Articles tagged with Breast Cancer
A recent study suggests that women with a BRCA gene mutation who undergo a double mastectomy have a significantly lower risk of death from breast cancer, with an estimated 48% reduction in mortality. This finding has implications for the treatment options available to young women with early-stage breast cancer and BRCA mutations.
A new study has strengthened the link between alcohol consumption and breast cancer development. Researchers found that a particular enzyme, CYP2E1, plays a role in controlling the growth of breast cancer cells.
A Canadian study of 89,000 women aged 40-59 found that annual breast screening did not reduce mortality from breast cancer beyond physical examination or usual care. The study also revealed that 22% of screen-detected cancers were over-diagnosed, with one over-diagnosed cancer for every 424 women screened.
A recent study published in Cancer journal found that smoking is significantly linked with an increased risk of estrogen receptor positive breast cancer among young women. Young women who have smoked a pack a day for 10 years or more experience a 60% higher risk of developing this type of breast cancer.
A TGen study has uncovered possible genetic origins of breast cancer that spreads to the brain, providing potential new methods of diagnosis and treatment. The study identified common genetic alterations linked to key mechanisms of cancer, such as cell proliferation and cell-cycle progression.
The new guideline aims to reduce unnecessary re-excision rates by identifying optimal margin widths that minimize ipsilateral breast tumor recurrence. Wider margin widths do not significantly lower the risk, and the choice of radiation technique should not depend on margin width.
A large-scale study of whole-genome testing has identified a unique treatment approach for women with advanced breast cancer, targeting genomic alterations in their tumors. The study found that around half of patients had targetable genomic alterations, and 39% had rare alterations, many of which no treatments currently exist.
Researchers at Clemson University are developing a new method of studying breast cancer cells by building 3D structures that mimic the complex behavior of cancer cells in human tissue. The 3D structures allow for the testing of various treatments and can be customized to represent different stages of cancer.
A new photon-counting technique improves cancer detection rates in digital mammography screening, particularly for ductal carcinoma in situ. The method reduces scattered radiation and noise, enabling lower doses and improved outcomes.
Scientists at the University of Veterinary Medicine in Vienna have created a model to investigate the role of STAT1 in various disease conditions. The genetically modified mice can produce an exact dose of protein, enabling researchers to examine the origins and course of many diseases.
A study led by UCSF breast cancer expert Laura J. Esserman recommends biennial mammography screening for women aged 50-74 to save $4.3 billion in healthcare costs. This approach is equally effective as annual screening while reducing false positive results and improving women's well-being.
Researchers have discovered a potential cure for triple negative breast cancer using a vaccinia virus engineered to make cancer cells produce radioiodine. The discovery, published in The FASEB Journal, has shown promising results in laboratory experiments and offers new hope for treating deadly and resistant forms of cancer.
A study published in Cancer Prevention Research found that atypical ductal hyperplasia and atypical lobular hyperplasia have similar potential to develop into breast cancer. The study followed over 700 women with biopsy-confirmed atypia for an average of 12.5 years, finding that the ratio of breast cancer development was the same in bo...
Researchers at UNC School of Medicine have developed a new ultrasound imaging technique that can visualize tumors using a contrast agent composed of tiny bubbles paired with an antibody. This method improves resolution and tumor-detecting ability, potentially leading to lower costs and increased accessibility for cancer treatment.
A study found that routine screening mammography in women aged 40-49 leads to earlier diagnosis of smaller tumors and reduced chemotherapy use. The researchers concluded that annual screenings starting at age 40 saves lives by identifying breast cancers in initial stages.
Researchers have identified 32 genes with recurring defects in muscle-invasive bladder cancer, offering a roadmap for targeted treatments. The study also found frequent alterations in chromatin regulation and viral DNA involvement in bladder cancer development.
A study published in PLOS ONE found that melatonin may inhibit tumor growth and cell production, as well as block the formation of new blood vessels in ER-negative breast cancer models. The results suggest that melatonin has the potential as a therapeutic agent for breast cancer.
New research from Berkeley Lab and the National Runners' and Walkers' Health Study found that runners had a significantly lower risk of breast cancer mortality compared to walkers. Exceeding current exercise recommendations may provide greater protection, with runners experiencing a 40% reduction in risk per MET hour.
Researchers found that SGLT2 inhibitors improved muscle insulin sensitivity and lowered fasting plasma glucose levels in type 2 diabetes patients. However, the use of these inhibitors also resulted in an increase in endogenous glucose production and decreased insulin secretion.
Researchers at the University of Toronto have developed a method to assemble gold nanoparticles using DNA as a vehicle to deliver cancer medications or markers directly into cancerous tumors. The particles can be precisely engineered to target specific tumor types and stages.
