Articles tagged with Breast Cancer
A new study shows that a small implantable device can attract and capture malignant cells in breast cancer patients, potentially giving doctors earlier warnings of relapse. The device exploits the natural attraction of cancer cells to specific areas of the body, slowing down their spread to other organs.
A new report finds breast cancer incidence is increasing in many low- and middle-income countries, while death rates are decreasing in most high-income countries. The study suggests that economic development and urbanization may be contributing factors to the rising incidence rates.
Two studies suggest alternative prevention strategies may render surgery unnecessary for women at high risk of breast and ovarian cancer. Researchers identify a new target to decrease breast cancer risk by blocking the effects of RANKL with OPG.
Researchers found that luteolin can inhibit growth of human breast cancer cells and reduce blood vessel formation, a promising alternative for postmenopausal women at increased risk. The study suggests luteolin may be effective in reducing breast cancer risk when administered through IV supplements.
A new NIH-funded study launched at UH Seidman Cancer Center aims to investigate the effects of physical activity on functional status, body composition, and biomarkers associated with breast cancer prognosis in older breast cancer survivors. The five-year clinical trial will focus on African American and low socioeconomic status women.
The UK's largest breast cancer physiotherapy trial, PROSPER, will investigate the impact of physiotherapy on women after breast cancer surgery. The study aims to inform national guidelines and improve treatment outcomes for women experiencing shoulder problems and chronic pain after their treatment.
A new study found that acupuncture significantly reduced hot flash frequency and severity in breast cancer survivors, while also inducing a stronger placebo effect than oral medications. The treatment showed sustained benefits even after the eight-week treatment period ended.
Research reveals mutant p53 proteins use epigenetics to drive aggressive cancer growth by targeting key genes and enzymes, such as MLL1 and MOZ. Inhibiting these regulators may lead to combinatorial epigenetic therapies for treating difficult-to-treat cancers.
The use of contralateral prophylactic mastectomy (CPM) among US men with breast cancer has increased significantly, rising from 3% to 5.6% between 2004 and 2011. The procedure was more common in younger, white, and privately insured patients.
Researchers discovered a mechanism that regulates blood vessel growth in diabetic mice, reducing tumor size without harming other organs. The approach may also treat diabetic complications like retinopathy and nephropathy.
Researchers at OU and Mercy Hospital OKC are developing two new short-term breast cancer risk prediction approaches to increase detection of breast MRI screenings. They aim to identify high-risk women with mammography-occult cancers and reduce repeated negative MRI screenings among those with elevated risk.
A study of 44,044 Medicare patients with early-stage breast cancer found that the 21-gene recurrence score assay was associated with decreased chemotherapy use in high-risk patients and increased use in low-risk patients. The genetic test appeared to influence chemotherapy use regardless of age.
A Cornell study reveals that stiffer breast tissue in obese women promotes tumor growth, changing the extracellular matrix's consistency similar to tumors. This finding may require finer-scale imaging techniques in mammograms for early detection.
The EORTC will present on precision medicine, including a discussion of molecular subgroups and randomized trials. The organization will also focus on survivorship care, exploring the importance of long-term follow-up and evidence-based approaches.
Researchers have developed a blood test that can identify patients at risk of breast cancer relapse months before visible signs appear. The test detects cancer DNA in the bloodstream, allowing for early intervention and personalized treatment.
A recent study by H. Lee Moffitt Cancer Center researchers found a significantly higher frequency of BRCA mutations in young black women with breast cancer, particularly among those under 50. This discovery may contribute to the disparity in aggressive breast cancer rates among black women compared to non-Hispanic white women.
Researchers at University of Illinois develop a data-based method to diagnose breast cancer using spatial light interference microscopy, promising fast and accurate results. The technique uses quantitative imaging parameters to analyze breast tissue lesions, overcoming limitations of manual inspection.
A study of 515 premenopausal patients found that younger women with stage 0-III hormone receptor-positive breast cancer are less likely to initiate or continue tamoxifen treatment due to concerns about side effects and fertility, highlighting the need for targeted interventions.
A study found that fertility concerns led a third of young women with breast cancer to decline or discontinue tamoxifen. The study also showed that a quarter of women who started tamoxifen stopped taking it before the recommended treatment period ended.
Researchers found that tumour pericytes manipulate the tumour environment to help cancer cells escape immune surveillance. Increasing pericyte numbers could potentially decrease IL-6 expression and improve cytotoxic T-cell activity.
A new study by Dr. Steven Narod finds that women diagnosed with ductal carcinoma in situ (DCIS) are twice as likely to die from breast cancer compared to the general US population. The study also reveals that black women and those under 35 have a higher risk of mortality.
