Articles tagged with Breast Cancer
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A new study from the University of Texas MD Anderson Cancer Center found that mastectomy plus reconstruction has the highest rate of complications and complication-related costs among guideline-concordant therapies for early breast cancer. The study also revealed that this treatment option is the most expensive in younger patients, wit...
A recent study found that PET/CT and whole-body MRI detect extraskeletal disease, changing cancer management. Combined administration of F-18 sodium fluoride (NaF) and F-18 fluorodeoxyglucose (FDG) in a single PET/CT scan showed higher sensitivity and accuracy than alternative methods.
A population-based study of 37,207 patients found that those who received breast-conserving surgery plus radiation therapy had improved overall survival after 10 years compared to those who received mastectomy without radiation. BCT was also associated with fewer regional recurrences and distant metastases.
A new study from MD Anderson Cancer Center found that delaying chemotherapy after surgery increases the risk of death for breast cancer patients, particularly those with triple-negative breast cancer. Patients who start treatment within 90 days have a lower risk of death compared to those who delay it.
Dr. Norman Wolmark will present the William L. McGuire Memorial Lecture on the NSABP Clinical Trials' impact on early breast cancer management. Established in 1992, the McGuire Lectureship commemorates Dr. William McGuire's contributions to oncology.
A recent study has found that mastectomy and reconstruction have higher complication rates and costs compared to lumpectomy and radiation. For younger women with private insurance, the risk of complications from mast+recon was two times higher than lump+WBI after adjusting for other differences in patients and treatment.
A phase III trial found that women with luminal A subtype of breast cancer had comparable 10-year disease-free survival rates regardless of whether or not they received adjuvant chemotherapy. In contrast, patients with non-luminal A subtypes who received chemotherapy were 50% less likely to have their disease recur in 10 years.
Patients with stage 2 or 3 triple-negative breast cancer (TNBC) who achieved a pathologic complete response (pCR) after presurgery chemotherapy had significantly improved event-free and overall survival compared to those with more than minimal residual invasive disease. This benefit was observed in patients with larger tumors or lymph ...
The ABCSG-18 clinical trial found that adding denosumab to adjuvant aromatase inhibitor therapy improved disease-free survival in postmenopausal patients with HR+ breast cancer. After a median follow-up of four years, patients assigned denosumab had an 18 percent reduced risk of disease recurring compared with those assigned placebo.
A phase III trial found that capecitabine improved disease-free survival for women with HER2-negative breast cancer that was not eliminated by presurgery chemotherapy. The study showed a 30% reduced risk of disease recurrence compared to standard therapy.
Results of a phase 1b clinical trial show ONT-380 achieves at least stable disease in 58% of patients with metastatic HER2+ breast cancer, including 11 partial responses and one complete response in patients with brain metastases.
A landmark clinical trial shows that beta blockers and ACE inhibitors effectively prevent heart function drop in patients with early-stage breast cancer. The study suggests these medications can improve breast cancer survival rates by limiting interruptions to chemotherapy treatment.
Recent studies present new data on the myRisk Hereditary Cancer test, highlighting its ability to identify patients with deleterious mutations who may have been missed by traditional genetic testing. The test demonstrated a significant increase in identifying BRCA-related mutations among those tested without BRCA1/2 results.
Adding carboplatin to presurgery chemotherapy significantly improved disease-free survival rates for patients with triple-negative breast cancer (TNBC). The study found that patients with pathologic complete responses had the lowest risk of relapse, supporting the use of carboplatin as a standard part of neoadjuvant therapy regimens.
A phase IIR/III clinical trial investigates whether surgery or stereotactic body radiation can control metastasis while continuing breast cancer therapy. Researchers aim to define parameters for determining which patients benefit from this 'weeding the garden' approach.
Researchers found that telomeres slow down and sometimes even reverse with weight loss and exercise in breast cancer survivors. Higher body fat levels are associated with shorter telomere length.
New studies from the University of Pennsylvania School of Medicine found that aspirin use is not associated with improved clinical outcomes or survival among breast cancer patients. However, another study suggests that aspirin may help reduce breast tissue density, which could lead to earlier detection of some breast cancers.
A study of over 21,000 women found that only 1 in 6 with increased breast cancer risk take preventive medication, despite being eligible for clinical trials. Most women who started the medication continued taking it for at least a year, but usage declined over time.
Researchers found that combining palbociclib with paclitaxel shrank tumors in nearly half of patients with estrogen-receptor positive breast cancer. The combination appears to be safe and may offer benefits over paclitaxel alone, suggesting a larger clinical trial is warranted.
