Articles tagged with Breast Cancer
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Researchers discovered that breast cancer cells exploit a signaling pathway used by normal mammary stem cells during pregnancy to produce faster-growing, more aggressive tumors. This connection may contribute to the increased short-term risk of highly aggressive breast cancers following each pregnancy.
A study of postmenopausal women found no link between bisphosphonate treatment and reduced breast cancer risk. Researchers analyzed data from two randomized trials, concluding that bisphosphonates do not protect against breast cancer in this population.
A new study led by researchers at UCSF analyzed the effect of two widely used osteoporosis drugs on breast cancer risk in post-menopausal women. The findings suggest that low estrogen levels, rather than the drugs themselves, may be protecting against breast cancer.
A comprehensive analysis of data from thousands of patients revealed that one in ten cancers would be classified differently using a new classification system based on molecular subtypes. The study provides a more refined, quantitative picture of cancer subtypes and could lead to different treatment options for those patients.
A new study analyzing over 3,500 tumor samples reveals that many cancers can be classified differently based on cellular and molecular criteria. The research suggests that patients may benefit from more accurate diagnoses and tailored treatments, with potential implications for personalized cancer therapy.
Researchers analyzed over 3500 tumors using multiple genomic platforms, revealing that cancers are more likely to be molecularly and genetically similar based on their cell type. The study proposes a new classification system that could lead to personalized cancer treatment and eligibility for novel therapeutics.
Researchers have completed the largest cancer genetic analysis ever conducted, revealing a new way of classifying cancers. The study found that one in 10 cancers would be classified differently using this new approach, which could lead to better treatment options for patients.
Researchers have uncovered a new gene fusion that may contribute to the development of luminal B breast cancer, a subtype associated with more aggressive forms and higher recurrence rates. The study found that this fusion is present in approximately 8% of tumor samples and can lead to increased cell motility and invasion.
A study published in the New England Journal of Medicine found that women with mutations in the PALB2 gene have a one in three chance of developing breast cancer by age 70. The study analyzed data from 154 families and found that risks were higher for those with family history of breast cancer.
A new study published in Radiology suggests that mammography screening for women over 75 may reduce the rate of more advanced breast cancers, leading to improved survival rates. Mammography-detected invasive breast cancer patients had a 10% reduction in mortality after five years.
A recent study published in the Journal of Clinical Oncology suggests that patient navigation can lead to better breast cancer care for high-risk populations, including minority women. Researchers found that patients assisted by trained navigators were more likely to start recommended treatments, such as hormonal therapy.
Researchers at MD Anderson Cancer Center have discovered that protein ZEB1 helps breast cancer cells repair DNA damage caused by radiation therapy, making them more resistant to treatment. This finding has significant implications for the development of new treatments targeting ZEB1 and other proteins involved in radioresistance.
Researchers have found a link between tumor suppressor mutations and missing segments of genetic material in squamous cell head and neck cancers. The study suggests that treating tumors with both markers may intensify treatment, while those with only one marker may benefit from de-intensified treatment.
A recent study published in Cancer Research found that women who recently used birth control pills containing high-dose estrogen had an increased risk for breast cancer. The study suggests that this risk may vary by oral contraceptive formulation, and it is essential to consider the established health benefits of oral contraceptive use...
A University of Houston study found that expressive writing can reduce fatigue, intrusive thoughts, and posttraumatic stress in Chinese-speaking breast cancer survivors. The intervention involved writing about emotions and benefits for 20 minutes each week over three weeks.
Researchers found that HSF1 activates a transcriptional program in both cancer cells and stromal cells, fueling malignant processes. HSF1 activation is associated with poor patient outcomes in breast and lung cancers, making it a potential biomarker for predicting tumor progression.
A study found that acupuncture significantly improved the quality of life for early-stage breast cancer patients taking aromatase inhibitors by reducing fatigue, anxiety, and depression. The intervention led to a significant reduction in these symptoms, with effects persisting for at least four weeks after treatment.
Researchers at Dana-Farber Cancer Institute found that subgroups within tumors drive growth, rather than the fastest-proliferating cells. Targeting these growth-driving cells could improve treatment outcomes and prevent tumor expansion.
Researchers will map out BRCA1 protein structures in healthy and mutated forms to identify molecular targets for new treatments. The goal is to improve treatment options for women with hereditary breast cancer.
Researchers discovered two distinct molecular clocks operating at different stages of tumor growth, with implications for chemotherapy resistance and prognosis. The study used single-cell genome sequencing to profile thousands of cells, providing insights into genomic diversity and its potential clinical applications.
