Articles tagged with Breast Cancer
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.
Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.
Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.
Practical application of scientific knowledge and engineering principles to solve real-world problems and develop innovative technologies. Encompasses all engineering disciplines, technology development, computer science, artificial intelligence, environmental sciences, agriculture, materials applications, energy systems, and industrial innovation. Bridges theoretical research with tangible solutions for infrastructure, manufacturing, computing, communications, transportation, construction, sustainable development, and emerging technologies that advance human capabilities, improve quality of life, and address societal challenges through scientific innovation and technological progress.
Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.
Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.
Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
Researchers have devised a strategy to specifically target cancer stem cells in some cancers and reduce their tumor-generating potential. Combining Nutlin-3 and Paclitaxel showed potentiated tumor response and prevented relapse in Numb-deficient tumors, suggesting the potential of these drugs as treatment options.
A phase 2 clinical trial of sacituzumab govitecan, an antibody-drug conjugate targeting Trop-2, achieved a response in 21 participants with advanced triple-negative breast cancer. The responses were early and durable, lasting up to 20 months, with improved overall survival.
A study published in the Journal of Oncology Practice found that over half of older women with early-stage breast cancer received more radiation therapy than necessary, adding to healthcare costs. The researchers estimate a potential savings of $164 million by reducing radiation therapy regimens from six weeks to four weeks.
Patients cured of Hodgkin lymphoma are at a significantly increased risk of developing a second type of cancer, particularly if they have a family history of the disease. The risk remains high even 30 years after treatment, and is higher in those with specific genetic markers or a history of certain cancers.
Researchers discovered that many breast cancer patients have mutational signatures similar to those with faulty BRCA1 or BRCA2 genes, suggesting they may also benefit from existing PARP inhibitor treatments. This opens up the possibility of treating up to 20% of women with these drugs.
Researchers from Mayo Clinic report that tumor genomic alterations did not differ significantly between chemotherapy-sensitive and -resistant tumors. However, the study identified an uncommon type of aggressive breast cancer with a unique mutation in p53, which was less likely to respond to chemotherapy.
Scientists have designed two new drug candidates that target specific types of cancer by binding to defective RNAs. The compounds, called Targapremir-18a and Targapremir-210, successfully kill prostate and triple negative breast cancer cells without causing broader side effects.
A study published in Health Communications shows that women at high risk for breast cancer who received a letter informing them of their options for additional imaging with contrast-enhanced MRI were more likely to return for additional screening. The researchers found that direct communication increased follow-up screening rates among...
A new compound has been found to reverse the allegiance of innate immune system cells, turning them from tumor enablers into tumor opponents. When combined with chemotherapy or another immunotherapy, it significantly extended the period of tumor remission.
A study found that women with breast cancer who engaged in regular exercise were 40% less likely to have a cardiovascular event and 60% less likely to die from coronary heart disease. Exercise may help mitigate the increased cardiovascular risk faced by cancer patients, reducing the risk of heart disease and its associated complications.
Researchers discovered that a metabolic enzyme called AKR1B1 drives aggressive basal-like breast cancer progression. An inhibitor of this enzyme, epalrestat, was shown to block the growth and metastasis of human basal-like breast cancer cells.
A new study published in Diabetologia found that having type 2 diabetes increases the risk of death from any form of cancer by 26%, even when controlling for other factors. The research also revealed statistically significant links between T2D and specific cancers, including liver, pancreas, breast, kidney, and endometrium.
Research suggests that high soy food intake may reduce mortality risk among breast cancer survivors, particularly those with hormone receptor-negative tumors. Isoflavones in soy products have been shown to slow cancer cell growth and possess antioxidant properties.
Researchers at JAX have received $2.8 million in federal grants to develop better diagnostics and treatments for triple-negative breast cancer (TNBC). The studies aim to understand the underlying mechanisms that control metastasis and identify promising therapeutic targets.
Researchers at Beth Israel Deaconess Medical Center have discovered a vulnerability in triple-negative breast cancer cells that can be exploited by blocking pyrimidine production. This finding provides a new strategy to combat the disease, which currently has limited treatment options.
A rheumatoid arthritis drug has been found to block a metabolic pathway that drives tumor growth in aggressive cancers with the PTEN gene mutation. Leflunomide kills human breast cancer cells in mice by damaging DNA produced through the pathway.
Researchers found that breast cancer cells express reelin, a protein typically found in the brain, to disguise themselves and avoid detection. This allows them to form new deadly brain tumors, leading to high mortality rates among women with HER2-positive breast cancer.
Breast cancer patients who receive nine-week Herceptin treatment experience significant increases in survival rates and quality-adjusted life-years. The study found that switching to the nine-week course could save the NHS over £100 million a year, while being just as effective as the current 12-month duration.
Histone deacetylases are an important family of proteins regulating gene expression; altering their function can induce tumors to develop. Researchers successfully isolated HDAC using SAHA as a molecular bait, paving the way for novel cancer treatments.