Researchers found that losing CD73 enzyme promotes tumor growth and progression in endometrial cancer by disrupting adenosine signaling, which normally regulates tissue function. The study provides new insights into the role of CD73 in cancer development.
A phase 1 clinical trial found that enzalutamide is active and well-tolerated alone and with fulvestrant in patients with advanced breast cancer. The study supports a larger trial of the combination, building on promising preclinical data and targeting androgen receptors in breast cancer.
A study found that breast cancer survivors with therapy-related leukemia often have inherited cancer susceptibility and gene mutations. Researchers suggest a long-term follow-up study to understand the impact of these genes on leukemia risk, enabling personalized conversations about treatment benefits and risks.
A new gene therapy platform uses a hydrogel and self-assembled nanoparticles to deliver microRNAs that suppress tumor tissue, increasing dosage at the site while reducing systemic side effects. The approach has shown promising results in shrinking tumors by nearly 90% in pre-clinical models.
A mindfulness-based stress reduction program has been shown to improve attention and reduce mistakes on difficult cognitive tasks in breast and colorectal cancer survivors. The program, known as MBSR, provides a creative solution for managing cancer-related cognitive impairment, which can be incapacitating.
UC Davis researchers have made significant progress in tumor treatment by combining guided ultrasound with nanoparticle chemotherapy, resulting in improved survival and consistent cure rates. The technique allows for complete destruction of tumors without thermal damage to surrounding tissue.
Research by Allison Cleary reveals that breast cancer cells work together to promote tumor growth, contradicting the long-held assumption of competitive interactions within tumors. Her findings have implications for developing novel treatments that target cooperative interactions in human breast cancers.
Researchers have isolated four distinct circulating tumor cell subsets, one of which marks genes known to be directly implicated in tumor cell dormancy. These findings may lead to a preventive treatment for metastatic cancer cells and provide insights into the mechanisms of breast cancer recurrence.
A study of over 20,000 women with stage IV breast cancer found improved survival rates, especially among those who received initial breast surgery. The median survival increased from 20 to 26 months, and age, tumor size, hormone receptor status, and year of diagnosis were associated with prolonged survival.
A new study suggests that breast density alone is not a significant risk factor for breast cancer in postmenopausal women. The study found no significant difference in breast density between breast cancer patients and control groups.
Women with a history of false-positive mammogram results may be at increased risk of developing breast cancer for up to 10 years after the initial false-positive result. A new study found that women who received a false-positive result had a 39% higher risk of subsequent breast cancer compared to those with true-negative results.
A feasibility study found that women with breast cancer experienced improved feelings of positivity, control, and meaning after tending small indoor 'garden bowls'. The benefits were attributed to the process of nurturing and reflecting on the garden, suggesting a simple ecotherapy-based intervention can have significant impacts.
A large Kaiser Permanente study contradicts previous concerns that antidepressants reduce tamoxifen's effectiveness in lowering subsequent breast-cancer risk. Researchers found no increased risk of recurrence among women who took antidepressants with tamoxifen.
Researchers at National Research Tomsk State University found that neoadjuvant chemotherapy can stimulate evolution of the tumor, leading to resistance and metastasis. The study analyzed biopsies from women with breast cancer before and after surgery, revealing a 23% increase in new tumor formation.
A randomized trial shows that cognitive-behavioral stress management improves survival and lengthens time to recurrence in women diagnosed with breast cancer. Women who received stress management training experienced greater length of survival and longer time till disease recurrence over eight to 15 years after diagnosis.
A study presented at the Radiological Society of North America meeting found that Medicaid expansion improved breast cancer screening rates among low-income women in US states. The analysis showed a significant increase in breast cancer screening adherence after implementation of Medicaid expansion programs in early adopter states.
A recent Yale University study found that black women with stage I-III cancer are less responsive to neoadjuvant chemotherapy compared to other racial groups. Despite presenting with more advanced-stage and aggressive tumors, the findings suggest biologic differences or disparities in treatment may be contributing factors.
Postmenopausal African American women who use female hormone supplements containing estrogen and progestin are at a 50% increased risk of estrogen receptor positive breast cancer. The study found greater increases in risk for recent and long-term users, highlighting the importance of limiting combination therapy.
A recent study published in Psycho-Oncology found that women with breast cancer who develop depression are at a 45% higher risk of death from all causes. The study suggests that targeted support for these individuals could improve survival rates and quality of life.
A study published in Radiology found that MRI-detected multicentric cancers are larger and potentially more aggressive than index cancers detected by mammography, necessitating treatment changes. In 25% of cases, these multicentric cancers were over 1 centimeter in size.
