Articles tagged with Breast Cancer
A pilot study found that a 12-month self-care program reduced lymphedema risk in 97% of breast cancer survivors by promoting lymph flow and optimizing body mass index (BMI). The Optimal Lymph Flow program empowered patients to take proactive steps, dispelling fear and anxiety.
A large clinical study found that MRI detected invasive breast tumours in female survivors of childhood Hodgkin lymphoma at very early stages. The study highlights the need for breast MRI screening from age 25 or eight years after chest radiation, as recommended by established guidelines.
Researchers used large population-based data to compare six common chemotherapy regimens, identifying those with the highest risk of hospitalization. The study found that TAC and AC+T were associated with high hospitalization rates in younger patients, while all regimens except ddAC+P had higher risks for older patients.
Researchers at IRB Barcelona have identified a new gene, RARRES3, that promotes breast cancer metastasis to the lung. The study reveals that loss of function of this gene enhances adhesion and differentiation in cancer cells, leading to increased malignant capacity.
The University of Houston will bolster its biomedical research capabilities with the recruitment of cancer imaging expert David Mayerich. Mayerich's work focuses on improving diagnosis and treatment through high-performance imaging and modeling of complex tumor structures.
Scientists have identified two genes, MLF2 and RPL39, that may affect the most lethal type of breast cancer. Suppressing these genes can reduce tumor formation and metastasis by interfering with blood vessel formation and recruitment.
Researchers found that calorie restriction decreased microRNA production, which promotes the extracellular matrix and prevents cancer cells from spreading. The study aims to test whether calorie restriction can improve outcomes for women with breast cancer in a clinical trial.
A team at Cold Spring Harbor Laboratory has validated a potentially powerful new approach to treating HER2-positive breast cancer by inhibiting the protein PTP1B. The discovery may lead to improved treatments for the disease, which affects one in four patients and is often resistant to existing therapies.
Researchers at SLU's Institute for Molecular Virology have discovered a small fragment of adenovirus that can repress HER2 cell growth and kill breast cancer cells. The discovery offers a promising new therapy for the deadly disease, which affects 20-30% of breast cancers.
Researchers have found chemical signals that enable breast cancer metastasis by recruiting normal cells from the host animal, providing a promising new direction for cancer treatment. Blocking these signals in mice with breast tumors significantly reduced their ability to spread.
Researchers at Cold Spring Harbor Laboratory have found a means of inhibiting PTP1B, which plays a critical role in the development of tumors in HER2-positive breast cancer. The discovery leads to the inhibition of tumor growth and prevention of metastasis.
A new study from the University of Michigan found that about 70% of women with breast cancer who underwent a double mastectomy had very low risk of developing cancer in their healthy breast. However, many of these women were driven by fear of recurrence rather than medical necessity.
A study of 2,290 women with breast cancer found that while many consider or undergo contralateral prophylactic mastectomy (CPM) to prevent cancer in the other breast, most do not have a clinically significant risk. The procedure is often associated with genetic testing, family history, and higher education.
Scientists at the University of Utah have uncovered the early steps of totipotency in sperm precursors, revealing a four-gene code that enables these cells to become stem cells and mature into various cell types. The discovery sheds light on the process of fertilization and provides insights into cancer and epigenetic regulation.
Women who participated in a 5-week cognitive behavioral training program showed significant improvements in mood, emotional well-being, and stress management skills. The Relaxation Training group also reported reduced disruptions in social activities and increased confidence in using relaxation techniques.
Researchers found that patients with tumor cells in their blood after surgery had a higher risk of relapse and poorer survival rates. The presence and count of tumor cells also predicted disease-free survival, with those having 5 or more CTCs at higher risk of recurrent disease.
Researchers have developed a new X-ray phase-contrast mammography technique that provides high-contrast images of breast tissue. This technique helps distinguish between different types of microcalcifications and can aid in assigning them to malignant lesions, enabling non-invasive detection of premalignant lesions.
Researchers are testing whether therapy incorporating advanced genomic technology will provide better outcomes than current treatments for women with an aggressive form of breast cancer. The trial uses targeted DNA sequencing to identify specific treatment choices that improve survival rates.
Researchers at University Hospitals Cleveland Medical Center presented data showing that the presence of tumor-infiltrating lymphocytes before treatment can predict a positive response to platinum-based therapy in women with triple-negative breast cancer. This discovery could lead to more personalized treatment decisions and improved p...
A recent study found that large panel genetic testing for breast cancer mutations yields limited results, with only 2.5% of patients having clinically actionable mutations. The test revealed reportable variants in over 30% of patients, leaving clinicians struggling to interpret the findings and provide accurate guidance.