Research suggests that dim light exposure at night can suppress melatonin production in rats with human breast tumors, making them resistant to the breast cancer drug tamoxifen. However, giving these rats a melatonin supplement during the night restored their tumor sensitivity to the drug.
A new study by Tulane University reveals that exposure to light at night can render breast cancer cells resistant to tamoxifen. In contrast, complete darkness and high melatonin levels significantly slow tumor growth and enhance tamoxifen's effectiveness.
A Cincinnati Cancer Center study finds that SapC-DOPS, a combination of lysosomal protein saposin C and phospholipid DOPS, targets and kills cancer cells, including those from breast and lung cancers. The treatment showed promise in animal models, with some tumors completely cured within 24 hours.
Researchers have identified three genetic changes linked to an increased risk of breast cancer in East Asian women. These findings provide new insights into the genetics and biology of breast cancer.
Researchers found that bioidentical hormone treatments reduced tumor recurrence and improved cardiovascular and bone health, while also increasing physical activity and cognition. The study's results are promising but require further validation, providing a new direction in the search for alternative hormone therapies.
A multi-disciplinary team of scientists has discovered that a gene called MED12 is altered in nearly 60% of fibroadenomas, the most common benign breast tumours diagnosed in women. The study's findings have potential applications in distinguishing fibroadenomas from breast cancer and developing targeted therapies.
Researchers at Yale University developed a diagnostic test to detect PD-L1 expression in early-stage breast cancers, with 60% showing high levels of PD-L1 and tumor-infiltrating lymphocytes. High levels predicted better survival rates for patients, suggesting an immune system's role in controlling these cancers.
A decade of research led by Dr. Tak Mak identified PLK4 as a promising therapeutic target for breast cancer treatment and developed a small molecule inhibitor to block it. The study showed significant antitumor activity in preclinical models, offering hope for personalized cancer medicine.
Huntsman Cancer Institute will become a key partner in the National Clinical Trials Network, providing access to clinical trials for patients across the Intermountain West region. The institute's unique research assets, including the Utah Population Database and Center for Quantitative Imaging Excellence, will enable multi-institutiona...
A recent study published in JNCI: Journal of the National Cancer Institute found that contralateral prophylactic mastectomy (CPM) may confer only a marginal life expectancy benefit depending on the type and stage of cancer. The procedure was more beneficial for younger women and those with stage I and ER-negative breast cancer.
A new study published in JNCI: Journal of the National Cancer Institute found that breast cancer screening costs increased substantially among older women between 2001 and 2009, despite unchanged detection rates of early-stage tumors. The study analyzed data from the SEER-Medicare linked database and found a significant increase in scr...
A new skin gel form of tamoxifen has been developed and tested on women with non-invasive breast cancer, reducing cancer cell growth while minimizing side effects. The gel application was found to be effective in reducing blood clot risk associated with oral tamoxifen, offering a safer treatment option.
A two-year study will examine the effects of cognitive behavioral and relaxation training on immune system functioning after surgery. Women who received these interventions reported reduced distress, improved mood, and enhanced emotional-well-being.
Researchers isolated breast cancer cells from patients' blood and expanded them in the lab, identifying new mutations and drug susceptibility. The study found a promising drug, Ganetspib, effective in killing tumor cells with specific genetic mutations.
Researchers at Massachusetts General Hospital developed a microchip-based device to capture and culture circulating tumor cells (CTCs) for genetic analysis and drug testing. The study found that cultured CTCs accurately reflect a tumor's genetic mutation over time, revealing new mutations and potential drug targets.
Researchers found that women with breast cancers involving the skin have widely varied survival rates, differing by tumor size and nodal involvement. They recommend adding a new staging category for tumors with skin involvement to accurately reflect a woman's chances of surviving her cancer.
A study of over 1 million patients in the UK found an association between high blood cholesterol and increased breast cancer risk. The researchers suggest that lowering cholesterol with statins may help prevent or treat breast cancer, warranting further investigation.
A study by Yale University researchers found that Medicare spending on breast cancer screening increased significantly between 2001 and 2009, despite no corresponding decrease in new breast cancer cases. The use of digital mammography technology, which is more expensive than standard film technology, contributed to the increase.
A 30-year follow-up study found no link between fertility drugs and breast, ovarian, and uterine cancers, except for extended use of clomiphene citrate. The study of 12,193 women treated for infertility showed a higher risk of invasive breast cancer with clomiphene use in 12 or more treatment cycles.
A recent study published in Nature Genetics has discovered a single gene that defines the difference between fast-growing, aggressive tumors and slow-growing, non-aggressive ones. The gene mutation GTF2l was found to be present in almost all indolent forms of thymoma, suggesting potential implications for treatment.
