Articles tagged with Breast Cancer
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A study led by Tufts University researchers reveals that SLUG transcription factor regulates stem cell function and determines breast cancer type, with potential implications for targeted therapies. The study found that SLUG-deficient mice exhibited defects in breast-cell differentiation and tumor formation.
A new study published in Cell Reports demonstrates that mice lacking one copy of the CTCF gene are predisposed to cancer due to abnormal DNA methylation. The research also reveals deletions or mutations in CTCF are common events in breast, endometrial, and other human cancers.
A protein called Kindlin-3 has been identified as a key player in both the formation and spread of breast cancer. The discovery suggests that targeting Kindlin-3 could lead to an entirely new class of breast cancer drugs, potentially slowing or reversing disease progression.
A new study reveals that clarity during consultations and the capability of clinical facilities significantly impact women's decisions regarding breast cancer surgery. Findings also show that MRI exams ordered less frequently in Canada led to fewer unnecessary prophylactic mastectomies compared to the US.
A Mayo Clinic study found that ultrasound images of underarm lymph nodes are more accurate in overweight and obese breast cancer patients than in those with a normal body mass index. The research suggests that soft fatty tissue can be compressed during ultrasounds, leading to better specificity and accuracy for these patients.
A new study from the University of Michigan Comprehensive Cancer Center found that nearly one-third of working women who had breast cancer were unemployed four years later. Women who received chemotherapy were most affected, with a significant increase in unemployment over time.
A new study elucidates how BRCA gene loss accelerates chromosome rearrangements, impairing homologous recombination repair. This discovery could help clinicians guide patient treatment for BRCA mutations of uncertain significance.
A gene expression profiling test analyzes patterns of 21 genes to predict cancer recurrence and benefit from chemotherapy. Many patients misunderstand the test's meaning, viewing it as a personalized and emotionally significant result rather than population-based statistics.
A study found that many women with early-stage breast cancer lose paid employment after diagnosis, particularly those who received chemotherapy. Women who received chemotherapy were 1.4 times more likely to be unemployed at follow-up.
A novel DNA vaccine targets TEM1, a protein overexpressed in tumors, reducing tumor vascularization and increasing immune cell infiltration. The vaccine induces epitope spreading, creating a secondary immune response against the tumor itself.
Researchers at the University of York discovered that breast cancer cells use a process similar to brain development to metastasize. Blocking sodium channels inhibits migration and invasiveness, making them a potential therapeutic target.
A new study by University of Western Ontario researchers reveals that specific interactions between breast cancer stem cells and lung-derived proteins contribute to lung metastasis. Understanding this phenomenon could lead to improved treatment options for breast cancer patients.
Researchers found that triclosan and octylphenol promote breast cancer cell growth and tumor development in lab tests. The study's findings suggest that exposure to these endocrine-disrupting chemicals may significantly increase the risk of breast cancer development.
Women with false-positive mammogram results experienced moderate to extreme anxiety, yet remained more likely to undergo future breast cancer screening. The study found a significant association between false-positives and increased anxiety, but not necessarily changed plans for future screening.
University of Houston junior Khanh Nguyen has been recognized as a 2014 Goldwater Scholar for her mathematical neuroscience research. She aims to pursue a Ph.D. in applied mathematics and apply her findings to medical and technological advances.
A large study has found that a larger waist circumference is associated with an increased risk of postmenopausal breast cancer. However, when adjusting for body mass index (BMI), the association disappeared. The research suggests that maintaining a healthy weight, regardless of body shape, may be key to reducing breast cancer risk.
A recent analysis by the RECIST Working Group found that modeling target lesion tumor growth did not improve prediction of overall survival beyond other components of progression. The study also revealed that new lesions and non-target progressive disease were linked with worse overall survival in multivariate models.
A new blood test, cMethDNA assay, has been developed to detect advanced breast cancer and monitor its response to treatment with high accuracy. The test detected cancer DNA in the blood of patients with metastatic breast cancers up to 95% of the time, making it a promising tool for early detection and treatment monitoring.
A study by researchers at Stanford University found that gene panels can help identify clinically actionable mutations in women with a personal or family history of breast or ovarian cancer. The technique, which focuses on a few select genes, is quicker, easier and cheaper than whole-genome sequencing.
Researchers found a genetic connection between APOBEC family of genes and breast cancer development. The study linked the genes to mutations present in half of all cancer types, supporting their role in cancer-causing processes.
