Articles tagged with Breast Cancer
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VIPA-based Brillouin spectroscopy enables accurate tissue stiffness measurement by suppressing unwanted light noise. The technique allows for noninvasive biological characterization of materials like chicken breast or potentially cancerous tumors.
A novel therapeutic approach has been discovered using a breast cancer drug to treat acute myeloid leukemia (AML) patients with FLT3 mutations. The compound blocks the production of the FLT3 gene and subsequently downregulates its activity, leading to the death of cancer cells.
A recent study found that minority and less educated women perceive breast cancer as a more common killer than heart disease, which may contribute to worse health outcomes. Researchers recommend that healthcare providers incorporate messages for both breast health and heart disease prevention to maximize impact.
Breast cancer tumor-initiating cells use mTOR signaling to recruit myeloid-derived suppressor cells (MDSCs), which are involved in suppressing the body's response against tumors. This interaction helps researchers understand the events leading to tumor growth and metastasis, identifying potential therapeutic targets.
Researchers at SISSA have developed a gene therapy approach targeting glioblastomas by introducing an active version of the Emx2 gene, which inhibits astrocyte growth and leads to tumour cell suicide. The treatment has demonstrated efficacy in both vitro and in vivo tests, with potential for preventing aggressive recurrence development.
Researchers have identified a promising approach to treating triple-negative breast cancer (TNBC) by targeting the MYC oncogene. The study found that selective killing of MYC-overexpressing TNBC cells can be achieved through inhibition of cell cycle progression and fatty acid oxidation.
SmartPractice has donated $50,000 to TGen to support the development of liquid biopsies, which can detect breast cancer earlier and more precisely. The donation aims to identify genetic biomarkers in blood that could help prevent cancer from spreading.
Women with early-stage breast cancer who used dietary supplements and complementary therapies were less likely to start chemotherapy. Dietary supplement usage was associated with a lower likelihood of initiating chemotherapy, while mind-body practices showed no relation.
Women with early-stage breast cancer who used dietary supplements and complementary medicine were less likely to start chemotherapy than nonusers, according to a new study. CAM use was associated with lower chemotherapy initiation rates among those for whom treatment was indicated.
Researchers at the University of Birmingham successfully trained breast cancer patients to achieve single prolonged breath holds of over five minutes, enabling targeted radiotherapy to be administered in just one dose. This breakthrough could improve long-term survival and quality of life for breast cancer patients.
A study published in JAMA found that longer periods of film readers interpreting screening mammograms did not result in a reduced rate of breast cancer detection. The researchers investigated the impact of changing the order in which two experts examined digital mammograms on cancer detection rates, but found no significant difference.
Researchers have identified 40 mutated genes that contribute to breast cancer progression, with one gene, PIK3CA, found to lower survival chances for three subtypes. The study's findings could help develop targeted treatments and improve diagnostic tests.
A study by Dr Sian Taylor-Phillips and her team found no decline in mammogram readers' accuracy, despite previous theories suggesting a 'vigilance decrement.' The researchers analyzed 1.2 million women's x-rays and found that cancer detection rates stayed constant throughout each batch of approximately 35 readings.
Research published in BMJ Open found that single dose targeted intraoperative radiotherapy can save patients thousands of hours of time, journeys, and CO2 emissions compared to standard treatment. The study estimates that widespread adoption of TARGIT could save millions of miles, tons of CO2, and hundreds of hours of travel time annually
A new study uses multiplexed immunostaining to examine protein expression in breast tumors, identifying clusters of co-expressed proteins within cancer cells. This technique enhances our understanding of tumor biology and signaling networks.
A new study published in the Journal of Clinical Sleep Medicine found that women who slept less than 7 hours per night and were frequent snorers before their cancer diagnosis had a poorer prognosis. The study suggests that poor sleep quality may contribute to accelerated tumor growth and shortened cancer survival.
A new study by researchers at the University of Pennsylvania's Abramson Cancer Center found that testing non-breast cancer genes in high-risk women does not add clinical benefit. The study analyzed a large panel of genes and found that many variants were of uncertain significance, adding complexity to genetic counseling.
Researchers at Duke University Medical Center have developed an antibody that selectively attacks cancer cells while sparing healthy ones. The antibody works by targeting a specific protein on cancer cells, disabling their defense mechanism and triggering an immune response.
Research suggests mango's anti-obesity, anti-cancer, anti-inflammatory, and intestinal health roles. Studies in mice and humans reveal potential benefits of mango consumption on body composition, glucose homeostasis, and gut inflammatory markers.
