Articles tagged with Breast Cancer
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Whole-genome gene expression and methylation data offer more predictive power than commonly-used clinical information in breast cancer survival predictions. Combining these data with clinical information improves predictions, suggesting a promising genomic approach for future clinic applications.
Researchers developed biomarker ratio imaging microscopy (BRIM) to differentiate between aggressive and non-aggressive ductal carcinoma in situ (DCIS). The technique combines traditional pathology and mathematical analysis, identifying biomarkers that can indicate the potential for cancer to become invasive.
Researchers have discovered a positive correlation between gene mutation 'hotspots' and better breast cancer outcomes, including lower tumor invasiveness and longer patient survival. These findings could inform prognosis and help identify patients who would best respond to immunotherapy and other treatments.
A new study published in JAMA Oncology found that women with BRCA1 mutations are at increased risk for developing aggressive serous/serous-like endometrial cancer after undergoing risk-reducing salpingo-oophorectomy (RRSO). The risk is estimated to be 2.6% by age 70.
Julia Ljubimova, MD, PhD, receives grant to advance research on tumor nanoimmunology and develop new generation of drugs for brain, breast, lung cancers. The goal is to improve immune system and block tumors from forming.
Researchers developed nanoparticles that target and deliver chemotherapy drugs to metastatic cancer tumors using radiation guidance. The approach exploits overexpression of P-selectin molecules in human cancers, allowing for selective tumor penetration.
Research has discovered a link between high levels of calpain and improved survival rates in breast cancer patients undergoing chemotherapy. The study found that patients with higher calpain levels had better outcomes, suggesting the protein may be a key target for improving patient outcomes.
A study of older women with newly diagnosed stage I to III breast cancer found that approximately one in five experienced functional decline within a year of treatment initiation. The Vulnerable Elders Survey was used to identify those at risk, showing promise for early identification and prevention of functional decline.
A new treatment developed by UTSA researcher Matthew Gdovin can kill up to 95% of cancer cells in two hours using a single dose and a beam of light. The method involves injecting a chemical compound into the tumor and then exposing it to a beam of light, causing the cells to become acidic and commit suicide.
Obese male mice produce female pups that are overweight and have delayed breast tissue development, linked to increased breast cancer risk. Researchers found epigenetic changes in miRNA signatures of dad's sperm and daughter's breast tissue
Research suggests that beneficial bacteria like Lactobacillus and Streptococcus may protect women from breast cancer by inducing anticarcinogenic properties. Probiotics could be a potential tool to boost these beneficial bacteria, potentially lowering the risk of breast cancer.
Researchers discovered that progesterone receptor dramatically alters how estrogen receptors interact with cell's DNA, leading to inhibition of cellular proliferation and metastasis. Combining tamoxifen with a progestin antagonist showed added benefit in shrinking tumors.
Mount Sinai scientists identified CBX8 as a protein that promotes tumor growth in the most lethal forms of breast cancer. This study highlights the need to focus on epigenetic factors and suggests new strategies against these aggressive cancers.
Consistent reductions in cancer incidence and mortality were observed with adherence to cancer prevention guidelines. These guideline adherence showed a significant reduction of 10-45% in all cancer incidence and 14-61% in all cancer mortality. The review also found consistent reductions in breast, endometrial, and colorectal cancers.
Researchers found that low doses of paclitaxel, a widely used breast cancer treatment, can actually increase cancer spread to the liver. This contradicts previous strategies of lowering dosage to reduce toxic side effects.
Research suggests that an extract from hops could help fend off breast cancer by boosting the cells' detoxification pathway, a process linked to a lower risk of developing breast cancer. The study found that one particular compound, 6-PN, had anti-cancer effects and may be a potential natural alternative to hormone replacement therapy.
A new study published in Radiology found that pre-operative supine MRI can provide more detailed and accurate information than prone MRI, helping surgeons detect remnant tumors and ensure clear margins. This could lead to effective tumor removal and reduce the need for re-operations.
Research from University of Eastern Finland and Kuopio University Hospital found that very low mammographic breast density is associated with worse prognosis in breast cancer patients. Low density combined with high hyaluronan levels in tumors predicted poorer survival rates.
Researchers discovered a new signaling pathway that helps cancer cells cope with hypoxia, allowing them to thrive in low-oxygen environments. The study found that the enzyme protein-tyrosine phosphatase 1B (PTP1B) regulates tumor response to hypoxia by controlling oxygen consumption, potentially leading to novel treatments.
Biologists from UNIGE reveal a mechanism of resistance to the anti-estrogenic drug tamoxifen, identifying eight factors that enable breast cancer cells to become refractory to treatment. The researchers suggest various approaches for developing new therapies targeting these factors.
