new analysis by American Cancer Society researchers found that breast cancer incidence rates are converging between white and African-American women. Incidence rates increased among African Americans from 2006 to 2010, bringing their rates closer to those of white women, particularly among women aged 50-59 years.
Researchers have developed a new blood test that can detect cancer metastasis in dogs by analyzing cell-free DNA in blood plasma. The test has shown promising results in detecting minimal residual disease and tracking tumor progression, with potential implications for human cancer treatment.
Researchers estimated that approximately 0.60 Gray of the daily radiotherapy dose is 'wasted' due to overnight and weekend tumor growth, suggesting shorter treatment schedules may be more effective against breast cancer recurrence. This finding supports current trends to deliver shorter radiotherapy schedules.
A new study has found that treating chest lymph nodes in early breast cancer patients improves overall survival without increasing side effects. The research involved 4004 patients from 43 centres and found that irradiating the IM-MS lymph nodes gave a better patient outcome than radiation therapy to the breast/thoracic wall alone.
A meta-analysis found that diabetic patients have an increased risk of developing both breast and colon cancer. The study also showed that diabetic patients are at a higher risk of dying from these cancers, with a 23% increased risk for breast cancer and a 38% increased risk for colon cancer compared to non-diabetic patients.
Research finds that increased government spending on health care is associated with decreased cancer mortality rates in Europe. Eastern European countries tend to have higher mortality rates, while Western Europe has better outcomes due to effective screening programs and treatments.
Researchers at Brigham Young University have developed a new breast cancer screening technique using sodium MRI that produces five-times more accurate images than previous methods. The device aims to reduce false positives and unnecessary biopsies by scanning for sodium levels in the breast.
The TH3RESA trial shows that T-DM1 significantly improves progression-free survival in women with advanced HER2 positive breast cancer, with a nearly three-month increase from 3.3 months to 6.2 months. The treatment also demonstrates a more favorable safety profile compared to standard therapy.
A study of Stage T1aN0 breast cancer patients found no significant increase in deaths from cardiac disease or secondary malignancies among those receiving external beam radiation therapy (XRT). Women who received XRT had better survival rates and fewer deaths from all causes compared to non-XRT groups.
The American College of Physicians recommends treating obstructive sleep apnea with weight loss and continuous positive airway pressure (CPAP) therapy as initial treatment. For patients who do not tolerate or comply with CPAP, a mandibular advancement device (MAD) is an alternative therapy option.
A new study published in CANCER journal found that many newly diagnosed older breast cancer patients experience difficulty with daily tasks. The research suggests that therapy to improve physical function could benefit these patients, particularly African-American women who are four times more likely to have functional disability.
Researchers have found that immune cells known as macrophages may help make the breast more susceptible to cancer at certain stages of the menstrual cycle. Hormonal fluctuations around menstruation may impact immune defenses in breast tissue, increasing risk of breast cancer.
Scientists at WashU Medicine have created human breast tumor models in mice, which maintain genetic errors and can help identify drivers of tumor growth. The models allow researchers to study specific patient tumors with detailed information on treatment regimens and consent.
Researchers cataloged interactions between breast cancer cells and normal cells in their environment, finding that most signals promoted cancer. Blocking multiple signals simultaneously inhibited tumor growth more effectively than blocking individual signals.
Research finds high levels of Fragile X Mental Retardation Protein (FMRP) in human breast tissue correlate with increased risk and spread of breast cancer. FMRP acts as a master regulator controlling aggressive cancer progression.
A MU researcher found that certain types of stories in patient decision-aids can inform patients' decisions without influencing their choices. Process narratives helped women search for information, while experience narratives improved their ability to envision treatment outcomes and evaluate their decisions more favorably.
Researchers found that a 3-week radiotherapy course is comparable to the traditional 5-week treatment in terms of tumour control rates. The study also revealed reduced damage to healthy tissue and fewer hospital visits with the shorter treatment schedule.
Lymphedema is a disease with no cure and little hope for sufferers, where the body fails to circulate lymphatic fluid leading to swelling and permanent tissue remodeling. A new engineering approach may lead to new technologies to test and treat lymphatic disease.