A study published in Cancer Epidemiology, Biomarkers & Prevention found that women who consumed a diet high in sugar-sweetened drinks and processed meats during adolescence or young adulthood had a higher risk of premenopausal breast cancer. The researchers recommend consuming a diet rich in vegetables, fruit, whole grains, nuts, seeds...
The risk of subsequent malignancies has decreased among childhood cancer survivors, particularly those treated with lower radiation doses. The study found that cumulative incidence rates of subsequent neoplasms and specific types of cancers, such as meningiomas and nonmelanoma skin cancers, were lower in recent treatment eras.
New study reveals improved cancer detection rates with digital mammography, but also increased abnormal interpretation rates leading to more unnecessary biopsies for benign conditions. The study highlights the need for quality improvement initiatives to address these trends.
African American women who carry a specific genetic variant of the p53 gene may have a nearly 70% increased risk of developing breast cancer before menopause. The study found an association between the polymorphism and breast cancer risk in premenopausal women, highlighting disparities in cancer research.
A new digital breast tomosynthesis technique has been shown to reduce screening recall rates and improve cancer detection, while minimizing radiation exposure. The technique, known as s2D mammography combined with DBT, detected 76.5% of invasive cancers at a lower rate than traditional methods.
A new study from Germany found that MRI screening improved early diagnosis of breast cancer in women with an average risk of developing the disease. The study detected 60 additional cancers, including 40 invasive cancers, for an overall supplemental cancer detection rate of 15.5 per 1,000 women.
Researchers at Michigan State University have shown that breast cancer treatment options can be predicted based on gene expression patterns. The study identified a three-drug combination effective in stopping triple-negative breast cancer growth and suggests a personalized approach to care.
Physical activity is most important lifestyle change to reduce breast cancer recurrence risk, with at least 30 minutes of moderate exercise per day recommended. Avoiding weight gain and maintaining adequate vitamin D levels also play a crucial role in reducing the risk of cancer recurrence.
A new study finds that high levels of a biomarker called nuclear KIFC1 are linked to poor prognosis in African-American patients with triple-negative breast cancer. In contrast, the same biomarker does not affect disease outcomes in white patients, highlighting racial disparities in breast cancer treatment.
Research from University of Utah Health reveals that mechanical tensions regulate cell division and death, with stretching cells dividing and crowding causing cell death. Understanding this process is essential for understanding cancer formation and developing new treatments for diseases like asthma.
A multicenter study found that scalp cooling reduced hair loss in certain breast cancer patients undergoing non-anthracycline adjuvant chemotherapy. The study, published in JAMA, showed that 67% of patients retained half or more of their hair after treatment.
A new study has found that radiotherapy for invasive breast cancer increases the risk of developing second primary lung cancer. The research, conducted in Taiwan, involved analyzing data from over 986,000 patients with breast cancer between 2000 and 2010. The results showed a significant increase in lung cancer incidence among women wh...
A retrospective analysis of 1,424 patients found that those with an intermediate risk recurrence score (RS) had similar outcomes whether they received chemotherapy or not. The study suggests that less is more for women with early-stage disease, potentially leading to a shift away from aggressive treatment protocols.
Researchers at the University of Illinois have developed a new tumor-targeting system that harnesses cancer cells' metabolism to deliver targeted treatments. The system, led by Jianjun Cheng, uses small-molecule sugars called azides to mark cancer cells and deliver therapeutic agents.
Scientists at Scripps Research Institute have been awarded $3.3 million to create a new class of anti-cancer drugs called antibody-drug conjugates (ADCs). These ADCs target aggressive breast cancer types with high efficiency.
Two studies found that scalp cooling devices can significantly reduce hair loss in women with breast cancer undergoing chemotherapy. In one study, patients who received scalp cooling had an average of 51% hair preservation compared to 0% in the control group. The other study also showed promising results, with 67% of patients experienc...
Researchers analyzed genetic data of 173 patients and identified CSDE1 and fusion genes in MAML3 as drivers of the disease, providing opportunities for molecular diagnosis and prognosis. The study also found four distinct subtypes, each driven by mutations in distinct biological pathways.
Researchers from Mayo Clinic have quantified the numbers of various immune cells associated with the risk of developing breast cancer. The study found that women who later developed breast cancer showed lower amounts of antibody-producing immune cells in their breast tissue.
Researchers from New York University Rory Meyers College of Nursing studied genetic and susceptibility risk factors for lymphedema in breast cancer survivors. They found significant associations between genotypes related to several lymphatic and inflammatory genes and symptom phenotypes of impaired limb mobility, fluid accumulation, an...
A national study from England reveals that older women are often excluded from immediate breast reconstruction after mastectomy. Clinicians should adopt standardized assessment tools to identify suitable patients for reconstructive surgery, the findings suggest.
