Articles tagged with Breast Cancer
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Researchers at MD Anderson Cancer Center have identified a protein complex called CSN and its subunit CSN6 as a key factor in cancer development. The study found that inhibiting CSN6 can quickly destabilize the master cancer gene Myc, greatly impairing tumor growth and metastasis.
A Vanderbilt study reveals a significant increase in the number of women with early-stage breast cancer choosing mastectomy over breast conservation surgery. The trend was most pronounced among younger women and those with smaller tumors, suggesting factors other than disease burden are at play.
Scientists at MD Anderson Cancer Center identified a long non-coding RNA called BCAR4 as playing a key role in the hedgehog signaling pathway's contribution to breast cancer metastasis. The study suggests that targeting this pathway with locked nucleic acids may provide a new approach for treating aggressive breast cancers.
Researchers have discovered that tumor cells secrete exosomes containing proteins capable of transforming neighboring cells into tumor cells, promoting tumor growth. Dicer protein is identified as a key factor in this process and may serve as a biomarker or therapeutic target.
A study using mathematical models shows that genetic testing can substantially improve breast cancer prevention by analyzing multiple gene variants. The research suggests that combining genetic data with other risk factors can identify the most at-risk women, who account for 32.2% of all breast cancer cases.
Researchers discovered that simvastatin inhibits the growth of uterine fibroid tumors, which are responsible for half of all hysterectomies. The study found that simvastatin impedes cell growth and induces calcium-dependent cell death mechanisms in fibroid tumor cells.
A study published in JAMA Surgery found that nearly a quarter of patients who underwent initial breast conservation surgery had a subsequent surgical intervention. The study, which included over 316,000 patients, identified patient and tumor factors associated with repeat surgeries.
Researchers from Uppsala University developed a therapeutic vaccine that selectively targets tumor vessels, reducing tumor burden and suppressing metastases in a mouse model of metastatic breast cancer. The vaccine induced an 80% reduction in metastasis, providing a cost-efficient alternative to monoclonal antibody-based therapies.
Researchers at City College of New York led by Dr. Debra Auguste have discovered a potential molecular target and biomarker for treating triple negative breast cancers, which have a high mortality rate due to aggressive proliferation and metastasis.
A phase II study led by the University of Pennsylvania School of Medicine found olaparib produced a 26% overall tumor response rate in patients with advanced cancers associated with BRCA1 and BRCA2 mutations. The treatment showed improved survival rates for patients with ovarian, breast, pancreatic, and prostate cancers.
Researchers have identified a key role for the FAK molecule in controlling breast cancer stem cell survival and predicting disease recurrence. Blocking FAK activity with a new drug significantly improved treatment outcomes, suggesting a potential method to predict which patients are most likely to experience recurrence.
Researchers discovered that bisphosphonates can inhibit cancer spread in some women with breast cancer by attaching to calcifications in tumors and being devoured by immune cells. This finding could lead to new, more effective ways of using these drugs to treat certain cancers.
The study found that meditation, yoga, and relaxation with imagery received an 'A' grade for easing anxiety and mood disorders common to breast cancer patients. Acupuncture was also recommended for controlling chemotherapy-induced nausea and vomiting.
More than 70% of women who have had breast cancer experience menopausal problems, including hot flushes that can persist for over five years and affect daily life. The study found that clinicians often underestimate the severity of these symptoms, with only 10-30% of patients experiencing severe hot flushes.
Researchers discovered genetic patterns that predict when breast cancers will spread to the brain, offering a potential early detection method. Faulty gene switches in the original tumor may serve as an early warning signal for brain metastasis.
Researchers at Lund University discovered that lactose intolerant people are at a reduced risk of developing lung, breast, and ovarian cancers. The study, which analyzed nationwide data from Sweden, suggests that diet plays a crucial role in protecting against these cancers.
LSU Health New Orleans has been awarded a $2.2 million grant to develop and implement strategic health education campaigns for young breast cancer survivors in the Gulf South region. The initiative aims to empower survivors to advocate for their care and access necessary services, improving quality of life.
A study has demonstrated a clear new evidence for mind-body connection in breast cancer survivors, showing that mindfulness meditation and support groups can influence telomere length. This suggests potential health benefits beyond the initial three-month period studied.
Women undergoing breast cancer surgery showed significant improvements in breast reconstruction processes of care after hospitals opened comprehensive breast centers. These centers enhanced patient care by assembling specialized practitioners for coordinated breast cancer care.
Researchers found that eribulin improves overall survival of women with metastatic triple negative breast cancer and HER2 negative breast cancer by nearly five months and two months respectively. Eribulin, originally developed from sea sponges, is a microtubule inhibitor that stops cancer cells from separating into new cells.
