Articles tagged with Breast Cancer
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Researchers at Case Western Reserve University have developed a magnetic resonance imaging (MRI) contrast agent that can detect small aggressive breast cancer tumors and micrometastases. The agent binds to molecular markers expressed in high-risk primary tumors and metastases, generating increased image contrast.
Researchers identified a unique doorway in the blood vessel wall that allows breast cancer cells to spread to other parts of the body. The discovery could lead to new treatments and better predict whether breast cancer will spread.
Two studies found hypofractionated radiation therapy to have substantially lower rates of acute and short-term toxic effects compared to conventionally fractionated therapy, with improved patient-reported outcomes. The treatment also showed comparable tumor control and lower costs.
Women with early-stage breast cancer who receive a shorter course of whole breast radiation therapy experience less toxicity and improved quality of life compared to those who undergo a longer course of treatment. The study suggests that hypofractionated treatment should be considered as a starting point for discussion between patients...
Researchers at Duke University have successfully packaged a widely used cancer drug into nanoparticles, more than doubling its effectiveness in mice. The new approach delivers the drug directly to tumors while reducing side effects and improving targeting, showing transformative results for patients.
A new Cancer Research UK study reveals that England's cancer survival rates remain lower than those of countries with similar healthcare systems, despite steady improvements. The study found five-year survival from breast cancer improved more in England than in four leading countries, but overall cancer survival was lowest in England.
The study found that regional node irradiation had a marginal impact on overall survival for patients with stage I, II, or III breast cancer. This was accompanied by improved disease-free and distant-disease-free survival rates, but long-term radiation effects remain unknown.
Researchers at Boston University School of Medicine have identified a new molecule named IL13RA2 as a potential marker for metastatic basal-like breast cancer (BLBC). The discovery suggests that targeting this molecule could slow tumor growth and spread, offering a glimmer of hope for patients with this aggressive form of breast cancer.
Breast cancer researchers have gained new insights into the phases of tumor growth by visualizing and quantifying tumor development in real-time. The study reveals that tumors undergo a dramatic increase in cell number after four weeks, providing valuable information for treatment selection and delivery.
A new approach to breast cancer surgery and reconstruction combines nipple-sparing mastectomy with immediate single-stage implant (SSI) breast reconstruction. This combined procedure, also known as the 'one and done' approach, offers important psychological benefits for patients, including an immediate return to normal body image.
A Pitt study reveals how ancient proteins like RAD51 paralogues repair damaged DNA and their potential role in tumor development. The findings suggest that targeting these proteins could be a way to tailor cancer therapies.
A study has identified a novel microRNA, miR-181a-5p, as a potential diagnostic breast cancer biomarker in the blood. The use of Droplet Digital PCR technology enabled the accurate quantification of this miRNA, which showed significant downregulation in the serum of patients with breast cancer.
A study by Moffitt researchers found significant economic and health disparities in the LGBTQ community, including higher rates of poverty, lack of health services, and certain types of cancer. The study highlights the need for increased awareness and targeted interventions to address these disparities.
Researchers found that breast cancer survivors who used liquid lidocaine on the vulvar vestibule experienced reduced pain and improved sexual function. The study's results suggest that this non-invasive treatment could alleviate physical and emotional pain associated with sex, making it more enjoyable for both individuals.
Two classes of inexpensive generic drugs, aromatase inhibitors and bisphosphonates, have been shown to improve survival prospects for postmenopausal women with early breast cancer. The combination of the two types of drug may also increase benefits while decreasing some side-effects.
A major study of over 30,000 women shows that aromatase inhibitors substantially reduce the risk of death from ER-positive breast cancer. Taking aromatase inhibitors for five years reduces the risk of death by 40% compared to tamoxifen.
A recent study published in Nature Communications found that genetic variation in the gene FOPNL is associated with poorer survival rates in multiple myeloma patients. The study, which included over 1,600 patients from North America and Europe, identified a significant link between the FOPNL variant and reduced survival.
A study found that additional radiation to lymph nodes reduces breast cancer recurrence, but does not increase overall survival. The treatment was associated with limited toxicity and is recommended for women with axillary node-positive or high-risk node-negative breast cancer.
A new study by Georgia State University researchers found that state regulations significantly influence when patients receive cancer diagnoses, particularly among people under 65. The study suggests that where people live is a strong predictor of whether they will receive potentially life-saving cancer screenings.
A new mouse model has provided early causal evidence that weekly alternating light-dark cycles may hasten certain health risks, including breast cancer development and weight gain. The study found that mice with a genetic predisposition to breast cancer developed tumors 8 weeks earlier when exposed to the alternative light-dark cycles.
