Articles tagged with Breast Cancer
A study published in Scientific Reports found that strawberry extract inhibited the proliferation of breast cancer cells in both in vitro and in vivo models. The extract reduced cell viability, blocked cell division, and inhibited migration, while also stimulating the expression of a gene that suppresses metastasis.
FAU researchers identified Zeb1 as a key factor that activates embryonic programme, leading to rapid dissemination and metastasis in pancreatic cancer. They also found that blocking Zeb1 reduces metastatic capacity in other tumour types.
A recent survey found that half of women with breast cancer who undergo genetic testing do not have high-risk mutations. This highlights the need for genetic counselors to help patients and physicians understand genetic test results. Many physicians surveyed in the study stated they manage patients with uncertain significance in the sa...
Researchers reprogram tumor blood vessels to block tumor growth and facilitate T cell arrival, improving cancer immunotherapy efficacy. A2V therapy inhibits metastasis and promotes anti-tumor immunity, which can be enhanced by PD-1 checkpoint blockade.
A new study found that language barriers, information overload, and cultural differences disadvantage some Latina breast cancer patients. However, no significant inequities were recorded in how doctors provide information. The research highlights the need for providers to be more culturally sensitive and patient-centered.
Recent guideline changes have led to disagreement among professional societies on best practices for mammography. Physician screening recommendations vary, with some recommending annual exams and others prioritizing biennial screenings.
A new study found that different breast cancer treatments have varying relative values based on complications and cost. Lumpectomy plus whole breast irradiation was the most commonly used treatment, while mastectomy plus reconstruction had nearly twice the complication risk and higher costs.
Scientists have discovered that cancer can commandeers immature immune cells, called MDSCs, to facilitate its spread. MDSCs are normally part of the immune system's anti-tumor response but, under the influence of tumor-secreted cytokines, they can help tumors grow and metastasize.
A new study found that surgeons' recommendations against contralateral prophylactic mastectomy (CPM) did not increase the likelihood of patients seeking a second opinion or receiving surgery from a different surgeon. In fact, many patients were satisfied with their treatment despite no discussion about CPM. The study surveyed 1,140 pat...
A large US study found that living in areas with high fine particle air pollution may increase the chance of dense breasts, a well-established breast cancer risk factor. Women with dense breasts were more likely exposed to high PM2.5 levels.
Researchers have developed a new method to diagnose cancer using ultrasound and microbubbles that can identify malignant tumors with high accuracy. The technique has shown promise in distinguishing between benign and malignant breast and ovarian tumors, potentially reducing unnecessary surgeries.
A study of over 3,000 childhood cancer survivors found that 12% carry germline mutations associated with increased cancer risk. Genetic screening is recommended for these patients to prevent future cancers and design personalized therapeutic approaches.
Scientists have identified a biomarker, SMARCE1, that distinguishes poorly invasive tumors from those likely to spread and metastasize in early-stage breast cancer. This discovery enables doctors to tailor therapies designed to match the behavior of each patient's cancer, improving treatment outcomes.
A demo version of a new Pathology Atlas will be presented on April 2-5 at AACR17, offering information on human gene expression levels and their relationship with cancer patients' clinical outcomes. The atlas provides analysis on nearly 8,000 cancer patients across various major cancers.
Researchers discovered that tumor blood vessels and the immune system interact, with immune cells promoting vessel normalization to improve anti-tumor therapies. This bidirectional regulation may lead to better cancer treatment outcomes when considering both vascular structure and immune response.
Exposure to BPS multiplies breast cancer cells, exhibiting estrogen-mimicking behavior, and may cause breast cancer to become more aggressive. The study confirms BPS as a potent endocrine disruptor.
Overall cancer death rates have decreased for 11 types of cancer in men and 13 in women between 2010-2014. Five-year survival improved significantly for prostate, kidney, non-Hodgkin lymphoma, and leukemia cancers.
Researchers found that cancer cells grew faster in fatty, obese tissue, suggesting the microenvironment surrounding cancer cells plays a crucial role in disease progression. Weight loss reversed changes to this microenvironment, correcting tumor growth, highlighting potential therapeutic targets for obesity-related cancers.
A study analyzing data from three national databases found significant racial gaps in immediate breast reconstruction (IBR) after mastectomy, with white patients having the highest rate of IBR. The disparities were similar among women with ductal carcinoma in situ (DCIS), and were up to 50% in California.
A study found nearly half of young breast cancer patients in five states undergo preventive mastectomy to remove the unaffected breast. The proportion of women receiving this procedure increased significantly between 2004 and 2012, particularly among those under 45, with regional variations across states.
