Articles tagged with Breast Cancer
Researchers developed a new tumor marker test that may predict breast cancer spread to the brain, based on alpha B-crystallin levels in breast tumors. The test found nearly three times higher likelihood of brain metastasis in women with alpha B-crystallin expression.
A new study suggests that postmenopausal women may be safely screened every two years, while premenopausal women over 40 may benefit from annual mammograms to increase early detection. The research also highlights the importance of considering menopausal status rather than age when determining screening intervals.
A study of over 869 pre-teen girls found that those from families with a history of breast cancer or genetic mutations did not show increased signs of anxiety and depression. However, they did express more worry about breast cancer, suggesting a potential benefit of early education about risk.
A recent study found that premenopausal women who received annual mammography screenings had smaller and less advanced tumors compared to those who received biennial screenings. In contrast, postmenopausal women did not show significant differences in tumor characteristics regardless of screening frequency.
The American Cancer Society recommends starting annual mammography screening at age 45 for average-risk women. Women between 40-44 can choose to begin annual screening. Clinical breast examination is no longer recommended due to lack of clear evidence on its effectiveness in detecting breast cancer.
Breast cancer researcher Dr Michalak aims to understand how normal and cancerous cells develop in the breast to identify suspicious tumors and develop better treatments. Her study focuses on epigenetic modifiers, which can influence DNA behavior, and may hold clues to preventing tumor spread.
Researchers have identified distinct microbial signatures in triple negative breast cancer tissue, suggesting potential diagnostic and therapeutic applications. The study found a predominantly viral and bacterial signature, with some fungi and parasites also present.
The Columbia Mailman School and Columbia University Medical Center site will focus on prevention and expand the study of risk factors that precede breast cancer. The researchers aim to understand the role of genetic and environmental factors in modifying breast cancer risk.
The UI Cancer Center and Governors State University have received a joint grant to conduct community-based research on reducing cancer-related health disparities in the region's south suburbs. The program will provide training for GSU junior faculty and support minority undergraduate and graduate students in health disparities research.
African-American women are more likely to develop aggressive breast cancer subtypes and receive substandard care compared to non-Hispanic white women. Minority women also experience disparities in treatment across all breast cancer stages, with significant differences in diagnosis timing and treatment approaches.
A study of 1533 cancer survivors revealed poor adherence to dietary guidelines, with lower intakes of fiber, vitamins, and minerals, but higher intakes of empty calories. Diet quality improved with age and education level.
Scientists discovered a malaria protein that targets sugar molecules found in placentas and most cancers, leading to the development of an anti-cancer drug. The new approach halted tumour growth in mice and showed promising results in treating non-Hodgkin's lymphoma, prostate cancer, and metastatic breast cancer.
Researchers discovered a malaria protein that binds to a common sugar molecule found on both placentas and cancer cells. A novel technology was developed to arm antibodies with high potency toxins to specifically kill cancer cells, showing promising results in clinical trials.
A five-year, $4.15 million grant will investigate how a high-fat diet interacts with common sunscreen chemicals like BP-3, which may mimic estrogen and increase breast cancer risk. The study aims to identify predictive markers for increased breast cancer susceptibility and develop prevention strategies.
Researchers at the University of York have discovered a specific sodium channel, Nav1.5, that indicates cancer cells and affects tumor growth rates in breast cancer patients. The study found higher levels of Nav1.5 in tumour cells compared to normal breast tissue.
Researchers discovered elephants have 38 additional modified copies of the p53 gene, which encodes a well-defined tumor suppressor. This unique genetic feature may protect elephants from cancer by enhancing their ability to kill damaged cells.
The Breast Cancer and the Environment Research Program is expanding its focus to prevention, involving new communities and studying risk factors like breast density. Researchers will explore links between environmental exposures and high breast density, aiming to identify new insights into prevention.
A novel two-hit therapy combining an immune-molecule-based mop-up therapy with a pathway-disabling approach eradicates specific breast tumors in mice. This therapy has the potential to reduce treatment costs and increase effectiveness for Her2-positive breast cancers.
A team of Singaporean scientists has identified the genetic landscape of fibroepithelial breast tumors, revealing how they progress from benign to cancerous types. The study's findings may improve diagnostic accuracy and enhance clinical intervention for patients with these tumors.
Researchers at Ohio State University suggest new ways to treat cancer by inhibiting overactive cancer-promoting genes and enhancing sluggish tumor-suppressor genes. The findings, published in Nature Communications and Nature Genetics, provide insights into the role of glucocorticoid receptors and epigenetic marks in cancer development.