A study of over 2,500 women with newly diagnosed breast cancer revealed a significant gap between the need for genetic testing and its availability. High-risk patients, particularly those from Asian backgrounds and older women, were under-tested due to lack of physician recommendation and inadequate assessment of patient risk and desire.
A recent study published in the journal Cancer found that breast cancer patients with dense breast tissue have almost a two-fold increased risk of developing disease in the contralateral breast. The researchers identified 680 stage I, II and III breast cancer patients who were treated at MD Anderson between 1997 and 2012.
A study found that many high-risk breast cancer patients are not recommended for genetic testing, despite being interested in it. The lack of testing puts doctors at risk of missing opportunities to prevent cancers in mutation carriers and their family members.
A new method called synthetic essentiality has been found to identify therapeutic targets in cancers lacking specific key tumor suppressor genes. By analyzing gene deletion patterns, researchers identified CHD1 as a potential treatment site for prostate and breast cancers with PTEN gene loss.
Researchers at Arizona State University have developed a new diagnostic method for detecting pancreatic cancer early in its development by identifying extracellular vesicles with the surface protein EphA2. This technique shows promise for rapid and sensitive detection of various diseases based on unique EV signatures.
A nationwide registry of over 1 million patients with hormone-sensitive breast cancer reveals that 1 in 6 women missed post-surgical adjuvant endocrine therapy, which can lower cancer recurrence risk by 29%. Despite improvements, 18% of eligible women remained untreated between 2004 and 2013
Researchers found that long-term soy consumption improves tamoxifen's effectiveness and reduces breast cancer recurrence. However, starting soy intake after diagnosis increases the risk of cancer recurrence.
A blood test detecting hypermethylation in tumor DNA predicts shorter survival for women with high levels of cancer-linked DNA, indicating worsening disease. The test, cMethDNA, may help identify breast cancers at higher risk for recurrence and track treatment success.
Researchers at Mayo Clinic are testing a vaccine that aims to establish lifelong immunity against precancerous breast lesions. The vaccine targets human epidermal growth factor 2 (HER-2) and has shown promise in a phase I clinical study, eliciting an immune response in all tested individuals.
Scientists have created a 'map' linking cell shape to genes turned on and off, matching it to real disease outcomes. The map revealed key areas controlling gene activity, including a protein called NF-kappaB that drives cancer cell growth and spread.
A new study has found that defects in the EMSY gene, similar to BRCA genes, spur cancer growth independently of BRCA1 and BRCA2 protection. The research suggests new treatment options for women with normal BRCA genes who develop breast and ovarian cancer.
Researchers found that Ewing sarcoma tumors display unique DNA methylation patterns, which influence gene activity and can lead to different outcomes. The study's results provide insights into the biology of Ewing sarcoma and may lead to personalized therapies with fewer side effects.
A study found that inhibiting CCR4 in a mouse model of renal cell carcinoma reduced tumor proliferation and changed the composition of immune cells. The results suggest anti-CCR4 antibodies as a potential therapeutic for multiple cancers linked to abnormal CCR4 expression.
A large study found that breast conserving therapy (BCT) is superior to mastectomy in early-stage breast cancer patients with no metastases. BCT, combined with radiation therapy, offers a survival advantage for patients aged over 50 years and those with comorbidity.
Researchers found that women with ductal carcinoma in situ (DCIS) are at a slightly lower risk of dying from any cause compared to the general population. After 10 years, DCIS patients had a 2.5% risk of dying from breast cancer and a 10% lower overall mortality rate.
Researchers at Huntsman Cancer Institute identified a protein called Macrophage Stimulating Protein (MSP) that causes bone destruction in metastatic breast cancer. A new drug, Ron inhibitor, blocks the activity of MSP, showing promising results in early clinical trials.
Cancer mortality in the US declined by 20.1% from 240 to 192 deaths per 100,000 population between 1980 and 2014. Distinct clusters of counties with high cancer mortality rates were found, varying by type of cancer and region.
Researchers have identified a link between chronic low-level inflammation and increased breast density, raising the risk of breast cancer. By targeting this underlying factor, new approaches to treating breast density and preventing breast cancer may become available.
The study found that the BRCA1 gene is required for the survival of blood forming stem cells, which could explain why patients with BRCA1 mutations do not have an elevated risk for leukemia. The researchers also suggest that these patients may have a tougher time with chemotherapy side effects.
Researchers at the University of Missouri have discovered that luteolin, a natural compound found in herbs and vegetables, can inhibit the growth of triple-negative breast cancer cells in mice. The study found that luteolin reduced metastasis risk by preventing cancer cell migration and viability.
A study found that nearly half of women treated for early stage breast cancer experienced at least one severe or very severe side effect from their treatment. The most common side effects were pain, skin irritation, and constipation, with Latina women being 30% more likely to report a severe side effect.