Articles tagged with Breast Cancer
ANG4043 shows therapeutic brain concentrations in healthy mice and in mice bearing intracranial HER2+ tumors, increasing median survival time by 78% in a HER2+ intracranial tumor model. This technology has the potential to create brain-penetrant mAbs for treating neurological diseases.
Researchers developed a blood test that detects changes in zinc isotopic composition to identify biomarkers of early breast cancer. A pilot study showed promising results, with the ability to detect key differences in zinc caused by cancer.
Researchers at MD Anderson Cancer Center discovered that targeting the non-coding microRNA miR569 can increase cell death in ovarian and breast cancers. The study also found that silencing miR569 expression improves survivability outcomes for ovarian patients.
A new study published in Annals of Internal Medicine found that breast density notification laws substantially increase costs and save relatively few lives. The study suggests that these laws would result in limited health gains and substantially increased expenses.
A team of researchers has discovered a way to make triple-negative breast cancer cells susceptible to chemotherapy by inhibiting the HIF protein network. The study found that HIF inhibitors can decrease tumor size and prevent relapse in mice, offering new hope for treatment-resistant patients.
A recent study published in Cancer journal reveals that older breast cancer patients continue to receive radiation therapy despite evidence suggesting limited benefits. The study analyzed data from a national health database and found that only about one-third of eligible women no longer receive radiation therapy.
Researchers found that HSP90 inhibition increases the ability of anti-estrogen agents to block cell cycle progression, thereby thwarting replication of tumor cells. The study provides a strong rationale for combining HSP90 inhibitors with hormonal therapy in ER+ breast cancer treatment.
A new analysis found that nearly two-thirds of elderly women with early stage breast cancer continue to receive radiation therapy despite clinical trial data suggesting it may not be effective. The findings highlight the challenges in implementing clinical trial results into practice patterns, particularly due to concerns about long-te...
Doubling breastfeeding duration for 7-18 months can save the NHS at least £31 million, while doubling neonatal unit breastfeeding rates saves an extra £6 million. Helping existing mothers extend breastfeeding periods is key to achieving these cost savings.
Research at Brunel University London found that increasing breastfeeding duration can save the NHS £31m annually by reducing infant illnesses. The study suggests that doubling breastfeeding duration could lead to significant cost savings, with a potential total of £40m per year.
Researchers at Virginia Tech have discovered a link between the body's sleep cycle and cancer incidence. The human period 2 protein, which regulates the sleep cycle, was found to protect against sporadic forms of cancers. This breakthrough may lead to new prevention strategies for populations at risk due to circadian disruption.
A new study found that digital breast tomosynthesis significantly increases cancer detection in women with dense breasts. In a population-based mammography screening program, tomosynthesis improved cancer detection rates by 30-40%, particularly for invasive cancers and those with fatty breasts.
A study found that risk-based screening for breast cancer in women aged 40-49 would miss over 75% of invasive cancers, potentially eliminating survival benefits. Strong family history and dense breast tissue were commonly absent in diagnosed cases.
Breast cancer patients undergoing chemotherapy and immediate breast reconstruction are at risk of thrombotic complications, which can delay or modify reconstructive plans. In some cases, these complications require anticoagulation therapy and may necessitate additional surgeries.
A Mayo Clinic-led study found that nearly 15% of triple-negative breast cancer patients have deleterious mutations in predisposition genes, including BRCA1 and BRCA2. This suggests a different origin for the disease compared to other forms of breast cancer.
A new breast cancer vaccine developed at Washington University School of Medicine has shown safety and preliminary evidence of biological efficacy in patients with metastatic breast cancer. The vaccine targets a protein called mammaglobin-A, found almost exclusively in breast tissue, and primes the immune system to attack tumor cells, ...
High levels of miR-21 in tumor stroma and epithelia are associated with poorer clinical outcomes in triple-negative breast cancer. The study found that changes in the tumor microenvironment play a crucial role in determining disease progression.
A new UK study published in BJPsych found that women with mental illness are significantly less likely to undergo mammography screening for breast cancer. This disparity could account for 90 avoidable deaths per year in the UK, highlighting the need for comparable care and education.
Researchers at A*STAR's Genome Institute of Singapore identified a biomarker called RASAL2 strongly associated with triple negative breast cancer, a highly aggressive form of the disease. High expression levels of RASAL2 in TNBC tumors correlate with lower survival rates and increased metastasis.
Researchers have developed a new vaccine strategy that targets unique features of cancer cells, enabling the immune system to destroy or drive into remission tumors. The vaccines, which use samples of DNA from patient tumors and normal tissue, have shown promising results in computer simulations, cell cultures, and animal models.
