Articles tagged with Breast Cancer
A study of 5,644 women found that diabetes treatment decreases mammographic density, while insulin use increases it. The researchers also urge women with and without diabetes to adopt simple lifestyle changes to reduce breast cancer risk.
Researchers have identified a genetic mutation associated with a high risk of breast cancer in the Chinese ethnic population. The RECQL mutation was found to be present in 0.54% of Southern Chinese women, suggesting it may be an important factor in genetic screening for women with a family history of breast cancer.
A study of 300 women with early stage breast cancer found that a high white blood cell ratio is associated with an increased risk of disease recurrence. Women with low NLR fared better at subsequent check-ups, with higher survival rates compared to those with high NLR.
A recent study found that women who underwent a double mastectomy showed little improvement in quality of life compared to those who had a single mastectomy. However, breast reconstruction was found to have a significant positive impact on psychosocial well-being and breast satisfaction.
Researchers at the University of Texas Health Science Center have discovered that BRCA1 serves as a limiter on a gene called COBRA1, regulating breast cell growth. This finding provides new insights into how BRCA1 mutations increase breast cancer risk in women.
A recent study shows that cancer cells work together with surrounding healthy cells to build new blood vessels, promoting tumor growth. Researchers found that collagen production is increased by a specific type of transfer RNA, allowing tumors to acquire the necessary resources to grow and spread.
Regular low-dose aspirin use for at least six years was associated with a modestly reduced overall risk for cancer, primarily due to a lower risk for gastrointestinal tract cancer. The study found that regular aspirin use may complement CRC screening and have an absolute benefit regardless of endoscopy status.
EPFL scientists have developed an animal model for estrogen receptor-positive breast cancer that faithfully captures the disease. The new model has been tested on human breast tissue in a pre-clinical context, providing crucial factors such as hormone action and molecular responses to therapies.
A study of 166 breast cancer patients found that 82.5% exhibited symptoms of PTSD following diagnosis, with more than half continuing to display symptoms one year later. The severity of psychological impact was underscored by the fact that some patients rated having breast cancer as their most severe traumatic event.
A new study published in Cancer Causes & Control found that Latinas who consume processed meats like bacon and sausage have an increased risk of breast cancer. The study also suggests that tuna consumption is associated with breast cancer risk in white women, but not significantly so among Latinas.
A Stanford study found that vitamin D deficiency in mice leads to faster-growing and more aggressive breast cancer tumors. Researchers also identified a direct link between vitamin D levels and the expression of the ID1 gene, which plays a role in tumor growth and metastasis.
A combination of palbociclib and fulvestrant delays cancer growth in around two thirds of women with advanced hormone-receptor-positive, HER2-negative breast cancer. The treatment allowed many patients to delay the start of chemotherapy.
A new treatment combination of palbociclib and fulvestrant has been shown to significantly extend progression-free survival in women with stage-4 breast cancer. The study found that patients treated with the combination experienced a prolonged disease control, which may translate to improved survival.
Researchers found that beta-blockers can decrease the invasive growth of aggressive breast cancer cells by blocking the beta2-adrenoceptor, a cell surface protein stimulated by adrenaline. This discovery suggests beta-blockers could be a useful adjuvant therapy for some aggressive breast cancers.
Researchers discovered novel genetic variants in a hormone receptor-positive male breast cancer patient, which led to a prolonged stable disease. The study provides new insights into the genomic landscape of male breast cancer and suggests potential benefits of combining treatments to block the PI3K/Akt/mTOR pathway.
Researchers found that early MRI screening can reduce breast cancer mortality in female survivors of childhood Hodgkin's lymphoma who received chest radiation. The study suggests that starting screening at age 25 with MRI can be more effective than mammography, but may lead to false positives.
Whitehead Institute researchers develop hydrogel scaffolds that support human mammary tissue growth from patient-derived cells, providing insights into normal breast development and cancer progression. The scaffold responds to hormones and allows for the study of gene perturbations.
A multicentre study found type 1 diabetes associated with higher cancer incidence, especially for cancers of the stomach, liver, pancreas, endometrium, ovary, and kidney. Women with type 1 diabetes had a smaller but still significant increased risk compared to men.
A study of 120,000 women found five genetic variants affecting breast cancer risk, which alter how cells respond to oestrogen. The variants are associated with changes in the expression of genes involved in oestrogen regulation, potentially leading to new breast cancer preventions.
A single dose of trastuzumab kick starts an immune response in certain HER2-positive breast cancers, with women having the highest rate of immune response being those with the HER2-enriched subtype. The immune-cell-activating properties of trastuzumab are likely related to the subtypes of breast cancer.