Researchers found that a tolerant immune system, characterized by high levels of regulatory T cells, increases the risk of certain types of cancer. The study analyzed blood samples from EPIC participants with cancer and controls, revealing a strong link between immunotolerance and increased lung and colon cancer risks.
A study of 173,797 female breast cancer patients found that catching cancers when they are small makes a difference to survival, even with modern therapies. Traditional factors such as tumour size and lymph node status have a significant influence on overall mortality independent of age and tumour biology.
A study identified significant DNA differences in the human kallikrein cluster among Eastern Asian populations, including those related to KLK4 gene activity. These findings may contribute to unique dental traits and a lower risk of skin conditions like eczema.
A predictive model that measures invasiveness facilitated by macrophages from each individual donor has been developed to guide treatment options for breast cancer. The model correlates the level of invasion through a collagen gel to chemical signals expressed by macrophages, providing an invasiveness index for each patient.
A large-scale Swedish study has discovered a link between height and cancer risk in both men and women. The research found that taller individuals have an increased risk of developing certain types of cancer, including breast cancer and melanoma, with the risk increasing by up to 30% per 10 cm of height.
A new pan-Canadian Dream Team, led by Tak W. Mak and Samuel Aparicio, will research novel approaches to treating aggressive breast cancers. The team aims to develop new therapies targeting genetic instability in tumor cells.
A team of researchers found specific variations in RNA splicing that may play a role in converting normal breast cells into tumors. The study identifies potential targets for therapies in some forms of breast cancer.
Researchers discovered genetic alterations in healthy breast cells associated with an increased risk of non-familial breast cancer. These findings can be used for future improvements in diagnostics to identify women at high risk before the tumor forms.
Researchers found no correlation between breast cancer's different structures and chromosomal abnormalities, challenging the idea that genetic mutations drive tumor heterogeneity. Instead, they discovered specific genes contributing to each structure's formation, suggesting alternative mechanisms driving morphological diversity.
A review article discusses the issues of overdiagnosis and overtreatment in breast cancer screening, highlighting the benefits of newer technologies like breast tomosynthesis. The study finds that this technology reduces false recall rates by 15-30% while increasing cancer detection rates by about 29%.
A major study published in the New England Journal of Medicine has identified a 21-gene test that can determine which breast cancer patients can safely avoid chemotherapy. The test, called Oncotype DX Recurrence Score, analyzes tumor samples and assigns scores between 0-100, indicating the risk of cancer recurrence.
The TAILORx trial found that 99.3% of patients with low Oncotype DX scores had no distant recurrence at 5 years after treatment with hormonal therapy alone. This study provides evidence supporting the clinical utility of Oncotype DX to risk-stratify patients with early stage breast cancer.
A recent study found that a costly computer-aided detection tool used in nearly all mammograms does not improve cancer detection rates and may even result in missed cancers. The study's findings have led some researchers to advocate for ending Medicare coverage of the tool, which could save millions annually.
A large national BCSC study found that computer-aided detection (CAD) of breast cancer screening does not improve accuracy or patient outcomes. CAD raised screening costs and increased false positives, but did not detect more cancers or improve outcomes for women in screening programs.
A new study found increased awareness of reconstructive breast surgery options after Angelina Jolie's decision to undergo a double mastectomy and subsequent reconstruction. The study indicates that media coverage can improve public knowledge about health topics.
Scientists have developed a new toolkit to examine the BRCA1 protein and its associated parts in near-native environments. This allows for direct visualization of macromolecular regulatory complexes in human patient-derived cancer cells, providing valuable insights into the molecular mechanisms underlying breast cancer.
A large study found that computer-aided detection (CAD) for mammography did not improve diagnostic accuracy in radiologists' interpretations. Despite increased use and FDA approval, CAD's effectiveness was not supported by the results, leading to calls for reduced reimbursement or reconsideration of its continued coverage.
Researchers found that adding hormonal treatment during chemotherapy reduced the risk of premature ovarian failure by 45% and increased pregnancy rates among young breast cancer patients. The use of LHRHa could be a potential standard strategy to preserve ovarian function and fertility in hormone receptor positive breast cancers.
The study found substantial differences in surgery, hormone therapy, and chemotherapy use among European countries for elderly breast cancer patients. Treatment approaches varied depending on the stage of the disease, with some countries omitting surgery or using more chemotherapy than others.
A global shortfall in radiotherapy resources has led to millions of unnecessary deaths, but investing in radiotherapy services could bring economic benefits of up to $365 billion over the next 20 years. Access to radiotherapy is currently unacceptably low, especially in Africa, where most countries have no facilities.
A study of 1,000 breast cancer patients found genetic differences between primary tumours and recurring cancers. The research identified potential targets for new therapies, including JAK inhibitors, to prevent cancer recurrence.
