Articles tagged with Breast Cancer
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According to research published in the Heart journal, cancer has overtaken cardiovascular disease as the primary cause of death in men, but not among women. Cardiovascular disease remains the leading cause of death among women.
A study of 1,949 women found that nearly half considered double mastectomy but only 37% knew it didn
The Universities of Leicester and Nottingham are developing a mini hybrid gamma ray camera to improve the diagnosis of tumours and lymph nodes from patients' bedsides. This handheld 'hybrid' technology combines optical and gamma imaging, allowing for more accurate surgical cancer treatments and reducing mortality and morbidity.
A new study finds that anastrozole significantly reduces breast cancer recurrence in postmenopausal women with non-invasive DCIS, outperforming tamoxifen. The treatment also improves disease-free survival and overall survival rates for patients.
A Yale University study found that removing more tissue during a partial mastectomy can spare thousands of breast cancer patients from a second surgery. The study showed that cavity shave margins reduced positive margin rates in half without compromising cosmetic outcomes or increasing complication rates.
The PALOMA-3 study found that palbociclib significantly extended progression-free survival for women with hormone-receptor-positive metastatic breast cancer, reducing cancer recurrence by 25% compared to chemotherapy alone. The treatment was well-tolerated and improved quality of life, offering a new hope for women with advanced disease.
ONT-380 demonstrates activity in stage IV HER2+ breast cancer patients, with one patient experiencing complete regression of brain metastases and improved overall survival. The drug's ability to target the HER2 growth factor receptor makes it a potential treatment for brain metastases.
The myRisk Hereditary Cancer test assesses 25 genes for mutations associated with eight hereditary cancers. Recent studies have found that the test identifies 100.8% more mutations than BRCA1/2 testing alone, including increased mutations in breast and ovarian cancer patients.
The myChoice HRD test predicts response to DNA-damaging agents in ovarian, breast, and pancreatic cancers. A score of ?42 indicates a loss of DNA repair function and reflects tumor sensitivity to PARP inhibitors and platinum-based therapies.
The global burden of disease study estimated 14.9 million new cancer cases and 8.2 million deaths in 2013. Lung and breast cancers were the leading causes of cancer-related deaths, with tracheal bronchus and lung cancer being the most common among men.
New cancer cases are increasing globally, with significant rises in prostate and breast cancer since 1990. However, death rates from cancer are falling in many countries due to prevention and treatment progress.
While advances in technology have made multigene testing useful in predicting breast cancer risk, clinicians need awareness of its limitations. Recent studies suggest that low-cost genetic testing solutions may cause undue anxiety and stress due to lack of information about many genetic variants.
Researchers discovered an enzyme called LysYl Oxidase (LOX) that enhances the spread of breast cancer to the bone. Treatment with bisphosphonate, a class of existing drugs for osteoporosis, has shown promise in preventing bone damage and tumour cell metastasis.
A two-year study found that female breast cancer survivors lost an average of 6% of their body weight through lifestyle changes, which may lower the risk of cancer recurrence. The study's results suggest that modest weight loss could become a routine part of oncology care to improve patient outcomes.
A new study by the University of Copenhagen found that women who received a false positive mammogram result showed signs of stress and depression years after the initial diagnosis was denied. Researchers are now urging for better information and support to be provided to women receiving false positives.
Researchers found that two different breast cancer models progressed at varying rates based on tumor microenvironment characteristics, with MMP9 playing a crucial role in promoting cancer growth. The study suggests that targeting MMP inhibitors may be more effective in specific patient populations.
Researchers found that HER2-positive breast cancer cells become addicted to the ERAD pathway, allowing them to survive chemotherapy. Inhibiting this pathway and promoting JNK activation selectively kills these cancer cells. The study proposes a new strategy for cancer treatment by maximizing cell stress.
Researchers at Cedars-Sinai Medical Center have developed a tiny drug-delivery system that can identify cancer cell types in the brain through MRI virtual biopsies and then attack the molecular structure of the disease. The nanodrug can distinguish and fight tumor cells in the brain without surgery.
A new study by the University of Maryland School of Medicine found that proton therapy significantly reduces toxic side effects in esophageal cancer patients. Proton therapy targets tumors while minimizing harm to surrounding tissues, leading to improved patient outcomes.
The Scripps Proton Therapy Center in San Diego is reporting exceptional results in delivering cancer treatment using pencil-beam scanning technology, enabling the treatment of a wide range of tumor sites. The center has treated patients with lung, brain, spinal column, and other tumors, offering greater precision and efficiency in radi...
