Articles tagged with Breast Cancer
A study found that women with Medicaid or Medicare had lower odds of receiving breast reconstruction compared to those with private insurance. Distance to the nearest plastic surgeon also predicted lower rates of reconstruction. The researchers highlight additional barriers to access beyond socioeconomic class, age, and race.
Researchers at University of Pittsburgh Cancer Institute found that tumor sampling techniques used with new breast cancer tests may lead to underestimation of risk. The study suggests that refining the sampling process is crucial to ensure accurate treatment plans for patients with more aggressive tumors.
A study of over 2,400 women with newly diagnosed breast cancer found that online communication is used to enhance decision making and care support, but barriers exist across age, race, and education levels.
Changes to HER2 testing guidelines have led to a doubling of HER2-positive breast cancers in women, resulting in additional testing and more women being labeled as HER2-positive. However, the effectiveness of targeted therapies like Herceptin is still uncertain, highlighting the need for accurate determination of HER2 status.
Researchers have identified BRCA1 mutations that predict treatment resistance in breast and ovarian cancers. Studies found that tumors with these mutations express a RING-deficient BRCA1 protein, leading to poor treatment responses.
Researchers at UMass Medical School developed a Salmonella 'nanobug' mimic to deliver the protein SipA, which naturally reduces a well-known drug-resistant molecule found in many types of cancer cells. The nanobug dramatically boosts tumor sensitivity to chemotherapeutic drugs, shrinking colon and breast cancer tumors in mice.
A study found that the dietary habits of rat fathers can influence their daughters' breast cancer risk, with high-fat diets increasing risk and vegetable fats reducing it. The researchers also discovered changes in microRNA and protein expression in male rats and their female offspring.
A study examined regional radiotherapy practice patterns for ductal carcinoma in situ (DCIS) and their effect on mastectomy use. Women living in areas with high radiotherapy rates were more likely to undergo mastectomy despite being eligible for breast-conserving surgery.
A new review of epidemiological evidence reveals a causal link between alcohol and cancer at seven sites: oropharynx, larynx, oesophagus, liver, colon, rectum, and female breast. The strongest evidence comes from meta-analyses and dose-response relationships.
Six Canadian innovations, including a low-cost drill system and an HIV self-test application, will receive $10 million in scale-up funding from Grand Challenges Canada. The projects aim to improve global health in developing countries by providing innovative solutions for diseases such as diarrhea, cervical cancer, and HIV.
Researchers found that replication fork protection is a major mechanism of drug resistance in BRCA1/2-mutant breast and ovarian cancers. Proteins such as PTIP, CHD4, and PARP1 promote destabilization of replication forks, making cells chemoresistant.
A study of 19,158 women who underwent IVF treatment and 5,950 women starting other fertility treatments found no association between IVF and increased breast cancer risk. Women with 7 or more IVF cycles had a significantly decreased risk compared to those treated with 1-2 cycles.
A high-fat Mediterranean diet with no restrictions on fat intake may reduce the risk of breast cancer, diabetes, and cardiovascular events. The diet's monounsaturated-to-saturated fat ratio, fruit and vegetable intake, and moderate red wine consumption are key components that contribute to these benefits.
The Nurses' Health Study has made significant advances in risk prediction for cancer, while also guiding recommendations from the US Surgeon General on smoking's adverse health effects. The study's findings have led to changes in regulation, such as reduced heart disease and diabetes risk associated with trans fats.
Researchers from OVC at the University of Guelph discovered a new way to boost immune responses against cancer by injecting oncolytic viruses into the spleen, bypassing traditional vaccine limitations. This breakthrough could lead to safer and more targeted cancer treatments for various types of cancer.
A new York University study suggests that fat cells can promote breast cancer growth in obese individuals but prevent it in lean people. Exercise has been shown to counteract the life-threatening effects of obesity and even completely prevent breast cancer growth.
A Mayo Clinic study reveals a drug combination of TLR agonists and cyclophosphamide to effectively treat advanced and metastatic cancers in mice. The treatment promotes the destruction of cancer cells and activates immune responses without toxicity.
A new study found that an enriched hops extract activates a chemical pathway in cells that could help prevent breast cancer. The research discovered a compound called 6-prenylnarigenin (6-PN), which increased a detoxification pathway linked to a lower risk of breast cancer.
A new digital image analytics test will enable accurate prediction of which women with ER+ breast cancer require chemotherapy or hormonal therapy. The test aims to reduce costs and improve patient outcomes by providing results in a day.
Two independent studies in mice show that fasting or caloric restriction mimetics during chemotherapy increases the presence of cancer-killing T cells, reducing tumor mass over time. The research provides proof of concept for two potentially safe approaches to enhance chemotherapy.
