Articles tagged with Breast Cancer
Research at Beth Israel Deaconess Medical Center identified an unexpected link between the transcription factor FOXP2 and metastatic colonization of breast cancer. Silencing FOXP2 enables breast cancer cells to acquire malignant traits, facilitating their survival and proliferation.
MIT researchers have developed a new way to model the effects of genetic mutations in mice using CRISPR, enabling rapid analysis of genes linked with cancer growth. This approach fills a gap in understanding the role of cancer-gene candidates and offers new ways for personalized treatments.
A novel methodology for investigation using modern mass spectrometry has been developed to investigate tumour-promoting activities of breast fibroblasts. This allows for the direct determination of undesirable cell activities in cancer-associated fibroblasts, which may promote tumour growth.
A long-term study of patients with HER2-positive breast cancer shows that adding trastuzumab to chemotherapy improves overall and disease-free survival by 37% and 40%, respectively. The regimen is now the standard of care for early stage HER2-positive breast cancer.
A genetic variant common in Latina women has been found to protect against breast cancer, with a significant reduction in risk. The variant, originating from indigenous Americans, is believed to interfere with the action of estrogen receptors and is more prevalent in Latina populations than previously thought.
A University of Georgia study found that disruption of the circadian rhythm, triggered by artificial light exposure, significantly increases breast cancer risk. The researchers analyzed studies on flight attendants who work night shifts and found a higher risk of developing breast cancer.
A federal prescription-subsidy program improved adherence to hormone therapy among low-income women with breast cancer. The program's success was attributed to lower out-of-pocket costs, which reduced disparities in adherence rates across racial and ethnic groups.
Researchers found that a particle size of 50 nm is optimal for anti-cancer nanomedicines, with enhanced performance in vivo and improved tumor inhibition.
University of Iowa researchers found a gene in an amoeba that functions similarly to the human PTEN gene, which suppresses tumor growth. They tested the gene in mice and found it fully overcompensated for defects caused by mutated PTEN genes, potentially leading to new cancer treatments.
CNIO researchers found that the simultaneous inhibition of Cdk4 and Cdk6 is more effective than individual inhibition in reducing tumour growth and promoting aggressive tumours in mice. The study also revealed that the combined activation of both oncogenes leads to uncontrolled cell division and an increased risk of developing leukemia.
Researchers found a potential link between inherited BRCA1 and BRCA2 mutations and increased risk of salivary gland cancer. The study suggests that people with these gene mutations may require earlier evaluation for salivary gland lesions.
Scientists at Brigham Young University have discovered two proteins that trigger autophagy in cancer cells, offering a potential therapeutic avenue for targeted treatment. The study's unique approach led to the identification of a protein pair responsible for switching on autophagy under stress conditions.
Researchers have found that circulating tumor cells in the blood can accurately reflect the genetic status of metastatic breast cancer patients. This discovery could help guide treatment decisions and track patient progress without requiring repeat biopsies.
Scientists at the University of Kansas have developed a miniaturized biomedical testing device for exosomes, promising earlier detection and improved survival rates for patients. The lab-on-a-chip technology uses magnetic beads to isolate exosomes from plasma samples, enabling minimally invasive and cost-effective cancer diagnosis.
Researchers are developing methods to restore mobility and recover function in individuals with neurological and musculoskeletal conditions. A new NIH-funded study led by Dr. Guang Yue will investigate the impact of high-effort training on muscle strength in women with breast cancer.
A study published in the Journal of the National Cancer Institute finds that osteoporosis treatment may also benefit breast cancer patients by slowing skeletal metastasis. Women who took oral bisphosphonates had a reduced risk of bone metastases, with longer medication use resulting in greater reduction.
The Kay Yow Cancer Fund has awarded a $100,000 young women's breast cancer research grant to the Knight Cancer Institute at Oregon Health & Science University. The grant will support research on non-steroidal anti-inflammatory drugs (NSAIDs) and their potential effectiveness in preventing metastasis of breast cancer in young women.
Researchers at Case Western Reserve University are working on two projects to deliver protection from aggressive breast cancer and deadly heart attacks using plant viruses. The first project aims to create a vaccine that tricks the immune system into attacking HER2 proteins, while the second project targets blood clots by delivering cl...
Researchers found that PET/CT imaging can help diagnose more aggressive tumors in young breast cancer patients, upstaging 21% of initial diagnoses. The study suggests considering patient age as a factor in staging decisions.
A team of researchers from InSilico Medicine has successfully mapped the molecular pathway for myeloid-derived suppressor cell (MDSC) cancer progression. The study identifies several proliferation and invasion-related pathways that are key to MDSC's immune-suppressive effects, opening up new avenues for therapy targeting these cells.