A study by North Carolina State University found that Angelina Jolie's announcement about her BRCA1 gene testing led to increased intentions among women to get tested for the same gene. Women who identified with Jolie or felt a parasocial relationship with her were more likely to consider genetic testing.
A new study by MD Anderson researchers found that protein 14-3-3 sigma opposes and reverses tumor-promoting metabolic programs in breast cancer. The study revealed that 14-3-3 sigma suppresses cancer glycosis, preventing tumors from converting glucose into pyruvate.
A study published in Cancer Epidemiology, Biomarkers & Prevention found that breast cancer survivors gained an average of 3.81 pounds more than cancer-free women within five years of diagnosis and treatment. Chemotherapy treatment was also significantly associated with weight gain, particularly among those treated recently.
A study by Johns Hopkins Kimmel Cancer Center researchers found that breast cancer survivors, particularly those with a family history of the disease, gained significantly more weight over four years compared to cancer-free women. The study also revealed that chemotherapy may be a contributing factor to weight gain among survivors.
A new study from Lund University found a significant correlation between low levels of the anti-stress hormone enkephalin and an increased risk of breast cancer. Women with the lowest levels of the hormone had a risk more than three times that of those with the highest levels.
A new NCI-funded study will investigate the impact of a meditation-based stress reduction program on cognitive impairment in breast cancer survivors. Researchers will assess the intervention's effects on objective and subjective cognitive functioning among 300 participants.
Scientists designed nanoparticles that release chemotherapy drugs paclitaxel in the presence of matrix metalloproteinases (MMPs), which enable cancer metastasis. The system effectively delivers high doses of the drug, halting tumor growth and reducing toxicity.
A new study found that longer periods of leisure time sitting were associated with a higher risk of total cancer risk in women, as well as increased risk of multiple myeloma, invasive breast cancer, and ovarian cancer. The association was not observed in men.
A groundbreaking online registry, Research for Her, has shown to enroll study participants more quickly than traditional paper-based registries. The Cedars-Sinai program has seen a 4.3 fold increase in registrations over a 14-month period, with an additional 50% boost in enrollment for the Gilda Radner Hereditary Cancer Program.
Researcher Laura Vandenberg is studying the role of BPS, an estrogen-mimicking chemical found in plastics and food packaging, on breast cancer risk. Exposure to these chemicals in the womb may increase breast cancer risk decades later.
Two studies examined end-of-life care for teens and young adults with cancer, finding that 68% received at least one medically intensive measure. Advances in care planning, such as durable power of attorney assignment and living wills, have increased over the past decade.
A new technique developed at the University of Adelaide has provided a unique insight into hormone regulation of breast cancers, leading to potential new treatments. The research discovered how receptors interact with DNA to control growth, shedding light on progesterone's role in hormone-driven breast cancer.
A recent study published in Nature has revealed that adding the female hormone progesterone to treatment could benefit around half of all breast cancer patients. The research, led by Cancer Research UK, showed how the progesterone receptor 'talks' to oestrogen receptors in breast cancer cells, ultimately slowing down tumour growth.
Researchers will investigate the function of MED1 and its pathways in cancer stem cell formation of HER2-driven tumors, with the goal of intervening for possible cancer therapy. They aim to develop new therapies targeting MED1 and HER2 for patients with HER2 and estrogen receptor positive breast cancer.
A review of randomised trials on cancer screening finds that mammographic screening may not reduce breast cancer mortality as expected. The study suggests that the benefits of mammography screening are likely to have been overestimated due to an unconventional statistical method used in earlier trials.
A study found that increased screening mammography was associated with more diagnoses of small breast cancers, but not significant changes in mortality or larger cancer incidence, suggesting overdiagnosis
Scientists at the University of Leeds discovered a new protein, DOCK4, that triggers blood vessel growth in breast cancer tumors. Withholding this protein slows tumor growth by impeding blood vessel formation.
MD Anderson researchers discovered a breast tumor marker that predicts metastasis by analyzing the gene expression signature of mouse embryos. Tumors with similar signatures to six-day-old embryos were more prone to metastasize than those with adult-like signatures.
Ghajar is investigating two approaches: keeping dormant cells asleep or destroying them altogether to prevent breast cancer metastasis. He aims to identify factors that keep cells asleep and profile molecules that mediate chemo resistance, potentially providing a lasting cure for cancer patients.
Pre-menopausal smokers with breast cancer are at a higher risk of dying from the disease and any cause, according to a new study. The research found that smoking can impact breast cancer survival rates, especially among women whose cancers express estrogen receptors.
