Articles tagged with Breast Cancer
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A comprehensive analysis confirms biennial mammography screening offers a favorable balance of benefits to harm for women ages 50-74 with an average risk of developing breast cancer. Screening strategies, including starting age and interval between exams, are analyzed to determine the optimal approach.
Researchers found that overnight fasting reduced postprandial glucose levels and associated them with lower breast cancer risk. Longer nighttime fasts were linked to fewer calories consumed per day and improved biomarker results.
Researchers develop a new drug combination that targets both estrogen-sensitive cells and cancer stem cells causing treatment resistance in breast cancer. The therapy combines Evgen's Wnt pathway-suppressing drug Sulforadex with standard hormonal treatments.
Breast cancer cells can survive detachment from the extracellular matrix by forming multicellular aggregates, stabilizing EGFR protein. Elevated Bim-EL protein in inflammatory breast cancer cells blocks anoikis through complex with Beclin-1 and LC8.
A new study by Women's College Hospital and ICES confirms a strong link between ethnicity and breast cancer stage at diagnosis for Canadian women. South Asian women are more likely to be diagnosed with later stage breast cancer compared to the general population.
Researchers discovered a molecular mechanism connecting breast tissue stiffness to tumor metastasis and poor prognosis. High stiffness causes TWIST1 protein to lose its anchor, enabling cancer cells to invade surrounding tissue and metastasize.
A gene expression model called COXEN predicts canine osteosarcoma response to doxorubicin, potentially allowing veterinary oncologists to choose the most effective drug. The approach validates human models used to predict drug response in clinical trials.
Researchers found that long-time consumption of soyfoods boosts immune response against breast tumors, reducing cancer recurrence. Genistein in soyfoods activates anti-tumor immune responses and reduces immunosuppressive mechanisms.
African-American women with ER+ breast cancer experience poorer outcomes due to increased activation of the unfolded protein response (UPR) pathway, reducing sensitivity to tamoxifen treatment. Strategies targeting this pathway could improve therapy effectiveness.
A new study by Ludwig-Maximilians-Universität München attributes mild cognitive defects in breast cancer patients to post-traumatic stress induced by diagnosis, not chemotherapy side-effects. The study found pretreatment cognitive impairment in breast cancer patients was due to stress associated with the disease.
Researchers analyzed over 12,000 proteins in triple-negative breast cancer cells, identifying subtypes and correlations with drug response. The findings suggest that treatments targeting cell spread may be effective against resistant tumors.
A new study found that cancer-related post-traumatic stress is associated with very limited cognitive impairment before treatment among newly diagnosed breast cancer patients. The study, published in the JNCI Journal of the National Cancer Institute, analyzed data from 166 breast cancer patients and 60 matched controls.
Researchers discovered that myeloid cells switch roles and become anti-therapy agents when angiogenesis inhibitors are used, leading to tumor growth and relapse. Targeting the PI3K signaling pathway may offer a way to prevent this phenomenon.
Analysis of two Women's Health Initiative clinical trials reveals a pattern of changing influences on breast cancer incidence over time, with estrogen plus progestin use linked to increased risk and estrogen alone showing reduced risk. The study suggests that ongoing influences after stopping hormone therapy require recalibration of br...
A new blood test has been developed to predict future breast cancer by analyzing metabolic profiles of over 57,000 people. The test shows a sensitivity of 80% in predicting the likelihood of developing breast cancer within two to five years.
A study by University of Manchester researchers has identified four subtypes of ductal carcinoma in situ (DCIS) that relate to disease recurrence. Patients with certain tumour characteristics, such as oestrogen receptor and progesterone receptor positivity, are less likely to experience cancer progression, while others are at higher risk.
Researchers validated a previously reported molecular finding on triple negative breast cancer, but found it was limited to a single patient and could not be applied to further clinical work. The study highlights the importance of independent study validation and careful assay development.
A recent study suggests that genetic testing for BRCA1 and BRCA2 mutations in women with ovarian cancer can help identify carriers and reduce their risk. The study found that 19% of women with the most common form of ovarian cancer carry these mutations, which is higher than previous estimates.
A study suggests that sequencing tumor genomes without comparing them to a patient's noncancerous tissue can lead to inaccurate treatment decisions and side effects. The researchers analyzed over 800 cancer patients' data, finding that nearly half of the identified genetic changes were not related to the cancer.
PharmaMar is presenting data on its anticancer candidates PM1183 and plitidepsin, showing synergistic effects against breast cancer cell lines and SCLC mouse tumor models. The company's studies also highlight the potential of plitidepsin as a novel therapeutic target in multiple myeloma.