Researchers developed a faster method for classifying benign and malignant human breast tissues using fresh samples. This automated method eliminates the need for time-consuming tissue preparation and specialist assessment, potentially improving breast cancer management in developing countries.
A large US study found that light to moderate drinking is associated with an increased risk of certain alcohol-related cancers in women, mainly breast cancer, and men who have ever smoked. Overall, the study suggests that women should not exceed one standard drink a day and men should not exceed two standard drinks a day.
Researchers updated their breast cancer risk model to include benign biopsy results, revealing a 300% increase in five-year risk for women with proliferative findings. The revised model enables more accurate identification of women at high risk who may benefit from chemoprevention.
A new study published in the Journal of Clinical Oncology found that music therapy significantly lowered anxiety levels for patients undergoing surgical breast biopsies. The study involved 207 patients who received either live or recorded music before surgery, with results showing a 43% reduction in anxiety compared to usual care.
Scientists have discovered a cytokine called MIF that regulates EGFR activation in the tumor microenvironment, promoting tumor progression. The findings could lead to new approaches in treating tumors by intervening in this self-regulating loop.
A £500,000 National Cancer Institute grant has enabled UK researcher Fredrick Onono to explore the potential connection between high-fat diets and breast cancer development. The study may uncover how fats contribute to cell malfunctions, potentially leading to treatment-resistant cases.
A study found that screening women with suspected hereditary breast or ovarian cancer risk for additional genes provides important information for changing clinical management. Most patients with identified mutations were recommended for enhanced screening or preventive measures, and close relatives should also be screened.
A study published in the Journal of American Geriatrics Society found that chemotherapy's effectiveness in prolonging life for older adults with most types of cancer is reduced for women over 80 with breast cancer. However, combining chemotherapy with another treatment may improve mortality risk reduction for this age group.
Researchers developed a new biomarker that uses magnetic resonance imaging (MRI) to detect micrometastases, tiny tumor cells with the potential to develop into secondary breast cancer tumors. This approach may offer an improved way to detect early recurrence of breast cancer in women and men.
Researchers at Case Western Reserve University have developed a magnetic resonance imaging (MRI) contrast agent that can detect small aggressive breast cancer tumors and micrometastases. The agent binds to molecular markers expressed in high-risk primary tumors and metastases, generating increased image contrast.
Researchers identified a unique doorway in the blood vessel wall that allows breast cancer cells to spread to other parts of the body. The discovery could lead to new treatments and better predict whether breast cancer will spread.
Two studies found hypofractionated radiation therapy to have substantially lower rates of acute and short-term toxic effects compared to conventionally fractionated therapy, with improved patient-reported outcomes. The treatment also showed comparable tumor control and lower costs.
Women with early-stage breast cancer who receive a shorter course of whole breast radiation therapy experience less toxicity and improved quality of life compared to those who undergo a longer course of treatment. The study suggests that hypofractionated treatment should be considered as a starting point for discussion between patients...
Researchers at Duke University have successfully packaged a widely used cancer drug into nanoparticles, more than doubling its effectiveness in mice. The new approach delivers the drug directly to tumors while reducing side effects and improving targeting, showing transformative results for patients.
A new Cancer Research UK study reveals that England's cancer survival rates remain lower than those of countries with similar healthcare systems, despite steady improvements. The study found five-year survival from breast cancer improved more in England than in four leading countries, but overall cancer survival was lowest in England.
The study found that regional node irradiation had a marginal impact on overall survival for patients with stage I, II, or III breast cancer. This was accompanied by improved disease-free and distant-disease-free survival rates, but long-term radiation effects remain unknown.
Researchers at Boston University School of Medicine have identified a new molecule named IL13RA2 as a potential marker for metastatic basal-like breast cancer (BLBC). The discovery suggests that targeting this molecule could slow tumor growth and spread, offering a glimmer of hope for patients with this aggressive form of breast cancer.
Breast cancer researchers have gained new insights into the phases of tumor growth by visualizing and quantifying tumor development in real-time. The study reveals that tumors undergo a dramatic increase in cell number after four weeks, providing valuable information for treatment selection and delivery.
A new approach to breast cancer surgery and reconstruction combines nipple-sparing mastectomy with immediate single-stage implant (SSI) breast reconstruction. This combined procedure, also known as the 'one and done' approach, offers important psychological benefits for patients, including an immediate return to normal body image.
