Articles tagged with Breast Cancer
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Researchers at UNC Lineberger Comprehensive Cancer Center developed a model that can predict which triple negative breast cancer patients will respond to chemotherapy. The model was moderately successful, accurately predicting response in 68% of cases with pathologic complete response.
A study found that women aged 65 years or older with metastatic breast cancer are more likely to have cancer-linked genetic alterations and receive targeted therapy than younger patients. Researchers emphasized the need to better understand and characterize genetic abnormalities in this age group to improve treatment options.
Rates of breast cancer brain metastasis have not substantially declined despite improved targeted treatments for HER2-positive metastatic breast cancer. Researchers found that the risk of death from brain metastasis is more than twice that of patients with metastasis to other areas of the body.
Researchers at the University of Pittsburgh Cancer Institute have discovered molecular changes in primary tumors of breast cancer patients who developed brain metastases. The findings suggest that targeted therapies should be tailored not only for the original breast cancer but also for the brain tumors.
Patients with large breast tumors and no axillary lymph node signs before chemotherapy showed low risk of recurrence with SLNB. Follow-up data revealed high disease-free survival rates comparable to ALND, suggesting SLNB as a safe alternative.
Researchers at Mayo Clinic found that inherited pathogenic variants in genes BARD1 and RAD51D increase a woman's likelihood of developing breast cancer. The study also confirmed the involvement of other genes such as ATM, CHEK2 and PALB2 in breast cancer risk.
A new study found that cancer cases are growing at an alarming rate in less developed countries, with a 50% increase between 2005 and 2015. The global burden of disease is heaviest for countries with high development levels, but the most rapid escalation can be seen in low-income nations where health services are often lacking.
Research papers in PLOS Medicine discuss progress in cancer genomics, including whole-genome sequencing and gene expression changes. Studies on breast cancer and brain tumors provide insights into tumor evolution and metastasis, potentially leading to new treatments and prognosis estimation.
A new class of NIR-absorbing biodegradable organic nanoparticles has been developed for the targeting and treatment of deep-tissue tumors. These molecules can be triggered by low-power lamp light, allowing for precise tumor-targeting therapy with minimal side effects.
Researchers at the Weizmann Institute of Science have identified a promising new combination therapy for triple negative breast cancer, which inhibits tumor growth and survival while preventing drug resistance. The therapy targets EGFR and PYK2 molecules, leading to a more potent therapeutic effect than inhibiting either molecule alone.
The study estimates 17.5 million cancer cases and 8.7 million cancer-related deaths worldwide in 2015, with prostate cancer being the most common in men and breast cancer in women. The report also highlights an increase in cancer incidence due to aging and demographic changes.
Renowned researchers Fergus Couch and Max Wicha are being honored by AACR for their significant work in breast cancer etiology, detection, diagnosis, treatment, or prevention. Their research has led to the identification of inherited genes and mutations that predispose to breast cancer.
Researchers found that blocking tumor interferon pathway with a JAK inhibitor improves checkpoint inhibitor drugs and bypasses the need for combinations, which often come with serious side effects. The study suggests a new approach to addressing cancer immunotherapies' limitations.
Research from Oregon State University reveals numerous gaps in survivorship care for Latinas, including unmet needs for information, symptom management, and coordination among specialists. The study highlights the importance of understanding cultural context and developing tailored support systems to address these gaps.
A phase I trial of LY3039478 showed the drug's ability to inhibit Notch signalling pathway in patients with various advanced cancers. The treatment resulted in tumour shrinkage and disease stabilisation, particularly in rare cancers like adenoid cystic carcinoma.
A proposed biosimilar drug has shown equivalent results to trastuzumab in treating metastatic breast cancer. The study's findings suggest that a biosimilar treatment option could increase global access to biologic cancer therapies, particularly for women in non-high-income countries.
A new optical fiber probe can distinguish between cancer and normal tissues in real-time, allowing for more precise removal of cancerous tissue during surgery. This technology has the potential to reduce the need for additional surgeries to remove leftover cancer.
Researchers at the University of Adelaide have developed an optical fiber probe that can distinguish breast cancer tissue from normal tissue. This technology has the potential to reduce unnecessary follow-up surgery for 15-20% of patients.
Researchers at Rice University have discovered that a diabetes drug can halt the production of glycoproteins that make up the protective mucus lining cells, allowing immune cells to target tumors. The study suggests that reducing mucin levels may be enough to breach the tumor's protective shield and allow for cancer cell destruction.
A phase I clinical trial has shown that the experimental drug TAS-114 can increase the effectiveness of chemotherapy while reducing side effects. The drug, combined with S-1, resulted in tumor shrinkage and stable disease progression in patients with various cancers, including non-small cell lung cancer, pancreatic cancer, and breast c...