PharmaMar has initiated a Phase II clinical trial for its antitumor drug PM184, targeting hormone-receptor positive and HER2-negative breast cancer patients. The trial aims to evaluate the efficacy of PM184 on four-month progression-free survival and assess safety and pharmacological profiles.
A new study compared four types of abdominal flaps used in breast reconstruction, revealing that muscle-sparing techniques like DIEP and msf-TRAM reduce hernia risks and improve patient satisfaction. The study found these methods to have lower rates of fat necrosis and abdominal morbidity compared to traditional flaps.
A new report from the American Brain Tumor Association reveals that malignant brain tumors are the most common cause of cancer-related deaths in adolescents and young adults aged 15-39. The study, which analyzed data from 2008-2012, also found a shift towards high-grade tumors with increasing age.
Researchers found that omega-3 supplementation reduced breast density in postmenopausal women with a body mass index above 29, bordering on obesity. The study suggests that DHA alone may be preferentially protective in these individuals, offering an example of personalized approach to breast cancer prevention.
Researchers at H. Lee Moffitt Cancer Center develop adaptive therapy to keep resistant cells in check, prolonging survival without disease progression in mouse models of triple-negative and ER+ breast cancer. The approach is being tested in a clinical trial for prostate cancer patients.
Mayo Clinic researchers found that using frozen section analysis during lumpectomies can reduce the need for second operations by 95%, saving patients time and financial burdens. The study estimates annual cost savings of $90.9 million to payers and $1.8 million to providers.
The American Cancer Society report reveals progress in reducing cancer death rates among African-Americans, but racial disparities persist in breast and colorectal cancers. The study finds that disparities in access to care and screening contribute to these disparities.
A consensus meeting of experts has established a framework for classifying bladder cancers based on genetic mutations. This development aims to improve patient outcomes by stratifying patients according to their tumor characteristics and response to therapy.
Researchers at the University of Toronto have developed shape-shifting nanoparticles that can target and deliver cancer drugs to specific tumor types. The system uses modular particles attached to DNA sequences to gain access to diseased tissue, minimizing collateral damage.
A study published in JAMA Oncology found that 3D mammography improved cancer detection and reduced call backs over three years. Regularly scheduled 3D mammography imaging maintained these benefits, even after a patient's first screening.
Researchers have developed a new nanoparticle that kills tumor cells in the eye by mimicking an enzyme used by immune cells, extending survival of mice with advanced breast cancer. The treatment offers advantages such as producing toxins per hour and being activated by light.
A new study found significant reductions in breast cancer screening outcomes after implementing digital breast tomosynthesis (DBT), including lower patient recall rates and a decline in interval cancers. The study suggests DBT can be sustained over time with improved outcomes.
The study found a significant decrease in breast conservation surgery (BCS) use overall, with the highest decline observed in younger women. Reoperation rates after BCS were also higher in certain surgeon groups, highlighting the importance of volume and expertise.
A new study found that more than half of young women with hormone receptor-positive breast cancer did not believe endocrine therapy was essential. The study emphasizes the need for better education on the benefits of endocrine therapy and medication adherence among this age group.
A recent discovery by FAU researchers reveals a mechanism that promotes metastasis and resistance to treatment in aggressive cancer types. They identified a gene set associated with particularly bad prognosis in breast cancer, enabling the development of biological markers for aggressive tumours.
A new test analyzing cell diversity in tumors can predict survival chances in high-grade breast cancer. The Ecosystem Diversity Index identified aggressive subgroups of breast cancer and was a stronger predictor of survival than established markers.
Researchers identified Gabra3 as a key driver of metastatic breast cancer progression. The gene promotes cell growth and invasion when activated by RNA editing.
Researchers discovered that obesity promotes pancreatic and breast cancer progression by increasing tumor-infiltrating immune cells and promoting a pro-tumor microenvironment. Blocking the VEGFR-1 pathway may prevent tumor growth and metastasis in obese patients, offering potential therapeutic targets for improving patient outcomes.
Rates of BRCA testing have increased among young women with breast cancer, with 87% reporting testing within a year after diagnosis. The high frequency is attributed to comprehensive genetic counseling services available at cancer centers.
Researchers have discovered a striking genomic signature shared by colon, lung, breast, stomach and endometrial cancers, which may be used to diagnose the disease at early stages. The methylation signature could lead to the development of a non-invasive blood test for cancer detection.
