Articles tagged with Breast Cancer
Women with a history of false-positive mammogram results may be at increased risk of developing breast cancer for up to 10 years after the initial false-positive result. A new study found that women who received a false-positive result had a 39% higher risk of subsequent breast cancer compared to those with true-negative results.
A feasibility study found that women with breast cancer experienced improved feelings of positivity, control, and meaning after tending small indoor 'garden bowls'. The benefits were attributed to the process of nurturing and reflecting on the garden, suggesting a simple ecotherapy-based intervention can have significant impacts.
A large Kaiser Permanente study contradicts previous concerns that antidepressants reduce tamoxifen's effectiveness in lowering subsequent breast-cancer risk. Researchers found no increased risk of recurrence among women who took antidepressants with tamoxifen.
Researchers at National Research Tomsk State University found that neoadjuvant chemotherapy can stimulate evolution of the tumor, leading to resistance and metastasis. The study analyzed biopsies from women with breast cancer before and after surgery, revealing a 23% increase in new tumor formation.
A randomized trial shows that cognitive-behavioral stress management improves survival and lengthens time to recurrence in women diagnosed with breast cancer. Women who received stress management training experienced greater length of survival and longer time till disease recurrence over eight to 15 years after diagnosis.
A study presented at the Radiological Society of North America meeting found that Medicaid expansion improved breast cancer screening rates among low-income women in US states. The analysis showed a significant increase in breast cancer screening adherence after implementation of Medicaid expansion programs in early adopter states.
A recent Yale University study found that black women with stage I-III cancer are less responsive to neoadjuvant chemotherapy compared to other racial groups. Despite presenting with more advanced-stage and aggressive tumors, the findings suggest biologic differences or disparities in treatment may be contributing factors.
Postmenopausal African American women who use female hormone supplements containing estrogen and progestin are at a 50% increased risk of estrogen receptor positive breast cancer. The study found greater increases in risk for recent and long-term users, highlighting the importance of limiting combination therapy.
A recent study published in Psycho-Oncology found that women with breast cancer who develop depression are at a 45% higher risk of death from all causes. The study suggests that targeted support for these individuals could improve survival rates and quality of life.
A study published in Radiology found that MRI-detected multicentric cancers are larger and potentially more aggressive than index cancers detected by mammography, necessitating treatment changes. In 25% of cases, these multicentric cancers were over 1 centimeter in size.
Researchers have successfully combined an antibody-drug conjugate with immunotherapy to treat breast cancer. The therapy has shown promising results in attacking tumor cells and improving the body's immune response.
The TransLUMINAL-B project aims to study metastasis formation in luminal breast cancers, a common type of the disease. By understanding how individual malignant cells spread through the body, researchers hope to predict prognosis and develop more targeted treatments.
Since Angelina Jolie's announcement, the number of preventative double mastectomies performed at a Manchester clinic more than doubled from January 2014 to June 2015. The increase is attributed to heightened awareness of the procedure, with many women citing Jolie as an inspiration for their own surgeries.
Researchers at Stanford University School of Medicine have identified a new class of RNA molecules that act as powerful tumor suppressors by inhibiting the cancer-causing protein KRAS. The study found that these RNAs, called SNORD50A/B, are deleted in over a quarter of common human cancers, leading to poorer survival rates for patients.
The study found that cancer metastasis is neither random nor unpredictable, with survival depending on the location of the first metastatic site. Breast cancer patients who developed metastasis in specific organs had significantly different chances of long-term survival.
Cancer researchers have developed an animal model to study and target the rare tumor angiosarcoma. By controlling mTORC1 activity, they found that blocking key targets effectively halted tumor development and growth.
A new study finds that pigeons can accurately categorize digitized microscope slides and mammograms of benign and malignant human breast tissue. With training, they perform as well as humans in this task, demonstrating a remarkable ability to perceive and process visual cues.
A new study found that pigeons can accurately distinguish between benign and malignant breast cancer slides, similar to human observers. With some training, pigeons performed just as well as humans in categorizing digitized microscope slides and mammograms of normal vs. cancerous breast tissue.
A University of Colorado Cancer Center study shows that breast cancer patients without prescription drug coverage are less likely to start and continue hormonal therapy due to high costs. Women from lower-income households were particularly affected, highlighting the need for affordable prescription coverage.
Researchers at UCLA have found a new way to reduce painful ascites, a common condition in ovarian cancer patients. The experimental drug inhibits macrophages, immune cells that help cancer spread, making the abdominal cavity less conducive to tumor growth.