A study has identified a molecular signature that drives the growth and survival of triple negative breast cancer cells. The research reveals that high levels of Myc protein and low levels of TXNIP correlate with poor patient outcomes.
Researchers at Cold Spring Harbor Laboratory have discovered that tumor cells can form tubular networks resembling blood vessels, facilitating metastasis in breast cancer. This phenomenon, known as vascular mimicry, allows tumor cells to access the bloodstream and colonize new sites.
A study by Professor Rama Khokha found that genetically modified mice without TIMP1 and TIMP3 experienced youthful breast tissue, with stem cells remaining functional throughout their lifetime. The results challenge the assumption that large numbers of stem cells increase cancer risk.
A test for 77 genetic risk factors showed a significant link between a woman's polygenic risk score and her breast cancer risk, with those in the top 20% being 1.8 times more likely to develop breast cancer than average women.
A study of over 31,000 women with BRCA1 and BRCA2 mutations found that the risk of breast and ovarian cancer varies by mutation type. The findings suggest that knowledge of mutation-specific risks could inform clinical decision-making among carriers.
Researchers found that specific BRCA mutations are linked to higher breast cancer risk and lower ovarian cancer risk, potentially leading to more personalized risk assessment and prevention strategies. The study analyzed data from over 31,000 women with BRCA1 or BRCA2 gene mutations.
A Yale University study found that higher breast cancer treatment costs are associated with better survival rates. Over a decade, Medicare costs increased from $18,100 to $32,600, while five-year survival improved from 38.5% to 51.9%. The cost increase was largely due to chemotherapy and radiation therapy.
A third of breast cancer patients report strong desire for genetic testing but many do not receive relevant discussions with healthcare professionals. This study highlights the unmet need for addressing genetic risk in these patients.
A Mayo Clinic-led team has combined 77 common genetic variants into a polygenic risk score to improve breast cancer identification. The score is associated with a higher or lower risk of developing breast cancer, and can be used in conjunction with traditional predictors to personalize estimates.
The 14th St. Gallen International Breast Cancer Consensus Conference highlighted the need to refine breast cancer classification and predict treatment responses. The conference recommendations will set the standard for breast cancer care for two years, taking into account variable resource limitations worldwide.
A University of Oklahoma research team, led by Hong Liu, has been awarded a $3 million grant to develop an innovative X-ray technique for enhanced breast cancer detection. This technique aims to reduce radiation dose and improve accuracy in diagnosis.
Researchers have developed an experimental drug, BHPI, that rapidly shrinks most tumors in a mouse model of human breast cancer. The drug works by hyperactivating the unfolded protein response pathway, driving cancer cells from using it for protection into making it a lethal pathway.
Breast tumors trick immune cells to produce neutrophils that block T-cell action, allowing cancer to spread. Anti-IL17 drugs already exist for inflammatory diseases, offering potential treatment for metastatic breast cancer.
A recent Loyola University Health System study found that breast ultrasound examinations can eliminate the need for biopsy in many cases. The study concluded that if breast masses meet certain criteria, biopsies may be unnecessary.
Australian researchers found a gene ID4 driving the most aggressive form of triple-negative breast cancer. The discovery shows that switching off ID4 may 'tame' these cancers, making them more responsive to existing treatments. Researchers plan to further study how to block the gene and test its potential in mice and humans.
A study of 2.7 million US breast cancer patients found that surgeons are increasingly removing only the 'gatekeeper' lymph nodes, rather than all underarm lymph nodes, when a biopsy shows cancer. This shift is attributed to the lower risks for patients who undergo sentinel lymph node biopsy alone.
Dr. Mitchell Gail recognized for pioneering statistical work in cancer research, including breast cancer risk prediction models. His research has led to the development of widely used tools like the NCI's Breast Cancer Risk Assessment Tool.
A new study by Women's College Hospital found that women with diabetes are more likely to be diagnosed with advanced stage breast cancer. The study analyzed data from over 38,000 women and found that those with diabetes were 14% more likely to present with Stage II or III breast cancer.
A new study finds that providing women with stress management skills during breast cancer treatment can lead to improved mood and quality of life many years later. Women who received the intervention had persistently less depressive symptoms and better quality of life up to 15 years post-treatment.
A new study by the University of Miami found that women who received stress management training during breast cancer treatment experienced improved mood and quality of life for up to 15 years. The study suggests that early stress management can have long-term benefits for psychosocial health.
Researchers found that MED15 overexpression is associated with higher mortality rates in HNSCC patients with cancer recurrence, particularly in oral cavity/oropharyngeal tumors. MED15 may serve as a prognostic marker for HNSCC recurrence and as a therapeutic target in HNSCC patients suffering from recurrences.