A study by Women's College Hospital found women with diabetes are 14% less likely to get mammograms, despite higher breast cancer risk. Low socioeconomic status exacerbates this disparity.
Researchers identified a new drug, AMPI-109, effective against triple-negative breast cancer by targeting the PTP4A3 oncogene. The study also provided molecular insights into the disease's biology.
Researchers have found epigenetic changes that increase the risk of developing cancer, which affect gene expression without altering the genes themselves. The study analyzed 3,500 tumors and identified genetic polymorphisms associated with an increased risk of cancer, highlighting DNA methylation as a key factor in the disease
Researchers found that high expression of tumor-suppressor ZMYND11 is associated with longer survival for patients with triple-negative breast cancer. ZMYND11 inhibits gene activation by connecting to a methylated histone variant, thereby fine-tuning gene expression in cancer cells.
UT Southwestern Medical Center received a $3.24 million grant from the National Cancer Institute to bolster its clinical cancer research and provide patients with access to cancer research trials. The center will expand its offerings of experimental cancer treatments, more than doubling adult participation in clinical trials.
Researchers at the Salk Institute discovered that BRCA1 plays a crucial role in creating healthy brains in mice, potentially explaining why some women with breast cancer experience brain seizures. The study found that eliminating BRCA1 led to significant neural damage and abnormalities in brain development.
A Western University study has discovered a unique population of microbes in the female breast associated with cancer risk. The research found that certain types of bacteria, including Proteobacteria, were present in and beside tumors.
The Mayo Clinic uses frozen section analysis during breast cancer lumpectomies, sparing patients the need for repeat surgeries in 96% of cases. This technique significantly lowers the 30-day reoperation rate from 13.2% nationally to 3.6% at Mayo.
The SU2C Phillip A. Sharp Innovation in Collaboration Awards aim to foster synergistic and innovative collaborations among SU2C scientists. The inaugural awards will support five grants totaling $950,000, focusing on projects that enhance the SU2C mission to accelerate cancer treatment development.
Researchers at Fox Chase Cancer Center have uncovered new insights into the genetic mechanisms that protect against breast cancer during pregnancy. By analyzing the genetic activity of women who had and had not given birth, scientists identified differences in gene expression related to cell differentiation and breast anatomy development.
A systematic evidence review found daily low-dose aspirin can prevent preeclampsia complications by 24% and preterm birth by 14%, with no identified harms. A new approach to breast cancer research suggests reevaluating mammography screening and focusing on prevention through lifestyle changes.
Researchers found that women who underwent radiotherapy for breast cancer have a small but significantly increased risk of developing a primary lung tumour. The risk increases with the amount of radiation absorbed by the tissue, with an estimated relative risk of 8.5% per delivered Gy to the lung.
In mice, obese fathers pass on their weight and gene expression changes to their daughters, increasing the risk of obesity and breast cancer later in life. This study provides evidence for a potential paternal link to cancer risk, challenging traditional research focus on maternal influences.
Researchers at UPMC Cancer Institute discover plant-derived compounds that selectively target breast cancer cells, inhibiting growth and inducing death. These findings offer potential new approaches to preventing and fighting breast cancer.
Researchers discovered two new genes, NEIL2 and OGG1, that modulate the risk of breast and ovarian cancer in women with high-risk mutations. The genes affect an alternative DNA repair pathway and may have implications for treatments like PARP inhibitors.
A study published in Cell Reports found that 90% of osteosarcomas, the most common childhood bone tumor, have mutations in the TP53 gene. This alteration helps explain why standard doses of radiation therapy are largely ineffective against these tumors.
Sanford-Burnham will present various cancer research findings at the AACR annual meeting, including novel methods of drug delivery and novel targets for breast, melanoma, and prostate cancers. Researchers will also discuss epigenetic mechanisms and cancer metastasis.
A study published in Cancer Epidemiology, Biomarkers & Prevention found that women who took clomiphene citrate or gonadotropins for fertility treatment did not have an increased risk of breast cancer over 30 years. However, a small number of women had a higher risk after multiple cycles of these medications.
A landmark study found pathological complete response after neoadjuvant chemotherapy to be an independent predictor of favorable clinical outcomes in all molecular subtypes of breast cancer. The treatment administered, taxane or non-taxane, was also shown to impact event-free survival.
A comprehensive review suggests that mammography screening benefits are often exaggerated while harms are understated. The study's findings emphasize the need for individualized approach to breast cancer screening based on clinical factors and personal preferences.
