Articles tagged with Breast Cancer
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The TAILORx trial found that 99.3% of patients with low Oncotype DX scores had no distant recurrence at 5 years after treatment with hormonal therapy alone. This study provides evidence supporting the clinical utility of Oncotype DX to risk-stratify patients with early stage breast cancer.
A recent study found that a costly computer-aided detection tool used in nearly all mammograms does not improve cancer detection rates and may even result in missed cancers. The study's findings have led some researchers to advocate for ending Medicare coverage of the tool, which could save millions annually.
A large national BCSC study found that computer-aided detection (CAD) of breast cancer screening does not improve accuracy or patient outcomes. CAD raised screening costs and increased false positives, but did not detect more cancers or improve outcomes for women in screening programs.
A new study found increased awareness of reconstructive breast surgery options after Angelina Jolie's decision to undergo a double mastectomy and subsequent reconstruction. The study indicates that media coverage can improve public knowledge about health topics.
Scientists have developed a new toolkit to examine the BRCA1 protein and its associated parts in near-native environments. This allows for direct visualization of macromolecular regulatory complexes in human patient-derived cancer cells, providing valuable insights into the molecular mechanisms underlying breast cancer.
A large study found that computer-aided detection (CAD) for mammography did not improve diagnostic accuracy in radiologists' interpretations. Despite increased use and FDA approval, CAD's effectiveness was not supported by the results, leading to calls for reduced reimbursement or reconsideration of its continued coverage.
Researchers found that adding hormonal treatment during chemotherapy reduced the risk of premature ovarian failure by 45% and increased pregnancy rates among young breast cancer patients. The use of LHRHa could be a potential standard strategy to preserve ovarian function and fertility in hormone receptor positive breast cancers.
The study found substantial differences in surgery, hormone therapy, and chemotherapy use among European countries for elderly breast cancer patients. Treatment approaches varied depending on the stage of the disease, with some countries omitting surgery or using more chemotherapy than others.
A global shortfall in radiotherapy resources has led to millions of unnecessary deaths, but investing in radiotherapy services could bring economic benefits of up to $365 billion over the next 20 years. Access to radiotherapy is currently unacceptably low, especially in Africa, where most countries have no facilities.
A study of 1,000 breast cancer patients found genetic differences between primary tumours and recurring cancers. The research identified potential targets for new therapies, including JAK inhibitors, to prevent cancer recurrence.
Scientists from UC San Francisco capture and study individual metastatic breast cancer cells, finding they express genes similar to mammary stem cells, which could lead to targeted therapies. The research suggests a new approach to understanding how cancer spreads and developing effective treatments.
A randomized trial will recruit 3,000 women with Stage II and III breast cancer to receive either aspirin or a placebo. The study aims to determine if aspirin can prevent breast cancer recurrence and death, with potential benefits including enhanced survival and reduced costs in developing nations.
Western University researchers have developed an artificial intelligence-powered tool that can predict a patient's response to paclitaxel and gemcitabine chemotherapy medications. The tool uses genetic analysis of tumours to identify the genetic signatures most important for determining resistance and remission for each medication. Wit...
Researchers found a biomarker that can predict which HER2-negative breast cancer patients will respond to bevacizumab treatment, allowing for early switch to more effective options. This discovery could spare patients from severe side effects and improve overall survival rates.
A new study found that a large majority of breast cancers in Cote d'Ivoire and Republic of Congo are detected at an advanced stage, with over two-thirds of tumors being 5 cm or larger in diameter. The study's results underscore the need for improved access to diagnosis and treatment in sub-Saharan Africa.
Scientists at TGen discovered 21 genes with increased methylation that could indicate metastatic breast cancer. A blood-based test using this signature may help improve treatment for women at risk of recurrence.
A study found that African American women with breast cancer have a higher prevalence of aggressive tumor characteristics, including the TP53 driver mutation and basal tumor subtype, which contribute to racial disparities in survival rates. The research may help develop targeted therapies against these subtypes.
PharmaMar has initiated a multicenter, international phase II Basket trial to evaluate the efficacy and safety of PM1183 (lurbinectedin) in patients with various advanced solid tumors. The trial will assess the overall response rate, duration of response, and pharmacokinetic properties of the drug.
Researchers at the University of Manchester have discovered a potential new approach to overcome hormone therapy resistance in ER+ breast cancer by targeting breast cancer stem cells driven by NOTCH4. This approach shows promise in improving treatment outcomes for patients with hormone therapy-resistant breast cancer.
A new hand-held probe using optical coherence tomography (OCT) technology has been found to correlate well with traditional pathologists' diagnoses in a clinical study, enabling reliable real-time guidance for surgeons. The device can identify differences between cancer cells and normal tissue with high sensitivity and specificity.
