Articles tagged with Breast Cancer
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The Fashion Footwear Association of New York and QVC presented $240,000 to the University of Pittsburgh Cancer Institute for breast cancer research. The grant will fund research on why breast cancer recurs and metastasizes, a potentially major impact on breast cancer survival rates.
Researchers developed a tool that uses mass spectrometry imaging to identify fatty acid substances in breast tissue, distinguishing between cancerous and normal tissue. The study found several fatty acids were more abundant in breast cancer tissue compared to normal tissue.
Research reveals a two-and-a-half-fold increase in referrals by GPs for June and July 2013 after Angelina Jolie's announcement, with continued rise through October. The study found that many women with family history of breast cancer were referred for testing, contradicting concerns about 'worried well' individuals.
The European Society for Medical Oncology calls for high-quality research and clinical trials for advanced breast cancer. Key areas of focus include treatment strategies for patients with liver or lung metastases, HER2-positive disease, and men receiving aromatase inhibitors.
The European Menopause and Andropause Society (EMAS) has published a position statement on breast cancer screening, recommending individualized screening based on familial risk and first screening mammogram results. This approach aims to reduce overdiagnosis and unnecessary treatments for slowly growing tumors.
Research suggests that lactation may reduce the risk of estrogen receptor-negative and triple-negative breast cancers in African American women. Parous women had a higher chance of developing these aggressive subtypes if they never breastfed, particularly those with four or more births.
Cancer patients with malignant spinal cord compression who receive a single dose of 10 Gy radiation therapy have preserved mobility, comparable to those receiving five daily doses of lower-radiation therapy. The study also found similar changes in bladder function and overall survival rates between the two groups.
A new study suggests that combination treatment may not be necessary for all patient populations with the disease. Patients over 65 years old with small tumors and low risk tumor sizes achieved comparable survival after treatment with adjuvant radiation therapy alone, without undergoing endocrine therapy.
Researchers found alterations in genes BAP1, KDM6A, and others contributing to bladder cancer development. These findings suggest potential therapeutic targets for specific subtypes of the disease.
A study in mice implanted with breast and melanoma cancers found that combining radiation therapy with a checkpoint inhibitor increases antitumor responses from the immune system. The combination also enhances memory T-cells, which retain memory of the tumor and can attack it long after treatment.
Research presented at ASTRO's 56th Annual Meeting found no association between radiation therapy and increased risk of lymphedema in women with clinically node-negative breast cancer. The study results provide reassurance for breast cancer patients regarding the impact of radiation therapy on lymphedema risk.
The study found a sharp increase in early-stage breast cancer cases among 70-75 year olds after national screening was introduced, suggesting overdiagnosis. The researchers argue that personalized screening decisions based on remaining life expectancy and individual risk factors are necessary to avoid unnecessary overtreatment.
Researchers found a significant racial disparity in breast reconstruction after mastectomy, with African American women receiving 55% fewer reconstructions. Hospitals' characteristics, such as location and volume of breast cancer surgeries, also impact reconstruction rates.
A study published by The Endocrine Society found that diverse gut bacteria are associated with a favorable ratio of estrogen metabolites, which may reduce the risk of breast cancer. Researchers analyzed fecal and urine samples from 60 postmenopausal women and discovered a relationship between bacterial diversity and estrogen levels.
The Phase I Clinical Trial of nintedanib combined with paclitaxel showed a 50% complete response rate in early HER-2-negative breast cancer patients. The study's results have validated the safety and efficacy of the drug combination, paving the way for a large-scale Phase II Clinical Trial.
Researchers have developed an electronic skin device that can detect and image small lumps in the breast, allowing for earlier identification of breast cancer. The device has been tested on a silicone breast model and shown to be highly accurate, with a potential survival rate increase of over 94%.
Georgetown Lombardi Comprehensive Cancer Center has received a five-year, $11.25 million P30 Cancer Center Support Grant to continue its laboratory science, clinical research and population-based programs. The NCI designation reaffirms the high quality work of dedicated cancer researchers at Georgetown.
Researchers at the University of Pennsylvania have identified over 30 previously undiscovered genetic mutations in microRNAs that may influence cancer susceptibility and severity. These mutations were found to be associated with increased risk of certain types of cancer, including breast, ovarian, and prostate cancer, in African popula...
A meta-analysis of 16 studies and 891,426 participants found that prediabetes increases the risk of cancer by 15%. The risk was higher for certain types of cancer, including stomach/colorectum, liver, pancreas, breast, and endometrium.
