Articles tagged with Breast Cancer
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.
Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.
Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.
Practical application of scientific knowledge and engineering principles to solve real-world problems and develop innovative technologies. Encompasses all engineering disciplines, technology development, computer science, artificial intelligence, environmental sciences, agriculture, materials applications, energy systems, and industrial innovation. Bridges theoretical research with tangible solutions for infrastructure, manufacturing, computing, communications, transportation, construction, sustainable development, and emerging technologies that advance human capabilities, improve quality of life, and address societal challenges through scientific innovation and technological progress.
Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.
Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.
Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
A new study found significant reductions in breast cancer screening outcomes after implementing digital breast tomosynthesis (DBT), including lower patient recall rates and a decline in interval cancers. The study suggests DBT can be sustained over time with improved outcomes.
The study found a significant decrease in breast conservation surgery (BCS) use overall, with the highest decline observed in younger women. Reoperation rates after BCS were also higher in certain surgeon groups, highlighting the importance of volume and expertise.
A new study found that more than half of young women with hormone receptor-positive breast cancer did not believe endocrine therapy was essential. The study emphasizes the need for better education on the benefits of endocrine therapy and medication adherence among this age group.
A recent discovery by FAU researchers reveals a mechanism that promotes metastasis and resistance to treatment in aggressive cancer types. They identified a gene set associated with particularly bad prognosis in breast cancer, enabling the development of biological markers for aggressive tumours.
A new test analyzing cell diversity in tumors can predict survival chances in high-grade breast cancer. The Ecosystem Diversity Index identified aggressive subgroups of breast cancer and was a stronger predictor of survival than established markers.
Researchers identified Gabra3 as a key driver of metastatic breast cancer progression. The gene promotes cell growth and invasion when activated by RNA editing.
Researchers discovered that obesity promotes pancreatic and breast cancer progression by increasing tumor-infiltrating immune cells and promoting a pro-tumor microenvironment. Blocking the VEGFR-1 pathway may prevent tumor growth and metastasis in obese patients, offering potential therapeutic targets for improving patient outcomes.
Rates of BRCA testing have increased among young women with breast cancer, with 87% reporting testing within a year after diagnosis. The high frequency is attributed to comprehensive genetic counseling services available at cancer centers.
Researchers have discovered a striking genomic signature shared by colon, lung, breast, stomach and endometrial cancers, which may be used to diagnose the disease at early stages. The methylation signature could lead to the development of a non-invasive blood test for cancer detection.
Researchers argue for greater support and research to help women make informed decisions about preventive mastectomies and ovary removal. The procedures can significantly reduce cancer risk but also carry risks and emotional challenges.
Researchers will compare surgery and active surveillance in women with low-grade DCIS, evaluating quality of life and psychosocial outcomes. The four-year study aims to answer whether invasive surgery is necessary for non-fatal disease.
A set of risk factors can predict the magnitude of survival benefit offered by radiation therapy following breast cancer surgery. Radiation therapy provides a significant survival benefit for patients with more aggressive cancer, particularly those with higher prognostic scores.
Researchers found that clusters of cancer cells migrate through the body together throughout all stages of metastasis. The study identified unique molecular signatures and genetic changes in these aggressive tumor clumps, including higher expression of desmosome genes and lower expression of antigen presentation genes.
Research suggests that cancer cells rarely form metastatic tumors on their own but instead travel in groups for increased chances of survival. These traveling cells differ from those within primary tumors and may be intrinsically resistant to chemotherapy due to molecular programs that facilitate their movement.
A new study published in Plastic and Reconstructive Surgery found that lipofilling, a technique using the patient's own fat cells for breast reconstruction, does not increase the risk of recurrent breast cancer. The study analyzed over 1,000 cases and compared rates of recurrent or new breast cancers with and without lipofilling.
Researchers found epigenetic alterations in normal breast tissue adjacent to cancer, marking susceptible precursor cells. These changes were associated with poorer prognosis and decreased survivorship from the disease. The study aims to decode how breast cancer develops and understand risk factors.
A new study found that nearly two-thirds of women aged 70 and older with stage I breast cancer who are eligible to safely omit subsequent radiation therapy do not receive it. Despite guidelines recommending against radiation therapy for this group, the study suggests a lack of compliance or poor awareness among healthcare providers.
University of Iowa researchers track cancerous human breast tissue cells' motion and accretion into tumors, discovering that only five percent of cancerous cells are needed to form a tumor. The team finds that cancer cells actively recruit healthy cells by extending cables to grab their neighbors, forming a larger mass.
A large study of over 20,600 breast cancer survivors found that those who quit smoking after diagnosis had a significantly lower risk of death from breast cancer. Quitting smoking led to a 33% reduction in mortality rate, with the highest risks observed among long-term smokers and former smokers.