According to a comprehensive report by the American Cancer Society, cancer is the second leading cause of death overall in the US, but it remains the leading cause of death among US Hispanics. Lung cancer is the primary concern, particularly for Hispanic men, who are more likely to die from this disease.
Researchers at IRB Barcelona have discovered the MAF gene is a reliable predictor of breast cancer bone metastasis. The study, published in JNCI, analyzed over 900 clinical samples and found that MAF-altered tumors are 14 times more likely to develop bone metastasis.
Researchers developed a new method using gold nanoparticles to enhance mammogram imaging, improving the detection of early signs of breast cancer. The technique boosts contrast and makes microcalcifications brighter on X-rays, potentially leading to more reliable diagnosis.
A new computational model measures disparities between biomedical research resources and disease burden, identifying unmet medical needs. The Research Opportunity Index (ROI) provides a data-driven framework to assess resource investment and allocate funds efficiently.
Researchers at Mayo Clinic's Florida campus have been awarded a $13.3 million grant to conduct a national, phase II clinical trial testing the ability of a folate receptor alpha vaccine to prevent recurrence of triple-negative breast cancer following initial treatment. The vaccine was designed by Dr. Keith Knutson and exploits the need...
Researchers analyzed breast tissue from 239 women, comparing samples with and without breast cancer for the presence of bovine leukemia virus. They found a significant association between BLV infection and an increased risk of breast cancer, with odds ratio higher than obesity, alcohol consumption, and post-menopausal hormone use.
A 20-year follow-up of the EORTC boost no-boost trial found that young age, high-grade invasive tumor, and ductal carcinoma in situ were associated with increased local recurrence rates. The study showed substantial benefits from academic clinical research, enabling long-term follow-up and analysis.
A study published in JAMA Internal Medicine found that women who followed a Mediterranean diet supplemented with extra virgin olive oil had a significantly lower risk of developing breast cancer. The study, which involved over 4,200 women, showed that the Mediterranean diet with olive oil reduced breast cancer risk by 68%.
Researchers at Salk Institute discovered a single master gene, Sox10, that controls the formation of mobile cancer factories. High levels of Sox10 in breast cancer tissue enable these stem-like cells to rapidly produce variants that can survive and spread to other tissues.
A new study shows that a small implantable device can attract and capture malignant cells in breast cancer patients, potentially giving doctors earlier warnings of relapse. The device exploits the natural attraction of cancer cells to specific areas of the body, slowing down their spread to other organs.
A new report finds breast cancer incidence is increasing in many low- and middle-income countries, while death rates are decreasing in most high-income countries. The study suggests that economic development and urbanization may be contributing factors to the rising incidence rates.
Two studies suggest alternative prevention strategies may render surgery unnecessary for women at high risk of breast and ovarian cancer. Researchers identify a new target to decrease breast cancer risk by blocking the effects of RANKL with OPG.
Researchers found that luteolin can inhibit growth of human breast cancer cells and reduce blood vessel formation, a promising alternative for postmenopausal women at increased risk. The study suggests luteolin may be effective in reducing breast cancer risk when administered through IV supplements.
A new NIH-funded study launched at UH Seidman Cancer Center aims to investigate the effects of physical activity on functional status, body composition, and biomarkers associated with breast cancer prognosis in older breast cancer survivors. The five-year clinical trial will focus on African American and low socioeconomic status women.
The UK's largest breast cancer physiotherapy trial, PROSPER, will investigate the impact of physiotherapy on women after breast cancer surgery. The study aims to inform national guidelines and improve treatment outcomes for women experiencing shoulder problems and chronic pain after their treatment.
A new study found that acupuncture significantly reduced hot flash frequency and severity in breast cancer survivors, while also inducing a stronger placebo effect than oral medications. The treatment showed sustained benefits even after the eight-week treatment period ended.
Research reveals mutant p53 proteins use epigenetics to drive aggressive cancer growth by targeting key genes and enzymes, such as MLL1 and MOZ. Inhibiting these regulators may lead to combinatorial epigenetic therapies for treating difficult-to-treat cancers.
The use of contralateral prophylactic mastectomy (CPM) among US men with breast cancer has increased significantly, rising from 3% to 5.6% between 2004 and 2011. The procedure was more common in younger, white, and privately insured patients.
Researchers discovered a mechanism that regulates blood vessel growth in diabetic mice, reducing tumor size without harming other organs. The approach may also treat diabetic complications like retinopathy and nephropathy.