A team led by Lin Zhang identified a non-protein-coding RNA, FAL1, whose expression is linked to ovarian cancer. The study found that blocking the activity of FAL1 reduces cancer cells' growth and may serve as a biomarker for BRCA-related cancer prognosis.
A new vaccine candidate, GP2, has shown a 57% reduction in recurrence rates among high-risk breast cancer patients. The vaccine targets CD8+ cells and was combined with an immune stimulant to enhance its effectiveness.
A population-based case-control study found no evidence that wearing a bra increases the risk of breast cancer among postmenopausal women. The study analyzed bra-wearing habits in relation to breast cancer risk using a rigorous epidemiological study design, providing reassurance to women about their bra-wearing habits.
A recent study has shown that the addition of carboplatin and/or bevacizumab to standard chemotherapy regimens can significantly increase pathologic complete response rates in stage II-III triple-negative breast cancer patients. This may lead to improved outcomes and reduced risk of relapse.
A study conducted by National Cancer Centre Singapore found that breast cancer surgery can be safely performed on women aged 80 and above. Most patients recovered without complications, while only 3% developed major complications. The results dispel the misconception that surgery is unsafe for elderly patients.
A recent MD Anderson study found that socio-economic barriers continue to preclude women from receiving breast-conserving therapy, despite overall rates improving. The study identified disparities related to insurance, income, and education, with significant disparities still existing in areas outside the medical field.
A study from the University of Texas M. D. Anderson Cancer Center found that women with Stage I disease who underwent breast conserving therapy (BCT) had superior five-year overall survival rates compared to those who received a mastectomy or BCS, even after adjusting for other risk factors.
Key studies explored preventive mastectomy, compliance with recommended screening mammography, and risk of recurrence after pre-surgery therapy. The symposium featured insights into patient decision-making and post-treatment risks, aiming to enhance treatment approaches and patient care.
A recent study published in JNCI Journal of the National Cancer Institute found that soy supplementation altered the expression of genes associated with breast cancer. The study involved 140 patients who were randomized to either soy supplementation or placebo, and observed changes in several genes that promote cell cycle progression a...
Dr. Rowan Chlebowski, a leading expert in women's health, has been recognized by the North American Menopause Society for his groundbreaking research on estrogen alone and joint symptoms. His work has significantly impacted clinical use of menopausal hormone therapy worldwide.
A study found a substantial increase in double mastectomy use among California women with early-stage breast cancer between 1998 and 2011. Despite the procedure's lack of association with lower mortality rates compared to breast-conserving surgery plus radiation, its higher risk of death was noted.
Researchers at Johns Hopkins Medicine discover that tumor cells can spread through lymphatic vessels by releasing signaling molecules, which attract and facilitate the growth of new blood vessels. The HIV drug maraviroc blocks these signals, preventing breast cancer metastasis when combined with a VEGF-blocking drug.
Scientists at UC San Diego have identified the UBC13 enzyme as a key regulator of breast cancer metastasis, allowing them to potentially block the spread of the disease. The study found that inhibiting this enzyme may prevent metastasis in breast cancer cells.
A large study found that breast cancer patients with bilateral mastectomy did not have better survival rates than those who underwent lumpectomy plus radiation. The study analyzed nearly 190,000 California women and found a slightly lower survival rate among those who had unilateral mastectomy.
CPRIT awards UT Southwestern $26 million to expand cancer screenings, investigate therapy effectiveness, and conduct cancer biology research. The grants also support recruitment efforts and innovative approaches to improve treatment and prevention of cancer.
A third of women in the UK breast screening program do not fully understand the risks of 'overdiagnosis', despite being informed about the concept. Research found that intentions to attend screening remained high despite uncertainty about the information provided.
Researchers at Massachusetts General Hospital found that CTC clusters are associated with poor prognosis and metastatic potential. The presence of CTC clusters in the blood of cancer patients may identify a novel target for therapy.
Researchers recommend using fluorochemicals only where absolutely essential, citing links to cancer, immune system damage, reproductive issues, and environmental contamination. They urge producers to test alternatives properly before market release.
Researchers developed a genomic-based system, IntClust, to classify breast cancer subtypes with high accuracy. The new system identified previously unnoticed subgroups of tumors, including those resistant to treatment, potentially leading to early detection and targeted therapies.
Kids Konnected and the Breast and Gyn Health Project in California will each receive $8,500 awards to support their work assisting cancer patients and their families. The organizations will also be featured at ASTRO's Annual Meeting in San Francisco.
Researchers at UNC Lineberger Comprehensive Cancer Center have developed a new integrated approach to pinpoint genetic drivers of cancer, identifying eight genes linked to luminal breast cancer. These findings offer hope for personalized medicine and potential targeted therapies.