New estimates suggest excess body weight causes around 481,000 new cancer cases annually in adults, with a quarter of these cases (118,000) avoidable by reducing rising BMI since 1982. Obesity-related cancer disproportionately affects women, particularly post-menopausal breast and endometrial cancers.
The CONCORD-2 study shows extreme variations in 5-year cancer survival estimates among countries, with some countries achieving high survival rates for certain cancers. Improvements are seen in developed countries and South America, but deficiencies remain in developing countries.
Researchers discovered that mitochondria are crucial for the survival of cancer stem cells and found sixty-two mitochondrial-related proteins showing increased levels. The study suggests new avenues for treatment by restricting cancer's ability to come back after treatment using MCT inhibitors.
A pathology specialist, Dr. Glenn Palomaki, contributes to the debate on breast cancer gene screening, citing concerns about population characteristics and feasibility. He suggests pilot trials for high-risk populations like Ashkenazi Jewish women before considering widespread screening.
Researchers have developed novel nanoparticle designs that detect and destroy cancer cells using photo-thermal therapy, detecting tumors early and killing them simultaneously. The nanoparticles target specific proteins on cancer cells, releasing heat that burns the abnormal cells without harming normal ones.
Researchers inhibit autotaxin, an enzyme that promotes cancer cell survival and metastasis, decreasing tumor growth by up to 70% and improving chemotherapy effectiveness. The discovery offers a new therapy potential for breast and thyroid cancer patients.
Researchers have identified a gene, MACROD2, whose presence may explain why some breast cancers are resistant to tamoxifen. The study found that MACROD2 overexpression was present in the majority of metastases in patients with tamoxifen-resistant tumors.
Researchers developed a new approach to breast cancer follow-up that considers individual risk factors. For postmenopausal women with moderate prognosis early breast cancer, less frequent surveillance may be more cost-effective, especially for those older than 70 years.
A $1.5 million NIH grant will fund a five-year study assessing the effectiveness of a culturally sensitive social support group, Joy Luck Academy, among Chinese-American breast cancer survivors. The study aims to improve quality of life, reduce depressive symptoms, and stress.
Researchers found that mastectomies increased by 3.5% among women with early-stage breast cancer, with younger women more likely to undergo the procedure. The study also showed a significant rise in bilateral mastectomies and breast reconstruction procedures.
Researchers at MD Anderson Cancer Center have identified a protein complex called CSN and its subunit CSN6 as a key factor in cancer development. The study found that inhibiting CSN6 can quickly destabilize the master cancer gene Myc, greatly impairing tumor growth and metastasis.
A Vanderbilt study reveals a significant increase in the number of women with early-stage breast cancer choosing mastectomy over breast conservation surgery. The trend was most pronounced among younger women and those with smaller tumors, suggesting factors other than disease burden are at play.
Scientists at MD Anderson Cancer Center identified a long non-coding RNA called BCAR4 as playing a key role in the hedgehog signaling pathway's contribution to breast cancer metastasis. The study suggests that targeting this pathway with locked nucleic acids may provide a new approach for treating aggressive breast cancers.
Researchers have discovered that tumor cells secrete exosomes containing proteins capable of transforming neighboring cells into tumor cells, promoting tumor growth. Dicer protein is identified as a key factor in this process and may serve as a biomarker or therapeutic target.
A study using mathematical models shows that genetic testing can substantially improve breast cancer prevention by analyzing multiple gene variants. The research suggests that combining genetic data with other risk factors can identify the most at-risk women, who account for 32.2% of all breast cancer cases.
Researchers discovered that simvastatin inhibits the growth of uterine fibroid tumors, which are responsible for half of all hysterectomies. The study found that simvastatin impedes cell growth and induces calcium-dependent cell death mechanisms in fibroid tumor cells.
A study published in JAMA Surgery found that nearly a quarter of patients who underwent initial breast conservation surgery had a subsequent surgical intervention. The study, which included over 316,000 patients, identified patient and tumor factors associated with repeat surgeries.
Researchers from Uppsala University developed a therapeutic vaccine that selectively targets tumor vessels, reducing tumor burden and suppressing metastases in a mouse model of metastatic breast cancer. The vaccine induced an 80% reduction in metastasis, providing a cost-efficient alternative to monoclonal antibody-based therapies.
Researchers at City College of New York led by Dr. Debra Auguste have discovered a potential molecular target and biomarker for treating triple negative breast cancers, which have a high mortality rate due to aggressive proliferation and metastasis.