A Pitt study reveals how ancient proteins like RAD51 paralogues repair damaged DNA and their potential role in tumor development. The findings suggest that targeting these proteins could be a way to tailor cancer therapies.
A study has identified a novel microRNA, miR-181a-5p, as a potential diagnostic breast cancer biomarker in the blood. The use of Droplet Digital PCR technology enabled the accurate quantification of this miRNA, which showed significant downregulation in the serum of patients with breast cancer.
A study by Moffitt researchers found significant economic and health disparities in the LGBTQ community, including higher rates of poverty, lack of health services, and certain types of cancer. The study highlights the need for increased awareness and targeted interventions to address these disparities.
Researchers found that breast cancer survivors who used liquid lidocaine on the vulvar vestibule experienced reduced pain and improved sexual function. The study's results suggest that this non-invasive treatment could alleviate physical and emotional pain associated with sex, making it more enjoyable for both individuals.
Two classes of inexpensive generic drugs, aromatase inhibitors and bisphosphonates, have been shown to improve survival prospects for postmenopausal women with early breast cancer. The combination of the two types of drug may also increase benefits while decreasing some side-effects.
A major study of over 30,000 women shows that aromatase inhibitors substantially reduce the risk of death from ER-positive breast cancer. Taking aromatase inhibitors for five years reduces the risk of death by 40% compared to tamoxifen.
A recent study published in Nature Communications found that genetic variation in the gene FOPNL is associated with poorer survival rates in multiple myeloma patients. The study, which included over 1,600 patients from North America and Europe, identified a significant link between the FOPNL variant and reduced survival.
A study found that additional radiation to lymph nodes reduces breast cancer recurrence, but does not increase overall survival. The treatment was associated with limited toxicity and is recommended for women with axillary node-positive or high-risk node-negative breast cancer.
A new study by Georgia State University researchers found that state regulations significantly influence when patients receive cancer diagnoses, particularly among people under 65. The study suggests that where people live is a strong predictor of whether they will receive potentially life-saving cancer screenings.
A new mouse model has provided early causal evidence that weekly alternating light-dark cycles may hasten certain health risks, including breast cancer development and weight gain. The study found that mice with a genetic predisposition to breast cancer developed tumors 8 weeks earlier when exposed to the alternative light-dark cycles.
A study by North Carolina State University found that Angelina Jolie's announcement about her BRCA1 gene testing led to increased intentions among women to get tested for the same gene. Women who identified with Jolie or felt a parasocial relationship with her were more likely to consider genetic testing.
A new study by MD Anderson researchers found that protein 14-3-3 sigma opposes and reverses tumor-promoting metabolic programs in breast cancer. The study revealed that 14-3-3 sigma suppresses cancer glycosis, preventing tumors from converting glucose into pyruvate.
A study published in Cancer Epidemiology, Biomarkers & Prevention found that breast cancer survivors gained an average of 3.81 pounds more than cancer-free women within five years of diagnosis and treatment. Chemotherapy treatment was also significantly associated with weight gain, particularly among those treated recently.
A study by Johns Hopkins Kimmel Cancer Center researchers found that breast cancer survivors, particularly those with a family history of the disease, gained significantly more weight over four years compared to cancer-free women. The study also revealed that chemotherapy may be a contributing factor to weight gain among survivors.
A new study from Lund University found a significant correlation between low levels of the anti-stress hormone enkephalin and an increased risk of breast cancer. Women with the lowest levels of the hormone had a risk more than three times that of those with the highest levels.
A new NCI-funded study will investigate the impact of a meditation-based stress reduction program on cognitive impairment in breast cancer survivors. Researchers will assess the intervention's effects on objective and subjective cognitive functioning among 300 participants.
Scientists designed nanoparticles that release chemotherapy drugs paclitaxel in the presence of matrix metalloproteinases (MMPs), which enable cancer metastasis. The system effectively delivers high doses of the drug, halting tumor growth and reducing toxicity.
A new study found that longer periods of leisure time sitting were associated with a higher risk of total cancer risk in women, as well as increased risk of multiple myeloma, invasive breast cancer, and ovarian cancer. The association was not observed in men.
A groundbreaking online registry, Research for Her, has shown to enroll study participants more quickly than traditional paper-based registries. The Cedars-Sinai program has seen a 4.3 fold increase in registrations over a 14-month period, with an additional 50% boost in enrollment for the Gilda Radner Hereditary Cancer Program.
Researcher Laura Vandenberg is studying the role of BPS, an estrogen-mimicking chemical found in plastics and food packaging, on breast cancer risk. Exposure to these chemicals in the womb may increase breast cancer risk decades later.