A pilot study found that invisible fluorescent tattoos can improve body confidence among breast cancer patients undergoing radiotherapy. Researchers compared the effects of visible and invisible tattoos on patients' self-esteem, finding that 56% of those with invisible tattoos felt better one month after treatment.
Researchers found that proton therapy costs comparable to traditional radiation therapies, challenging the assumption that it's more expensive. The study suggests that insurance coverage should be considered, enabling patients to participate in clinical research.
Two studies found pediatric breast cancer patients experienced longer time between diagnosis and treatments, often diagnosed at later stages. Pediatric colon cancer patients had lower five-year survival rates than adults due to more aggressive tumors and treatments.
Researchers at Vanderbilt University have developed a technique to test the effectiveness of anti-cancer drugs on individual patients' tumors in a dish, using fluorescence imaging to monitor the response. The test can detect significant drops in metabolic activity levels within 72 hours, allowing doctors to identify the most effective ...
A study found that combining digital mammography with tomosynthesis screening is more effective in detecting breast cancer among women with dense breasts. This combined approach avoids false-positive results and unnecessary procedures, making it a cost-effective option.
A new study found that chest radiation in childhood cancer patients increases their risk of developing breast cancer later in life. Nearly 20% of female survivors who received chest radiation developed breast cancer by age 40 compared to 0.3% of those who did not receive radiation.
Breast cancer patients taking brand name aromatase inhibitors had higher discontinuation rates and nonadherence compared to those on generic AIs. Higher copayments of $15-$30 per month were also linked to discontinued use.
A Dartmouth study found that Diffuse Optical Spectroscopic Tomography (DOST) imaging can accurately predict which patients will respond well to neoadjuvant chemotherapy, enabling earlier and more effective treatment. This breakthrough could significantly improve disease-free survival rates for breast cancer patients.
Researchers at St. Jude Children's Research Hospital identified a promising triple-drug combination therapy that exploits DNA repair problems in Ewing sarcoma tumors, showing over 70% success rate in mice treated with the combination of chemotherapy drugs and PARP inhibitors.
A new drug, OTS964, can eradicate aggressive human lung cancers transplanted into mice by inhibiting the action of a protein overproduced by several tumor types. The drug was well-tolerated and effective when taken as a pill or injected intravenously.
Research at Beth Israel Deaconess Medical Center identified an unexpected link between the transcription factor FOXP2 and metastatic colonization of breast cancer. Silencing FOXP2 enables breast cancer cells to acquire malignant traits, facilitating their survival and proliferation.
MIT researchers have developed a new way to model the effects of genetic mutations in mice using CRISPR, enabling rapid analysis of genes linked with cancer growth. This approach fills a gap in understanding the role of cancer-gene candidates and offers new ways for personalized treatments.
A novel methodology for investigation using modern mass spectrometry has been developed to investigate tumour-promoting activities of breast fibroblasts. This allows for the direct determination of undesirable cell activities in cancer-associated fibroblasts, which may promote tumour growth.
A long-term study of patients with HER2-positive breast cancer shows that adding trastuzumab to chemotherapy improves overall and disease-free survival by 37% and 40%, respectively. The regimen is now the standard of care for early stage HER2-positive breast cancer.
A genetic variant common in Latina women has been found to protect against breast cancer, with a significant reduction in risk. The variant, originating from indigenous Americans, is believed to interfere with the action of estrogen receptors and is more prevalent in Latina populations than previously thought.
A University of Georgia study found that disruption of the circadian rhythm, triggered by artificial light exposure, significantly increases breast cancer risk. The researchers analyzed studies on flight attendants who work night shifts and found a higher risk of developing breast cancer.
A federal prescription-subsidy program improved adherence to hormone therapy among low-income women with breast cancer. The program's success was attributed to lower out-of-pocket costs, which reduced disparities in adherence rates across racial and ethnic groups.
Researchers found that a particle size of 50 nm is optimal for anti-cancer nanomedicines, with enhanced performance in vivo and improved tumor inhibition.
University of Iowa researchers found a gene in an amoeba that functions similarly to the human PTEN gene, which suppresses tumor growth. They tested the gene in mice and found it fully overcompensated for defects caused by mutated PTEN genes, potentially leading to new cancer treatments.
CNIO researchers found that the simultaneous inhibition of Cdk4 and Cdk6 is more effective than individual inhibition in reducing tumour growth and promoting aggressive tumours in mice. The study also revealed that the combined activation of both oncogenes leads to uncontrolled cell division and an increased risk of developing leukemia.