A new imaging device developed by Modulated Imaging Inc. uses low-power LEDs to project light onto the breast, measuring absorption and scattering properties to quantify skin health. The device aims to predict acute and late skin damage effects from radiation therapy in breast cancer patients.
Researchers at Mayo Clinic have identified an interaction between focal adhesion kinase and myosin that drives the production of secreted cancer-promoting proteins. This discovery may lead to the development of new drugs to inhibit cancer progression by blocking this interaction.
Researchers developed a new method to design more effective breast cancer treatments by combining patient-derived xenografts and proteogenomic integration. This approach allows for the identification of potential targets for drugs and has shown promise in suppressing tumor growth in laboratory models.
Researchers analyzed proteins in breast tumors and found multiple protein targets that could respond to drugs, including PI3K inhibitors and mTOR inhibitors. The study also identified potential benefits for HER2 positive breast cancer patients if analysis of tumor proteins is taken into consideration.
Researchers found that over 60% of BRCA tests performed on unaffected women have increased since 2004, mainly driven by marketing efforts. However, study findings suggest that this trend may not lead to better diagnosis of those at risk, as many women without harmful mutations are still being tested.
A new study found that the proportion of women without a history of cancer who underwent BRCA testing rose sharply from 2004 to 2014. However, many high-risk patients remain unidentified, highlighting the need for effective testing strategies to maximize detection of mutation carriers.
Researchers discovered new genes that cooperate with PTEN to prevent cancer development in mice. The study also found potential drug targets for cancers with a faulty PTEN gene.
Scientists have found that two immune system molecules, interleukin 1 beta (IL1β) and tumor necrosis factor alpha (TNFα), may drive drug resistance in estrogen-driven breast cancers by modifying the shape of the estrogen receptor. This finding could lead to novel therapeutic approaches.
A new study funded by Cancer Research UK finds that smokers treated for breast cancer have significantly higher risks of developing lung cancer or heart attacks due to radiotherapy. The long-term risk of death from these conditions is around 5% for smokers, compared to 0.5% for non-smokers.
A new study by UCR psychology professor Megan Robbins found that using positive emotion words and balanced pronouns, such as
The ABC Global Alliance, led by ESO, has launched a call-to-action to improve and extend the lives of patients with advanced breast cancer by 2025. The initiative outlines key gaps and actionable imperatives across patient care, societal support, and scientific investment for mBC.
Researchers have devised a strategy to specifically target cancer stem cells in some cancers and reduce their tumor-generating potential. Combining Nutlin-3 and Paclitaxel showed potentiated tumor response and prevented relapse in Numb-deficient tumors, suggesting the potential of these drugs as treatment options.
A phase 2 clinical trial of sacituzumab govitecan, an antibody-drug conjugate targeting Trop-2, achieved a response in 21 participants with advanced triple-negative breast cancer. The responses were early and durable, lasting up to 20 months, with improved overall survival.
A study published in the Journal of Oncology Practice found that over half of older women with early-stage breast cancer received more radiation therapy than necessary, adding to healthcare costs. The researchers estimate a potential savings of $164 million by reducing radiation therapy regimens from six weeks to four weeks.
Patients cured of Hodgkin lymphoma are at a significantly increased risk of developing a second type of cancer, particularly if they have a family history of the disease. The risk remains high even 30 years after treatment, and is higher in those with specific genetic markers or a history of certain cancers.
Researchers discovered that many breast cancer patients have mutational signatures similar to those with faulty BRCA1 or BRCA2 genes, suggesting they may also benefit from existing PARP inhibitor treatments. This opens up the possibility of treating up to 20% of women with these drugs.
Researchers from Mayo Clinic report that tumor genomic alterations did not differ significantly between chemotherapy-sensitive and -resistant tumors. However, the study identified an uncommon type of aggressive breast cancer with a unique mutation in p53, which was less likely to respond to chemotherapy.
Scientists have designed two new drug candidates that target specific types of cancer by binding to defective RNAs. The compounds, called Targapremir-18a and Targapremir-210, successfully kill prostate and triple negative breast cancer cells without causing broader side effects.
A study published in Health Communications shows that women at high risk for breast cancer who received a letter informing them of their options for additional imaging with contrast-enhanced MRI were more likely to return for additional screening. The researchers found that direct communication increased follow-up screening rates among...
A new compound has been found to reverse the allegiance of innate immune system cells, turning them from tumor enablers into tumor opponents. When combined with chemotherapy or another immunotherapy, it significantly extended the period of tumor remission.