A study of adoptees found that genetics play a significant role in the development of these three types of cancer. The risk was 80% higher when an adoptee had at least one biological parent with the same cancer.
Researchers found that triple-negative breast cancer tumors rely on an antiviral pathway driving inflammation, which can be treated with JAK inhibitors. Patients missing both p53 and ARF genes may benefit from these anti-inflammatory drugs.
Researchers have found a consistent pattern of gene expression associated with tumor spreading in mice, which was also found in human oral cancer samples. A transcriptional signature predicting metastatic disease was identified with about 93% accuracy.
Researchers identified an epigenetic signature in blood samples from women with a BRCA1 mutation that increased cancer risk and lower survival rates. The same signature was found in women without the mutation who developed breast cancer, indicating it may predict breast cancer risk several years before diagnosis.
Researchers at Drexel University found a significant spike in Google searches for autism in April, with an average increase of 26 percent between March and April. The study analyzed web search trends from 2004 to 2014 and also found a long-term increasing trend for Asperger's disorder searches.
A study by Princeton University researchers found that the Metadherin gene, implicated in promoting breast cancer tumors, only stimulates growth when bound to its partner protein SND1. The research reveals that MTDH plays a role in both initial tumor growth and metastasis, but not normal cell growth or development.
Activation of estrogen receptor β (ERβ) has been shown to limit tumor cell growth in breast cancer. In mouse models, cancer cells with activated ERβ did not grow well. Conversely, breast cancer patients with activated ERβ in their tissue had increased disease-free survival rates.
Researchers discovered that a virus called AAV2 can kill triple-negative breast cancer cells and tumors in mice, with no adverse effects. The virus initiates apoptosis, or natural cell death, without affecting healthy cells, offering new possibilities for treatment of aggressive breast cancer.
A recent study published in JAMA found that 3D mammography significantly improves detection of invasive breast cancers, reducing call-back rates by 15%. This technology has shown promise in improving breast cancer screening outcomes, particularly for younger women and those with dense breast tissue.
The study found that adding tomosynthesis to mammography increased cancer detection rates by 27% and reduced false-positive results, while also decreasing unnecessary tests and biopsies. This technology has the potential to optimize patient outcomes from mammography screening.
A large retrospective study published in JAMA found that 3D mammography significantly increases detection of invasive cancers (41% increase) while reducing unnecessary recalls for false alarms. The technology also improves detection of all breast cancers by 29%.
A new imaging technique combining four approaches can distinguish between malignant and benign breast tumors with high accuracy, potentially avoiding unnecessary biopsies. The multiparameter PET-MRI method showed a 96% success rate in distinguishing malignant from benign tumors.
Researchers found that BPA increases breast cancer cell proliferation and diminishes the effect of treatments for inflammatory breast cancer cells. The study suggests a possible link between BPA exposure and treatment resistance in breast cancer patients.
A new study shows that even triple negative breast cancers with low androgen receptor expression can benefit from anti-androgen receptor therapy. The treatment, which targets the androgen receptor, was found to increase programmed cell death, inhibit growth, and increase necrosis in animal models.
Researchers discovered that the androgen receptor may play a crucial role in treating estrogen receptor-positive breast cancer. The study found that women with high levels of androgen receptors were more likely to experience cancer recurrence during tamoxifen treatment.
Researchers have developed a clinically relevant mouse model for squamous cell lung cancer, driven by the misregulation of genes sox2 and lkb1. The discovery uncovers new treatment strategies and provides insights into potential targeted therapies.
Researchers at Albert Einstein College of Medicine will study how breast cancer cells move and spread in the body. They aim to develop a test that predicts which breast cancer tumors will metastasize, based on the presence of a trio of cells called a tumor microenvironment of metastasis.
Research from the University of Texas MD Anderson Cancer Center found that African American women with early-stage invasive breast cancer were 12% less likely to receive axillary sentinel lymph node biopsy, a minimally invasive technique. The study also showed that those who received older, more invasive axillary lymph node dissection ...
Researchers identified racial disparities in the use of sentinel lymph node biopsy (SLNB) among black and white women with early-stage breast cancer. Black women were 12% less likely to undergo SLNB, contributing to higher risk for lymphedema compared to white patients.
A recent study by Dartmouth-Hitchcock Norris Cotton Cancer Center found that 22 out of 552 women had their tumor type incorrectly classified using conventional HER2 testing. The study confirmed the importance of accurate HER2 testing, as incorrect classification can have significant implications for treatment decisions.