A systematic review of 30 observational studies found that disruption of sensory nerves in the axilla during armpit lymph node surgery is associated with chronic pain. Younger age and radiation therapy are also risk factors for developing chronic post-surgical pain.
A systematic review of 30 studies found that axillary lymph node dissection increases the risk of chronic pain by 21%. Younger age, radiation therapy, and acute pain after surgery were also associated with chronic pain. The study calls for more research into risk factors and techniques to reduce pain.
A diagnosis of high cholesterol is associated with reduced mortality and improved survival in four common cancers: lung, breast, prostate, and bowel cancer. Statins are linked to lower risk of death, with significant reductions seen in all four types of cancer.
A new study by Northwestern University finds that moderate-to-vigorous physical activity is associated with improved subjective memory in breast cancer survivors. Higher levels of physical activity are linked to lower distress, less fatigue, and higher self-confidence, which in turn aids memory.
Researchers at The Wistar Institute have discovered a specific network of proteins present in the mitochondria of cancer cells that enables their ability to proliferate, migrate, and spread. By targeting this pathway, they believe it may be possible to develop new treatments for various types of tumors
Two groundbreaking studies published in New England Journal of Medicine found that patients with specific subtypes of breast cancer responded better to neratinib and veliparib combinations before surgery. These findings have led to the fast-tracking of experimental drugs for large-scale phase 3 trials.
A new study found that acupressure reduced persistent fatigue in women treated for breast cancer, improving sleep quality and overall quality of life. Two-thirds of participants achieved normal fatigue levels after six weeks of relaxing acupressure.
The NCI's largest-ever study of breast cancer genetics in black women aims to identify genetic factors contributing to racial disparities in breast cancer. The study will investigate inherited genetic variations and gene expression in tumor samples.
Researchers are seeking to understand why African-American women die at a higher rate and experience more aggressive breast tumors than white women. The new study aims to identify genetic variants related to breast cancer in African-American women, which may lead to better treatments and prevention.
A study found that women with early-stage breast cancer prioritize their own judgments over surgeon and partner input when making surgical decisions. The majority of women with mastectomies identified themselves as the most influential factor in their decision, while those with lumpectomies prioritized surgeons.
The research team will explore the biological and genetic underpinnings of breast cancer in African-American women, with a focus on identifying novel genes and gene pathways. The study aims to improve knowledge of breast cancer biology, particularly for this population.
Whole-genome gene expression and methylation data offer more predictive power than commonly-used clinical information in breast cancer survival predictions. Combining these data with clinical information improves predictions, suggesting a promising genomic approach for future clinic applications.
Researchers developed biomarker ratio imaging microscopy (BRIM) to differentiate between aggressive and non-aggressive ductal carcinoma in situ (DCIS). The technique combines traditional pathology and mathematical analysis, identifying biomarkers that can indicate the potential for cancer to become invasive.
Researchers have discovered a positive correlation between gene mutation 'hotspots' and better breast cancer outcomes, including lower tumor invasiveness and longer patient survival. These findings could inform prognosis and help identify patients who would best respond to immunotherapy and other treatments.
A new study published in JAMA Oncology found that women with BRCA1 mutations are at increased risk for developing aggressive serous/serous-like endometrial cancer after undergoing risk-reducing salpingo-oophorectomy (RRSO). The risk is estimated to be 2.6% by age 70.
Julia Ljubimova, MD, PhD, receives grant to advance research on tumor nanoimmunology and develop new generation of drugs for brain, breast, lung cancers. The goal is to improve immune system and block tumors from forming.
Researchers developed nanoparticles that target and deliver chemotherapy drugs to metastatic cancer tumors using radiation guidance. The approach exploits overexpression of P-selectin molecules in human cancers, allowing for selective tumor penetration.
Research has discovered a link between high levels of calpain and improved survival rates in breast cancer patients undergoing chemotherapy. The study found that patients with higher calpain levels had better outcomes, suggesting the protein may be a key target for improving patient outcomes.
A study of older women with newly diagnosed stage I to III breast cancer found that approximately one in five experienced functional decline within a year of treatment initiation. The Vulnerable Elders Survey was used to identify those at risk, showing promise for early identification and prevention of functional decline.
A new treatment developed by UTSA researcher Matthew Gdovin can kill up to 95% of cancer cells in two hours using a single dose and a beam of light. The method involves injecting a chemical compound into the tumor and then exposing it to a beam of light, causing the cells to become acidic and commit suicide.