A new virtual breast test using ultrasound elastography could significantly improve cancer detection accuracy, especially for women with suspicious mammograms.
Researchers found that estrogen pre-activates the unfolded-protein response (UPR), a pathway that prepares cells to divide and grow. UPR activation is linked to cell proliferation and poor survival in estrogen-receptor-positive breast cancer, making it a potential prognostic marker.
A global trial involving over 8,000 women has reaffirmed trastuzumab's superiority in treating HER2-positive breast cancer. The study showed that patients receiving trastuzumab had better outcomes than those treated with lapatinib alone, including lower rates of disease recurrence and improved overall survival.
The CLEOPATRA study demonstrated a significant survival benefit of 15.7 months with the combination therapy, outperforming previous studies. The long-term safety profile and cardiac safety were also maintained.
Children exposed to chemotherapy or radiotherapy in utero suffer no negative impacts on mental or cardiac development, according to international studies presented at ESMO 2014. These findings confirm that chemotherapy and radiotherapy during pregnancy do not endanger the fetus and its subsequent development.
Women facing breast cancer diagnosis can use decision analysis to evaluate alternatives for breast reconstruction, incorporating patient preferences and values. The process creates a 'decision tree' with options, outcomes, and values assigned to each outcome.
Researchers found significant variations in approval times for cancer drugs between the US, Canada, and Europe, with patients in some regions waiting years longer than others. The study emphasizes the need for coordinated action to reduce disparities in drug access and improve patient outcomes.
A study of over 93,000 women found that increases in skirt size are strongly associated with a higher risk of postmenopausal breast cancer. Women who gained one size every 10 years were 33% more likely to develop the disease, while those who gained two sizes faced an 77% greater risk.
A Mayo Clinic study found that most women with breast cancer who underwent double mastectomies report being satisfied with their decision, regardless of whether they opted for breast reconstruction. The majority of women who had reconstruction also reported higher self-esteem and feeling more feminine.
A study found that postpartum mice develop metastatic disease due to dying tumor cells triggering anti-inflammatory cytokines that promote wound healing. Mice lacking a receptor for macrophage clearance of dying cells did not develop metastasis, highlighting potential targets for limiting postpartum breast cancer severity.
The Fashion Footwear Association of New York and QVC presented $240,000 to the University of Pittsburgh Cancer Institute for breast cancer research. The grant will fund research on why breast cancer recurs and metastasizes, a potentially major impact on breast cancer survival rates.
Researchers developed a tool that uses mass spectrometry imaging to identify fatty acid substances in breast tissue, distinguishing between cancerous and normal tissue. The study found several fatty acids were more abundant in breast cancer tissue compared to normal tissue.
Research reveals a two-and-a-half-fold increase in referrals by GPs for June and July 2013 after Angelina Jolie's announcement, with continued rise through October. The study found that many women with family history of breast cancer were referred for testing, contradicting concerns about 'worried well' individuals.
The European Society for Medical Oncology calls for high-quality research and clinical trials for advanced breast cancer. Key areas of focus include treatment strategies for patients with liver or lung metastases, HER2-positive disease, and men receiving aromatase inhibitors.
The European Menopause and Andropause Society (EMAS) has published a position statement on breast cancer screening, recommending individualized screening based on familial risk and first screening mammogram results. This approach aims to reduce overdiagnosis and unnecessary treatments for slowly growing tumors.
Research suggests that lactation may reduce the risk of estrogen receptor-negative and triple-negative breast cancers in African American women. Parous women had a higher chance of developing these aggressive subtypes if they never breastfed, particularly those with four or more births.
Cancer patients with malignant spinal cord compression who receive a single dose of 10 Gy radiation therapy have preserved mobility, comparable to those receiving five daily doses of lower-radiation therapy. The study also found similar changes in bladder function and overall survival rates between the two groups.
A new study suggests that combination treatment may not be necessary for all patient populations with the disease. Patients over 65 years old with small tumors and low risk tumor sizes achieved comparable survival after treatment with adjuvant radiation therapy alone, without undergoing endocrine therapy.
Researchers found alterations in genes BAP1, KDM6A, and others contributing to bladder cancer development. These findings suggest potential therapeutic targets for specific subtypes of the disease.
A study in mice implanted with breast and melanoma cancers found that combining radiation therapy with a checkpoint inhibitor increases antitumor responses from the immune system. The combination also enhances memory T-cells, which retain memory of the tumor and can attack it long after treatment.
Research presented at ASTRO's 56th Annual Meeting found no association between radiation therapy and increased risk of lymphedema in women with clinically node-negative breast cancer. The study results provide reassurance for breast cancer patients regarding the impact of radiation therapy on lymphedema risk.