A new breast cancer risk-prediction model for Hispanic women has been developed using data from the San Francisco Bay Area Breast Cancer Study. The model incorporates factors such as age at first full-term pregnancy, age at first menstrual period, history of benign breast disease, and family history of breast cancer to estimate risk.
A package of targeted priority interventions can significantly decrease the cancer burden in low-income countries by 2030 and even greater declines by 2050. The essential package includes access to opioid-based pain medications, tobacco control measures, and HPV vaccination, which are feasible, cost-effective, and affordable.
Researchers at Case Western Reserve University are creating a 'pathology image informatics platform' to analyze and share digital pathology imaging data, focusing on prostate and breast cancers. The project aims to unlock the potential of images in cancer prediction.
Researchers propose using cerebrospinal fluid as a liquid biopsy for early diagnosis, prognosis, therapeutic management, and tracking of brain cancer. Concentrations of circulating central nervous system tumor DNA are higher in CSF than in plasma.
A new study suggests that rare 'missense' mutations in the HER2 gene may not cause breast cancer growth or spread on their own. The research team found that such mutations may also fail to predict response to anti-cancer drugs targeting the HER2 gene, unlike common amplification alterations.
A new clinical trial is proposed to investigate the best ways for identifying and treating advanced breast cancer patients who can survive for long periods without their disease progressing. The guidelines emphasize the importance of harnessing technology to improve cancer treatment, particularly for patients in remote areas.
PharmaMar's novel Antibody-Drug Conjugate (ADC) MI130004 demonstrates potent anticancer activity against HER2-expressing breast, gastric, and ovarian cancers. The ADC impairs tubulin polymerization, causing mitotic failures and halting cell division in tumor cells.
Researchers found that insulin resistance is associated with a significantly worse prognosis for metastatic breast cancer patients. Lifestyle changes, such as diet and exercise, may help improve outcomes. Insulin targeting therapies could also be beneficial.
This week in BMJ Case Reports highlights the risks of accidental overdosing on herbal medicines, severe iron deficiency associated with heavy head lice infestation, and a rare complication involving a hair pin pierced through a child's kidney.
Experts discuss the impact of affordable medicines on breast cancer treatment, highlighting the importance of healthcare structures in improving patient outcomes. The lack of effective systems can negate even new, expensive treatments.
Researchers identified a key protein secreted by basal-like breast cancer cells that supports cancer stem cells. Disrupting this protein or its receptor leads to reduced CSCs and impaired tumor formation.
A new study published by Bielefeld University found that only one in three women participating in Germany's mammography screening programme (MSP) are well-informed about it. The study also showed that women with higher levels of education and those from Turkish migration backgrounds are more likely to make an informed decision.
A recent study published in International Journal of Gynecological Cancer found that protein CK5 marks ovarian cancers likely to be resistant to cisplatin. This marker could help predict and analyze platinum resistance, potentially improving treatment outcomes.
Scientists tracked breast cancer development using tumour DNA shed into bloodstream, reflecting genetic changes and treatment response. The study provides proof-of-principle for real-time monitoring of cancer, potentially reducing need for invasive biopsies.
A new study published in The Lancet found that adding ultrasound to standard mammography tests results in higher rates of detection for breast cancer in Japanese women. The J-START trial showed a sensitivity of 91% with ultrasound combined with mammography, compared to 77% for mammography alone.
Researchers found that analyzing circulating tumor DNA can track a patient's cancer evolution and identify the best treatments. The liquid biopsy test is less invasive and less costly than conventional tissue biopsies, providing up-to-date information on how a patient's cancer is changing.
Patient advocates urge medical professionals and policymakers to consider the long-term effects of advanced breast cancer treatments. They highlight the need for accessible therapies that extend patients' lives, while also addressing financial, employment, and family challenges associated with prolonged illness. Experts note that curre...
Researchers used a new method to evaluate health-care access in Appalachia, finding that insurance and geospatial access played crucial roles in late-stage diagnosis and adjuvant hormone therapy. The study suggests traditional metrics like travel times may not accurately capture the barriers faced by patients.
Mathematicians at Duke University develop a method to compare common tumor growth models using only two time-point measurements of tumor size. The results suggest breast and liver tumors grow exponentially, while neurological tumors follow the two-thirds power law.
A recent study found that antiangiogenic breast cancer treatment primarily benefits patients with highly perfused tumors. The treatment reduced pressure within tumors and improved blood vessel density, but its effectiveness depends on the tumor's microvascular density before treatment.