A phase II study led by the University of Pennsylvania School of Medicine found olaparib produced a 26% overall tumor response rate in patients with advanced cancers associated with BRCA1 and BRCA2 mutations. The treatment showed improved survival rates for patients with ovarian, breast, pancreatic, and prostate cancers.
Researchers have identified a key role for the FAK molecule in controlling breast cancer stem cell survival and predicting disease recurrence. Blocking FAK activity with a new drug significantly improved treatment outcomes, suggesting a potential method to predict which patients are most likely to experience recurrence.
Researchers discovered that bisphosphonates can inhibit cancer spread in some women with breast cancer by attaching to calcifications in tumors and being devoured by immune cells. This finding could lead to new, more effective ways of using these drugs to treat certain cancers.
The study found that meditation, yoga, and relaxation with imagery received an 'A' grade for easing anxiety and mood disorders common to breast cancer patients. Acupuncture was also recommended for controlling chemotherapy-induced nausea and vomiting.
More than 70% of women who have had breast cancer experience menopausal problems, including hot flushes that can persist for over five years and affect daily life. The study found that clinicians often underestimate the severity of these symptoms, with only 10-30% of patients experiencing severe hot flushes.
Researchers discovered genetic patterns that predict when breast cancers will spread to the brain, offering a potential early detection method. Faulty gene switches in the original tumor may serve as an early warning signal for brain metastasis.
Researchers at Lund University discovered that lactose intolerant people are at a reduced risk of developing lung, breast, and ovarian cancers. The study, which analyzed nationwide data from Sweden, suggests that diet plays a crucial role in protecting against these cancers.
LSU Health New Orleans has been awarded a $2.2 million grant to develop and implement strategic health education campaigns for young breast cancer survivors in the Gulf South region. The initiative aims to empower survivors to advocate for their care and access necessary services, improving quality of life.
A study has demonstrated a clear new evidence for mind-body connection in breast cancer survivors, showing that mindfulness meditation and support groups can influence telomere length. This suggests potential health benefits beyond the initial three-month period studied.
Women undergoing breast cancer surgery showed significant improvements in breast reconstruction processes of care after hospitals opened comprehensive breast centers. These centers enhanced patient care by assembling specialized practitioners for coordinated breast cancer care.
Researchers found that eribulin improves overall survival of women with metastatic triple negative breast cancer and HER2 negative breast cancer by nearly five months and two months respectively. Eribulin, originally developed from sea sponges, is a microtubule inhibitor that stops cancer cells from separating into new cells.
A pilot study found that invisible fluorescent tattoos can improve body confidence among breast cancer patients undergoing radiotherapy. Researchers compared the effects of visible and invisible tattoos on patients' self-esteem, finding that 56% of those with invisible tattoos felt better one month after treatment.
Researchers found that proton therapy costs comparable to traditional radiation therapies, challenging the assumption that it's more expensive. The study suggests that insurance coverage should be considered, enabling patients to participate in clinical research.
Two studies found pediatric breast cancer patients experienced longer time between diagnosis and treatments, often diagnosed at later stages. Pediatric colon cancer patients had lower five-year survival rates than adults due to more aggressive tumors and treatments.
Researchers at Vanderbilt University have developed a technique to test the effectiveness of anti-cancer drugs on individual patients' tumors in a dish, using fluorescence imaging to monitor the response. The test can detect significant drops in metabolic activity levels within 72 hours, allowing doctors to identify the most effective ...
A study found that combining digital mammography with tomosynthesis screening is more effective in detecting breast cancer among women with dense breasts. This combined approach avoids false-positive results and unnecessary procedures, making it a cost-effective option.
A new study found that chest radiation in childhood cancer patients increases their risk of developing breast cancer later in life. Nearly 20% of female survivors who received chest radiation developed breast cancer by age 40 compared to 0.3% of those who did not receive radiation.
Breast cancer patients taking brand name aromatase inhibitors had higher discontinuation rates and nonadherence compared to those on generic AIs. Higher copayments of $15-$30 per month were also linked to discontinued use.
A Dartmouth study found that Diffuse Optical Spectroscopic Tomography (DOST) imaging can accurately predict which patients will respond well to neoadjuvant chemotherapy, enabling earlier and more effective treatment. This breakthrough could significantly improve disease-free survival rates for breast cancer patients.
Researchers at St. Jude Children's Research Hospital identified a promising triple-drug combination therapy that exploits DNA repair problems in Ewing sarcoma tumors, showing over 70% success rate in mice treated with the combination of chemotherapy drugs and PARP inhibitors.
A new drug, OTS964, can eradicate aggressive human lung cancers transplanted into mice by inhibiting the action of a protein overproduced by several tumor types. The drug was well-tolerated and effective when taken as a pill or injected intravenously.