Researchers identify protein p66ShcA as a biomarker for predicting breast cancer outcomes and identifying poor-prognosis cancers. The discovery aids understanding of epithelial to mesenchymal transition, a process enabling tumor cells to metastasize.
Researchers estimated the risk of premature menopause in women treated for Hodgkin lymphoma, providing precise estimates based on treatment types and ages. The study found that certain treatments, such as ovarian radiotherapy and chemotherapy, significantly increased the risk of early menopause.
The European Society for Medical Oncology (ESMO) recognizes the contributions of three outstanding individuals in cancer research and treatment. Carsten Bokemeyer receives the ESMO Award for his work on malignant germ cell tumours, while Peter Boyle wins the Lifetime Achievement Award for his long-standing contribution to cancer epidem...
A new study found that women with severe disabilities are screened for breast cancer less often, at 61%, compared to those with moderate disabilities, who were screened more frequently. This disparity highlights the persistence of health disparities in breast cancer screening, particularly among vulnerable populations.
A study at Huntsman Cancer Institute found compound mutations containing T315I confer complete resistance to all available TKIs, highlighting the need for new treatment options. Researchers have created a dataset that can help clinicians decide which drug will be most effective for each mutation combination.
A study published in JAMA Surgery found that only 24.8% of women who underwent mastectomy in the US had breast reconstruction, with factors including race, education level, and age being significant predictors. The main reasons for not undergoing reconstruction were avoiding additional surgery or feeling reconstruction was not important.
Researchers have identified a biomarker, STAT3 protein, strongly associated with basal-like breast cancer, a highly aggressive and resistant carcinoma. This finding suggests a potential target for new therapeutics designed to treat this deadly cancer subtype.
Scientists have identified a novel gene that predicts both breast cancer relapse and response to chemotherapy, enabling doctors to classify patients for more effective treatment. The discovery could help reduce metastasis and increase the effectiveness of chemotherapy.
Researchers at Loyola University Chicago Stritch School of Medicine discovered that dasatinib causes cancer cells to clump together, preventing metastasis. The drug targets a protein called BCR-ABL found in various malignancies, including breast and skin cancers.
Researchers, led by UC Santa Cruz's Seth Rubin, are developing a new class of drugs to treat breast cancer by targeting the inactivated retinoblastoma tumor suppressor protein. The innovative approach may have fewer toxic side effects and be less vulnerable to drug resistance.
Research at VHIO confirms Myc inhibition as a sound and effective therapeutic strategy for glioma, with no evidence of resistance or side effects. The study reveals new insights into the biology of Myc and its potential to halt normal cell division, leading to tumor cell death.
Researchers have found that an antibody against EphA3 can slow tumour growth and kill cancer cells by disrupting blood vessels and the tumour micro-environment.
Regular use of aspirin or other NSAIDs has been found to reduce the risk of hormone-related breast cancer recurrence by half in overweight and obese women. The study suggests that limiting inflammatory signaling may be an effective approach to altering the cancer-promoting effects of obesity.
Researchers found that NSAID use reduces ERα positive breast cancer recurrence by 50% and extends patients' disease-free period by more than two years. The study suggests a new possibility for reducing breast cancer recurrence among overweight and obese postmenopausal women.
Researchers at Trinity College Dublin found that women taking regular aspirin before diagnosis had lower rates of breast cancer spreading and death. The study suggests a possible link between aspirin use and reduced mortality from breast cancer, with further research needed to understand the mechanism and optimal dosage.
Researchers found that patients taking COX2 inhibitors, such as aspirin or ibuprofen, had a lower breast cancer recurrence rate compared to those not taking these medications. This reduced the risk of ERα positive breast cancer by 50% and extended disease-free periods by more than two years.
Regular exercise, including brisk walking, is associated with a lower rate of breast cancer in African American women. Women who exercised vigorously for seven or more hours each week were 25% less likely to develop breast cancer compared to those who exercised less.
A UK study published in The Lancet found that being overweight or obese increases the risk of developing 10 common cancers, with over 12,000 cases estimated each year in the UK. The study also estimates that a population-wide 1 kg/m² increase in average BMI could result in an additional 3,790 cases annually.
A phase I clinical trial for MicroVAX's cancer vaccine has begun in Singapore, assessing safety and immune response against breast, prostate, colon, ovary, and lung cancers. The vaccine targets a common protein on many types of cancer.
A study published in Cancer Epidemiology, Biomarkers & Prevention found that postmenopausal women who exercised at least four hours of walking per week had a 10% decreased risk of invasive breast cancer. The benefits of regular physical activity were rapid and short-lived, disappearing if exercise stopped.