Scientists from UC San Francisco capture and study individual metastatic breast cancer cells, finding they express genes similar to mammary stem cells, which could lead to targeted therapies. The research suggests a new approach to understanding how cancer spreads and developing effective treatments.
A randomized trial will recruit 3,000 women with Stage II and III breast cancer to receive either aspirin or a placebo. The study aims to determine if aspirin can prevent breast cancer recurrence and death, with potential benefits including enhanced survival and reduced costs in developing nations.
Western University researchers have developed an artificial intelligence-powered tool that can predict a patient's response to paclitaxel and gemcitabine chemotherapy medications. The tool uses genetic analysis of tumours to identify the genetic signatures most important for determining resistance and remission for each medication. Wit...
Researchers found a biomarker that can predict which HER2-negative breast cancer patients will respond to bevacizumab treatment, allowing for early switch to more effective options. This discovery could spare patients from severe side effects and improve overall survival rates.
A new study found that a large majority of breast cancers in Cote d'Ivoire and Republic of Congo are detected at an advanced stage, with over two-thirds of tumors being 5 cm or larger in diameter. The study's results underscore the need for improved access to diagnosis and treatment in sub-Saharan Africa.
Scientists at TGen discovered 21 genes with increased methylation that could indicate metastatic breast cancer. A blood-based test using this signature may help improve treatment for women at risk of recurrence.
A study found that African American women with breast cancer have a higher prevalence of aggressive tumor characteristics, including the TP53 driver mutation and basal tumor subtype, which contribute to racial disparities in survival rates. The research may help develop targeted therapies against these subtypes.
PharmaMar has initiated a multicenter, international phase II Basket trial to evaluate the efficacy and safety of PM1183 (lurbinectedin) in patients with various advanced solid tumors. The trial will assess the overall response rate, duration of response, and pharmacokinetic properties of the drug.
Researchers at the University of Manchester have discovered a potential new approach to overcome hormone therapy resistance in ER+ breast cancer by targeting breast cancer stem cells driven by NOTCH4. This approach shows promise in improving treatment outcomes for patients with hormone therapy-resistant breast cancer.
A new hand-held probe using optical coherence tomography (OCT) technology has been found to correlate well with traditional pathologists' diagnoses in a clinical study, enabling reliable real-time guidance for surgeons. The device can identify differences between cancer cells and normal tissue with high sensitivity and specificity.
According to a comprehensive report by the American Cancer Society, cancer is the second leading cause of death overall in the US, but it remains the leading cause of death among US Hispanics. Lung cancer is the primary concern, particularly for Hispanic men, who are more likely to die from this disease.
Researchers at IRB Barcelona have discovered the MAF gene is a reliable predictor of breast cancer bone metastasis. The study, published in JNCI, analyzed over 900 clinical samples and found that MAF-altered tumors are 14 times more likely to develop bone metastasis.
Researchers developed a new method using gold nanoparticles to enhance mammogram imaging, improving the detection of early signs of breast cancer. The technique boosts contrast and makes microcalcifications brighter on X-rays, potentially leading to more reliable diagnosis.
A new computational model measures disparities between biomedical research resources and disease burden, identifying unmet medical needs. The Research Opportunity Index (ROI) provides a data-driven framework to assess resource investment and allocate funds efficiently.
Researchers at Mayo Clinic's Florida campus have been awarded a $13.3 million grant to conduct a national, phase II clinical trial testing the ability of a folate receptor alpha vaccine to prevent recurrence of triple-negative breast cancer following initial treatment. The vaccine was designed by Dr. Keith Knutson and exploits the need...
Researchers analyzed breast tissue from 239 women, comparing samples with and without breast cancer for the presence of bovine leukemia virus. They found a significant association between BLV infection and an increased risk of breast cancer, with odds ratio higher than obesity, alcohol consumption, and post-menopausal hormone use.
A 20-year follow-up of the EORTC boost no-boost trial found that young age, high-grade invasive tumor, and ductal carcinoma in situ were associated with increased local recurrence rates. The study showed substantial benefits from academic clinical research, enabling long-term follow-up and analysis.
A study published in JAMA Internal Medicine found that women who followed a Mediterranean diet supplemented with extra virgin olive oil had a significantly lower risk of developing breast cancer. The study, which involved over 4,200 women, showed that the Mediterranean diet with olive oil reduced breast cancer risk by 68%.
Researchers at Salk Institute discovered a single master gene, Sox10, that controls the formation of mobile cancer factories. High levels of Sox10 in breast cancer tissue enable these stem-like cells to rapidly produce variants that can survive and spread to other tissues.