Researchers argue for greater support and research to help women make informed decisions about preventive mastectomies and ovary removal. The procedures can significantly reduce cancer risk but also carry risks and emotional challenges.
Researchers will compare surgery and active surveillance in women with low-grade DCIS, evaluating quality of life and psychosocial outcomes. The four-year study aims to answer whether invasive surgery is necessary for non-fatal disease.
A set of risk factors can predict the magnitude of survival benefit offered by radiation therapy following breast cancer surgery. Radiation therapy provides a significant survival benefit for patients with more aggressive cancer, particularly those with higher prognostic scores.
Researchers found that clusters of cancer cells migrate through the body together throughout all stages of metastasis. The study identified unique molecular signatures and genetic changes in these aggressive tumor clumps, including higher expression of desmosome genes and lower expression of antigen presentation genes.
Research suggests that cancer cells rarely form metastatic tumors on their own but instead travel in groups for increased chances of survival. These traveling cells differ from those within primary tumors and may be intrinsically resistant to chemotherapy due to molecular programs that facilitate their movement.
A new study published in Plastic and Reconstructive Surgery found that lipofilling, a technique using the patient's own fat cells for breast reconstruction, does not increase the risk of recurrent breast cancer. The study analyzed over 1,000 cases and compared rates of recurrent or new breast cancers with and without lipofilling.
Researchers found epigenetic alterations in normal breast tissue adjacent to cancer, marking susceptible precursor cells. These changes were associated with poorer prognosis and decreased survivorship from the disease. The study aims to decode how breast cancer develops and understand risk factors.
A new study found that nearly two-thirds of women aged 70 and older with stage I breast cancer who are eligible to safely omit subsequent radiation therapy do not receive it. Despite guidelines recommending against radiation therapy for this group, the study suggests a lack of compliance or poor awareness among healthcare providers.
University of Iowa researchers track cancerous human breast tissue cells' motion and accretion into tumors, discovering that only five percent of cancerous cells are needed to form a tumor. The team finds that cancer cells actively recruit healthy cells by extending cables to grab their neighbors, forming a larger mass.
A large study of over 20,600 breast cancer survivors found that those who quit smoking after diagnosis had a significantly lower risk of death from breast cancer. Quitting smoking led to a 33% reduction in mortality rate, with the highest risks observed among long-term smokers and former smokers.
A new transparent, bending insensitive pressure sensor was developed by Japanese and American teams to measure pressure distribution on rounded surfaces. The sensor can maintain its sensing accuracy even when bent over a radius of 80 micrometers, equivalent to just twice the width of a human hair.
A new procedure, Targeted Axillary Dissection (TAD), reduces need for invasive surgery in select patients with axillary metastasis. TAD involves removing sentinel lymph nodes and additional cancerous lymph nodes found during diagnosis, improving staging accuracy and reducing complications.
Biomedical engineers have created microscopic 'depots' to trap drugs inside cancer tumors, increasing their effectiveness. The technique uses nanocarriers and enzymes to release the drugs gradually, maximizing their impact on tumor growth.
Chemotherapy can reduce the body's immune response, leaving breast cancer survivors vulnerable to illnesses. Researchers found that levels of lymphocytes and antibodies dropped significantly after chemotherapy, with only partial recovery in some cases.
A study found that 15.7% of individuals 65 or older received nonrecommended screenings for prostate and breast cancers due to limited life expectancy, costing the US healthcare system $1.2 billion annually. States with high rates of nonrecommended screening showed similar patterns in both prostate and breast cancer screenings.
Researchers have made significant progress in developing fluorescent chemical probes that can target specific cancer cells, allowing for more accurate tumor removal. These probes have the potential to improve patient outcomes and reduce the need for repeat surgeries.
A new study suggests that combining PARP inhibitors with c-MET inhibitors may improve treatment outcomes for patients with breast cancer and high c-MET expression levels.
The USPSTF recommends regular mammography screening for women aged 50-74, with a recommended frequency of every two years. Women in their 40s should make an individual decision with their doctor about starting screening, considering factors like health history and preferences. The Task Force also notes that screening is less effective ...
A systematic review of breast density studies found unreliable determinations and a significant risk of re-categorization. Supplemental diagnostic screenings for women with dense breasts may find additional cancers but also greatly increase false positive results, highlighting the need for more research on evaluation methods.
A comprehensive modeling study found that breast cancer screening with digital mammography poses only a small risk of radiation-induced breast cancer for most women. However, the research showed increased risk for women with large breasts or breast implants. The study suggests biennial screening from ages 50 to 74 may be the safest opt...