A study published in Genome Medicine has identified a specific subtype of pancreatic cancer that expresses high levels of the HER2 gene, which could be treated with existing breast and gastric cancer therapies. The research suggests using personalized medicine strategies to target this subtype, potentially improving patient outcomes.
A survey of young women with breast cancer found many overestimate the benefits of prophylactic mastectomy, despite knowing it has little impact on survival rates. The study suggests that improving risk communication and addressing anxiety are crucial to helping patients make informed decisions.
The study, conducted by UC Davis and EWC researchers, found that starting mammography screening biennially at age 50 is strongly supported by the model results. This approach aims to maximize impact on reducing breast cancer deaths while working within limited program funding.
A survey of young breast cancer patients found that nearly all chose prophylactic mastectomy to reduce risk of contralateral breast cancer, despite knowing it doesn't improve survival rates. The study highlights the need for better risk communication strategies to help patients make informed decisions.
The EORTC will present various cancer research studies, including a phase III trial on breast cancer radiation therapy and a study on the use of data warehouses for response measurements. The organization will also showcase its clinical trials and discuss regulatory issues.
The SHIVA trial is the first randomised trial to look at patient outcomes after treatments were chosen according to individual molecular profiles. Preliminary results show that this approach works, paving the way for personalized treatment and a potential major change in cancer drug development.
Researchers found that high levels of miR-200 expression boost survival rates for patients with lung, ovarian, renal, and triple-negative breast cancers. MicroRNAs regulate gene activation and expression, and targeting IL-8 and CXCL1 can inhibit angiogenesis and cancer progression.
A new gene-expression-based biomarker, the Breast Cancer Index (BCI), accurately identifies patients at continued risk of breast cancer recurrence after five years of treatment. The BCI distinguishes between high and low-risk patients, enabling prolonged treatment for those who remain at risk and avoiding unnecessary side effects.
Exposure to ionizing radiation during puberty increases the risk of developing aggressive ER negative breast cancers later in life. Researchers discovered that self-renewal of stem cells is the primary mechanism behind this increased risk.
Researchers are identifying genetic biomarkers in patient blood samples to predict aggressive breast cancer progression. Large oncosomes, tumor-derived vesicles, may serve as valuable insights into disease progression.
A California-based group has developed a website to address the implications of breast density notification laws, which require patients with dense breasts to receive written notification. The group recommends an individualized risk-based approach to guiding decision-making on supplementary screening.
A new analysis reveals that regular mammograms before age 50 significantly reduce breast cancer deaths in younger women. The study analyzed data from invasive breast cancers diagnosed between 1990 and 1999, finding that only 13% of cases occurred in women aged 70 or older.
A new analysis confirms the importance of regular mammography screening in reducing breast cancer deaths, especially among younger women. The study found that 71% of confirmed breast cancer deaths occurred in the 20% of patients who did not receive annual mammograms.
Researchers identified a gene mutation that predisposes children to the most common form of childhood leukemia. The PAX5 mutation was found in multiple generations of two families, leading to a marked reduction of normal PAX5 activity in leukemia cells.
A new study from Memorial Sloan Kettering Cancer Center found that MRI use in women with early breast cancer did not reduce local recurrence or contralateral breast cancer rates. The study, which looked at over 2,300 patients, suggests that the benefits of MRI may be limited to other patient groups.
Studies find radiation therapy for DCIS does not increase cardiovascular disease risk, while MRI scans may be unnecessary. Additionally, most women have inaccurate perceptions of their personal breast cancer risk, sparking the need for better communication between patients and doctors.
A new study found that hormone replacement therapy (HRT) use is associated with an increased risk of breast cancer among postmenopausal women, but the relationship varies depending on factors such as race/ethnicity, body mass index (BMI), and breast density. The study suggests that HRT may be used for some women without increasing thei...
Researchers found that ERBB3 expression was enhanced in luminal breast cancers compared to other subtypes. The addition of an ERBB3 antibody promoted cancer cell death and decreased tumor growth in vitro.
Researchers have identified a potential new target for breast cancer treatment: ERBB3, an oncogene that promotes tumor growth. The study also found peritoneal dialysis to be effective in reducing brain damage after stroke by lowering glutamate levels.
Researchers identified a protein that correlates with breast cancer aggressiveness and may predict prognosis; small molecule inhibitors could be developed as therapeutic drugs for breast cancer treatment.