Researchers at the University of Otago have identified key genetic mutations underlying deadly hereditary stomach and lobular breast cancers. The team found that these mutations also create vulnerabilities in cancer cells, making them susceptible to existing drug therapies targeting other cellular mechanisms.
A Cancer Research UK study found that text message reminders increased breast cancer screening attendance by 20% among women aged 47-53. The trial, which sent text messages to over 450 women, showed that 72% of those who received the reminders attended their appointments compared to 60% of those who did not.
A Dartmouth investigator found an mHealth app acceptable to diverse and low-income women for breast health risk assessment. The study showed that 11 of the 15 participants preferred using the mobile health device over a paper tool.
A study published in Nature Structural & Molecular Biology reveals that human DNA polymerase theta may be a promising drug therapy target for inhibiting breast cancer. The researchers used X-ray crystallography to determine the first crystal structures of POLQ, providing insights into its role in DNA repair and genomic instability.
Researchers found that exercise significantly improved blood vessel formation around tumors, leading to better oxygenation and reduced tumor growth. Exercise also enhanced the efficacy of chemotherapy drugs, shrinking tumors more effectively than sedentary animals.
A large cohort study found no association between dietary dioxin exposure and breast cancer risk in post-menopausal women, contradicting previous studies on environmental contact with dioxins. Higher dioxin intake was linked to a decreased risk of hormone-independent breast cancer.
Researchers discovered that Shp2 blocks protection program senescence, boosting tumor growth in breast cancer. Senescent cells secrete messenger molecules to trigger the immune system's defense against cancer.
Research shows exercise slows tumor growth and improves blood vessel perfusion, leading to reduced hypoxia and better response to chemotherapy. Exercise combined with chemotherapy results in slower tumor growth compared to sedentary mice or those treated with the drug alone.
A Swiss Institute of Bioinformatics-led trial demonstrates the potential of mathematical modelisation and experimentation in treating breast cancer. By combining clinical and experimental oncology with modelisation, researchers identified mechanisms that enable tumour cells to shape monocyte activities for their advantage.
A new study from NYU Langone Medical Center found that over 40% of low-risk prostate and breast cancer patients in certain US regions received inappropriate tests. The research suggests that regional culture and infrastructure play a significant role in the use of imaging tests, with some areas exhibiting more appropriate use than others.
Women with very low breast tissue density experience shorter disease-free survival and overall life expectancies compared to those with high-density breasts. A six-year follow-up study of 270 breast cancer patients found that lower breast tissue density is an independent poor prognostic factor for breast cancer.
A study published in JAMA Oncology found high rates of inappropriate imaging for both prostate cancer and breast cancer, suggesting that regional culture and infrastructure play a role in health care utilization patterns. The researchers estimated that 30% of healthcare resources in the US do not improve patient health.
The Wistar Institute has received a $1.1 million grant from the Jayne Koskinas Ted Giovanis Foundation to support the work of three scientists researching metastatic breast cancer. The researchers aim to develop novel targeted therapies by understanding the pathways essential to breast cancer cells.
A study by Sanford-Burnham Medical Research Institute identifies a protein called RNF5 that determines breast cancer response to paclitaxel, a chemotherapy drug. The researchers found that RNF5 causes degradation of glutamine carrier proteins, leading to sensitization of breast cancer tumors to death.
Scientists have identified 15 new genetic 'hot-spots' linked to an increased risk of breast cancer, with some women having multiple variations that double their risk and others being three times more likely to develop the disease. The discovery could help identify high-risk women and improve cancer screening and prevention.
A family history of prostate cancer in first-degree relatives increases breast cancer risk by 14%, according to a study of 78,171 women. Women with both breast and prostate cancer histories face an almost 2-fold increase in breast cancer risk
A new analysis of a large national database found that breast cancer survivors have an increased risk of developing thyroid cancer, especially within five years of their diagnosis. Women who received radiation therapy for breast cancer were more likely to develop aggressive thyroid cancer, but with smaller tumors and fewer treatments.
A study published in LGBT Health found that transgender veterans are at higher risk of developing breast cancer, with ten new cases identified. The study also highlights the importance of sensitively discussing screening methods with transgender individuals, regardless of hormone use.
The use of the 21-gene recurrence score assay increased from 1.1% to 10.1% among Medicare beneficiaries diagnosed with breast cancer between 2005 and 2009. The majority of tests were performed in patients with intermediate-risk disease, and rates of chemotherapy remained similar during this period.