Articles tagged with Breast Cancer
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Researchers from the University of Pennsylvania School of Medicine identified a process where cancer cells instruct normal cells to act like viruses, enabling tumors to spread and resist treatment. This 'virus mimic' is detected in the blood of cancer patients and could explain why some breast cancers are more aggressive than others.
Researchers have discovered that inhibiting 20-HETE, an acid metabolite overexpressed in cancer cells, reduces breast cancer tumor size and ability to spread. The study found that the drug HET0016 blocks key pathways that enable cancer cells to create a distant microenvironment.
Researchers at University of Missouri found that hormone replacement therapies can induce growth and metastasis in breast cancer by enriching specialized cancer cells like stem cells. The study suggests targeting these rare cells and immunotherapies to combat the disease.
Scientists from the University of Plymouth have discovered that cellular prion protein is over-produced in schwannoma cells, contributing to tumor growth and patient prognosis. The study identified existing drugs that could manage this protein overproduction and potentially lead to an effective therapy for neurofibromatosis 2 patients.
A team led by Gang Han has designed a human protein-based, tumor-targeting Magnetic Resonance Imaging (MRI) contrast that can be easily cleared by the body. This discovery holds promise for clinical applications, including enhanced MRI contrast for early-stage tumor detection.
The Damon Runyon Cancer Research Foundation has awarded four physician-scientists with over $1.8 million in funding to pursue cancer research. The awards provide critical support to enhance translation and clinical research, addressing the financial disincentives that often deter physicians from pursuing a research career.
A high-fat diet during pregnancy significantly increases breast cancer susceptibility in offspring for three generations, according to a Georgetown University Medical Center study. Genetic changes were observed in mammary tissue of high-fat diet progeny compared to control group's offspring.
TGen is developing 'liquid biopsies' that can help clinicians accurately treat patients with high-risk breast cancer. These non-invasive blood tests could enable continuous monitoring of a patient's progress, reducing the need for surgery, chemotherapy, and radiation.
Nicole F. Steinmetz receives two NIH grants to develop microscopic drug-delivery systems for triple negative breast cancer patients and patients at risk of serious blood clots. The funding will enable her team to explore mechanisms behind anti-tumor effects and develop dual-pronged therapeutic approaches.
A new clinical study led by UC San Francisco has identified a molecular test that can pinpoint breast cancer patients with the lowest risk of death, even 20 years after diagnosis. The test, called MammaPrint®, can accurately identify ultralow-risk tumors, which are associated with an excellent prognosis and minimal toxic effects.
A study of nearly 4,000 women at high risk of developing breast cancer found that those who took tamoxifen were more likely to stop treatment due to symptoms like nausea or vomiting, hot flushes, and gynaecological issues. Researchers suggest better communication with patients could improve adherence to medication.
Scientists are working on more precise diagnostics for cancer using advanced imaging techniques and nano-sensors that can detect biomarkers within the body. These tools have the potential to significantly increase early detection of breast cancer with minimal risk and cost.
A new study found that nearly three-quarters of women relied on a support network to discuss their treatment options and attend appointments. Larger support networks were associated with more deliberation about treatment, suggesting patients are thinking through pros and cons.
Researchers discovered that combining palbociclib with autophagy inhibitors can significantly reduce side effects and improve treatment efficacy for ER+ breast cancer patients. The study found that Rb and cytoplasmic cyclin E biomarkers predict response to therapy, allowing for personalized treatment approaches.
A study analyzing genetic test results, family histories, and disease status of nearly 95,600 women found that eight mutations are positively associated with breast cancer, while eleven are linked to ovarian cancer. The research provides clarity on the relative risk of developing cancer for women carrying these mutations.
Researchers found a way to improve the anti-cancer effect of Smac mimetics by inhibiting MK2 protein, leading to a potent new combination therapy for acute myeloid leukemia (AML). The discovery provides hope for developing safer and more powerful treatments for cancers with few treatment options.
A new microscope can rapidly image tumor margins during surgery, reducing the need for second surgeries. It also enables pathologists to view tissue in 3D, potentially leading to improved diagnosis and treatment decisions.
Women living in lower-income areas were more likely to be diagnosed with late-stage breast cancer after a substantial rollback of Medicaid coverage, according to a new analysis. The study found a significant shift towards later stage diagnosis in low-income areas compared to higher-income areas.
A recent study found that the percentage of breast cancers diagnosed at early Stage 1 increased by 3.6 percentage points after the Affordable Care Act took effect. This increase was particularly notable among African American and Latina patients, who saw significant gains in Stage 1 diagnoses.
A multicenter study found that MRI screening added 3.8 additional cancers per 1,000 women compared to mammography alone, while ultrasonography added 2.4 additional cancers. Women treated with breast conservation surgery and radiotherapy remain at increased risk for second breast cancers.