A landmark clinical trial conducted by researchers at the University of Alberta found that beta blockers and ACE inhibitors effectively prevent a drop in heart function from cancer treatment. The study showed improved safety for breast cancer patients undergoing chemotherapy, with potential benefits to survival rates.
Researchers at Courage Kenny Rehabilitation Institute present studies on improving walking speed in stroke patients and managing cancer-related cognitive dysfunction, also known as chemobrain. Occupational therapy was found to improve everyday functioning and manage issues like mood, stress, and fatigue in cancer survivors.
Researchers at Thomas Jefferson University discovered that a protein called TIGAR promotes the growth of breast cancer cells by altering cell metabolism, which could be targeted with existing drugs like metformin and doxycycline. These therapies have already passed safety testing in humans and may help reduce tumor growth.
A large study analyzed over 5.6 million screening mammograms and found a gradual upward trend in cancer detection rates and positive predictive values with increasing age, but no clear evidence for age-based mammography cessation. The findings support guidelines encouraging individual patient decisions based on health status.
A study published by The Menopause Society confirms electro-acupuncture's effectiveness in reducing hot flash severity and improving sleep quality in breast cancer survivors. Electro-acupuncture has been shown to affect neurotransmitters associated with sleep, such as serotonin and melatonin.
PharmaMar is conducting a Phase I study to determine the recommended dose of PM1183 in Japanese patients, with secondary objectives including safety profile and antitumor activity evaluation. The study focuses on patients born in Japan or with Japanese ancestry affected by solid tumors.
Researchers discovered that low-dose chemotherapy regimens can prevent the secretion of proteins by fibroblast cells surrounding tumors, reducing the likelihood of tumor recurrence. Mice with breast or pancreatic cancer treated with these regimens survived longer than those receiving high-dose chemotherapy.
A new study found that most women in Virginia are unaware of the increased cancer risk associated with dense breasts. Only 1 in 8 women knew their breast density was a risk factor for breast cancer.
A recent study found that metformin treatment inhibits abnormal mitochondrial metabolism and activates anti-proliferation signaling in individuals with Li-Fraumeni syndrome. This inhibition leads to lower rates of tumor formation and increased survival time, suggesting metformin as a potential strategy for cancer prevention.
Researchers found that triple-negative breast cancer cells are addicted to cystine and die rapidly when deprived of it, suggesting a potential new treatment. Cystine-blocking molecules may be effective in targeting this pathway, which is also used by other aggressive cancers.
Researchers at Scripps Research Institute have developed a new structure-based drug design strategy to target the estrogen receptor, reducing resistance and side effects in hormone-driven breast cancer treatments. The approach uses x-ray crystallography to visualize how drugs interact with the receptor, allowing for the creation of bio...
The updated guideline suggests that more breast cancer patients can benefit from accelerated partial breast irradiation (APBI), including younger patients and those with low-risk ductal carcinoma in situ (DCIS). The guideline provides direction for the use of intraoperative radiation therapy (IORT) for early-stage breast cancer patients.
New report predicts 7,100 cancer deaths annually by 2035 linked to alcohol, with oesophageal cancer seeing largest increase. The NHS will face a £2 billion treatment bill, while over 1.2 million hospital admissions are forecasted.
The 2016 AAAS Kavli Science Journalism Awards honored journalists for their consequential medical research stories, including a Swedish documentary that raised questions about a surgeon's research conduct. The awards also recognized investigative reporting on topics such as breast cancer and research ethics.
A new study has identified BRD4 protein as a crucial driver of breast cancer cell dissemination, offering a promising new target for therapy. The findings may provide hope for patients with triple-negative breast cancer, the most aggressive and difficult-to-treat subtype.
Researchers at Texas A&M University found that breast cancer cells may evade treatment by consuming stem cells from bone marrow, making them difficult to kill. This mechanism could explain cancer recurrence and lead to new treatments, such as delivering toxic agents directly to cancer cells using stem cells as a delivery vehicle.
A study published in the Journal of General Internal Medicine found that Asian Americans have a high prevalence of undiagnosed type 2 diabetes and are less likely to undergo recommended screening. Only 47.1% of Asian Americans received appropriate screening, compared to 60.2% of non-Hispanic blacks.
Researchers created a new cancer drug using gold nanoparticles to deliver paclitaxel directly to tumors, increasing effectiveness while reducing devastating side effects such as hair loss and nerve pain. Early lab tests showed the therapy to be nearly as effective as a high dose of paclitaxel alone.
A new study by researchers at the University of Victoria and Australia's National Drug Research Institute found a statistically significant dose-response relationship between alcohol intake and risk of prostate cancer. Current drinkers who consumed high volumes had an increased risk, even at low-volume drinking levels.