Researchers at OU and Mercy Hospital OKC are developing two new short-term breast cancer risk prediction approaches to increase detection of breast MRI screenings. They aim to identify high-risk women with mammography-occult cancers and reduce repeated negative MRI screenings among those with elevated risk.
A study of 44,044 Medicare patients with early-stage breast cancer found that the 21-gene recurrence score assay was associated with decreased chemotherapy use in high-risk patients and increased use in low-risk patients. The genetic test appeared to influence chemotherapy use regardless of age.
A Cornell study reveals that stiffer breast tissue in obese women promotes tumor growth, changing the extracellular matrix's consistency similar to tumors. This finding may require finer-scale imaging techniques in mammograms for early detection.
The EORTC will present on precision medicine, including a discussion of molecular subgroups and randomized trials. The organization will also focus on survivorship care, exploring the importance of long-term follow-up and evidence-based approaches.
Researchers have developed a blood test that can identify patients at risk of breast cancer relapse months before visible signs appear. The test detects cancer DNA in the bloodstream, allowing for early intervention and personalized treatment.
A recent study by H. Lee Moffitt Cancer Center researchers found a significantly higher frequency of BRCA mutations in young black women with breast cancer, particularly among those under 50. This discovery may contribute to the disparity in aggressive breast cancer rates among black women compared to non-Hispanic white women.
Researchers at University of Illinois develop a data-based method to diagnose breast cancer using spatial light interference microscopy, promising fast and accurate results. The technique uses quantitative imaging parameters to analyze breast tissue lesions, overcoming limitations of manual inspection.
A study of 515 premenopausal patients found that younger women with stage 0-III hormone receptor-positive breast cancer are less likely to initiate or continue tamoxifen treatment due to concerns about side effects and fertility, highlighting the need for targeted interventions.
A study found that fertility concerns led a third of young women with breast cancer to decline or discontinue tamoxifen. The study also showed that a quarter of women who started tamoxifen stopped taking it before the recommended treatment period ended.
Researchers found that tumour pericytes manipulate the tumour environment to help cancer cells escape immune surveillance. Increasing pericyte numbers could potentially decrease IL-6 expression and improve cytotoxic T-cell activity.
A new study by Dr. Steven Narod finds that women diagnosed with ductal carcinoma in situ (DCIS) are twice as likely to die from breast cancer compared to the general US population. The study also reveals that black women and those under 35 have a higher risk of mortality.
Researchers developed a faster method for classifying benign and malignant human breast tissues using fresh samples. This automated method eliminates the need for time-consuming tissue preparation and specialist assessment, potentially improving breast cancer management in developing countries.
A large US study found that light to moderate drinking is associated with an increased risk of certain alcohol-related cancers in women, mainly breast cancer, and men who have ever smoked. Overall, the study suggests that women should not exceed one standard drink a day and men should not exceed two standard drinks a day.
Researchers updated their breast cancer risk model to include benign biopsy results, revealing a 300% increase in five-year risk for women with proliferative findings. The revised model enables more accurate identification of women at high risk who may benefit from chemoprevention.
A new study published in the Journal of Clinical Oncology found that music therapy significantly lowered anxiety levels for patients undergoing surgical breast biopsies. The study involved 207 patients who received either live or recorded music before surgery, with results showing a 43% reduction in anxiety compared to usual care.
Scientists have discovered a cytokine called MIF that regulates EGFR activation in the tumor microenvironment, promoting tumor progression. The findings could lead to new approaches in treating tumors by intervening in this self-regulating loop.
A £500,000 National Cancer Institute grant has enabled UK researcher Fredrick Onono to explore the potential connection between high-fat diets and breast cancer development. The study may uncover how fats contribute to cell malfunctions, potentially leading to treatment-resistant cases.
A study found that screening women with suspected hereditary breast or ovarian cancer risk for additional genes provides important information for changing clinical management. Most patients with identified mutations were recommended for enhanced screening or preventive measures, and close relatives should also be screened.
A study published in the Journal of American Geriatrics Society found that chemotherapy's effectiveness in prolonging life for older adults with most types of cancer is reduced for women over 80 with breast cancer. However, combining chemotherapy with another treatment may improve mortality risk reduction for this age group.
Researchers developed a new biomarker that uses magnetic resonance imaging (MRI) to detect micrometastases, tiny tumor cells with the potential to develop into secondary breast cancer tumors. This approach may offer an improved way to detect early recurrence of breast cancer in women and men.
Researchers at Case Western Reserve University have developed a magnetic resonance imaging (MRI) contrast agent that can detect small aggressive breast cancer tumors and micrometastases. The agent binds to molecular markers expressed in high-risk primary tumors and metastases, generating increased image contrast.