Articles tagged with Breast Cancer
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A new study published by Bielefeld University found that only one in three women participating in Germany's mammography screening programme (MSP) are well-informed about it. The study also showed that women with higher levels of education and those from Turkish migration backgrounds are more likely to make an informed decision.
A recent study published in International Journal of Gynecological Cancer found that protein CK5 marks ovarian cancers likely to be resistant to cisplatin. This marker could help predict and analyze platinum resistance, potentially improving treatment outcomes.
Scientists tracked breast cancer development using tumour DNA shed into bloodstream, reflecting genetic changes and treatment response. The study provides proof-of-principle for real-time monitoring of cancer, potentially reducing need for invasive biopsies.
A new study published in The Lancet found that adding ultrasound to standard mammography tests results in higher rates of detection for breast cancer in Japanese women. The J-START trial showed a sensitivity of 91% with ultrasound combined with mammography, compared to 77% for mammography alone.
Researchers found that analyzing circulating tumor DNA can track a patient's cancer evolution and identify the best treatments. The liquid biopsy test is less invasive and less costly than conventional tissue biopsies, providing up-to-date information on how a patient's cancer is changing.
Patient advocates urge medical professionals and policymakers to consider the long-term effects of advanced breast cancer treatments. They highlight the need for accessible therapies that extend patients' lives, while also addressing financial, employment, and family challenges associated with prolonged illness. Experts note that curre...
Researchers used a new method to evaluate health-care access in Appalachia, finding that insurance and geospatial access played crucial roles in late-stage diagnosis and adjuvant hormone therapy. The study suggests traditional metrics like travel times may not accurately capture the barriers faced by patients.
Mathematicians at Duke University develop a method to compare common tumor growth models using only two time-point measurements of tumor size. The results suggest breast and liver tumors grow exponentially, while neurological tumors follow the two-thirds power law.
A recent study found that antiangiogenic breast cancer treatment primarily benefits patients with highly perfused tumors. The treatment reduced pressure within tumors and improved blood vessel density, but its effectiveness depends on the tumor's microvascular density before treatment.
Researchers found that tumor RNA carried in platelets can distinguish among healthy individuals and those with six types of cancer, determine the primary tumor location and identify therapeutic approaches. Platelet RNA signatures provide valuable information on tumor type and guide treatment selection.
Breast cancer incidence rates have increased among African American women, converging with those of white women. The rise is attributed to ER positive breast cancers and may reflect rising obesity rates. Black women are more likely to be diagnosed at later stages and have poorer survival rates due to lack of access to timely treatment.
Research review finds no consistent evidence that antidepressants increase bleeding, breast cancer, or other adverse outcomes in patients undergoing plastic surgery. However, the underlying depression may pose a risk to postoperative problems. Plastic surgeons should consider the impact of depression on surgical complications.
Researchers have identified a new cancer-predisposing gene, SEC23B, associated with thyroid cancer and Cowden syndrome. This gene is involved in protein transport within cells and has been found to promote aggressive growth of thyroid cells.
Regular physical activity can help women at high risk of breast cancer delay drastic measures by reducing estrogen-sensitive breast tissue. Women who engage in 30-60 minutes of aerobic exercise per day for five days a week may experience a 10% drop in estrogen-sensitive breast tissue over 100 minutes of exercise.
Researchers have discovered a genomic molecular fingerprint, signature 3, that highlights certain gastric cancers susceptible to treatment with platinum drugs or PARP inhibitor drugs. This biomarker could guide targeted therapy for breast, ovarian and pancreatic cancers as well.
Ahnna Parkhurst, a 15-year-old racing prodigy, is raising awareness and research dollars for the Translational Genomics Research Institute (TGen) through Laurie's Fund. Her efforts have raised over $111,000 to support cancer research and treatments.
Despite progress, cancer care in Latin America remains hindered by significant gaps in public expenditure on health and cancer care. The region still faces major challenges, including limited palliative care services, inadequate training in pain management, and underutilization of new technologies.
The FDA has approved talimogene laherparepvec (T-VEC), a herpes cold sore virus designed to kill tumor cells, as a treatment for late-stage melanoma. The therapy showed a durable response in 16% of patients, with some experiencing no signs of cancer after treatment.
A new meta-analysis shows breastfeeding is associated with a lower risk of developing hormone-receptor negative breast cancer. Women who breastfed had a reduced risk of up to 20%, making it a protective strategy against the most aggressive subtypes.
Scientists from Van Andel Research Institute found that cabozantinib inhibits growth of triple-negative breast cancer subtypes and impedes progression by targeting the MET protein. This new therapy shows promise for treating this aggressive form of breast cancer.