A meta-analysis of 44 studies found that breastfeeding, tubal ligation, and oral contraceptives are associated with reduced rates of ovarian cancer in BRCA1 mutation carriers. Smoking may raise the risk of breast cancer for patients with a BRCA2 mutation.
The University of Chicago Medicine Comprehensive Cancer Center has been awarded a five-year, $3.9-million grant to serve as a Lead Academic Participating Site for the National Clinical Trials Network. The new network aims to improve cancer clinical trials' speed and efficiency.
A nationwide dataset analysis found that black women are 1.84 times more likely to be diagnosed with triple-negative breast cancer, a subtype with poorer prognosis. Asian/Pacific Islander women were also more likely to be diagnosed with HER2-overexpressing breast cancer.
Researchers at Hebrew University of Jerusalem found Erbin acts as a brake against excessive heart muscle growth. The protein's damage leads to decreased function and severe growth, which may be targeted for cardiac gene therapy in heart failure and breast cancer patients.
Three NSU professors received patents for their innovative solutions: a novel cancer treatment called JFD that starves tumors, a surface modification technology for ceramic materials in dentistry, and a computer-based system to predict law school admissions. The patents demonstrate NSU's focus on developing novel products and services.
Researchers from the University of Notre Dame have uncovered a novel mechanism by which carcinoma-associated fibroblasts (CAFs) contribute to tumor progression. CAFs block cell death through insulin-like growth factor-binding proteins, highlighting potential therapeutic targets for slowing breast cancer metastasis. Further pre-clinical...
AURORA is a large international molecular screening programme for metastatic breast cancer aiming to improve understanding of the disease and its response to treatments. The study will analyze over 1300 patients' tissue and plasma samples, enabling scientists to identify genetic characteristics that predict treatment outcomes.
A retrospective chart review found that high-risk lesions were predominantly identified in screened patients, enabling the administration of chemoprevention and reducing the risk of subsequent breast cancer development. Supplemental screening MRI may also detect future mammographically occult malignancies in these patients.
The GW Cancer Institute has received a $100,000 grant from the Avon Foundation to support a patient navigator. The patient navigator will help remove barriers and coordinate access to care for over 1,000 patients with breast cancer in the Washington D.C. area.
A new study finds that higher sleep efficiency is associated with lower mortality in women with advanced breast cancer. Mean survival was 68.9 months for efficient sleepers compared to 33.2 months for those with poor sleep efficiency.
A study led by Tufts University researchers reveals that SLUG transcription factor regulates stem cell function and determines breast cancer type, with potential implications for targeted therapies. The study found that SLUG-deficient mice exhibited defects in breast-cell differentiation and tumor formation.
A new study published in Cell Reports demonstrates that mice lacking one copy of the CTCF gene are predisposed to cancer due to abnormal DNA methylation. The research also reveals deletions or mutations in CTCF are common events in breast, endometrial, and other human cancers.
A protein called Kindlin-3 has been identified as a key player in both the formation and spread of breast cancer. The discovery suggests that targeting Kindlin-3 could lead to an entirely new class of breast cancer drugs, potentially slowing or reversing disease progression.
A new study reveals that clarity during consultations and the capability of clinical facilities significantly impact women's decisions regarding breast cancer surgery. Findings also show that MRI exams ordered less frequently in Canada led to fewer unnecessary prophylactic mastectomies compared to the US.
A Mayo Clinic study found that ultrasound images of underarm lymph nodes are more accurate in overweight and obese breast cancer patients than in those with a normal body mass index. The research suggests that soft fatty tissue can be compressed during ultrasounds, leading to better specificity and accuracy for these patients.
A new study from the University of Michigan Comprehensive Cancer Center found that nearly one-third of working women who had breast cancer were unemployed four years later. Women who received chemotherapy were most affected, with a significant increase in unemployment over time.
A new study elucidates how BRCA gene loss accelerates chromosome rearrangements, impairing homologous recombination repair. This discovery could help clinicians guide patient treatment for BRCA mutations of uncertain significance.
A gene expression profiling test analyzes patterns of 21 genes to predict cancer recurrence and benefit from chemotherapy. Many patients misunderstand the test's meaning, viewing it as a personalized and emotionally significant result rather than population-based statistics.
A study found that many women with early-stage breast cancer lose paid employment after diagnosis, particularly those who received chemotherapy. Women who received chemotherapy were 1.4 times more likely to be unemployed at follow-up.
