Articles tagged with Breast Cancer
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Researchers found significant reductions in red and processed meat consumption and increased fruit and vegetable intake among patients who received nutrition education. This led to lower BMI and reduced oxidative stress, potentially decreasing the risk of cancer reoccurrence.
A New York University study found that adherence to cancer prevention guidelines was associated with reduced risk of obesity-related cancers. The study highlights the importance of low alcohol consumption and a plant-based diet in reducing cancer risk, particularly for breast, prostate, and colorectal cancers.
A Mayo Clinic study found that women with atypical hyperplasia have an increased risk of developing breast cancer over time. After five years, 7% had developed the disease, and after 10 years, 13%. The study suggests that these women should be considered high-risk and screened more intensively.
A recent study by UT Southwestern Medical Center researchers confirms that whole-genome sequencing can successfully identify cancer-related mutations in patients. The method was used to analyze the genomes of 258 cancer patients, detecting nearly 90% of clinically identified mutations and discovering additional cancer gene mutations.
A new study published in the Journal of Clinical Oncology found that the risk of developing leukemia after radiation therapy or chemotherapy for early-stage breast cancer is twice as high as previously reported. The study analyzed data from 20,063 breast cancer patients and found a cumulative risk of 0.5 percent.
A study by The Wistar Institute found that a polymorphism in the TLR5 gene affects tumor progression and inflammation in breast and ovarian cancers. In individuals with functional TLR5 expression, commensal bacteria stimulate IL-6 production, leading to suppressed antitumor immune activity.
Researchers Stanton McHardy and Rong Li will lead a collaborative team to develop next-generation breast cancer treatment drugs, with the goal of harnessing anti-tumor activity against breast cancers. They aim to analyze new small molecules that regulate the ER-beta pathway, which has shown promise in treating breast cancer.
Researchers have developed a microwave imaging system that can produce 3D images of the breast, including the location of cancerous tissue. The system uses dielectric properties to differentiate between normal and cancerous tissue, offering better specificity than current methods.
Research shows adding chemotherapy drug carboplatin or blood vessel-targeting drug bevacizumab to standard preoperative chemotherapy increases pathologic complete response rates for women with basal-like triple-negative breast cancer. The drugs also showed benefits in certain gene signatures associated with aggressive disease.
The study found that Herceptin significantly improved 10-year survival from 75 percent to 84 percent when added to chemotherapy. Additionally, the 10-year disease-free survival rate increased from 62 percent to 74 percent with the addition of trastuzumab.
Researchers found that too much Rbm38 reduces p53 levels, increasing cancer risk, while too little Rbm38 causes premature aging. The study suggests manipulating Rbm38 could have therapeutic benefits by targeting p53 in tumor cells.
The EORTC10085/TBCRC/BIG/NABCG International Male Breast Cancer Program found significant improvements in survival for men with breast cancer, but not as high as for women. The study revealed distinct biological characteristics of male breast cancer, including lower rates of hormonal therapy and breast-conserving surgery.
A recent study published in JNCI Journal of the National Cancer Institute found no association between migraine and breast cancer. The researchers analyzed data from 115,378 women and concluded that migraine was not associated with breast cancer risk or differences in endogenous sex hormone levels.
Dr. Jane Holland's study identified the main driver of basal breast cancer's aggressiveness and targeted treatments to combat it. Her work aims to test inhibitors in human breast cancer tissue, potentially leading to new and effective treatments.
The study found tamoxifen reduced breast cancer rates by around 30% and oestrogen receptor positive invasive cancer by 35%. After 20 years, the estimated risk of developing breast cancer was 8% in the tamoxifen group, compared to 12% in the placebo group.
Research reveals that blocking androgen receptors can reduce the growth of estrogen-positive breast cancers and kill triple-negative breast cancer cells. Combining these drugs with HER2 or mTOR-targeting therapies shows promise for increased effectiveness in treating breast cancer.
A phase-Ib clinical trial found durable responses in almost one out of five patients with metastatic triple-negative breast cancer treated with pembrolizumab. The treatment produced significant activity, with five patients experiencing complete or partial responses, and seven others showing stable disease.
A new study reveals that two-thirds of women treated for early-stage breast cancer in the US receive longer radiation therapy than necessary, despite multiple randomized trials and professional society guidelines showing that hypofractionated radiation is clinically effective and less costly.
Researchers identified two subtypes of breast cancer, Epi-Basal and Epi-Luminal B, which differ in their epigenetic patterns. The subtype Epi-Luminal B is associated with reduced survival rates and requires adjuvant chemotherapy.
A study published in JAMA found that many breast cancer surgery patients do not receive shorter radiation treatment, despite guidelines recommending it for selected patients. Hypofractionated WBI has been shown to be equally effective as conventional WBI but with lower health care costs and reduced treatment burden.
