Articles tagged with Breast Cancer
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Researchers investigate how queuine, produced by gut bacteria, affects breast cancer risk and growth. High levels of queuine-modified tRNAs may speed up protein production in rapidly dividing cancer cells.
Researchers at University of Granada found telerehabilitation through Skype reduces pain, fatigue, and improves strength in women with breast cancer. An 8-week exercise program led to significant benefits that lasted 6 months after completion.
The study, involving 1,531 women, found that breast reconstruction following mastectomy for breast cancer yields similar benefits for all age groups, with no significant increase in complication risk. The procedure is generally successful and should not be disqualifying based on age alone.
The ECOG-ACRIN Cancer Research Group is recruiting medical facilities for the Tomosynthesis Mammography Imaging Screening Trial (TMIST), a large-scale breast cancer screening trial comparing digital breast tomosynthesis with standard digital mammography. The study aims to provide a modern basis for continued use of mammography.
A study found that tumor genome testing helped physicians identify patients who could benefit from chemotherapy, while those for whom it could be safely omitted received personalized recommendations. The test eliminated racial/ethnic disparities in testing or treatment, but many women inaccurately recalled their results.
A new cancer treatment combines four therapies to activate both branches of the immune system, leading to complete disappearance of large tumors in mice. The approach allows the immune system to remember the target and destroy new cancer cells that appear after treatment.
A study at McGill University Health Centre found that women with tumors expressing the prolactin receptor had a less aggressive breast cancer and better prognosis. The research suggests screening for the prolactin receptor could indicate which patients might benefit from new treatments, potentially revolutionizing breast cancer therapies.
A new study found that a genetic test assessing breast cancer recurrence risk is being used to guide chemotherapy decisions in early-stage breast cancer patients. The test, which looks at 21 genes known to increase the risk of cancer recurrence, has been shown to align treatment recommendations with individual patient profiles.
Researchers found a specific rearrangement of collagen fibers surrounding tumors associated with early death, which may indicate poorer survival rates. The study suggests that understanding collagen's role in cancer could lead to new therapeutic targets for pancreatic cancer.
A multidisciplinary team has developed a new method to automate the screening of breast cancer histopathology images, improving detection rates. The technique uses image-processing methods to identify cancerous cells, overcoming challenges posed by clustered and vague boundaries.
Researchers have identified a mechanism by which tumors recruit bone mesenchymal stem cells and convert them into cancer-associated fibroblasts, facilitating tumor progression. Basic fibroblast growth factor (bFGF) signaling plays a crucial role in this process, suggesting new therapeutic targets for suppressing tumor growth.
African American women are diagnosed with breast cancer at younger ages and face higher mortality rates due to more aggressive ER-negative tumors. Researchers identified modifiable risk factors, including breastfeeding and waist-to-hip ratio, that may help reduce personal risk of ER-negative breast cancer.
A study found that nearly 30% of women with breast cancer are not getting the recommended annual mammogram and surveillance imaging. Factors such as younger age, black race, and lack of insurance are associated with underutilization of breast imaging.
Eleven cancers causing most loss of healthy life years in the US are closely associated with preventable risk factors like smoking and alcohol. Lung cancer accounts for 24% of the burden, followed by breast, colorectal, pancreatic, prostate, leukemia, liver, brain, non-Hodgkin lymphoma, and ovarian cancers.
Contralateral prophylactic mastectomy (CPM) is being performed at a rate more than double what it was 10 years ago, with fear of recurrence as the leading reason. Studies found that patients are misinformed about CPM being the best treatment for breast cancer, which may be driving its increased popularity.
Researchers develop artificial cell-like spheres from natural proteins to study drug transport and variability. Variants in genes ABCB1 and CYP19A1 associated with anastrozole concentrations and joint pain in breast cancer patients.
New research from The Wistar Institute found that estrogen signaling is responsible for immunosuppressive effects in the tumor microenvironment across various cancers. This discovery paves the way for combining anti-estrogen therapy with immunotherapeutic treatments to extend survival in patients.
University of Oklahoma researchers have designed a novel photothermal therapy that eliminates tumors without affecting healthy cells. The therapy uses single-walled carbon nanotubes to target specific cancer cells in breast, bladder, esophageal, and melanoma cancers.
PharmaMar's Phase 2 study shows significant reduction in tumor size and improved survival rates for patients with BRCA 1/2 metastatic breast cancer. The trial achieved an overall response rate of 41% with a 61% response rate in the BRCA 2 subgroup.
A Phase III trial found ribociclib improved PFS of post-menopausal women with hormone receptor-positive metastatic breast cancer by 44 percent compared to hormone therapy alone. The study also showed a higher ORR in patients receiving ribociclib, with serious adverse events occurring less than five percent overall.