Obese male mice produce female pups that are overweight and have delayed breast tissue development, linked to increased breast cancer risk. Researchers found epigenetic changes in miRNA signatures of dad's sperm and daughter's breast tissue
Research suggests that beneficial bacteria like Lactobacillus and Streptococcus may protect women from breast cancer by inducing anticarcinogenic properties. Probiotics could be a potential tool to boost these beneficial bacteria, potentially lowering the risk of breast cancer.
Researchers discovered that progesterone receptor dramatically alters how estrogen receptors interact with cell's DNA, leading to inhibition of cellular proliferation and metastasis. Combining tamoxifen with a progestin antagonist showed added benefit in shrinking tumors.
Mount Sinai scientists identified CBX8 as a protein that promotes tumor growth in the most lethal forms of breast cancer. This study highlights the need to focus on epigenetic factors and suggests new strategies against these aggressive cancers.
Consistent reductions in cancer incidence and mortality were observed with adherence to cancer prevention guidelines. These guideline adherence showed a significant reduction of 10-45% in all cancer incidence and 14-61% in all cancer mortality. The review also found consistent reductions in breast, endometrial, and colorectal cancers.
Researchers found that low doses of paclitaxel, a widely used breast cancer treatment, can actually increase cancer spread to the liver. This contradicts previous strategies of lowering dosage to reduce toxic side effects.
Research suggests that an extract from hops could help fend off breast cancer by boosting the cells' detoxification pathway, a process linked to a lower risk of developing breast cancer. The study found that one particular compound, 6-PN, had anti-cancer effects and may be a potential natural alternative to hormone replacement therapy.
A new study published in Radiology found that pre-operative supine MRI can provide more detailed and accurate information than prone MRI, helping surgeons detect remnant tumors and ensure clear margins. This could lead to effective tumor removal and reduce the need for re-operations.
Research from University of Eastern Finland and Kuopio University Hospital found that very low mammographic breast density is associated with worse prognosis in breast cancer patients. Low density combined with high hyaluronan levels in tumors predicted poorer survival rates.
Researchers discovered a new signaling pathway that helps cancer cells cope with hypoxia, allowing them to thrive in low-oxygen environments. The study found that the enzyme protein-tyrosine phosphatase 1B (PTP1B) regulates tumor response to hypoxia by controlling oxygen consumption, potentially leading to novel treatments.
Biologists from UNIGE reveal a mechanism of resistance to the anti-estrogenic drug tamoxifen, identifying eight factors that enable breast cancer cells to become refractory to treatment. The researchers suggest various approaches for developing new therapies targeting these factors.
Researchers identified denosumab as a potential non-surgical option to prevent breast cancer in women with elevated genetic risk. The study showed that the drug switched off cell growth and curtailed breast cancer development in laboratory models.
A new study from Lund University found that smoking affects the efficacy of aromatase inhibitor treatment for breast cancer, leading to a threefold higher risk of recurrence. Smoking also increases the risk of dying from breast cancer or other illnesses during treatment.
Researchers have developed a new device that enables existing breast cancer imagers to provide up to six times better contrast of tumors in the breast while maintaining the same or better image quality. The Variable Angle Slant Hole Collimator reduces radiation dose to patients by half, potentially improving imaging of other organs.
A new study finds that a shorter radiation course with higher doses per fraction is equivalent to a longer, lower-dose course in terms of cosmetic, functional, and pain outcomes. The results support the use of hypofractionated whole-breast irradiation as the preferred treatment for early-stage breast cancer patients.
A new study has identified a connection between a cancer gene and the metabolic processes that fuel the rapid growth and movement of aggressive cancer cells. Researchers discovered that the RhoC gene regulates cell metabolism and energy production, driving cancer cells to move faster than normal.
Researchers have discovered a new way to slow the growth of aggressive triple negative breast cancer by targeting hypoxia, or low oxygen levels. The study found that drug JQ1 can alter how cancer cells respond to hypoxia, slowing tumour growth and limiting blood vessel production.
A new study reverses resistance to antiangiogenic drugs by adding an antidiabetic agent, inhibiting tumor growth up to 92%. Researchers found that this mechanism can be targeted to attack cancer cells, with potential for improved treatment outcomes. The discovery has the potential to prolong patient benefit from antiangiogenic treatments.
A study found that breast cancer patients who did not adhere to their medication schedule for chronic conditions before diagnosis were twice as likely to skip oral adjuvant hormonal therapy. Non-adherence rates were higher among women with certain age groups, medical specialties, and co-payments.
A study published in JAMA Oncology shows that intrinsic molecular subtyping of breast cancer can predict patient outcomes and guide treatment decisions. The research found that the genomic classification of tumors is a key prognostic factor, outperforming traditional variables such as age and number of metastases.