A phase II trial found that a combination of bortezomib and fulvestrant delayed disease progression in post-menopausal women with hormone-receptor-positive metastatic breast cancer. The study showed a doubled rate of survival at 12 months compared to fulvestrant alone.
A University of Colorado Cancer Center study reveals that triple-negative breast cancer cells process tryptophan to promote survival while detached, allowing them to metastasize. The kynurenine pathway, specifically the enzyme TDO2, plays a key role in degrading tryptophan and evading anoikis.
The German Breast Group study found nab-paclitaxel (ABRAXANE) demonstrates significant benefit for patients with early high-risk breast cancer when compared to conventional solvent-based paclitaxel. Nab-paclitaxel achieved a 9% absolute improvement in pathological complete response rate, outperforming traditional chemotherapy.
Researchers have identified a novel therapeutic approach using gamma secretase inhibitors (GSI) to inhibit Notch and block critical genes involved in tumor growth. The study suggests that GSI may optimize existing endocrine therapies and overcome resistance to cancer drugs.
Researchers found that trastuzumab benefits HER2-positive breast cancer patients do not depend on the number of tumor-infiltrating lymphocytes (S-TILs) in their tumors. The study, which measured S-TILs at diagnosis in over 1,000 patients, showed improved recurrence-free survival when chemotherapy alone was used.
Myriad Genetics announced new studies on its myRisk Hereditary Cancer test, detecting 105% more mutations than conventional BRCA testing. The test also showed promising results in triple negative breast cancer (TNBC) by predicting response to platinum-based therapy. Additionally, the company's BRACAnalysis molecular diagnostic test sig...
Researchers found that women with BRCA1/2 mutations and treated with anthracycline-based chemotherapy have low risk of cardiac dysfunction. Most participants had normal heart function, with only a few showing borderline reductions in heart function.
James Ingle, a renowned breast cancer expert at Mayo Clinic, has been awarded the 2014 William L. McGuire Memorial Lecture Award for his groundbreaking research on pharmacogenomics in breast cancer treatment. His work aims to develop personalized approaches to prevent breast cancer in high-risk women by identifying genetic biomarkers t...
A new study suggests that supplementing breast cancer screening for women with dense breasts may not be the most effective approach. Instead, it could lead to an increase in unnecessary biopsies, highlighting the need for alternative methods to screen these high-risk individuals.
Researchers found that up to 45% of breast tumors exhibit genetic alterations affecting the CYP2D6 gene, leading to distorted patient genotypes. This has significant implications for tamoxifen therapy, which relies on accurate CYP2D6 testing to guide treatment.
ANG4043 shows therapeutic brain concentrations in healthy mice and in mice bearing intracranial HER2+ tumors, increasing median survival time by 78% in a HER2+ intracranial tumor model. This technology has the potential to create brain-penetrant mAbs for treating neurological diseases.
Researchers developed a blood test that detects changes in zinc isotopic composition to identify biomarkers of early breast cancer. A pilot study showed promising results, with the ability to detect key differences in zinc caused by cancer.
Researchers at MD Anderson Cancer Center discovered that targeting the non-coding microRNA miR569 can increase cell death in ovarian and breast cancers. The study also found that silencing miR569 expression improves survivability outcomes for ovarian patients.
A new study published in Annals of Internal Medicine found that breast density notification laws substantially increase costs and save relatively few lives. The study suggests that these laws would result in limited health gains and substantially increased expenses.
A team of researchers has discovered a way to make triple-negative breast cancer cells susceptible to chemotherapy by inhibiting the HIF protein network. The study found that HIF inhibitors can decrease tumor size and prevent relapse in mice, offering new hope for treatment-resistant patients.
A recent study published in Cancer journal reveals that older breast cancer patients continue to receive radiation therapy despite evidence suggesting limited benefits. The study analyzed data from a national health database and found that only about one-third of eligible women no longer receive radiation therapy.
Researchers found that HSP90 inhibition increases the ability of anti-estrogen agents to block cell cycle progression, thereby thwarting replication of tumor cells. The study provides a strong rationale for combining HSP90 inhibitors with hormonal therapy in ER+ breast cancer treatment.
A new analysis found that nearly two-thirds of elderly women with early stage breast cancer continue to receive radiation therapy despite clinical trial data suggesting it may not be effective. The findings highlight the challenges in implementing clinical trial results into practice patterns, particularly due to concerns about long-te...
Doubling breastfeeding duration for 7-18 months can save the NHS at least £31 million, while doubling neonatal unit breastfeeding rates saves an extra £6 million. Helping existing mothers extend breastfeeding periods is key to achieving these cost savings.
Research at Brunel University London found that increasing breastfeeding duration can save the NHS £31m annually by reducing infant illnesses. The study suggests that doubling breastfeeding duration could lead to significant cost savings, with a potential total of £40m per year.