A new study suggests that cognitive-behavioral therapy can help prevent long-term memory issues caused by chemotherapy. The therapy, called Memory and Attention Adaptation Training (MAAT), was developed to increase awareness of situations where memory problems arise and develop skills to compensate for memory dysfunction.
Researchers have discovered that a combination of 5-azacytidine and the HDAC inhibitor butyrate reduces the number of cancer stem cells in breast cancer patients. This targeted approach may improve survival rates and provide a new treatment option for breast cancer.
The study uncovered five new genes associated with breast cancer and 13 new mutational signatures that influence tumour development. The analysis revealed the genetic variations in breast cancers and their distribution across the genome.
A new study found that younger women with early breast cancer who undergo breast conserving therapy (BCT) have a 13% higher risk of local recurrence and a doubled risk of metastasis compared to those who receive mastectomy. This contrasts with older women, where BCT is deemed safe without increased risks.
A study published in Plastic and Reconstructive Surgery found that DIEP flap breast reconstruction provides good long-term quality of life for women who have undergone mastectomy for breast cancer. The reconstruction method allowed patients to maintain a good QOL in the long-term, comparable to women without breast cancer.
A large number of Phase III radiotherapy trials failed to publish their results, exposing patients to unnecessary risks. Researchers found that only 47% of eye cancer trials were published, while 100% of testicular and anal cancer trials went unpublished.
A new study has identified a long non-coding RNA that plays a crucial role in the repair of DNA breaks in triple-negative breast cancer cells. The research found that blocking this RNA significantly increases sensitivity to radiation therapy, providing new insight into the biology of this tough-to-treat breast cancer subtype.
Researchers at Scripps Research Institute identify structural changes in estrogen receptor binding molecules linked to regulating cancer growth. The study reveals predictive features of ligand-specific signaling through the receptor, moving closer to developing more effective treatments for breast cancer.
A new gene testing technology has been developed to identify mutations and prioritize variants in breast and ovarian cancer genes. The method reveals gene variants that were missed by conventional genetic testing, increasing the number of patients that can be properly diagnosed.
A study published in JAMA found that adding tomosynthesis to digital mammography significantly increased cancer detection rates and reduced recall rates for women with dense breasts. The findings suggest that supplemental breast cancer screening using tomosynthesis may improve outcomes for women with varying levels of breast density.
A new study found that dense breast notifications are often poorly readable and understandable, creating uncertainty for women making decisions about supplemental screening. The study suggests that efforts should focus on enhancing the readability of these notifications to inform women accurately about their breast density status.
A study by Nancy R. Kressin and colleagues found that dense breast notifications sent to women after mammography contain poor readability and understandability, potentially exacerbating disparities in breast cancer screening. Only three states' notifications met the recommended readability level of grades 7-8 or above.
A review paper suggests that estrobolome disparities could help develop microbiome-based biomarkers for mitigating certain cancers. The gut bacterial genes capable of metabolizing estrogens play a crucial role in shaping systemic estrogen levels.
Sir Richard Peto, Bob Langer, and Alimuddin Zumla receive Honorary Doctor of Medicine degrees for groundbreaking work in epidemiology, biotechnology, and infectious diseases. Their achievements have transformed the pharmaceutical industry and improved human health worldwide.
A study published in JAMA Oncology found that aromatase inhibitors, used to treat breast cancer, do not increase the risk of fatal cardiovascular events. However, women taking these drugs had a higher risk of less serious cardiovascular events, such as abnormal heartbeats and pericarditis.
Breast cancer survivors undergoing anthracycline-based chemotherapy did not experience greater risk of lasting cognitive decline, according to a recent study. Neuropsychological tests revealed comparable cognitive function between groups up to seven years after treatment.
Researchers identified gene alterations that may explain treatment resistance in TNBC, suggesting a potential role for JAK2 inhibitors. The study found that JAK2 amplification was more frequent in chemotherapy-treated tumors and associated with poorer outcomes.
A study analyzing 727 articles found that 45% of media coverage about celebrity diagnoses mentioned double mastectomy. Meanwhile, the number of women undergoing double mastectomy at a Michigan hospital nearly five-fold during this time. The
A recent multi-centre study found that breast cancer patients undergoing treatment with trastuzumab-containing regimens are at significant risk of heart damage, regardless of age. The study suggests that younger patients should also be equally monitored for heart damage.
The I-SPY 2 trial shows that a combination of T-DM1 and pertuzumab before surgery can eradicate residual disease in more patients compared to paclitaxel plus trastuzumab. This new approach may improve outcomes for women with HER2-positive invasive breast cancer.