A study published in the British Journal of Cancer predicts that more than 352,000 people will be diagnosed with cancer each year in the UK by 2035, a rise of 150,000 cases annually. The projected increase is largely attributed to an ageing and growing population, as well as lifestyle factors such as obesity and smoking.
A report by Brain Tumour Research reveals that brain tumours are the biggest killer of children and young adults, with only £4 million spent on research per death. The charity is campaigning for increased funding to advance treatments and find a cure.
A new study suggests that combining an experimental PARP inhibitor with an epigenetic drug can strengthen treatment effectiveness against breast cancer cells without BRCA mutations, as well as leukemia cells. The combination therapy resulted in a strong antitumor response and halted tumor growth.
A new study from MD Anderson found substantial variation in the costs of breast cancer treatment for different chemotherapy regimens, with varying prices by up to $20,354. The researchers suggest that informed choice of chemotherapy could impact costs nationally by $1 billion annually.
A new study finds that breast cancer chemotherapy regimens with similar efficacy have significantly varying costs, affecting patients' financial burden. The study highlights the need for accessible information to inform treatment decisions and promote well-informed shared decisions regarding treatment options.
Researchers found that fulvestrant significantly increases progression-free survival in hormone-receptor-positive advanced breast cancer patients, especially those with lower-volume disease. The treatment also showed similar health-related quality of life compared to anastrozole and was well-tolerated.
The MONALEESA2 study shows a significant improvement in progression-free survival for postmenopausal women with hormone receptor-positive advanced breast cancer when treated with ribociclib plus letrozole. The combination also resulted in higher objective response rates and improved clinical benefits.
A study by University of Minnesota researchers found that elevated levels of APOBEC3B in breast cancer cells lead to reduced response to tamoxifen therapy. Depletion of the protein accelerates development of resistance, while increased production speeds it up.
Despite previous concerns, a new review of evidence suggests that night shift work is unlikely to increase breast cancer incidence. A meta-analysis of three large UK studies and seven previously published studies found no significant association between night shift work and breast cancer risk.
Studies suggest that population commitment, physician implication, and reassurance in screening can improve participation rates. A patient-centred approach in Australia improved screening participation by offering a combined cancer screening service. Additionally, nurse-led clinics can provide effective early diagnosis and prevention o...
A large study of over 1.4 million women found no increased risk of breast cancer associated with night shift work, including long-term shifts. The research combined data from multiple studies and provided new insights into the topic.
Researchers harness microRNA therapy to block movement of cancer cells from primary tumors, preventing fatal proliferation and metastasis. The study's results suggest a promising approach for human breast cancer treatment.
PharmaMar presents updated clinical trial data for its antitumoral compounds Yondelis and lurbinectedin, demonstrating efficacy in treating solid tumors such as breast, soft tissue sarcomas, and colorectal cancer. These findings support the potential of these molecules as treatments for various types of solid tumors.
Women with extremely high breast density are more likely to develop breast cancer, and current mammography technology may miss tumors. Researchers are working to improve breast cancer diagnosis and health outcomes for women through education and better utilization of screening methods.
A recent study published in npj Breast Cancer found that postmenopausal breast cancer patients taking tamoxifen have a lower risk of uterine cancer than expected. The study suggests that a normal ultrasound before treatment may provide additional reassurance for women concerned about endometrial side effects.
The Houston Methodist Research Institute has established a research center focused on the physics of cancer immunotherapy, exploring physiological changes during cancer progression. The CITO will combine cancer immunology, biotechnology, and transport oncophysics to reveal how immunotherapy works in cancer patients.
NRG-RTOG 0232 study found no significant difference in 5-year progression-free survival between external beam radiation therapy plus brachytherapy and brachytherapy alone. The treatment combination also resulted in fewer late genitourinary effects, mostly noted in the brachytherapy only arm.
Researchers found that inhibiting glucose-regulated protein 78 (GRP78) restores sensitivity to tamoxifen in resistant breast cancer. Silencing GRP78 toxically stresses breast cancer cells, leading to cell death. Adding tamoxifen to a GRP78 inhibitor offers an effective combination, enhancing the treatment's effectiveness.
A Phase III randomized trial comparing intensity modulated radiation therapy (IMRT) to standard RT found that patients treated with IMRT had better bowel and bladder functions scores and required fewer anti-diarrheal medications. Quality of life measures also showed less decline for patients treated with IMRT.
