Articles tagged with Breast Cancer
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Researchers found 33 places in breast cancer genomes where tandem duplications were most often found, leading to further cancerous changes. These 'hotspots' may create new driver mutations, making tumours more aggressive and potentially responsive to different treatments.
Researchers found that breast cancer tumors evolve to produce their own estrogen supply, making treatments like aromatase inhibitors ineffective. The study, published in Nature Genetics, aims to increase treatment options for patients whose cancer has returned and spread.
Researchers at UNC have engineered platelets to carry cancer-fighting antibodies, allowing them to target and kill microtumors before they can grow or spread. This innovative approach has shown promising results in animal studies, potentially offering a new hope for patients with recurring cancer after surgery.
Research found that successful immunotherapy activates peripheral 'memory' immune cells, key to long-term defense against cancer. A system-wide immune response is crucial for broadening immunotherapy's effectiveness.
Researchers found that African-American breast cancer patients who receive chemotherapy prior to surgery exhibit reduced regional and distant tumor recurrence rates. Early-stage patients with African-American ancestry display higher tumor recurrence rates compared to European-Americans.
A study by Stanford researchers found that a systemic, whole-body immune response is essential for effectively attacking and eradicating tumors. The researchers used mass cytometry to monitor the physical attributes of individual cells in samples of millions or billions, revealing an increase in immune cells and regulatory T cells in s...
A study published in Health Affairs found that the Affordable Care Act resulted in an 8% increase in early-stage colorectal cancer diagnoses among U.S. seniors aged 65 and older, but had no distinguishable effect on breast cancer diagnoses over the same time period.
Massachusetts General Hospital investigators identified a protein called G3BP2 that helps maintain aggressive tumor-initiating cells in breast cancer. Compounds like C108 can reduce the survival of these cells and slow tumor growth.
Scientists at Huntsman Cancer Institute discovered distinct types of tumors within small cell lung cancer that respond differently to treatment. A targeted drug combination showed improved outcomes for one specific tumor type, suggesting a need for genetic testing and personalized therapies.
Research has discovered a new biological target for reducing tumour spread in cancer patients. The Spns2 gene was found to be involved in regulating the spread of cancers, with targeting it leading to a three-quarters reduction in tumour spread.
A Phase 1 clinical trial found that tucatinib significantly improved outcomes in heavily pretreated patients with HER2+ breast cancer. The drug demonstrated stable disease at 24 weeks or more in 27% of patients, showcasing its potential as a game-changing treatment option.
Researchers from UGR and hospitals Virgen de las Nieves and San Cecilio found that telerehabilitation reduces side effects of breast cancer treatment, such as pain and fatigue. The online exercise program showed excellent results for patients, maintaining benefits even after 6 months.
Researchers at Mayo Clinic have identified a key drug target, CDK4/6, which regulates the spread of triple-negative breast cancer. The study found that inhibiting this protein with CDK 4/6 inhibitors can prevent the metastasis of triple-negative breast cancer to distant organs.
A Danish cohort study found that breast cancer screening was not associated with a reduction in advanced tumors, but rather an increase in nonadvanced tumors and ductal carcinoma in situ (DCIS). The study estimates that approximately 1 in 3 invasive tumors diagnosed in screened women represent overdiagnosis.
Researchers identified LATS as a key player in breast cancer development and treatment. The enzyme's absence leads to increased luminal precursor cells, which can give rise to tumors, and stabilized proteins YAP and TAZ that boost cell proliferation.
A new mouse model has revealed the role of CCN6 protein in developing metaplastic breast cancer, a rare and aggressive subtype of triple-negative breast cancer. The study identified potential genes to target with therapeutics, offering hope for better treatment options for patients.
Researchers have identified a gene mutation driving the formation of metaplastic breast cancer, a subtype of triple negative breast cancer. A therapeutic compound has been validated to slow tumor growth and increase chemotherapy efficacy.
A study published in JNCI Journal of the National Cancer Institute found that high consumption of grilled, barbecued, and smoked meats may increase mortality risk after breast cancer diagnosis. The research evaluated the link between these meat types and survival time among 1508 Long Island women with breast cancer.
A new HER2-targeted dendritic cell vaccine has shown promising results in a clinical trial, stimulating an immune response in 80% of patients and inducing regression of early-stage breast tumors. The vaccine was well-tolerated and effective in both invasive and non-invasive disease settings.
A large study found that 45% more women with breast cancer experience cognitive impairment compared to healthy individuals. Factors like anxiety, younger age, and black race contribute to cognitive decline.