Researchers have successfully combined an antibody-drug conjugate with immunotherapy to treat breast cancer. The therapy has shown promising results in attacking tumor cells and improving the body's immune response.
The TransLUMINAL-B project aims to study metastasis formation in luminal breast cancers, a common type of the disease. By understanding how individual malignant cells spread through the body, researchers hope to predict prognosis and develop more targeted treatments.
Since Angelina Jolie's announcement, the number of preventative double mastectomies performed at a Manchester clinic more than doubled from January 2014 to June 2015. The increase is attributed to heightened awareness of the procedure, with many women citing Jolie as an inspiration for their own surgeries.
Researchers at Stanford University School of Medicine have identified a new class of RNA molecules that act as powerful tumor suppressors by inhibiting the cancer-causing protein KRAS. The study found that these RNAs, called SNORD50A/B, are deleted in over a quarter of common human cancers, leading to poorer survival rates for patients.
The study found that cancer metastasis is neither random nor unpredictable, with survival depending on the location of the first metastatic site. Breast cancer patients who developed metastasis in specific organs had significantly different chances of long-term survival.
Cancer researchers have developed an animal model to study and target the rare tumor angiosarcoma. By controlling mTORC1 activity, they found that blocking key targets effectively halted tumor development and growth.
A new study finds that pigeons can accurately categorize digitized microscope slides and mammograms of benign and malignant human breast tissue. With training, they perform as well as humans in this task, demonstrating a remarkable ability to perceive and process visual cues.
A new study found that pigeons can accurately distinguish between benign and malignant breast cancer slides, similar to human observers. With some training, pigeons performed just as well as humans in categorizing digitized microscope slides and mammograms of normal vs. cancerous breast tissue.
A University of Colorado Cancer Center study shows that breast cancer patients without prescription drug coverage are less likely to start and continue hormonal therapy due to high costs. Women from lower-income households were particularly affected, highlighting the need for affordable prescription coverage.
Researchers at UCLA have found a new way to reduce painful ascites, a common condition in ovarian cancer patients. The experimental drug inhibits macrophages, immune cells that help cancer spread, making the abdominal cavity less conducive to tumor growth.
A new breast cancer risk-prediction model for Hispanic women has been developed using data from the San Francisco Bay Area Breast Cancer Study. The model incorporates factors such as age at first full-term pregnancy, age at first menstrual period, history of benign breast disease, and family history of breast cancer to estimate risk.
A package of targeted priority interventions can significantly decrease the cancer burden in low-income countries by 2030 and even greater declines by 2050. The essential package includes access to opioid-based pain medications, tobacco control measures, and HPV vaccination, which are feasible, cost-effective, and affordable.
Researchers at Case Western Reserve University are creating a 'pathology image informatics platform' to analyze and share digital pathology imaging data, focusing on prostate and breast cancers. The project aims to unlock the potential of images in cancer prediction.
Researchers propose using cerebrospinal fluid as a liquid biopsy for early diagnosis, prognosis, therapeutic management, and tracking of brain cancer. Concentrations of circulating central nervous system tumor DNA are higher in CSF than in plasma.
A new study suggests that rare 'missense' mutations in the HER2 gene may not cause breast cancer growth or spread on their own. The research team found that such mutations may also fail to predict response to anti-cancer drugs targeting the HER2 gene, unlike common amplification alterations.
A new clinical trial is proposed to investigate the best ways for identifying and treating advanced breast cancer patients who can survive for long periods without their disease progressing. The guidelines emphasize the importance of harnessing technology to improve cancer treatment, particularly for patients in remote areas.
PharmaMar's novel Antibody-Drug Conjugate (ADC) MI130004 demonstrates potent anticancer activity against HER2-expressing breast, gastric, and ovarian cancers. The ADC impairs tubulin polymerization, causing mitotic failures and halting cell division in tumor cells.
Researchers found that insulin resistance is associated with a significantly worse prognosis for metastatic breast cancer patients. Lifestyle changes, such as diet and exercise, may help improve outcomes. Insulin targeting therapies could also be beneficial.
This week in BMJ Case Reports highlights the risks of accidental overdosing on herbal medicines, severe iron deficiency associated with heavy head lice infestation, and a rare complication involving a hair pin pierced through a child's kidney.
Experts discuss the impact of affordable medicines on breast cancer treatment, highlighting the importance of healthcare structures in improving patient outcomes. The lack of effective systems can negate even new, expensive treatments.
Researchers identified a key protein secreted by basal-like breast cancer cells that supports cancer stem cells. Disrupting this protein or its receptor leads to reduced CSCs and impaired tumor formation.