Researchers identified denosumab as a potential non-surgical option to prevent breast cancer in women with elevated genetic risk. The study showed that the drug switched off cell growth and curtailed breast cancer development in laboratory models.
A new study from Lund University found that smoking affects the efficacy of aromatase inhibitor treatment for breast cancer, leading to a threefold higher risk of recurrence. Smoking also increases the risk of dying from breast cancer or other illnesses during treatment.
Researchers have developed a new device that enables existing breast cancer imagers to provide up to six times better contrast of tumors in the breast while maintaining the same or better image quality. The Variable Angle Slant Hole Collimator reduces radiation dose to patients by half, potentially improving imaging of other organs.
A new study finds that a shorter radiation course with higher doses per fraction is equivalent to a longer, lower-dose course in terms of cosmetic, functional, and pain outcomes. The results support the use of hypofractionated whole-breast irradiation as the preferred treatment for early-stage breast cancer patients.
A new study has identified a connection between a cancer gene and the metabolic processes that fuel the rapid growth and movement of aggressive cancer cells. Researchers discovered that the RhoC gene regulates cell metabolism and energy production, driving cancer cells to move faster than normal.
Researchers have discovered a new way to slow the growth of aggressive triple negative breast cancer by targeting hypoxia, or low oxygen levels. The study found that drug JQ1 can alter how cancer cells respond to hypoxia, slowing tumour growth and limiting blood vessel production.
A new study reverses resistance to antiangiogenic drugs by adding an antidiabetic agent, inhibiting tumor growth up to 92%. Researchers found that this mechanism can be targeted to attack cancer cells, with potential for improved treatment outcomes. The discovery has the potential to prolong patient benefit from antiangiogenic treatments.
A study found that breast cancer patients who did not adhere to their medication schedule for chronic conditions before diagnosis were twice as likely to skip oral adjuvant hormonal therapy. Non-adherence rates were higher among women with certain age groups, medical specialties, and co-payments.
A study published in JAMA Oncology shows that intrinsic molecular subtyping of breast cancer can predict patient outcomes and guide treatment decisions. The research found that the genomic classification of tumors is a key prognostic factor, outperforming traditional variables such as age and number of metastases.
Researchers at Michigan Medicine identified a promising new compound for targeting triple-negative breast cancer. UM-164 blocks the kinase c-Src and inhibits another pathway, p38, involved in this subtype. The compound had very few side effects in mice.
A study led by Loyola Medicine researchers found that taking tamoxifen for breast cancer reduces the risk of uterine cancer in postmenopausal patients. The study also showed that a normal ultrasound before treatment may provide additional reassurance.
LA BioMed researchers find a new study on aromatase inhibitors to prevent breast cancer recurrence is reassuring. The study's findings have direct application for clinical practice, with implications for cardiologists and oncologists.
A new study from MD Anderson Cancer Center found substantial variation in costs of breast cancer treatment for different chemotherapy regimens, with insurer costs varying by as much as $20,354. Choosing equally effective but less costly regimens could impact the cost of breast cancer care nationally by $1 billion every year.
A crowd-sourcing strategy leveraging social media and advocacy groups has connected over 2,000 patients from all 50 states with the Metastatic Breast Cancer Project. This approach empowers patients to directly participate in research, improving outcomes for advanced breast cancer patients.
Researchers found that patients who used metformin before diagnosis had a higher risk of death, while those who started using it after diagnosis were more likely to survive. Metformin also showed promise as a treatment for endometrial hyperplasia, with 56% of patients responding to treatment.
Researchers have discovered a new protein compound that binds to two HER2 receptors simultaneously, preventing growth signals and killing cancer cells. This innovative solution shows great promise in treating invasive breast cancer more effectively.
A new treatment shows promise against a rare and deadly eye cancer by blocking the protein ARF6, which distributes cancer-promoting signals. The study found that inhibiting ARF6 inhibited eye tumors in mice, suggesting a potential strategy for treating other cancers as well.
An international clinical trial led by University of Pittsburgh Cancer Institute (UPCI) professor Atilla Soran found that surgery to remove the primary tumor followed by standard therapy adds months to patients' lives compared to standard therapy alone. Surgery resulted in nearly 42% of women living to five years after diagnosis.
A new compound called Fasnall has been discovered to impede the proliferation of breast cancer cells in mice. By inhibiting the normal activity of fatty acid synthase, an enzyme that regulates cell growth and proliferation, Fasnall also contributed to the death of existing cancer cells.
New research suggests that fluctuations in tRNA levels can have a dramatic impact on cellular function, driving metastatic breast cancer. The study found that two specific tRNAs were associated with increased metastasis, leading to changes in gene expression and protein production.
A new study from Mount Sinai researchers reports a high success rate for a personalized medicine program that uses an integrated genomic approach to guide cancer treatment. The program led to therapeutic recommendations for 91% of patients, outperforming targeted cancer panels in clinical use.