A novel DNA vaccine targets TEM1, a protein overexpressed in tumors, reducing tumor vascularization and increasing immune cell infiltration. The vaccine induces epitope spreading, creating a secondary immune response against the tumor itself.
Researchers at the University of York discovered that breast cancer cells use a process similar to brain development to metastasize. Blocking sodium channels inhibits migration and invasiveness, making them a potential therapeutic target.
A new study by University of Western Ontario researchers reveals that specific interactions between breast cancer stem cells and lung-derived proteins contribute to lung metastasis. Understanding this phenomenon could lead to improved treatment options for breast cancer patients.
Researchers found that triclosan and octylphenol promote breast cancer cell growth and tumor development in lab tests. The study's findings suggest that exposure to these endocrine-disrupting chemicals may significantly increase the risk of breast cancer development.
Women with false-positive mammogram results experienced moderate to extreme anxiety, yet remained more likely to undergo future breast cancer screening. The study found a significant association between false-positives and increased anxiety, but not necessarily changed plans for future screening.
University of Houston junior Khanh Nguyen has been recognized as a 2014 Goldwater Scholar for her mathematical neuroscience research. She aims to pursue a Ph.D. in applied mathematics and apply her findings to medical and technological advances.
A large study has found that a larger waist circumference is associated with an increased risk of postmenopausal breast cancer. However, when adjusting for body mass index (BMI), the association disappeared. The research suggests that maintaining a healthy weight, regardless of body shape, may be key to reducing breast cancer risk.
A recent analysis by the RECIST Working Group found that modeling target lesion tumor growth did not improve prediction of overall survival beyond other components of progression. The study also revealed that new lesions and non-target progressive disease were linked with worse overall survival in multivariate models.
A new blood test, cMethDNA assay, has been developed to detect advanced breast cancer and monitor its response to treatment with high accuracy. The test detected cancer DNA in the blood of patients with metastatic breast cancers up to 95% of the time, making it a promising tool for early detection and treatment monitoring.
A study by researchers at Stanford University found that gene panels can help identify clinically actionable mutations in women with a personal or family history of breast or ovarian cancer. The technique, which focuses on a few select genes, is quicker, easier and cheaper than whole-genome sequencing.
Researchers found a genetic connection between APOBEC family of genes and breast cancer development. The study linked the genes to mutations present in half of all cancer types, supporting their role in cancer-causing processes.
A study by Women's College Hospital found women with diabetes are 14% less likely to get mammograms, despite higher breast cancer risk. Low socioeconomic status exacerbates this disparity.
Researchers identified a new drug, AMPI-109, effective against triple-negative breast cancer by targeting the PTP4A3 oncogene. The study also provided molecular insights into the disease's biology.
Researchers have found epigenetic changes that increase the risk of developing cancer, which affect gene expression without altering the genes themselves. The study analyzed 3,500 tumors and identified genetic polymorphisms associated with an increased risk of cancer, highlighting DNA methylation as a key factor in the disease
Researchers found that high expression of tumor-suppressor ZMYND11 is associated with longer survival for patients with triple-negative breast cancer. ZMYND11 inhibits gene activation by connecting to a methylated histone variant, thereby fine-tuning gene expression in cancer cells.
UT Southwestern Medical Center received a $3.24 million grant from the National Cancer Institute to bolster its clinical cancer research and provide patients with access to cancer research trials. The center will expand its offerings of experimental cancer treatments, more than doubling adult participation in clinical trials.
Researchers at the Salk Institute discovered that BRCA1 plays a crucial role in creating healthy brains in mice, potentially explaining why some women with breast cancer experience brain seizures. The study found that eliminating BRCA1 led to significant neural damage and abnormalities in brain development.
A Western University study has discovered a unique population of microbes in the female breast associated with cancer risk. The research found that certain types of bacteria, including Proteobacteria, were present in and beside tumors.
The Mayo Clinic uses frozen section analysis during breast cancer lumpectomies, sparing patients the need for repeat surgeries in 96% of cases. This technique significantly lowers the 30-day reoperation rate from 13.2% nationally to 3.6% at Mayo.
The SU2C Phillip A. Sharp Innovation in Collaboration Awards aim to foster synergistic and innovative collaborations among SU2C scientists. The inaugural awards will support five grants totaling $950,000, focusing on projects that enhance the SU2C mission to accelerate cancer treatment development.
Researchers at Fox Chase Cancer Center have uncovered new insights into the genetic mechanisms that protect against breast cancer during pregnancy. By analyzing the genetic activity of women who had and had not given birth, scientists identified differences in gene expression related to cell differentiation and breast anatomy development.