Researchers at Scripps Florida Institute developed a novel approach for identifying how chemicals in the environment can produce infertility and promote breast cancer. The new method uses high-resolution imaging techniques to visualize the effects of estrogenic chemicals on cells.
Molecular imaging techniques have the potential to revolutionize cancer diagnosis, monitoring, and treatment by providing non-invasive alternatives to traditional biopsies. By identifying specific biomarkers, these methods can help doctors choose the most effective treatments, minimize side effects, and predict patient outcomes.
A new study reveals that women with advanced kidney disease are at a higher risk of developing cancer, highlighting the importance of targeted screening strategies.
A new study reveals that inhibiting AXL signaling increases anti-tumor immune response, sensitizes tumors to radiation, and enhances efficacy of anticancer therapies. Aravive-S6 acts as a decoy receptor, binding Gas-6 to prevent AXL activation.
A study analyzing 740 early-stage NSCLC patients treated with SBRT found that Squamous Cell Carcinoma (SqCC) has a significantly higher rate of local failure compared to other histological subtypes. SqCCs are more resistant to SBRT, which may require treatment optimization based on histological subtype.
A new study found that nearly half of early-stage breast cancer patients considered having a double mastectomy, despite knowing it offers little benefit. Patients were unaware of the surgery's risks and benefits, with many choosing it for peace of mind.
A study found that surgeons' recommendations play a crucial role in determining the rate of contralateral prophylactic mastectomy (CPM) in breast cancer patients. Among patients without clinical indications, CPM use was substantial when patients did not receive a recommendation against it, but low when they did.
Researchers at IRB Barcelona have discovered 10 new drug combinations that show high synergy in treating breast cancer, outperforming individual treatments. These combinations aim to overcome treatment resistance by attacking tumour cells from multiple angles.
A new breast cancer model developed by Kaiser Permanente researcher Matthew P. Banegas accurately predicts breast cancer risk in Hispanic patients based on data from Hispanic women. The model, added to the National Cancer Institute's online tool, corrects underestimation of breast cancer risk in Hispanic women.
University of Minnesota researchers have provided unprecedented images of cancer genome-mutating enzymes acting on DNA, offering vital clues into how these enzymes promote tumor evolution. The findings suggest ways to block enzyme activity in cancer, potentially making current anti-cancer therapies more effective.
A genetic biomarker, rs28714259, identifies women with breast cancer at increased risk for anthracycline-induced congestive heart failure. The marker is associated with low ventricular ejection fraction and may help oncologists provide more precise predictions of treatment risks.
A new UCL-led phase III clinical trial found that vascular-targeted photodynamic therapy (VTP) can effectively kill cancer cells while preserving healthy tissue. Around half of patients treated with VTP went into complete remission, compared to 13.5% in the control group.
A subgroup analysis of the MONALEESA-2 trial found that ribociclib improves progression-free survival in Asian patients with HR-positive advanced breast cancer. The treatment was well-tolerated and demonstrated efficacy regardless of geographic region or self-reported race.
A recent study by University of British Columbia researchers found that excessive reoperations in breast cancer surgeries result in significant costs to the Canadian healthcare system. The study concludes that with current reoperation rates being over double recommended targets, the additional cost is substantial.
Research by Dr. Josef Penninger found that RANKL inhibition can delay and prevent breast cancer development in mice with mutated BRCA1. The loss of RANK also impaired tumor progression, raising the possibility of a novel targeted approach for breast cancer prevention.
A study of over 5,500 women found that younger patients and those who had taken hormone replacement therapy were less likely to adhere to their medicine. The researchers identified several factors that contributed to non-adherence, including socioeconomic status and marital status, highlighting the need for targeted strategies to impro...
Researchers developed RNA nanoparticles that selectively bind to HER2-overexpressing breast tumors, eliminating MED1 expression and sensitizing them to tamoxifen treatment. The nanoparticles also reduced cancer stem cell content, a promising strategy for treating advanced metastatic breast cancer.
A study found a 64% spike in genetic tests for breast cancer following Angelina Jolie's op-ed piece, but no uptick in mastectomy rates. The tests did not lead to additional breast cancer diagnoses, suggesting overtesting among low-risk groups.
US women saw a sharp increase in breast cancer gene testing after Angelina Jolie's article, with daily rates rising 64% immediately. However, there was no change in overall mastectomy rates, suggesting that celebrity endorsements may not effectively target high-risk groups.
A UT Dallas biologist and his team discovered that NQO1 and HIF-1a, two enzymes previously linked to cancer cell survival, actually work in tandem to promote tumor growth. The researchers found that NQO1 binds to HIF-1a, stabilizing it and preventing its degradation.