A new large study finds that women who are diagnosed with breast cancer and have a family history of the disease face no worse of a prognosis after treatment than other women with breast cancer. Successful treatment for breast cancer is just as likely in young patients with a family history of breast cancer, as in those without.
A national survey found that only one in ten Australians report being told about the risk of overdiagnosis by their doctors, while over 90% believe people should be informed. Overdiagnosis occurs when someone is diagnosed with a disease that will never cause harm due to unnecessary labelling and treatment.
The DATECAN initiative has published guidelines for time-to-event end point definitions in breast cancer trials, aiming to standardize endpoint usage. This guidance helps researchers compare clinical trial results and make informed decisions about treatment efficacy.
A new blood test has been developed to detect breast cancer metastasis significantly earlier than current methods, according to researchers at Lund University. The test uses circulating tumor DNA in the blood to identify genetic mutations specific to each tumor.
A study published in Annals of Internal Medicine suggests that women with extremely dense breasts do not necessarily need additional imaging after a normal mammogram. However, those with high-risk dense breasts should discuss supplemental screening strategies with their doctors. The American College of Physicians advises 'smarter' canc...
A three-year study of 2,000 cancer survivors found that information needs differ depending on cancer type and stage. Breast cancer survivors sought more information about late effects and family risks in early years, while female colon cancer survivors increased their interest in these topics later on.
Research published in JAMA Oncology finds that smoking induces epigenetic changes in cheek cells, which can also be seen in non-smoking related cancers. This discovery provides a potential tool for early detection of breast and gynaecological cancers.
A new study found cancer survivors in the US experience significant annual economic burdens, with nonelderly colorectal and breast cancer survivors facing substantial excess medical expenditures and employment disability. Elderly survivors have lower but still notable economic burdens, highlighting varying impact by age group and cance...
Myriad Genetics presented 19 clinical studies on advanced companion diagnostic and molecular diagnostic tests for cancer treatment and prevention. The company's research focuses on personalized medicine, including selecting effective pharmaceuticals, preventing disease through hereditary cancer tests, and optimizing treatment decisions...
A Dartmouth team developed a novel approach for near infrared optical measurements of resected breast tissue using molecular dyes used for surgical specimen margin orientation. This method allows for intraoperative assessment during breast conserving surgery and avoids follow-up resections.
A recent study found that women in states without Medicaid expansion are less likely to receive breast and cervical cancer screenings compared to those in expanding states. The disparity is significant, with uninsured women facing a 7.9% lower rate of mammograms and a 4.9% lower rate of Pap tests.
Researchers have developed nanoparticles carrying siRNA to silence the β3 integrin gene, which regulates cancer cell spread. The treatment significantly inhibited metastasis in mouse models, including five mice with human triple-negative breast cancer.
A new study suggests that background parenchymal enhancement (BPE) on MRI scans may help tailor screening and management strategies to individual breast cancer risk. Women with elevated BPE levels were nine times more likely to be diagnosed with breast cancer, while mammographic density showed no significant relationship.
Research by Cancer Research UK has identified a link between high estrogen levels and an increased risk of male breast cancer. Men with the highest levels of oestrogen were two and a half times more likely to develop breast cancer.
Researchers have discovered a crucial gene, DNMT1, that maintains breast and cancer stem cells. High levels of DNMT1 expression are associated with increased risk of breast cancer, particularly in women over 30. Restoration of the opposing ISL1 gene significantly reduces stem cell populations and cancer growth.
Women with luminal A subtype breast cancer who are older than 60 and taking hormone therapy may not need radiation treatment, according to a new study. The research found that local breast radiation did not add benefit to their outcome, saving the healthcare system up to $3 million annually in Ontario.
A new non-invasive PET scan with C-11-vorozole detects aromatase in all body organs, potentially identifying cancer patients who may benefit from aromatase inhibitor treatment. The study also finds sex-dependent differences in radiation exposure and hormonal status.
Following a healthy lifestyle, including diet and physical activity guidelines, is associated with improved survival when diagnosed with bowel cancer. A large study of over 500,000 participants found that men with a high lifestyle score had a lower risk of mortality, while women who breastfed also showed increased survival.
A new screening method, tomosynthesis, has been found to detect 40% more breast cancers than traditional mammography. The technique uses 3D X-ray images and reduces discomfort and pain during the examination.
Scientists from Houston Methodist report that porous silicon microparticles can potentiate anti-tumor immunity by enhancing cross-presentation and inducing a type I interferon response. This approach shows promise for treating HER2+ breast cancer patients, with potential applications for other types of cancers.