A new study found that full-field digital mammography (FFDM) is associated with lower recall and biopsy rates than screen film mammography (SFM), reducing the number of unnecessary diagnostic workups. FFDM implementation led to lower false positive screening exams and fewer biopsies with benign outcomes.
A review of scientific literature suggests that routine mammograms for women over 75 may not be beneficial and could lead to unnecessary treatment. The authors conclude that doctors should consider life expectancy when making screening decisions for this age group.
Researchers identify two distinct types of cells responsible for different breast cancer subtypes, shedding light on the origins of breast cancer diversity. This breakthrough discovery has the potential to revolutionize personalized treatment for patients, reducing unnecessary treatments and improving outcomes.
Researchers developed a predictive tool that analyzes gene expression changes to predict patient survival. The tool, based on mouse studies, has shown promise in predicting treatment risk for early-stage breast cancer and certain lung cancers.
A new study found that adjuvant chemotherapy increases markers of molecular aging in the blood of BC survivors, including p16INK4a and ARF expression. These age-promoting effects may last for several years after treatment and even be permanent.
Researchers at Queen's University Belfast have discovered a link between high levels of oestrogen and DNA damage in breasts and ovaries, driving cancer in women with the BRCA1 mutation. This breakthrough could lead to alternative treatments to surgery, such as drugs that chemically reduce oestrogen production.
A faster and cheaper DNA sequencing technique, NGS, will improve care for patients with breast cancer by providing genetic mutation results before treatment begins. This may lead to more women opting for mastectomy instead of breast-conserving surgery, highlighting the need for close monitoring of at-risk patients.
UCSF researchers found that breast tissue stiffening in cancer development leads to tumor progression, triggering the production of a molecule associated with worse clinical outcomes. The discovery may lead to more accurate prognosis and new treatment strategies targeting structural changes in breast cancers.
Researchers discovered that breast cancer tumors can hijack patients' repressive gene regulatory machinery, permanently blocking cancer-killing genes. This allows the cancer to continue growing despite treatment with aromatase inhibitors, which block estrogen synthesis.
A Texas A&M AgriLife Research study found that peach extract inhibits breast cancer metastasis in mice by targeting metalloproteinases. Consuming two to three peaches per day may provide similar benefits for humans, according to the study published in the Journal of Nutritional Biochemistry.
A study by University of Michigan Comprehensive Cancer Center researchers found that 25% of breast cancer survivors reported financial decline after treatment. Racial disparities were also noted, with Spanish-speaking Latinas and Blacks being more likely to experience financial hardships.
A recent study published in Applied and Environmental Microbiology has identified a distinct population of microbes in the breast tissue, with Proteobacteria being the dominant phylum. The presence of beneficial bacteria like Lactobacillus and Bifidobacteria suggests a potential protective effect for both mother and child.
A new treatment option for metastatic breast cancer patients with liver metastases shows promise in slowing disease progression and improving quality of life. Yttrium-90 radioembolization was safe and provided disease stabilization in 98.5% of treated liver tumors, with many experiencing significant tumor shrinkage.
Researchers at Dartmouth's Norris Cotton Cancer Center have compiled a review of genetic-based testing in breast cancer diagnosis and treatment. Genomic testing enables personalized therapy, increasing precision and success rates for patients.
A gene previously unassociated with breast cancer plays a pivotal role in the growth and progression of triple negative breast cancer, a particularly deadly strain. Targeting XBP1 may offer a new approach to treating this disease.
A UK study found that approximately one third of women are at higher risk of developing breast cancer and may require more frequent mammograms. Women with dense breast tissue were 2.9-fold more likely to develop breast cancer, highlighting the importance of personalized screening frequency.
Research from The Netherlands found that extending national breast cancer screening programs to women aged 70 and over does not decrease advanced stage cancer detection, but rather increases early-stage tumors. This leads to a large proportion of women being over-treated and at risk from the harmful effects of treatment.
Breast cancer mortality rates in Europe have decreased from 1989 to 2010 due to improved treatments and enhanced access to care. However, notable variations between countries remain, with France showing a modest decrease despite devoting substantial resources to cancer care.
A meta-analysis of 37 studies found that regular physical activity reduces breast cancer risk by 12% compared to the least active women. The protective effect of exercise seems to be cancelled out in women taking hormone replacement therapy, but this trend may change as HRT use decreases.
Research finds that obese patients have a higher risk of cancer recurrence and metastasis after neoadjuvant chemotherapy. Diabetes also affects cancer outcomes, particularly in hormone receptor-positive tumours, increasing the risk of death from all causes by 49%.