Researchers found that tumor RNA carried in platelets can distinguish among healthy individuals and those with six types of cancer, determine the primary tumor location and identify therapeutic approaches. Platelet RNA signatures provide valuable information on tumor type and guide treatment selection.
Breast cancer incidence rates have increased among African American women, converging with those of white women. The rise is attributed to ER positive breast cancers and may reflect rising obesity rates. Black women are more likely to be diagnosed at later stages and have poorer survival rates due to lack of access to timely treatment.
Research review finds no consistent evidence that antidepressants increase bleeding, breast cancer, or other adverse outcomes in patients undergoing plastic surgery. However, the underlying depression may pose a risk to postoperative problems. Plastic surgeons should consider the impact of depression on surgical complications.
Researchers have identified a new cancer-predisposing gene, SEC23B, associated with thyroid cancer and Cowden syndrome. This gene is involved in protein transport within cells and has been found to promote aggressive growth of thyroid cells.
Regular physical activity can help women at high risk of breast cancer delay drastic measures by reducing estrogen-sensitive breast tissue. Women who engage in 30-60 minutes of aerobic exercise per day for five days a week may experience a 10% drop in estrogen-sensitive breast tissue over 100 minutes of exercise.
Researchers have discovered a genomic molecular fingerprint, signature 3, that highlights certain gastric cancers susceptible to treatment with platinum drugs or PARP inhibitor drugs. This biomarker could guide targeted therapy for breast, ovarian and pancreatic cancers as well.
Ahnna Parkhurst, a 15-year-old racing prodigy, is raising awareness and research dollars for the Translational Genomics Research Institute (TGen) through Laurie's Fund. Her efforts have raised over $111,000 to support cancer research and treatments.
Despite progress, cancer care in Latin America remains hindered by significant gaps in public expenditure on health and cancer care. The region still faces major challenges, including limited palliative care services, inadequate training in pain management, and underutilization of new technologies.
The FDA has approved talimogene laherparepvec (T-VEC), a herpes cold sore virus designed to kill tumor cells, as a treatment for late-stage melanoma. The therapy showed a durable response in 16% of patients, with some experiencing no signs of cancer after treatment.
A new meta-analysis shows breastfeeding is associated with a lower risk of developing hormone-receptor negative breast cancer. Women who breastfed had a reduced risk of up to 20%, making it a protective strategy against the most aggressive subtypes.
Scientists from Van Andel Research Institute found that cabozantinib inhibits growth of triple-negative breast cancer subtypes and impedes progression by targeting the MET protein. This new therapy shows promise for treating this aggressive form of breast cancer.
Researchers developed a new method to grow 3D pancreatic tumor cultures from patients' surgical tissue, recreating the patient's cancer biology and morphology. This approach can help identify patient-specific sensitivities to novel therapeutics and assist in making treatment decisions.
A new study suggests that lower doses of parabens, commonly found in personal care products, may stimulate breast cancer cell growth at concentrations 100 times lower than previously thought. The researchers also found that parabens can interact with other agents to increase breast cancer risk.
Researchers at Columbia University and others present an alternative approach, Partition Retention, which displays strong power in prediction. This method identifies highly predictive variables that are not statistically significant, reducing prediction error rates from 30% to 8% for breast cancer gene analysis.
Researchers have developed a hand-held optical scanner that can image breast tissues in real time, offering benefits over mammography without ionizing radiation. The device uses near-infrared laser diode source to map optical absorption, which may indicate higher blood flow due to abnormalities like tumors.
A recent study by Allina Health found that most breast cancer patients with invasive lobular carcinoma can be treated with hormones alone, reducing treatment time, cost, and side effects. The study identified a model that predicts recurrence risk using characteristics such as progesterone receptor expression and patient age.
A study published in the Journal of the American College of Radiology describes a successful intervention to decrease anxiety related to mammography, increasing breast cancer screening rates. The study found that information about the logistics and outcomes of mammography reduced anxiety and improved understanding among participants.
Researchers found that mice with BRCA1 mutations exhibited enhanced responsiveness to male scent, which stimulated their estrous cycles and ovary function. This discovery suggests a potential indirect link between sense of smell and breast, ovarian cancer risk in women carrying BRCA1 mutations.
A study found that low BRCA1 protein expression in glioblastoma tumors correlates with longer overall survival, suggesting a potential predictive biomarker for treatment responses to DNA-damaging therapies.
A new test predicts whether breast cancer will spread to the brain by analyzing high activity in a particular gene called alpha beta-crystallin. Women with aggressive forms of breast cancer are three times more likely to develop secondary brain tumors if they test positive.