Researchers developed a new method to grow 3D pancreatic tumor cultures from patients' surgical tissue, recreating the patient's cancer biology and morphology. This approach can help identify patient-specific sensitivities to novel therapeutics and assist in making treatment decisions.
A new study suggests that lower doses of parabens, commonly found in personal care products, may stimulate breast cancer cell growth at concentrations 100 times lower than previously thought. The researchers also found that parabens can interact with other agents to increase breast cancer risk.
Researchers at Columbia University and others present an alternative approach, Partition Retention, which displays strong power in prediction. This method identifies highly predictive variables that are not statistically significant, reducing prediction error rates from 30% to 8% for breast cancer gene analysis.
Researchers have developed a hand-held optical scanner that can image breast tissues in real time, offering benefits over mammography without ionizing radiation. The device uses near-infrared laser diode source to map optical absorption, which may indicate higher blood flow due to abnormalities like tumors.
A recent study by Allina Health found that most breast cancer patients with invasive lobular carcinoma can be treated with hormones alone, reducing treatment time, cost, and side effects. The study identified a model that predicts recurrence risk using characteristics such as progesterone receptor expression and patient age.
A study published in the Journal of the American College of Radiology describes a successful intervention to decrease anxiety related to mammography, increasing breast cancer screening rates. The study found that information about the logistics and outcomes of mammography reduced anxiety and improved understanding among participants.
Researchers found that mice with BRCA1 mutations exhibited enhanced responsiveness to male scent, which stimulated their estrous cycles and ovary function. This discovery suggests a potential indirect link between sense of smell and breast, ovarian cancer risk in women carrying BRCA1 mutations.
A study found that low BRCA1 protein expression in glioblastoma tumors correlates with longer overall survival, suggesting a potential predictive biomarker for treatment responses to DNA-damaging therapies.
A new test predicts whether breast cancer will spread to the brain by analyzing high activity in a particular gene called alpha beta-crystallin. Women with aggressive forms of breast cancer are three times more likely to develop secondary brain tumors if they test positive.
Researchers developed a new tumor marker test that may predict breast cancer spread to the brain, based on alpha B-crystallin levels in breast tumors. The test found nearly three times higher likelihood of brain metastasis in women with alpha B-crystallin expression.
A new study suggests that postmenopausal women may be safely screened every two years, while premenopausal women over 40 may benefit from annual mammograms to increase early detection. The research also highlights the importance of considering menopausal status rather than age when determining screening intervals.
A study of over 869 pre-teen girls found that those from families with a history of breast cancer or genetic mutations did not show increased signs of anxiety and depression. However, they did express more worry about breast cancer, suggesting a potential benefit of early education about risk.
A recent study found that premenopausal women who received annual mammography screenings had smaller and less advanced tumors compared to those who received biennial screenings. In contrast, postmenopausal women did not show significant differences in tumor characteristics regardless of screening frequency.
The American Cancer Society recommends starting annual mammography screening at age 45 for average-risk women. Women between 40-44 can choose to begin annual screening. Clinical breast examination is no longer recommended due to lack of clear evidence on its effectiveness in detecting breast cancer.
Breast cancer researcher Dr Michalak aims to understand how normal and cancerous cells develop in the breast to identify suspicious tumors and develop better treatments. Her study focuses on epigenetic modifiers, which can influence DNA behavior, and may hold clues to preventing tumor spread.
Researchers have identified distinct microbial signatures in triple negative breast cancer tissue, suggesting potential diagnostic and therapeutic applications. The study found a predominantly viral and bacterial signature, with some fungi and parasites also present.
The Columbia Mailman School and Columbia University Medical Center site will focus on prevention and expand the study of risk factors that precede breast cancer. The researchers aim to understand the role of genetic and environmental factors in modifying breast cancer risk.
The UI Cancer Center and Governors State University have received a joint grant to conduct community-based research on reducing cancer-related health disparities in the region's south suburbs. The program will provide training for GSU junior faculty and support minority undergraduate and graduate students in health disparities research.
African-American women are more likely to develop aggressive breast cancer subtypes and receive substandard care compared to non-Hispanic white women. Minority women also experience disparities in treatment across all breast cancer stages, with significant differences in diagnosis timing and treatment approaches.
A study of 1533 cancer survivors revealed poor adherence to dietary guidelines, with lower intakes of fiber, vitamins, and minerals, but higher intakes of empty calories. Diet quality improved with age and education level.