The study found a sharp increase in early-stage breast cancer cases among 70-75 year olds after national screening was introduced, suggesting overdiagnosis. The researchers argue that personalized screening decisions based on remaining life expectancy and individual risk factors are necessary to avoid unnecessary overtreatment.
Researchers found a significant racial disparity in breast reconstruction after mastectomy, with African American women receiving 55% fewer reconstructions. Hospitals' characteristics, such as location and volume of breast cancer surgeries, also impact reconstruction rates.
A study published by The Endocrine Society found that diverse gut bacteria are associated with a favorable ratio of estrogen metabolites, which may reduce the risk of breast cancer. Researchers analyzed fecal and urine samples from 60 postmenopausal women and discovered a relationship between bacterial diversity and estrogen levels.
The Phase I Clinical Trial of nintedanib combined with paclitaxel showed a 50% complete response rate in early HER-2-negative breast cancer patients. The study's results have validated the safety and efficacy of the drug combination, paving the way for a large-scale Phase II Clinical Trial.
Researchers have developed an electronic skin device that can detect and image small lumps in the breast, allowing for earlier identification of breast cancer. The device has been tested on a silicone breast model and shown to be highly accurate, with a potential survival rate increase of over 94%.
Georgetown Lombardi Comprehensive Cancer Center has received a five-year, $11.25 million P30 Cancer Center Support Grant to continue its laboratory science, clinical research and population-based programs. The NCI designation reaffirms the high quality work of dedicated cancer researchers at Georgetown.
Researchers at the University of Pennsylvania have identified over 30 previously undiscovered genetic mutations in microRNAs that may influence cancer susceptibility and severity. These mutations were found to be associated with increased risk of certain types of cancer, including breast, ovarian, and prostate cancer, in African popula...
A meta-analysis of 16 studies and 891,426 participants found that prediabetes increases the risk of cancer by 15%. The risk was higher for certain types of cancer, including stomach/colorectum, liver, pancreas, breast, and endometrium.
A team led by Lin Zhang identified a non-protein-coding RNA, FAL1, whose expression is linked to ovarian cancer. The study found that blocking the activity of FAL1 reduces cancer cells' growth and may serve as a biomarker for BRCA-related cancer prognosis.
A new vaccine candidate, GP2, has shown a 57% reduction in recurrence rates among high-risk breast cancer patients. The vaccine targets CD8+ cells and was combined with an immune stimulant to enhance its effectiveness.
A population-based case-control study found no evidence that wearing a bra increases the risk of breast cancer among postmenopausal women. The study analyzed bra-wearing habits in relation to breast cancer risk using a rigorous epidemiological study design, providing reassurance to women about their bra-wearing habits.
A recent study has shown that the addition of carboplatin and/or bevacizumab to standard chemotherapy regimens can significantly increase pathologic complete response rates in stage II-III triple-negative breast cancer patients. This may lead to improved outcomes and reduced risk of relapse.
A study conducted by National Cancer Centre Singapore found that breast cancer surgery can be safely performed on women aged 80 and above. Most patients recovered without complications, while only 3% developed major complications. The results dispel the misconception that surgery is unsafe for elderly patients.
A recent MD Anderson study found that socio-economic barriers continue to preclude women from receiving breast-conserving therapy, despite overall rates improving. The study identified disparities related to insurance, income, and education, with significant disparities still existing in areas outside the medical field.
A study from the University of Texas M. D. Anderson Cancer Center found that women with Stage I disease who underwent breast conserving therapy (BCT) had superior five-year overall survival rates compared to those who received a mastectomy or BCS, even after adjusting for other risk factors.
Key studies explored preventive mastectomy, compliance with recommended screening mammography, and risk of recurrence after pre-surgery therapy. The symposium featured insights into patient decision-making and post-treatment risks, aiming to enhance treatment approaches and patient care.
A recent study published in JNCI Journal of the National Cancer Institute found that soy supplementation altered the expression of genes associated with breast cancer. The study involved 140 patients who were randomized to either soy supplementation or placebo, and observed changes in several genes that promote cell cycle progression a...
Dr. Rowan Chlebowski, a leading expert in women's health, has been recognized by the North American Menopause Society for his groundbreaking research on estrogen alone and joint symptoms. His work has significantly impacted clinical use of menopausal hormone therapy worldwide.
A study found a substantial increase in double mastectomy use among California women with early-stage breast cancer between 1998 and 2011. Despite the procedure's lack of association with lower mortality rates compared to breast-conserving surgery plus radiation, its higher risk of death was noted.