Researchers have identified a new subtype of triple negative breast cancer that may be more responsive to treatment, including immunotherapies. The study found that patients with BRCA deficient tumors had better survival rates and higher burdens of mutations that could be targeted by the immune system.
The new guidelines recommend forego routine axillary lymph node dissection in most women with no evidence of cancer on sentinel node biopsy. This approach can reduce the risk of painful and costly side effects such as lymphedema, infections, and reduced range of motion.
A new study found that socially isolated breast cancer survivors had a 40% higher risk of recurrence, a 60% higher risk of dying from breast cancer, and a 70% higher risk of dying from any cause. Women with larger social networks experienced better outcomes.
Researchers discovered an antibody that normalizes tumor blood vessels, reducing volume and improving anti-cancer drug delivery. The antibody, ABTAA, restores vascular integrity in breast, lung, and brain tumors, leading to better oxygen supply and reduced metastasis.
A large Kaiser Permanente study found that socially integrated women had lower breast cancer death rates and disease recurrence compared to socially isolated women. The study suggests that specific types of social ties, such as friendships and family members, are beneficial for different sociodemographic groups.
A new study at SABCS finds EndoPredict, a second-generation test, superior to Oncotype Dx in predicting breast cancer recurrence. The test accurately identified patients with low risk of recurrence, allowing them to forgo chemotherapy.
A new Penn study sheds light on racial disparities in cancer-causing genetic mutations, finding differences in mutation patterns between African American and Caucasian women. The research suggests biological differences and potentially different genetic factors may be at play, guiding targeted care for at-risk patients.
A study published by University of Texas MD Anderson Cancer Center found that older women with breast cancer who underwent less radiation therapy reported improved cosmetic satisfaction. However, reduced radiation was also associated with a slightly increased risk of disease recurrence. The researchers suggest that there may be an opti...
A new study by SWOG found that duloxetine can significantly reduce joint pain in postmenopausal women with early stage breast cancer. The randomized trial tested the effectiveness of duloxetine against aromatase inhibitors, a common treatment for breast cancer, and showed rapid relief from pain.
A recent study published in Nature Reviews Cancer suggests that progesterone could be a game-changer in treating recurring breast cancers. The hormone, when used in combination with current treatments, may reprogram estrogen action in the breast to improve cancer outcomes. Two new clinical trials are underway to test this approach.
Women taking tamoxifen for breast cancer prevention experienced nausea and vomiting, which led them to discontinue the medication. A new analysis suggests that these symptoms were sometimes mistaken for tamoxifen side effects, highlighting the importance of accurate information on preventive therapies.
A pilot study at MD Anderson Cancer Center found that image-guided biopsies accurately predicted residual disease in breast cancer patients after chemotherapy and/or targeted therapy. The study suggests that certain patients may be able to avoid surgery, paving the way for personalized treatment.
Global breast cancer mortality rates declined between 1987-2013, with 39 countries showing a decrease, including the US and most developed European nations. However, South Korea experienced an 83% increase, while Latin America saw scattered increases in mortality, except for Argentina and Chile.
A new study reveals that many breast cancer survivors experience unmet needs for symptom management, leading to increased levels of anxiety and depression. Researchers are calling on healthcare providers to incorporate symptom management into routine follow-up care.
Researchers identified two drug combinations that could improve survival rates for breast cancer patients, including anti-inflammatory and lipid modifiers. The study analyzed data from nearly 10,000 women with breast cancer and found three pairs of drug interactions associated with better outcomes.
A study by researchers at UNC Lineberger Comprehensive Cancer Center identified biomarkers that predict how patients with HER2-positive breast cancer will respond to targeted treatment trastuzumab and chemotherapy. The biomarkers are based on gene signatures, genetic mutations, and immune responses.
A large multicenter cohort study found that radiation therapy increased complications and impaired patient-reported satisfaction with reconstructed breasts in breast cancer patients who received implant reconstruction. However, no worsening of outcomes was observed in those who received autologous reconstruction. The study suggests tha...
A team of scientists tracked the genetics of disseminated tumour cells in breast cancer patients, finding they are genetically similar to the original tumour. This knowledge could help clinicians choose the most effective therapy, potentially leading to better outcomes and a more accurate prognosis.
A new study finds that women who have implant reconstruction following radiation therapy had more complications from the surgery and were less satisfied with the result. Autologous reconstruction showed similar results, regardless of radiation treatment. The study suggests alternative approaches for breast cancer patients
A researcher at UH Seidman Cancer Center is presenting a phase II clinical trial testing the effectiveness of combining chemotherapy with an immunotherapeutic agent, pembrolizumab, for patients with metastatic triple-negative breast cancer. The trial aims to improve survival rates and reduce disease recurrence.