Researchers from Notre Dame and Moi University are examining the unique manifestation of breast cancer in Kenya. The collaboration aims to identify novel insights into the mechanisms of breast cancer progression, which could ultimately help women worldwide.
Research from Washington University School of Medicine links increased breast cancer risk to drinking between early adolescence and first full-term pregnancy. Drinking daily can increase risk by 13% if averaged during this period, according to the study.
A recent study published in Critical Reviews in Oncology/Hematology found that calcium and vitamin D supplements do not prevent bone mineral density loss in women undergoing breast cancer treatment. Women with breast cancer experience a higher rate of bone loss than healthy counterparts, increasing their risk of fractures.
Researchers at Mayo Clinic have discovered that decitabine can halt the ability of cancer cells to separate from a tumor and spread to distant organs. The study found that treating genes silenced in aggressive triple negative breast cancer with decitabine may promote re-expression of PRKD1.
A multicenter trial found that BI-RADS 3 breast lesions have a malignancy rate of 0.8%, with most cancers detected at 12-month follow-up imaging. The study suggests that extending the follow-up interval from six to 12 months for these lesions may reduce unnecessary biopsies and exams.
A study by an international consortium of researchers found that reducing the expression of NEET proteins significantly reduced cancer cell proliferation and tumor size. The overabundance of these proteins is linked to the progression of the disease, making them a prime target for anticancer drugs.
A new analysis found that breastfeeding for over 6 months may safeguard nonsmoking mothers against breast cancer, with a 10-year delay in diagnosis compared to shorter breastfeeding periods. In contrast, smoking mothers did not benefit from longer breastfeeding
A new study from the University of Michigan Comprehensive Cancer Center found that nearly 20% of women did not believe their breast cancer risk, citing concerns about family history and personal health habits. The study highlights the need for improved communication and understanding of risk information to make informed medical decisions.
A study by Yale School of Medicine researchers found a significant increase in preoperative breast MRI use among older women with breast cancer, leading to more aggressive surgical treatment. Women who received an MRI were more likely to undergo bilateral mastectomy and contralateral prophylactic mastectomy.
A UCLA study found that women diagnosed with breast cancer who created personal websites experienced reduced depressive symptoms, improved mood, and increased appreciation for life. The project, Project Connect Online, provided a platform for breast cancer patients to share their experiences and connect with friends and family online.
A study led by Boston Children's Hospital researchers found that triple-negative breast cancers rely on active proteasomes to survive. Inhibiting these proteins with existing medications like bortezomib may offer new treatment options for this aggressive type of cancer.
Researchers found that regulatory elements (DEREs) control multiple target genes in response to estrogen stimulation, contributing to tumor development. Decreasing DERE copies may have therapeutic potential for treating women with estrogen receptor-positive breast cancers.
Researchers discovered that early pregnancy reduces mammary gland progenitor cells, which can divide into milk-producing cells, reducing the risk of breast cancer. The study aims to develop a protective treatment mimicking the effects of early childbearing.
Researchers discovered the OGF-OGFr axis can inhibit proliferation in human triple-negative breast cancer cells, reducing growth within 24 hours. The therapy also confers protection against paclitaxel treatment, a standard breast cancer therapy, and has minimal side effects.
Researchers have developed a strain of engineered rice that produces a rotavirus-specific antibody, protecting both normal and immune-deficient mice from the disease. This study provides a low-cost strategy for preventing rotavirus infection.
Researchers at Duke University found that tumor microenvironment alterations promote cancer progression by altering signaling in tumor-associated immune cells. The study supports the use of TGF-β inhibitors to enhance therapy efficacy.
Researchers found that AXL receptor pairs with EGFR to make tumors resistant to ErbB inhibitors. Combining drugs targeting AXL and EGFR receptors could offer a better way to fight tumors, according to the study.
A global study found that tamoxifen halves the breast cancer risk for women with BRCA1 or BRCA2 mutations. The medication has been used to treat breast cancer for decades and also prevents new cancers in many women.
A study of 602 new mothers found that extroverted and emotionally stable individuals are more likely to breastfeed and continue breastfeeding. Mothers who were introverted or anxious faced challenges with breastfeeding, including feelings of self-consciousness and difficulty accessing support services.