A large-scale study of women carrying faults in cancer genes found that family history, gene position, and precise mutation type impact cancer risk. Estimates provide more confidence for counselling and clinical management.
A study of nearly 10,000 women with BRCA1 and BRCA2 mutations found age-specific breast and ovarian cancer risks that vary by mutation location and family history. The findings indicate a need for individualized counseling incorporating both family history profiles and mutation location to inform preventive strategies.
Researchers developed a new drug delivery platform that uses ultrasound waves to trigger the dispersal of chemotherapy-containing nanoparticles precisely at tumor sites. The platform resulted in a two-fold increase in targeting efficacy and a dramatic reduction in both tumor size and drug-related toxicity.
A study found that PD-L2 protein expression was associated with clinical response to pembrolizumab in patients with HNSCC, independent of PD-L1 expression. Clinical response rates were higher among patients whose tumors expressed both PD-L1 and PD-L2.
A recent study published in CANCER found that Asian women are less likely to receive timely follow-up tests after an abnormal mammogram compared to non-Hispanic White women. The study highlights disparities in breast cancer screening and outcomes among Asian ethnic groups, with Vietnamese and Filipino women facing the longest delays.
Researchers have developed new breast cancer risk prediction models to identify patients at higher risk of developing occult cancers not visible on mammography. The clinical trial, funded by the National Institutes of Health/National Cancer Institute, aims to significantly increase cancer detection rates through MRI screenings.
Scientists have identified a type of protein called Proline-Rich Homeodomain (PRH) that can help suppress the growth of breast cancer tumors. Monitoring PRH levels or activity in patients with breast cancer could be crucial for determining their prognosis.
A study has identified eight new genetic locations associated with an increased risk of testicular germ cell tumors. The findings, published in Nature Genetics, could help doctors understand which men are at the highest risk of developing the disease and signal them to screen those patients.
Researchers at Huntsman Cancer Institute discovered a new science that could provide better therapeutic options for Philadelphia chromosome-positive ALL patients. The new drug inhibits DNA repair proteins, reducing leukemia load by 50-70% in mouse models.
Researchers found that irradiation of breast fat triggers an inflammatory response, protecting remaining cancer cells and allowing tumors to grow. Agents that block inflammation could improve radiotherapy effectiveness, potentially revolutionizing breast cancer treatment.
Researchers at Walter and Eliza Hall Institute have found a new way to use immunotherapy to treat triple negative breast cancers arising in women with BRCA1 mutations. The combination of two immunotherapy drugs effectively controls tumour growth and improves survival rates in laboratory models.
Research found that slow-growing breast cancers with favorable biologic factors have an excellent prognosis, often outliving patients. The study suggests that large, aggressive tumors are more likely to cause harm and should be prioritized for screening.
Scientists from Griffith University and partners have engineered a new tool to detect cancer by recognizing an unusual sugar present on tumor cells. The innovation utilizes the E. coli toxin, which binds to Neu5Gc, a substance produced by tumor cells.
A study published in the New England Journal of Medicine found that wealthier individuals are more likely to receive cancer diagnoses due to increased testing. However, mortality rates from these cancers have been decreasing, largely due to improved treatments. The authors suggest alternative payment models and reduced financial confli...
A research team from IDIBELL has characterized the complete epigenomes of the most frequent tumors, including those of colon, lung and breast cancer. The study reveals that anti-cancer genes slow down their activity in cancer-affected organs, but also identifies alterations in distant chromosomal regions.
Researchers have discovered a novel mechanism behind treatment resistance in brain metastatic breast cancers, and a potential treatment strategy that may overcome this resistance. Targeting the Human Epidermal Growth Factor Receptor 3 (HER3) protein has been shown to significantly slow tumor growth and improve survival.
A phase III clinical trial suggests that adding pertuzumab to standard trastuzumab treatment after surgery may help reduce the risk of invasive breast cancer by 19% in patients with HER2-positive disease. The benefit is most pronounced in women with node-positive and hormone receptor-negative breast cancer.
A new computer-aided diagnostic technique uses cutting-edge imaging technology and artificial intelligence to differentiate between benign and malignant tissues. The technique achieved a classification accuracy of over 90%, reducing the need for second breast cancer surgeries.
A population-based study found that a 2014 consensus statement endorsing minimal negative margins led to decreased reoperations and increased rates of breast-conserving surgery. Final surgical treatment rates also shifted towards mastectomy, resulting in overtreatment reduction.
In a phase III clinical trial, olaparib reduced cancer progression by 42%, delaying it by 3 months compared to standard chemotherapy. Tumors shrunk in about 60% of patients who received olaparib.