Scientists discovered a malaria protein that targets sugar molecules found in placentas and most cancers, leading to the development of an anti-cancer drug. The new approach halted tumour growth in mice and showed promising results in treating non-Hodgkin's lymphoma, prostate cancer, and metastatic breast cancer.
Researchers discovered a malaria protein that binds to a common sugar molecule found on both placentas and cancer cells. A novel technology was developed to arm antibodies with high potency toxins to specifically kill cancer cells, showing promising results in clinical trials.
A five-year, $4.15 million grant will investigate how a high-fat diet interacts with common sunscreen chemicals like BP-3, which may mimic estrogen and increase breast cancer risk. The study aims to identify predictive markers for increased breast cancer susceptibility and develop prevention strategies.
Researchers at the University of York have discovered a specific sodium channel, Nav1.5, that indicates cancer cells and affects tumor growth rates in breast cancer patients. The study found higher levels of Nav1.5 in tumour cells compared to normal breast tissue.
Researchers discovered elephants have 38 additional modified copies of the p53 gene, which encodes a well-defined tumor suppressor. This unique genetic feature may protect elephants from cancer by enhancing their ability to kill damaged cells.
The Breast Cancer and the Environment Research Program is expanding its focus to prevention, involving new communities and studying risk factors like breast density. Researchers will explore links between environmental exposures and high breast density, aiming to identify new insights into prevention.
A novel two-hit therapy combining an immune-molecule-based mop-up therapy with a pathway-disabling approach eradicates specific breast tumors in mice. This therapy has the potential to reduce treatment costs and increase effectiveness for Her2-positive breast cancers.
A team of Singaporean scientists has identified the genetic landscape of fibroepithelial breast tumors, revealing how they progress from benign to cancerous types. The study's findings may improve diagnostic accuracy and enhance clinical intervention for patients with these tumors.
Researchers at Ohio State University suggest new ways to treat cancer by inhibiting overactive cancer-promoting genes and enhancing sluggish tumor-suppressor genes. The findings, published in Nature Communications and Nature Genetics, provide insights into the role of glucocorticoid receptors and epigenetic marks in cancer development.
Researchers found that a tolerant immune system, characterized by high levels of regulatory T cells, increases the risk of certain types of cancer. The study analyzed blood samples from EPIC participants with cancer and controls, revealing a strong link between immunotolerance and increased lung and colon cancer risks.
A study of 173,797 female breast cancer patients found that catching cancers when they are small makes a difference to survival, even with modern therapies. Traditional factors such as tumour size and lymph node status have a significant influence on overall mortality independent of age and tumour biology.
A study identified significant DNA differences in the human kallikrein cluster among Eastern Asian populations, including those related to KLK4 gene activity. These findings may contribute to unique dental traits and a lower risk of skin conditions like eczema.
A predictive model that measures invasiveness facilitated by macrophages from each individual donor has been developed to guide treatment options for breast cancer. The model correlates the level of invasion through a collagen gel to chemical signals expressed by macrophages, providing an invasiveness index for each patient.
A large-scale Swedish study has discovered a link between height and cancer risk in both men and women. The research found that taller individuals have an increased risk of developing certain types of cancer, including breast cancer and melanoma, with the risk increasing by up to 30% per 10 cm of height.
A new pan-Canadian Dream Team, led by Tak W. Mak and Samuel Aparicio, will research novel approaches to treating aggressive breast cancers. The team aims to develop new therapies targeting genetic instability in tumor cells.
A team of researchers found specific variations in RNA splicing that may play a role in converting normal breast cells into tumors. The study identifies potential targets for therapies in some forms of breast cancer.
Researchers discovered genetic alterations in healthy breast cells associated with an increased risk of non-familial breast cancer. These findings can be used for future improvements in diagnostics to identify women at high risk before the tumor forms.
Researchers found no correlation between breast cancer's different structures and chromosomal abnormalities, challenging the idea that genetic mutations drive tumor heterogeneity. Instead, they discovered specific genes contributing to each structure's formation, suggesting alternative mechanisms driving morphological diversity.
A review article discusses the issues of overdiagnosis and overtreatment in breast cancer screening, highlighting the benefits of newer technologies like breast tomosynthesis. The study finds that this technology reduces false recall rates by 15-30% while increasing cancer detection rates by about 29%.
A major study published in the New England Journal of Medicine has identified a 21-gene test that can determine which breast cancer patients can safely avoid chemotherapy. The test, called Oncotype DX Recurrence Score, analyzes tumor samples and assigns scores between 0-100, indicating the risk of cancer recurrence.