A new transparent, bending insensitive pressure sensor was developed by Japanese and American teams to measure pressure distribution on rounded surfaces. The sensor can maintain its sensing accuracy even when bent over a radius of 80 micrometers, equivalent to just twice the width of a human hair.
A new procedure, Targeted Axillary Dissection (TAD), reduces need for invasive surgery in select patients with axillary metastasis. TAD involves removing sentinel lymph nodes and additional cancerous lymph nodes found during diagnosis, improving staging accuracy and reducing complications.
Biomedical engineers have created microscopic 'depots' to trap drugs inside cancer tumors, increasing their effectiveness. The technique uses nanocarriers and enzymes to release the drugs gradually, maximizing their impact on tumor growth.
Chemotherapy can reduce the body's immune response, leaving breast cancer survivors vulnerable to illnesses. Researchers found that levels of lymphocytes and antibodies dropped significantly after chemotherapy, with only partial recovery in some cases.
A study found that 15.7% of individuals 65 or older received nonrecommended screenings for prostate and breast cancers due to limited life expectancy, costing the US healthcare system $1.2 billion annually. States with high rates of nonrecommended screening showed similar patterns in both prostate and breast cancer screenings.
Researchers have made significant progress in developing fluorescent chemical probes that can target specific cancer cells, allowing for more accurate tumor removal. These probes have the potential to improve patient outcomes and reduce the need for repeat surgeries.
A new study suggests that combining PARP inhibitors with c-MET inhibitors may improve treatment outcomes for patients with breast cancer and high c-MET expression levels.
The USPSTF recommends regular mammography screening for women aged 50-74, with a recommended frequency of every two years. Women in their 40s should make an individual decision with their doctor about starting screening, considering factors like health history and preferences. The Task Force also notes that screening is less effective ...
A systematic review of breast density studies found unreliable determinations and a significant risk of re-categorization. Supplemental diagnostic screenings for women with dense breasts may find additional cancers but also greatly increase false positive results, highlighting the need for more research on evaluation methods.
A comprehensive modeling study found that breast cancer screening with digital mammography poses only a small risk of radiation-induced breast cancer for most women. However, the research showed increased risk for women with large breasts or breast implants. The study suggests biennial screening from ages 50 to 74 may be the safest opt...
A multi-institutional international study has revealed new information about the interaction between long non-coding RNAs and HIF-1 signaling pathways in triple-negative breast cancer. The study identifies four previously unknown phosphorylation sites, which predict a worse outcome for TNBC patients, suggesting that these sites could s...
Research teams confirm biennial mammography for women aged 50-74 offers favorable balance of benefits to harm. Screening frequency impacts mortality and false positives, with biennial screening reducing breast cancer deaths by 25.8%.
Researchers at Boston University School of Medicine identified a metastasis suppressor gene called serum deprivation response (SDPR), which plays a role in breast cancer progression. Over-expression of SDPR reduces the incidence of metastatic disease in models of aggressive, metastatic breast cancer cells.
Experts argue that cancer screening has never been shown to 'save lives' due to reduced overall mortality rates. Harms associated with screening, such as overdiagnosis and false positives, are significant concerns. The authors call for higher standards of evidence and consideration of harms in cancer screening.
A new injectable agent, LUM015, has been tested in a trial and found to identify cancerous tissue in human patients without adverse effects. The technology could significantly change the treatment of sarcoma by allowing surgeons to remove 100% of the tumor on the first attempt.
A study of 200,000 twin individuals found an increased cancer risk among those whose co-twin was diagnosed with cancer. The risks varied by type and were higher for monozygotic twins.
A recent study at MD Anderson Cancer Center found that dietary sugar, particularly fructose, can increase the risk of breast cancer tumors and lung metastasis in mice. The research suggests that high sugar intake activates an inflammatory pathway called 12-LOX, leading to increased tumor growth and spread.
A study published in Plastic and Reconstructive Surgery found that long travel distances continue to be a significant barrier to breast reconstruction after mastectomy for US women. Reconstruction rates varied by type of hospital and distance traveled, with greater disparities observed at academic hospitals and high-volume centers.
Researchers have identified a specific weakness in the immune system of patients with HER2-positive breast cancer, which may be corrected with a HER2-targeted vaccine. T cells from patients with recurrent cancer showed weaker response to the HER2 receptor protein compared to those without recurrence.
A novel PET/CT imaging method has been shown to accurately measure HER2 expression in metastatic breast cancer, potentially leading to more optimal individualized treatments. This non-invasive technique may one day substitute traditional tissue sampling.
The new oral drug Palbociclib has shown promise in combating various types of cancer beyond breast cancer, including lymphoma, sarcoma, and teratoma. Early trials have demonstrated its effectiveness in slowing tumor growth and improving survival rates in patients with these conditions.