A retrospective study of 1,200 women found that pregnancy after breast cancer diagnosis did not increase the risk of cancer recurrence and death. However, survivors with estrogen receptor-positive tumors may want to consider their personal risk for recurrence when deciding how long to wait before becoming pregnant.
A new genomic sequencing approach detected circulating tumor DNA at a high rate in 89% of patients, identifying genetic changes that can be matched to targeted therapies. The study found 73% of genetic changes in tumor samples were also detected in blood samples.
A large study of over 1,200 women found that pregnancy after breast cancer diagnosis does not increase the chance of cancer recurrence or death. The findings confirm that women with ER-positive cancer can safely become pregnant without increasing their risk of recurrence.
A phase II randomized clinical trial found that the Conquer Fear psychological intervention significantly reduced fear of cancer recurrence in survivors. The intervention lowered general anxiety, cancer-specific distress, and improved quality of life compared to relaxation training.
The immunotherapy drug pembrolizumab has been shown to shrink tumors in patients with metastatic triple negative breast cancer, regardless of prior treatment. In a Phase II clinical trial, the drug demonstrated activity in both PD-L1-positive and -negative tumors.
Researchers have developed a new technique using Cerenkov luminescence imaging (CLI) to assess tumor margins during breast tumor surgery. This method combines optical and molecular imaging, providing high-resolution images of the tumor and surrounding tissue.
Researchers found that radiation therapy can improve the delivery of cancer nanomedicines up to 600% by attracting macrophages to tumor blood vessels, leading to increased nanoparticle uptake. This combination strategy shows promise for enhanced treatment efficacy and could be tested in clinical trials quickly.
Researchers found a link between isolated white communities and late-stage breast cancer diagnoses, with one-third of new patients diagnosed at a late stage in the US. Concerted public health efforts may explain lower risk disparities in black and Hispanic neighborhoods.
Researchers found that combining pembrolizumab with epacadostat improved pathological complete response rates in patients with triple-negative breast cancer. The treatment also showed promising responses in other cancers, such as non-small cell lung cancer and squamous cell head and neck cancer.
The study shows that open-access BRCA testing to Ashkenazi women enables the identification of carriers who would otherwise have been missed. Carrying one of the mutations for the BRCA genes means that women affected have a 50-80% risk of developing breast cancer and a 20-50% risk for ovarian cancer.
Researchers at George Washington University found a co-occurrence of COMT and BRCA 1/2 variants in women who remained cancer-free, suggesting potential protective effects. Further research is needed to confirm the findings and explore the mechanisms behind this association.
A recent study led by Massachusetts General Hospital researchers has identified a novel mechanism behind the resistance of HER2-positive breast cancer metastases to treatment. The study found that overexpression of the HER3 gene contributes to this resistance, and combining anti-HER2 and anti-HER3 therapies can slow tumor growth.
A study at Fred Hutchinson Cancer Center found that asymptomatic women with early-stage breast cancer often undergo unnecessary advanced imaging and tests, which provide little medical benefit but may have harmful effects and increase financial burden. ASCO guidelines recommend against routine surveillance testing for these patients.
A new report by the American Institute for Cancer Research reveals that drinking just one glass of wine or other alcoholic drink a day increases breast cancer risk, while vigorous exercise decreases risk. The study also found links between diet and breast cancer risk, including non-starchy vegetables and dairy products.
A new blood test called Videssa Breast has shown high sensitivity and specificity for detecting breast cancer in women under age 50. The test can help reduce the use of breast biopsies by up to 67 percent, ruling out breast cancer with a positive predictive value of 25.2 percent.
Research published in the British Journal of Cancer found that carrying excess body fat can increase cancer risk, with waistline and hip measurements being key indicators. The study combined data from over 43,000 participants and found that adding just 11cm to the waistline increased obesity-related cancer risk by 13%.
A study analyzing 3,640,229 patients in the SEER database found that lung cancer diagnoses are associated with a nearly 420% higher suicide rate compared to the general population. The highest suicide risk was observed in lung cancer patients, particularly older individuals, widowed patients, and those with metastatic disease.
A recent study published in Nature Cell Biology identified a small RNA molecule, miR-199a, that helps maintain the activity of stem cells in both healthy and cancerous breast tissue. The microRNA promotes particularly deadly forms of breast cancer and inhibiting its effects could improve existing breast cancer therapies.
A new study estimates that more than 150,000 US women are currently living with distant metastatic breast cancer, a form of the disease that has spread to distant sites in the body. Despite poor prognosis, survival rates for women diagnosed with MBC at younger ages have been increasing significantly.
Researchers have identified the same access paths for two molecules to reach the active site of an enzyme involved in female hormone synthesis, leading to more selective and effective drug development. The study, published in the Journal of Physical Chemistry Letters, has implications for treating breast cancer.