Researchers found that black men under 65 diagnosed with early-stage breast cancer had a 76% higher risk of death than white men, despite similar treatment. The study suggests that poverty may play an important role in racial disparities in breast cancer mortality.
A new study led by UMass Amherst epidemiologist Katherine Reeves is assessing the relationship between phthalate exposure and breast cancer risk. The three-year study will analyze urine samples from 500 women with invasive breast cancer and 1,000 healthy controls to measure levels of 11 phthalate metabolites.
The European Organisation for Research and Treatment of Cancer (EORTC) is part of the CANCER-ID consortium, a €22.7 million project exploring blood-based biomarkers for cancer diagnosis and treatment monitoring.
Breast cancer in young women is characterized by more aggressive disease and increased risk of treatment-related toxicities. Research priorities focus on risk factors, fertility, pregnancy, quality of life, and metastases to improve patient outcomes.
Researchers mapped human genes triggered by soy phytonutrients, revealing a complex role in breast cancer prevention and promotion. Soy flour stimulates tumor-suppressing genes, while purified isoflavones stimulate oncogenes, promoting tumor growth.
A new analysis of the Surveillance, Epidemiology, and End Results (SEER) database found significant variation in health insurance coverage among cancer patients based on demographics and cancer type. Younger, non-White, and rural patients were more likely to be uninsured, while males were less likely than females to have insurance.
Researchers at Women's College Hospital identified a new breast cancer gene, RECQL, strongly linked to the onset of breast cancer in two populations of Polish and French-Canadian women. The study found that specific mutations in the gene were associated with a high risk of developing breast cancer.
Researchers developed an imageable mouse model of brain-metastatic breast cancer and tested a stem-cell-based therapy that eliminates metastatic cells from the brain, prolonging survival. The treatment also prevents negative consequences by targeting tumor-specific molecules.
Researchers found that only 3% of newly diagnosed patients with stage III ILC benefited from systemic staging with FDG PET/CT, suggesting CT and bone scan are sufficient instead.
Scientists have identified 35 genes and three long intervening noncoding RNA molecules that spur aggressive activity in HER2+ breast cancer. These findings provide a new target for treatment approaches, potentially leading to RNA-based therapeutics.
Digital breast tomosynthesis (DBT) increases cancer detection rates among women with dense breasts, with a significant improvement seen in those with dense breasts called back for mass and asymmetry. The study found a striking increase in detection among these groups, offering new insights into DBT's effectiveness.
A new study by Brigham and Women's Hospital finds that breast conserving therapy was successful in over 90% of women who became eligible after treatment with chemotherapy. Despite this, 31% of those eligible chose mastectomy, highlighting the need for further exploration of patient and surgeon factors.
A study found that oophorectomy significantly reduced breast cancer death risk in women with a BRCA1 gene mutation. The procedure also showed promise in reducing all-cause mortality, particularly among estrogen receptor-negative breast cancer patients.
Researchers identified specific genetic markers in African American women with triple negative breast cancer, associated with improved survival rates. The study suggests that these molecular differences may hold the key to improving treatment outcomes for this high-risk population.
The Association for Molecular Pathology compiles current research on liquid biopsy approaches for cancer diagnostics. The review supports the notion that these minimally invasive tests allow for earlier diagnosis, faster and more targeted treatment, reduced costs, and increased quality of life.
Most breast and general surgeons still advocate for annual mammography starting at age 40, despite a 2009 USPSTF recommendation to screen biennially from 50 to 74. Researchers found 88% of breast surgeons and 82% of general surgeons recommend annual screenings.
A new study confirms that moderate coffee consumption reduces breast cancer recurrence risk in women treated with tamoxifen. The study found that caffeine and caffeic acid in coffee inhibit tumor growth and cell division.
Researchers have tested an experimental immune system drug, MPDL3280A, in a preliminary human study and found it to be generally safe and well-tolerated. The therapy aims to restore the immune system's ability to recognize and attack cancer cells, with promising results in controlling disease in some patients.
Researchers at Cold Spring Harbor Laboratory have identified a previously unknown signaling pathway in HER2-positive breast cancer cells. The pathway involves protein tyrosine phosphatase PTPD2, which regulates abnormal cell growth when the HER2 pathway is activated.
A collaborative study by the University of Colorado Cancer Center and National Cancer Institute reports TERT gene promoter alterations in 69% of bladder cancers. The study suggests these alterations may be an early precursor to the disease and could lead to genetic testing for screening.