Practicing yoga for three months can significantly reduce fatigue and lower inflammation in breast cancer survivors, according to new research. The study found that women who practiced yoga experienced a 57% reduction in fatigue and up to 20% lower inflammation compared to those who did not practice yoga.
Researchers discovered that breast stem cells and their 'daughters' have a much longer lifespan than previously thought, actively maintaining breast tissue throughout life. This finding has implications for identifying the cells of origin of breast cancers and developing new treatment strategies.
Researchers at Cardiff University have identified a compound that potently inhibits Bcl3 and completely halts the spread of metastatic tumors in mice. The development aims to create a therapeutic agent capable of blocking metastatic disease in breast cancer and various tumor types.
Researchers have made refinements to a technique combining MRI and near-infrared spectroscopy (NIRS) to improve image quality and accuracy in detecting breast cancer. The new design allows for increased coverage of the chest, providing improved visibility for 'hard-to-see' areas, and has shown promising results in clinical trials.
A study suggests that moderate doses of radiation therapy to the unaffected breast can kill premalignant cells and reduce the risk of second breast cancers. The treatment could prevent tens of thousands of cases, according to researchers at Columbia University Irving Medical Center.
The University of South Florida and FORCE have received a PCORI award to expand a health data network for hereditary breast and ovarian cancer research. The ABOUT Network will collect comprehensive clinical data, engage patients, and advance patient-centered studies.
Researchers developed a mathematical model to predict how tumors will behave and which treatments are most effective, focusing on genetic diversity within tumors. The study found that tumors with less genetic diversity are more likely to respond to treatment, providing new insights into personalized cancer care.
Researchers developed a tool to predict which direction a breast cancer tumor is most likely to go and how it will respond to chemotherapy. The study's findings reveal general rules, including genetic diversity within tumors and the importance of analyzing individual cells.
The Jackson Laboratory will receive a five-year, $7.5 million grant to develop new mouse models and tumor repository for cancer genomics research. The collaboration with Seoul National University aims to advance individualized cancer diagnosis and treatment.
A new study by University of Kentucky researchers identified four key barriers to cancer screening in Appalachian women, including embarrassment about Pap tests and lack of health insurance. These barriers contribute to higher mortality rates for invasive cervical cancer in the region, with a 67% increase compared to national averages.
Researchers have found that trastuzumab can improve outcomes for bladder cancer patients with HER2 amplification, a known driver of aggressive tumors. The study identified 15% of MPUC patients had HER2 amplification, leading to faster growth and higher recurrence rates.
Research published in PLOS ONE found that high doses of folic acid supplements promote the growth of existing breast cancer cells in rats. The study suggests a potential link between folic acid consumption and increased risk of developing breast cancer, particularly among women taking multivitamins or supplements.
Researchers identified four subtypes of HER2+ breast cancer, including Luminal A, Luminal B, HER2-enriched, and Basal-Like, with varying responses to anti-HER2 therapy and chemotherapy. The study suggests that personalized treatment strategies may improve treatment outcomes for patients.
Researchers identified critical complex mechanisms involved in TNBC metastasis, including the interaction between WAVE3 and TGF-β proteins. The discovery has the potential to develop new treatments to kill metastatic tumors in TNBC, with the goal of moving into clinical trials within three years.
Patients with multiple sclerosis in Taiwan may be at a significantly higher risk of developing cancer, particularly breast cancer, according to a recent study published in European Journal of Neurology. The nationwide population-based cohort study found an 85% increased risk of cancer development among MS patients compared to controls.
Researchers found a correlation between DNA methylation levels and breast cancer risk in high-risk families. High levels of DNA methylation were associated with increased breast cancer clustering within families.
Cancer death rates have declined by 20% over the past two decades, with middle-aged black men experiencing a 50% reduction in mortality. The American Cancer Society estimates that there will be 1,665,540 new cancer cases and 585,720 cancer deaths in 2014.
Researchers found that alphaB-crystallin enhances breast cancer cells' ability to penetrate the blood-brain barrier and form metastases in the brain. Tumors expressing this protein had a poorer prognosis and were more likely to be triple-negative breast cancers.
A novel breast-cancer therapy has been developed that partially reverses the cancerous state in cultured breast tumor cells and prevents cancer development in mice. The therapy uses a sophisticated method to identify genes that drive cancer and blocks them using RNA interference, offering new hope for early-stage treatment without surg...
Researchers found that chronic preoperative pain, chemotherapy, and depression were linked to persistent pain in breast cancer patients 12 months post-surgery. The study included over 800 women with nonmetastasized breast cancer treated between 2006-2010.