A new mobile app, TOLF, is being developed to assist breast cancer survivors in identifying and treating lymphedema through self-assessment tools, avatar videos for exercise guidance, and symptom management features. Researchers found that 90% of participants reported no problems using the system.
Researchers found that pharmacological and genetic RANK pathway inhibition significantly reduced recurrences and metastases in a mouse animal model of breast cancer. This suggests RANK inhibitors used in osteoporosis treatment may also be effective against breast cancer.
A new long-term analysis of prognostic factors among patients with breast cancer reveals that young age and ductal carcinoma in situ (DCIS) adjacent to invasive tumors are associated with increased ipsilateral breast tumor recurrence. High-grade invasive tumors also relapsed more frequently during the first five years.
An animal study suggests that resistance to tamoxifen therapy in some estrogen receptor positive breast cancers may originate from in utero exposure to endocrine disrupting chemicals. Researchers identified four genes linked to tamoxifen resistance and poor prognosis of breast cancer.
Researchers developed a computer program to automatically count the number of tubules in breast cancer tissue specimens, finding a correlation with Oncotype DX gene expression test risk scores. The study aims to provide an affordable and quick alternative to current genomic tests for predicting chemotherapy needs.
Research from the University of Sydney found that physical activity can decrease cancer and all-cause mortality risks in drinkers. The study found moderate to heavy drinking increased cancer risk, but regular exercise offset this risk.
Researchers at RIT and Rochester Regional Health are advancing thermal imaging techniques for detecting early-stage breast cancer. The collaboration aims to increase the accuracy of screening using a potentially safer and less invasive diagnostic tool.
Researchers identified nuclear transport genes, particularly XPO1, as key players in tamoxifen resistance. Combining tamoxifen with selinexor improves sensitivity and prevents tumor recurrence.
The European Society for Medical Oncology (ESMO) has awarded four distinguished recipients for their outstanding contributions to cancer treatment and research. Alberto Sobrero received the ESMO Award for his world-renowned research on gastrointestinal cancer, while Sir Richard Peto was recognized for his important contributions to bre...
Researchers identified a unique oscillating pattern of a key cancer gene that may contribute to disease progression and treatment resistance. The study found that simultaneous treatment with chemotherapy and targeted drugs can suppress tumor cell growth in both ER+/HER2- and HER2+ subpopulations.
Researchers at Thomas Jefferson University found that African American breast cancer survivors face unique challenges, including emotional and physical problems. The study suggests that addressing these issues can help reduce cancer disparities and improve health outcomes.
A new study found that breastfeeding for longer than 6 months is associated with reduced breast cancer-specific and overall survival among women treated for breast cancer. The study, published in Breastfeeding Medicine, confirms the long-term maternal health benefits of breastfeeding.
A new report from UC Davis Institute for Population Health Improvement highlights areas where increased cancer screening and control efforts can save lives. Effective screening tests exist for several cancers, yet many Californians remain under-screened, leading to late-stage diagnoses and reduced treatment success.
A nationwide study in England has collected data on 30-day mortality for patients with breast and lung cancer treated with chemotherapy, identifying factors such as age, general well-being, and NHS trusts with higher-than-expected rates of mortality. The study aims to improve patient care and inform clinical decision-making.
Researchers at Houston Methodist developed an AI software that reliably interprets mammograms to predict breast cancer risk. The software achieves 99% accuracy in 30 times human speed, reducing unnecessary biopsies and saving physician hours.
Researchers have discovered a potential new approach to treating triple negative breast cancer by targeting enhanced mitochondrial function. Mice studies showed that inhibiting mitochondrial protein translation could slow tumor growth, suggesting this strategy may be a successful treatment option.
A new study by Brigham and Women's Hospital investigators shows that trained radiologists can identify abnormal mammograms at better than chance levels when shown images for only half a second. The researchers found that finer details of breast tissue texture help radiologists make the correct diagnosis more frequently.
Researchers discovered that functional regulatory components outside of genes contribute to breast cancer development. Epigenetic changes identified as key drivers of the disease.
A new epigenetic test can diagnose the primary tumor responsible for metastasis in patients with Cancer of Unknown Primary (CUP), allowing for more specific treatments. This test, EPICUP, analyzes a patient's DNA to identify the type of cancer, resulting in improved survival rates.
Researchers found a mixture of HER2-positive and HER2-negative breast cancer cells in patients' blood samples, which can lead to tumor progression and resistance to treatment. Combining therapies targeting both populations may be effective in eliminating these cells.
CPRIT awards UT Southwestern Medical Center $9.6 million for various cancer research projects, including lung cancer treatment and prevention efforts. The funding will support research into how cancer cells grow, target breast cancer survivors with active living interventions.