Researchers at Virginia Tech have discovered a link between the body's sleep cycle and cancer incidence. The human period 2 protein, which regulates the sleep cycle, was found to protect against sporadic forms of cancers. This breakthrough may lead to new prevention strategies for populations at risk due to circadian disruption.
A new study found that digital breast tomosynthesis significantly increases cancer detection in women with dense breasts. In a population-based mammography screening program, tomosynthesis improved cancer detection rates by 30-40%, particularly for invasive cancers and those with fatty breasts.
A study found that risk-based screening for breast cancer in women aged 40-49 would miss over 75% of invasive cancers, potentially eliminating survival benefits. Strong family history and dense breast tissue were commonly absent in diagnosed cases.
Breast cancer patients undergoing chemotherapy and immediate breast reconstruction are at risk of thrombotic complications, which can delay or modify reconstructive plans. In some cases, these complications require anticoagulation therapy and may necessitate additional surgeries.
A Mayo Clinic-led study found that nearly 15% of triple-negative breast cancer patients have deleterious mutations in predisposition genes, including BRCA1 and BRCA2. This suggests a different origin for the disease compared to other forms of breast cancer.
A new breast cancer vaccine developed at Washington University School of Medicine has shown safety and preliminary evidence of biological efficacy in patients with metastatic breast cancer. The vaccine targets a protein called mammaglobin-A, found almost exclusively in breast tissue, and primes the immune system to attack tumor cells, ...
High levels of miR-21 in tumor stroma and epithelia are associated with poorer clinical outcomes in triple-negative breast cancer. The study found that changes in the tumor microenvironment play a crucial role in determining disease progression.
A new UK study published in BJPsych found that women with mental illness are significantly less likely to undergo mammography screening for breast cancer. This disparity could account for 90 avoidable deaths per year in the UK, highlighting the need for comparable care and education.
Researchers at A*STAR's Genome Institute of Singapore identified a biomarker called RASAL2 strongly associated with triple negative breast cancer, a highly aggressive form of the disease. High expression levels of RASAL2 in TNBC tumors correlate with lower survival rates and increased metastasis.
Researchers have developed a new vaccine strategy that targets unique features of cancer cells, enabling the immune system to destroy or drive into remission tumors. The vaccines, which use samples of DNA from patient tumors and normal tissue, have shown promising results in computer simulations, cell cultures, and animal models.
New estimates suggest excess body weight causes around 481,000 new cancer cases annually in adults, with a quarter of these cases (118,000) avoidable by reducing rising BMI since 1982. Obesity-related cancer disproportionately affects women, particularly post-menopausal breast and endometrial cancers.
The CONCORD-2 study shows extreme variations in 5-year cancer survival estimates among countries, with some countries achieving high survival rates for certain cancers. Improvements are seen in developed countries and South America, but deficiencies remain in developing countries.
Researchers discovered that mitochondria are crucial for the survival of cancer stem cells and found sixty-two mitochondrial-related proteins showing increased levels. The study suggests new avenues for treatment by restricting cancer's ability to come back after treatment using MCT inhibitors.
A pathology specialist, Dr. Glenn Palomaki, contributes to the debate on breast cancer gene screening, citing concerns about population characteristics and feasibility. He suggests pilot trials for high-risk populations like Ashkenazi Jewish women before considering widespread screening.
Researchers have developed novel nanoparticle designs that detect and destroy cancer cells using photo-thermal therapy, detecting tumors early and killing them simultaneously. The nanoparticles target specific proteins on cancer cells, releasing heat that burns the abnormal cells without harming normal ones.
Researchers inhibit autotaxin, an enzyme that promotes cancer cell survival and metastasis, decreasing tumor growth by up to 70% and improving chemotherapy effectiveness. The discovery offers a new therapy potential for breast and thyroid cancer patients.
Researchers have identified a gene, MACROD2, whose presence may explain why some breast cancers are resistant to tamoxifen. The study found that MACROD2 overexpression was present in the majority of metastases in patients with tamoxifen-resistant tumors.
Researchers developed a new approach to breast cancer follow-up that considers individual risk factors. For postmenopausal women with moderate prognosis early breast cancer, less frequent surveillance may be more cost-effective, especially for those older than 70 years.
A $1.5 million NIH grant will fund a five-year study assessing the effectiveness of a culturally sensitive social support group, Joy Luck Academy, among Chinese-American breast cancer survivors. The study aims to improve quality of life, reduce depressive symptoms, and stress.
Researchers found that mastectomies increased by 3.5% among women with early-stage breast cancer, with younger women more likely to undergo the procedure. The study also showed a significant rise in bilateral mastectomies and breast reconstruction procedures.