A study published in JNCI Journal of the National Cancer Institute found that ultrasound sensitivity is comparable to mammography, but with a higher false-positive rate. The researchers suggest considering ultrasound as a supplemental test for women with dense breasts or those unable to tolerate MRI.
A new American Cancer Society study reveals that excess medical expenditures and productivity losses vary significantly among cancer survivors by age and cancer site. Nonelderly survivors of colorectal and breast cancers experience higher annual expenditures compared to those without a cancer history.
A study found that women with breast cancer who received chemotherapy and triptorelin had a higher long-term probability of ovarian function recovery without affecting pregnancy rates or disease-free survival. The treatment showed modest benefits regarding potential prevention of treatment-associated infertility.
A new analysis of genetic information from over 4,000 cancer cases reveals rare germline mutations in 114 genes associated with cancer. The study found varying frequencies of these mutations across 12 cancer types, including a surprising inherited component to stomach cancer.
A team at Cold Spring Harbor Laboratory has discovered a novel drug that targets an abnormal RNA molecule called Malat1 in metastatic breast cancer. The drug reduces tumor growth by 70% and prevents metastasis, suggesting that targeting this RNA may be a promising therapeutic approach for treating aggressive breast cancer.
A plant virus shell triggers a potent immune response in mice, wiping out tumors and preventing metastatic disease. The treatment, using cowpea mosaic virus nanoparticles, shows promise as an effective and low-toxicity alternative to traditional therapies.
A study found that postmenopausal women with periodontal disease were more likely to develop breast cancer than those without the condition. The risk was particularly high among women who had quit smoking recently, suggesting a potential link between bacterial exposure and breast cancer risk.
Researchers at NYU College of Nursing developed a method to detect breast cancer-related lymphedema by counting symptoms, showing high sensitivity and specificity. The study found that a diagnostic cutoff of three symptoms can distinguish healthy adults from those with lymphedema with 94% sensitivity.
The PALOMA3 trial confirms the efficacy of combining palbociclib with fulvestrant in Asian patients with hormone receptor-positive, HER2-negative advanced breast cancer. The combination shows positive results in progression-free survival for postmenopausal women, while a longer follow-up is needed to confirm overall survival.
A NYU nursing study found that obesity is a significant risk factor for breast cancer-related lymphedema, which can be managed with early and appropriate treatment. The study suggests that general instructions on nutrition-balanced diets and physical activities can help maintain pre-surgery weight.
Researchers at Berkeley Lab have created a clinically relevant mouse model of human breast cancer, bearing resemblance to the most prevalent form of breast cancer. The model, '184AA3,' will enable testing of therapies for aggressive ER+ breast cancers and studying the biology and etiology of luminal cancers.
A new study by TSRI scientists suggests a potent new therapeutic approach for hard-to-treat breast cancers, targeting the enzyme casein kinase 1´ (CK1´), which is overexpressed in many breast cancer types. The study found that a highly selective and potent CK1´ inhibitor, SR-3029, triggers rapid tumor cell death.
Liquid biopsies may help predict treatment responses and genetic mutations that impact prognosis in advanced breast cancer. The tests analyzed tumor DNA in blood samples, revealing potential benefits and risks of combining therapies.
The T-DM1 trial showed that the treatment increased median overall survival for heavily pretreated HER2-positive breast cancer patients by 22.7 months compared to treatment of physician's choice. The study also found reduced incidence of grade 3 or higher adverse events among those assigned T-DM1.
Researchers found similar outcomes for disease recurrence between women taking anastrozole and those taking tamoxifen, but noted significant differences in side effects. Women on anastrozole had fewer endometrial and ovarian cancers, while those on tamoxifen experienced more major thromboembolic events.
A study of postmenopausal women with DCIS found that anastrozole and tamoxifen caused different symptom profiles. Hot flashes were more common in the tamoxifen group, while musculoskeletal complaints and vaginal problems were more prevalent in those receiving anastrozole.
Studies found that patients with delayed breast cancer surgery and chemotherapy had poorer overall and disease-specific survival rates. A delay of up to 90 days in receiving chemotherapy was associated with no adverse outcomes, but prolonged delays led to increased risks of death from the disease.
Researchers found that D538G and Y537S mutations in the estrogen receptor 1 (ESR1) gene are common in ER-positive breast cancer patients, associated with poorer outcomes and reduced response to everolimus treatment. The study suggests that these mutations may predict different responses to therapies.
Researchers investigated the reasons behind tamoxifen's varying efficacy in women. Genetic variants on the CYP2D6 gene were initially linked to worse survival rates, but subsequent studies found no association. Advanced statistical modeling suggests that genotyping errors may have contributed to these findings.
A recent study suggests that elevated levels of the enzyme APOBEC3B drive tamoxifen resistance in estrogen receptor-positive breast cancer. Higher APOBEC3B levels were associated with shorter progression-free survival times.