Researchers found a potential link between inherited BRCA1 and BRCA2 mutations and increased risk of salivary gland cancer. The study suggests that people with these gene mutations may require earlier evaluation for salivary gland lesions.
Scientists at Brigham Young University have discovered two proteins that trigger autophagy in cancer cells, offering a potential therapeutic avenue for targeted treatment. The study's unique approach led to the identification of a protein pair responsible for switching on autophagy under stress conditions.
Researchers have found that circulating tumor cells in the blood can accurately reflect the genetic status of metastatic breast cancer patients. This discovery could help guide treatment decisions and track patient progress without requiring repeat biopsies.
Scientists at the University of Kansas have developed a miniaturized biomedical testing device for exosomes, promising earlier detection and improved survival rates for patients. The lab-on-a-chip technology uses magnetic beads to isolate exosomes from plasma samples, enabling minimally invasive and cost-effective cancer diagnosis.
Researchers are developing methods to restore mobility and recover function in individuals with neurological and musculoskeletal conditions. A new NIH-funded study led by Dr. Guang Yue will investigate the impact of high-effort training on muscle strength in women with breast cancer.
A study published in the Journal of the National Cancer Institute finds that osteoporosis treatment may also benefit breast cancer patients by slowing skeletal metastasis. Women who took oral bisphosphonates had a reduced risk of bone metastases, with longer medication use resulting in greater reduction.
The Kay Yow Cancer Fund has awarded a $100,000 young women's breast cancer research grant to the Knight Cancer Institute at Oregon Health & Science University. The grant will support research on non-steroidal anti-inflammatory drugs (NSAIDs) and their potential effectiveness in preventing metastasis of breast cancer in young women.
Researchers at Case Western Reserve University are working on two projects to deliver protection from aggressive breast cancer and deadly heart attacks using plant viruses. The first project aims to create a vaccine that tricks the immune system into attacking HER2 proteins, while the second project targets blood clots by delivering cl...
Researchers found that PET/CT imaging can help diagnose more aggressive tumors in young breast cancer patients, upstaging 21% of initial diagnoses. The study suggests considering patient age as a factor in staging decisions.
A team of researchers from InSilico Medicine has successfully mapped the molecular pathway for myeloid-derived suppressor cell (MDSC) cancer progression. The study identifies several proliferation and invasion-related pathways that are key to MDSC's immune-suppressive effects, opening up new avenues for therapy targeting these cells.
A new virtual breast test using ultrasound elastography could significantly improve cancer detection accuracy, especially for women with suspicious mammograms.
Researchers found that estrogen pre-activates the unfolded-protein response (UPR), a pathway that prepares cells to divide and grow. UPR activation is linked to cell proliferation and poor survival in estrogen-receptor-positive breast cancer, making it a potential prognostic marker.
A global trial involving over 8,000 women has reaffirmed trastuzumab's superiority in treating HER2-positive breast cancer. The study showed that patients receiving trastuzumab had better outcomes than those treated with lapatinib alone, including lower rates of disease recurrence and improved overall survival.
The CLEOPATRA study demonstrated a significant survival benefit of 15.7 months with the combination therapy, outperforming previous studies. The long-term safety profile and cardiac safety were also maintained.
Children exposed to chemotherapy or radiotherapy in utero suffer no negative impacts on mental or cardiac development, according to international studies presented at ESMO 2014. These findings confirm that chemotherapy and radiotherapy during pregnancy do not endanger the fetus and its subsequent development.
Women facing breast cancer diagnosis can use decision analysis to evaluate alternatives for breast reconstruction, incorporating patient preferences and values. The process creates a 'decision tree' with options, outcomes, and values assigned to each outcome.
Researchers found significant variations in approval times for cancer drugs between the US, Canada, and Europe, with patients in some regions waiting years longer than others. The study emphasizes the need for coordinated action to reduce disparities in drug access and improve patient outcomes.
A study of over 93,000 women found that increases in skirt size are strongly associated with a higher risk of postmenopausal breast cancer. Women who gained one size every 10 years were 33% more likely to develop the disease, while those who gained two sizes faced an 77% greater risk.
A Mayo Clinic study found that most women with breast cancer who underwent double mastectomies report being satisfied with their decision, regardless of whether they opted for breast reconstruction. The majority of women who had reconstruction also reported higher self-esteem and feeling more feminine.
A study found that postpartum mice develop metastatic disease due to dying tumor cells triggering anti-inflammatory cytokines that promote wound healing. Mice lacking a receptor for macrophage clearance of dying cells did not develop metastasis, highlighting potential targets for limiting postpartum breast cancer severity.