The BRCA1 gene's ubiquitin ligase activity is crucial for error-free DNA repair through homologous recombination. Cells lacking this function are sensitive to DNA damaging agents and may develop cancer.
A study by Dr. Sarah Saxena found that breast cancer patients need fewer painkillers after non-opiate anesthesia, which may reduce side effects like nausea and vomiting. Non-opiate anesthesia could also potentially lower cancer recurrence rates, but further research is needed to confirm these findings.
New research suggests that women with a high genetic risk of breast cancer can reduce their risk by following a healthy lifestyle, including eating right, exercising, and quitting smoking. The study found that approximately 30% of breast cancer cases could be prevented by modifying known risk factors.
Researchers developed a model to estimate absolute breast cancer risk, finding that up to 28.9% of breast cancers could be prevented by reducing modifiable risk factors in white US women. The study included 92 genetic susceptibility variants and various epidemiologic factors.
SWOG investigators report on clinical trials for lung, prostate, breast, and other cancers, including Lung-MAP precision medicine trial. Trial results also highlight the reliability of CT scan tumor measurements for evaluating new drug effectiveness.
A recent study published in The Lancet found that the global economic crisis was associated with an increase in cancer mortality, particularly among treatable cancers. Universal health care coverage may protect patients from the health consequences of rising unemployment and reduced public-sector healthcare spending.
A multi-institutional team has completed the first large-scale proteogenomic study of breast cancer, linking DNA mutations to protein signaling and identifying genes that drive cancer. The study highlights the power of integrating genomic and proteomic data to yield a more complete picture of cancer biology.
A phase I clinical trial showed that abemaciclib achieved durable clinical activity in patients with breast cancer, non-small cell lung cancer, glioblastoma, and melanoma. Radiographic responses were observed for some patients with hormone receptor-positive breast cancer and NSCLC.
A prospective economic study published in Annals of Internal Medicine found that computed tomographic angiography and functional diagnostic testing strategies for diagnosing coronary artery disease have similar costs through 3 years of follow-up. The study included 9,649 patients enrolled in a clinical trial between 2010 and 2013.
Researchers at Boston University School of Medicine found similarities in genetic and epigenetic alterations between breast and ovarian cancers. The study suggests that better understanding of these changes may lead to more effective chemotherapeutics and strategies to circumvent drug resistance.
Researchers at Sylvester Comprehensive Cancer Center identified a novel treatment option for triple-negative breast cancer (TNBC) by targeting vitamin D and androgen receptors. This approach showed promising results in reducing the sustainability of cancer cells, offering new hope for patients with this aggressive form of breast cancer.
Researchers at Dana-Farber Cancer Institute present studies on the influence of tumor location on colorectal cancer survival, breast cancer clinical trial participation among older patients, and support for medical marijuana use in children with cancer. The findings suggest that consistent reporting of tumor location is crucial for imp...
A study published in Cancer Epidemiology, Biomarkers & Prevention found that adolescent girls with high saturated-fat diets and low unsaturated-fat intake had higher breast densities, which may increase their risk for breast cancer later in life. The researchers analyzed data from 177 women and observed a significant association betwee...
A research team identified low expression of methylation-controlled J protein (MCJ) as a marker of poor response to chemotherapy in triple-negative breast cancer patients. They found that MCJ-expressing tumors had reduced relapse-free survival and that mice deficient in MCJ had larger tumors and increased chemoresistance.
Researchers have developed a single-layer organic nanometer-scale transistor that can detect molecules associated with neurodegenerative diseases and some types of cancer. The device uses glutathione and glutathione S-transferase to identify target molecules, offering sensitivity and potential for rapid diagnosis.
A recent study by Johns Hopkins Kimmel Cancer Center scientists reveals that the HOXA5 protein plays a crucial role in maintaining normal breast cells' traits, such as adhesion and cell plasticity. The loss of HOXA5 leads to increased tumor aggressiveness and poorer outcomes for patients.
A study published in Cancer Epidemiology, Biomarkers & Prevention found that consuming high amounts of saturated fat or low amounts of mono- and polyunsaturated fats during adolescence is associated with higher breast density in young adulthood. This increased risk of breast cancer was observed after adjusting for multiple variables.
A new study using mice and lab-grown human cells shows a triple-drug cocktail can shrink triple-negative breast cancers by killing off cancer cells and halting new tumor growth. The combination treatment, EAD therapy, reduced the size of tumors in mice and decreased tumor growth in spheres grown from patients' metastatic cells.
Researchers designed a novel mTOR inhibitor, Rapalink, to combat drug-resistant tumors. In animal experiments, Rapalink reduced the size of tumors resistant to earlier-generation inhibitors.