The project aims to improve diagnosis and tailor treatment by analyzing the genome and expressed genes of tumour cells from 250 breast cancer patients. This personalized approach will help doctors choose the best treatment for individual patients, potentially increasing survival rates and reducing side effects.
A study by TSRI researchers reveals that macrophages can create vessel-like structures for delivering oxygen and nutrients to growing tumors, promoting cancer progression. This finding could lead to novel cancer therapies targeting immune system cells.
A randomized clinical trial found that both treatment arms met the primary safety endpoint, with improvements reported in vaginal atrophy and sexual interest for all patients. The study also revealed that 37% of patients had elevated estradiol levels at baseline, which could be attributed to estrogen-containing supplements.
Higher vitamin D levels in blood are associated with better overall survival in breast cancer patients, according to a new study published in JAMA Oncology. The research found stronger associations between higher vitamin D levels and improved survival in premenopausal women.
Researchers identified genetic mutations that distinguish aggressive rhabdoid meningiomas from benign forms, suggesting a potential new approach for clinical decision-making. The study found patients with BAP1 mutations had poor clinical outcomes and shorter disease progression times.
Women with higher vitamin D levels after a breast cancer diagnosis had significantly better long-term outcomes, including lower mortality and recurrence rates. The study found stronger associations among premenopausal women for breast-cancer-specific survival.
Ludwig researchers discover a targeted drug that overcomes suppressive immune cells, leading to improved responses to immune checkpoint blockade therapy in tumors with high concentrations of these cells. The findings offer a potential precision medicine approach for personalized treatment regimens.
Researchers found that tailored dose-dense chemotherapy did not improve 5-year breast cancer recurrence-free survival, overall survival, or distant disease-free survival compared to standard chemotherapy. However, the tailored group experienced more nonhematologic toxic effects.
A new study of over 200,000 cancer survivors found that those diagnosed at younger ages have a higher risk of death from heart disease. Cancer survivors diagnosed between 15-19 years old had a 4.2 times higher risk compared to the general population.
Pancreatic cancer is expected to become the third leading cause of death from cancer in the EU by 2017. The number of deaths from pancreatic cancer will overtake breast cancer mortality rates in the EU, with 91,500 estimated deaths next year.
A new study found that around 17% of women diagnosed with breast cancer visit their doctor with a symptom other than a lump. Non-lump symptoms, such as nipple abnormalities and breast pain, were more likely to delay diagnosis compared to those with a breast lump alone.
Breast cancer cells may use mesenchymal stem cells in bone marrow to spread to bone tissue. A study using a 3D scaffold model found that tumor-derived factors can promote maturation of MSCs into bone cells, with mechanical compression stimulating further bone development.
Researchers at Eindhoven University of Technology have created a breast-friendly method for detecting cancer without radiation, generating 3D images with improved accuracy. The new technology uses echography and blood vessel structure analysis to identify cancerous tumors.
A new series published in The Lancet highlights the need for international efforts to end preventable deaths from breast and cervical cancer, particularly in low- and middle-income countries. Cost-effective interventions, such as routine HPV vaccination and cervical screening, can significantly reduce mortality rates if implemented.
Researchers found that high levels of Manganese Superoxide Dismutase (MnSOD) trigger aggressive breast cancer cell behavior. By targeting MnSOD, scientists hope to develop effective therapeutic strategies against triple-negative breast cancer.
Scientists at The Wistar Institute discovered how MEK inhibitor trametinib controls tumor progression by reducing immune suppression and allowing anti-tumor T cells to target tumors. This finding provides new insights into the effects of targeted therapies on antitumor immunity.
Researchers silenced SIRT2 to accelerate the degradation of Slug protein, reducing tumor growth and invasiveness in basal-like breast cancer cells. The study revealed a direct relationship between SIRT2, Slug stability, and malignant behavior, providing new insights into treating aggressive basal-like breast cancers.
A new study suggests that a widely available web-based program can help cancer survivors reporting cognitive symptoms. The 15-week program improved self-reported cognitive function, lowered anxiety and depression, and improved fatigue. Objective neuropsychological function test results were not different between the two groups.
A study found that an online neurocognitive learning program reduced cognitive symptoms in cancer patients following chemotherapy. Participants who used the program showed improved cognitive function, reduced anxiety and depression, and better quality of life compared to those receiving standard care.
Researchers link PIP to cell-mediated immunity, suggesting its potential as a new target for immunotherapeutic agents. PIP may help the immune system recognize and destroy foreign cells, including tumor cells, offering a protective effect against breast cancer.
Researchers developed a three-dimensional mammary gland model that mimics healthy breast tissue structure and function. The model enables the study of disease mechanisms and drug screening, providing a significant breakthrough in understanding breast cancer.