A study found that women with breast cancer who engaged in regular exercise were 40% less likely to have a cardiovascular event and 60% less likely to die from coronary heart disease. Exercise may help mitigate the increased cardiovascular risk faced by cancer patients, reducing the risk of heart disease and its associated complications.
Researchers discovered that a metabolic enzyme called AKR1B1 drives aggressive basal-like breast cancer progression. An inhibitor of this enzyme, epalrestat, was shown to block the growth and metastasis of human basal-like breast cancer cells.
A new study published in Diabetologia found that having type 2 diabetes increases the risk of death from any form of cancer by 26%, even when controlling for other factors. The research also revealed statistically significant links between T2D and specific cancers, including liver, pancreas, breast, kidney, and endometrium.
Research suggests that high soy food intake may reduce mortality risk among breast cancer survivors, particularly those with hormone receptor-negative tumors. Isoflavones in soy products have been shown to slow cancer cell growth and possess antioxidant properties.
Researchers at JAX have received $2.8 million in federal grants to develop better diagnostics and treatments for triple-negative breast cancer (TNBC). The studies aim to understand the underlying mechanisms that control metastasis and identify promising therapeutic targets.
Researchers at Beth Israel Deaconess Medical Center have discovered a vulnerability in triple-negative breast cancer cells that can be exploited by blocking pyrimidine production. This finding provides a new strategy to combat the disease, which currently has limited treatment options.
A rheumatoid arthritis drug has been found to block a metabolic pathway that drives tumor growth in aggressive cancers with the PTEN gene mutation. Leflunomide kills human breast cancer cells in mice by damaging DNA produced through the pathway.
Researchers found that breast cancer cells express reelin, a protein typically found in the brain, to disguise themselves and avoid detection. This allows them to form new deadly brain tumors, leading to high mortality rates among women with HER2-positive breast cancer.
Breast cancer patients who receive nine-week Herceptin treatment experience significant increases in survival rates and quality-adjusted life-years. The study found that switching to the nine-week course could save the NHS over £100 million a year, while being just as effective as the current 12-month duration.
Histone deacetylases are an important family of proteins regulating gene expression; altering their function can induce tumors to develop. Researchers successfully isolated HDAC using SAHA as a molecular bait, paving the way for novel cancer treatments.
A study published in Cancer Epidemiology, Biomarkers & Prevention found that women who consumed a diet high in sugar-sweetened drinks and processed meats during adolescence or young adulthood had a higher risk of premenopausal breast cancer. The researchers recommend consuming a diet rich in vegetables, fruit, whole grains, nuts, seeds...
The risk of subsequent malignancies has decreased among childhood cancer survivors, particularly those treated with lower radiation doses. The study found that cumulative incidence rates of subsequent neoplasms and specific types of cancers, such as meningiomas and nonmelanoma skin cancers, were lower in recent treatment eras.
New study reveals improved cancer detection rates with digital mammography, but also increased abnormal interpretation rates leading to more unnecessary biopsies for benign conditions. The study highlights the need for quality improvement initiatives to address these trends.
African American women who carry a specific genetic variant of the p53 gene may have a nearly 70% increased risk of developing breast cancer before menopause. The study found an association between the polymorphism and breast cancer risk in premenopausal women, highlighting disparities in cancer research.
A new digital breast tomosynthesis technique has been shown to reduce screening recall rates and improve cancer detection, while minimizing radiation exposure. The technique, known as s2D mammography combined with DBT, detected 76.5% of invasive cancers at a lower rate than traditional methods.
A new study from Germany found that MRI screening improved early diagnosis of breast cancer in women with an average risk of developing the disease. The study detected 60 additional cancers, including 40 invasive cancers, for an overall supplemental cancer detection rate of 15.5 per 1,000 women.
Researchers at Michigan State University have shown that breast cancer treatment options can be predicted based on gene expression patterns. The study identified a three-drug combination effective in stopping triple-negative breast cancer growth and suggests a personalized approach to care.
Physical activity is most important lifestyle change to reduce breast cancer recurrence risk, with at least 30 minutes of moderate exercise per day recommended. Avoiding weight gain and maintaining adequate vitamin D levels also play a crucial role in reducing the risk of cancer recurrence.
A new study finds that high levels of a biomarker called nuclear KIFC1 are linked to poor prognosis in African-American patients with triple-negative breast cancer. In contrast, the same biomarker does not affect disease outcomes in white patients, highlighting racial disparities in breast cancer treatment.
Research from University of Utah Health reveals that mechanical tensions regulate cell division and death, with stretching cells dividing and crowding causing cell death. Understanding this process is essential for understanding cancer formation and developing new treatments for diseases like asthma.