A new study finds that patients with advanced cancer often view palliative care as a stigma due to its association with death. Experts suggest that education and rebranding could help break down this stigma, promoting a more positive view of the service.
A low-fat diet for eight years improved breast cancer survival rates and reduced mortality in postmenopausal women. The study, conducted by the Women's Health Initiative, found that a sustained low-fat diet increased survival rates among women diagnosed with breast cancer.
Researchers have slowed glioblastoma tumor growth in mouse models using a high-fat, low-carbohydrate diet. The modified diet increased life expectancy by 50% and reduced tumor progression by a similar amount.
A multi-institution study found that nipple-sparing mastectomies are as effective as traditional mastectomy in preventing breast cancer in women with a genetic mutation called BRCA. The procedure, which preserves the nipple and surrounding skin, was found to be safe and effective in reducing breast cancer risk.
A randomized clinical trial found neratinib plus paclitaxel to delay central nervous system (CNS) metastases and reduce their frequency compared to trastuzumab plus paclitaxel in women with ERBB2-positive breast cancer. However, median progression-free survival was similar between the two groups.
Research from Lund University found that cartilage protein COMP is linked to breast cancer development and metastasis. Women with high levels of COMP experienced increased mortality rates, suggesting the protein may serve as an indicator of aggressive breast cancer.
Researchers at Sanford Research have created an animal model to study choroid plexus carcinoma, a pediatric brain tumor. The study identified a new genetic pathway and targeted the Sonic Hedgehog protein as a potential treatment.
Gloria Heppner's 1984 article "Tumor Heterogeneity" has stood the test of time, cited more than any other article in Cancer Research history. The article's longevity is attributed to its clarity and interpretation of data, making it a landmark in cancer research.
A large study of 43,313 women found that infertility and hormone treatment may be linked to higher breast density, a known risk factor for breast cancer. The association was strongest among women who had undergone controlled ovarian stimulation (COS), a common fertility treatment.
A study found that older black women are less likely to receive trastuzumab, a targeted drug improving survival by nearly 40%, than white women. Approximately half of women in the study did not receive any therapy, highlighting disparities in access to proven yet expensive treatment.
A UK-based clinical trial is being conducted to explore the effectiveness of a holistic rehabilitation program for people with and beyond cancer. The study aims to address the lack of support for those living with cancer in the UK, who often experience physical and emotional challenges after treatment.
Drexel University researchers developed a strategy to overcome biological barriers in cancer medication delivery. By decorating nanovehicles with enzymes and adding an extra layer of polyethylene glycol, the particles can penetrate solid tumors more effectively, increasing antitumor efficacy.
A new study reveals that cancer cells can adapt to treatment by actively co-opting blood vessels from nearby tissues, leading to drug resistance. The researchers hope their findings will lead to the development of new therapies targeting vessel co-option, which could be particularly effective when used alongside existing treatments.
Researchers have identified a molecular marker in normal breast tissue that can predict a woman's risk of developing breast cancer. The study found that women with higher levels of the marker were five times more likely to develop cancer.
A metabolic pathway up-regulated in certain breast cancers promotes disease progression by activating the cell signaling protein Arf6, according to a recent study. Statin-like drugs may be effective treatments for patients whose tumors express high levels of Arf6 signaling proteins.
Researchers discovered that breast cancer cells require fatty acids from the extracellular environment to proliferate. LIPG enzyme is crucial for tumor growth, and its inhibition may lead to more efficient chemotherapy treatments.
Researchers investigate how changes in light exposure may contribute to breast cancer development. Extended periods of nighttime illumination disrupted normal cellular behaviors and gene expression, particularly in hormone-dependent tissues like the breast.
A Kaiser Permanente study found that Latina women who received 'Promotora' visits had nearly twice the screening rate of those who did not receive visits. The study showed a modest but significant increase in screening rates, with over 19% of participants completing a mammogram within a year.
A new hybrid molecule has been developed by NYU Tandon researchers that can carry and deliver anti-cancer drugs to malignant cells. The protein-gold nanoparticle composite enhances small-molecule loading, sustained release, and increased uptake in breast cancer cells.
A new study found that BPA directly affects the mammary gland of mouse embryos, potentially raising breast cancer risk. The research, presented at the Endocrine Society's annual meeting, suggests that exposure to endocrine disruptors like BPA in utero may be a key factor in increased breast cancer incidence.
A study found that short nightly fasts of less than 13 hours increased breast cancer recurrence risk, while longer fasts were associated with lower HbA1c levels and longer sleep duration. Prolonging nightly fasting may be a simple strategy to reduce chronic disease risks.