Researchers at Johns Hopkins University have discovered that low oxygen conditions inside tumors trigger the production of proteins RhoA and ROCK1, enabling breast cancer cells to become mobile and invasive. High levels of these proteins are associated with poorer patient outcomes and increased tumor spread.
Younger women with aggressive tumors and higher recurrence risks are less likely to receive radiotherapy after breast conserving surgery, according to a nationwide database analysis. Factors affecting non-compliance among younger women include family structures and region of residence.
A small study found that both real and sham acupuncture eased hot flashes and side effects of anticancer drug treatment in postmenopausal breast cancer patients. Researchers noted improvements in depression, quality of life, and menopausal symptoms in both groups.
Researchers at the University of Maryland School of Medicine found that both real and sham acupuncture reduce hot flashes and other symptoms in breast cancer patients taking an aromatase inhibitor. The study suggests that acupuncture may be a reasonable alternative to drug therapy with fewer side effects.
A new analysis found that both real and sham acupuncture may help alleviate breast cancer drug side effects. Patients who received real acupuncture experienced less joint/muscle discomfort and menopausal symptoms compared to those receiving sham acupuncture.
A new analysis found that both real and sham acupuncture treatments alleviate side effects of breast cancer drugs, including hot flashes and joint/muscle pain. Women who received real acupuncture had a greater reduction in symptoms if they were African American.
A survey of over 2,500 Americans revealed that Angelina Jolie's public announcement about her preventive double mastectomy did not translate to increased knowledge of breast cancer risk and the BRCA gene mutation, highlighting a need for further education.
Eating a tomato-rich diet for 10 weeks increased adiponectin levels by 9 percent in postmenopausal women, reducing breast cancer risk. Regular consumption of fruits and vegetables is believed to promote breast cancer prevention in at-risk populations.
A new research study at Cedars-Sinai Medical Center is investigating the predictors, mechanisms for development, and persistence of post-treatment fatigue in breast cancer patients. The study will examine biological, behavioral, and social risk factors to identify women at high risk for fatigue.
Berkeley Lab researchers show that aerobic glycolysis is not the consequence of cancerous activity but a cancerous event. Increased sugar uptake in breast cells activates oncogenic signaling pathways, leading to cancerous growth. The study provides possible new targets for diagnosis and therapeutics.
A study by Manchester scientists found that women who undergo risk-reducing surgery have increased survival rates compared to those who don't. The research suggests that removing ovaries and fallopian tubes can reduce the risk of both ovarian and breast cancer by half.
A new clinical trial design, I-SPY 2, has enabled researchers to quickly identify effective treatments for high-risk breast cancer patients. Veliparib has shown a 91% probability of success in triple-negative breast cancer patients.
A phase III clinical trial found that adding ramucirumab to chemotherapy drug docetaxel did not delay disease progression for patients with HER2-negative, advanced breast cancer. Researchers will analyze biomarkers to identify potential subgroups of patients who may benefit from the therapy.
A new trial found that adding chemotherapy carboplatin and the molecularly targeted drug veliparib to standard presurgery chemotherapy improved pathologic complete response rates for patients with triple-negative breast cancer. The study's adaptive design showed a 92% predictive probability of success in a phase III trial.
A phase III clinical trial presented at the 2013 San Antonio Breast Cancer Symposium found that bisphosphonate zoledronate had no effect on event-free survival in women with chemoresistant breast cancer. Researchers also reported that patients with hormone receptor-positive disease were more common, which may impact treatment outcomes.
A nationwide study found that adding carboplatin to standard chemotherapy significantly increased tumor shrinkage in patients with triple-negative breast cancer. The results suggest that carboplatin could be used as an alternative or addition to current treatments.
A randomized, phase II clinical trial found that adding carboplatin and/or bevacizumab to standard presurgery chemotherapy increased the number of patients with no residual cancer detected at surgery. The study showed significant increases in pathologic complete response rates for patients treated with these combinations.
A phase III clinical trial found that switching to a different chemotherapy did not improve overall survival or time to progression for women with metastatic breast cancer and elevated circulating tumor cells. Patients with low CTCs before starting chemotherapy had a median overall survival of 35 months, while those with elevated CTCs ...
A new study published in The Lancet found that anastrozole significantly reduced the risk of breast cancer in postmenopausal women with a family history or other risk factors. After five years, 40 women in the treatment group developed breast cancer compared to 85 in the placebo group.
A study from the University of Texas M.D. Anderson Cancer Center found that 37% of younger, early-stage breast cancer patients underwent unnecessary staging tests, including PET, CT, and tumor markers. Women with PPO insurance coverage and those under 35 years old were at higher risk of receiving these tests.