A study of 197 patients with breast cancer found that more selective use of biomarker testing could save up to $117 million annually. Testing larger excisional biopsies instead of reflexively testing smaller core biopsies would help pick up tumors eligible for targeted therapy, reducing unnecessary costs.
A study found that 86% of women with early-stage breast cancer in Ontario underwent imaging to detect metastatic cancer, despite international guidelines recommending against it. The use of advanced imaging increased and varied by geographic region and hospital type, highlighting a need for improved knowledge translation strategies.
Researchers found that stress hormones, including glucocorticoids used to treat chemotherapy side effects, can stimulate growth of breast cancer cells resistant to anti-estrogen therapy. However, adding prolactin may prevent this expansion, offering a potential countermeasure.
A new study found that higher levels of soluble TNF receptor type two (sTNF-RII) are linked to reduced memory performance among breast cancer patients before treatment. Memory impairment was observed in patients compared to age-matched control subjects.
A study by Moffitt Cancer Center researchers highlights the need for stress management tools for Latina women undergoing chemotherapy for breast cancer. Despite facing significant stress-inducing factors, many patients reported a lack of access to these resources.
A new study uses massively parallel gene function assays to characterize nearly 2000 BRCA1 variants, providing a potential solution for sorting out harmful and harmless variants. The approach demonstrates promise but is not yet ready for use in the clinic.
The study found that breast-conserving therapy (BCT) is being used more widely, with a steady increase in rates over the last 13 years. However, disparities persist, particularly among patients without insurance or those living far from treatment facilities.
The percentage of patients with early-stage breast cancer undergoing breast-conserving therapy increased from 54.3% in 1998 to 60.1% in 2011, despite socioeconomic barriers persisting. The use of BCT was higher among patients with private insurance and those living closer to treatment facilities.
A study by researchers at Lund University found that high levels of ALK1 protein in blood vessels increase the risk of metastases. The drug Dalantercept can prevent this spread by blocking ALK1, offering new hope for breast cancer patients.
Women exposed to higher levels of DDT in utero were nearly four times more likely to be diagnosed with breast cancer as adults. Elevated o,p'-DDT levels were associated with a nearly four-fold increase in the daughter's risk of breast cancer.
A recent study by MD Anderson researchers identified DAPK1 as a novel therapeutic target for breast and other cancers with TP53 mutations. High levels of DAPK1 are associated with poor prognosis and increased cancer growth in these tumors.
Researchers found that high levels of ALK1 protein in breast tumor vasculature correlate with increased risk of metastatic disease. An investigational drug targeting ALK1 prevented disease spread in preclinical studies, offering a potential new therapeutic approach for treating metastatic breast cancer.
Researchers at Helmholtz Munich developed an assay to rebuild mammary gland tissue architecture using human breast epithelial cells. The mini-mammary glands exhibit properties similar to those of aggressive breast cancer cells, suggesting a link between normal breast stem cell function and tumor progression.
A large-scale analysis found that postmenopausal women who were overweight and obese had a higher risk of invasive breast cancer compared to those of normal weight. The study, published in JAMA Oncology, suggests that obesity may contribute to an increased risk of breast cancer.
A lab study found that daily aspirin was effective at blocking breast tumor growth. Aspirin appears to affect cancer stem cells, preventing them from reproducing. Experts recommend consulting a doctor before starting a daily aspirin regimen due to potential risks and side effects.
A recent study found that pre-diagnostic short sleep duration and frequent snoring are associated with significantly poorer cancer-specific survival rates among women with breast cancer. The research suggests that improving sleep patterns may motivate and empower cancer patients to enhance their survival rates.
Researchers at the University of Edinburgh discovered a trigger that allows breast cancer cells to spread to the lungs. Blocking these signals in mice significantly reduces secondary tumor formation. The study's findings may lead to new treatments to stop breast cancer progression.
Researchers discovered that TLR4 can function as a growth suppressor in wild-type TP53 cells but promotes growth in TP53 mutant cells. This balance affects survival rates and treatment outcomes.
Screening for colorectal cancer increased among lower-income and least-educated adults following the Affordable Care Act's removal of cost-sharing provisions. This increase was observed, particularly among Medicare-insured individuals, suggesting that ACA's provision may have contributed to the rise in screening rates.
Women who attend breast cancer screening between ages 50-69 have a 40% reduced risk of dying from breast cancer. Regular screening is also associated with a 23% risk reduction, resulting in approximately eight deaths prevented per 1,000 women regularly attending screening.