Articles tagged with Breast Cancer
A new study found that women with early-stage breast cancer are more likely to consider double mastectomy due to their decision-making habits and values. Researchers surveyed 2,362 women and discovered that those who were worried about making a bad decision and wanted to make their own choices were more likely to consider the aggressiv...
The Patient-Centered Outcomes Research Institute's Board approved $115 million to fund 20 comparative clinical effectiveness research (CER) studies on various conditions. These studies will investigate the most effective approaches to care planning, opioid prescribing, palliative care and more.
A new study highlights the significance of educating men to encourage women to seek medical help earlier due to cultural and religious barriers. Community nurses are found to be the most effective channel in raising breast cancer awareness in India's urban areas.
Scientists have found that breast cancer cells spread to other parts of the body relatively late in disease development. This discovery supports the importance of early diagnosis and treatment, which can increase the chances of preventing cancer cell spread and improving survival rates.
A study found that older cancer patients and their caregivers often differ in assessing the patient's physical abilities, with caregivers rating them as having poorer function. This disparity is associated with greater caregiver burden. The researchers suggest considering caregiver burden when assessing patients' needs.
Experts emphasize the importance of communicating cancer prevention messages to young adults (18-44 years) to reduce future cancer risk. The articles highlight various factors contributing to cancer risk, including health behaviors, chronic conditions, and social drivers, and propose tailored interventions to mitigate risks.
A new analysis shows that breast cancer prognoses have significantly improved for young women treated with breast conserving surgery between 1997 and 2010. The study found a dramatic reduction in breast cancer recurrences and deaths after the implementation of new diagnostic and treatment strategies in 2005.
The LSU Health New Orleans School of Public Health will receive a $15 million grant over five years to support its cancer education, early detection, and control programs. The funding will help improve cancer screening rates and reduce disparities in cancer care across the state.
A study published in Hormones & Cancer found that obese rats with sensitive androgen receptors had more aggressive tumors, even after anti-estrogen treatment. Researchers identified inflammation and cytokine interleukin 6 as key factors contributing to this sensitivity, highlighting the potential for personalized therapeutic strategies.
Researchers hope IBM's Watson will help people with cancer by providing detailed information on genetic mutations and targeted therapies. With Watson, pathologists can analyze multiple genes simultaneously, including those that are not currently tested, to provide more personalized care to patients.
Researchers found that paclitaxel, a breast cancer treatment, can fuel the spread of disease to lungs by creating an environment hospitable to cancer cells. The study identified a gene called Atf3 as key to this process, which helps distribute 'seeds' (cancer cells) and fertilize the 'soil' (lungs).
Researchers found that black women are more likely to have aggressive breast cancer subtypes, such as basal-like and HER2-enriched tumors. The study suggests that genomic testing could help explain the disparity in survival rates between black and white women with breast cancer.
A collection of articles on hereditary cancer syndromes, including Li-Fraumeni and Lynch syndromes, has been published in JAMA Oncology. The studies focus on the effectiveness of intensive cancer surveillance programs for individuals with these rare syndromes.
A new trial has shown that targeted radiotherapy can limit the side effects of breast cancer treatment without compromising its effectiveness. The study found that women who received partial-breast radiotherapy reported fewer long-term changes to their breast appearance and feel, compared to those who underwent whole-breast radiotherapy.
Researchers have developed a new class of anti-cancer agents targeting cancer cells' 'Achilles' heel', improving outcomes for aggressive triple negative and HER2-positive breast cancers. The treatment, S63845, was found to be highly effective when combined with standard therapies.
Researchers identified a new HER2 mutation that activates tyrosine kinase, triggering tumor formation. A circulating tumor DNA analysis was developed to diagnose and monitor patients with this mutation, showing promise for treatment with neratinib.
A large cohort study found that women with periodontal disease were at increased risk of developing any type of cancer, with the strongest association seen for esophageal cancer. Certain cancers were associated with higher risks in smokers or nonsmokers with periodontal disease.
A recent University of Alberta study found that irradiation of breast fat can trigger an inflammatory response in cancer patients, enabling cancer cells to survive. The research team is developing an experimental autotaxin inhibitor to counteract this effect and improve radiotherapy's effectiveness.
A study by the Lung Cancer Mutation Consortium identified HER2 mutations in 24 lung cancer patients (3%), with median survival doubling when treated with HER2-directed therapy. This finding suggests a significant population of HER2+ lung cancer patients, highlighting the need for targeted therapies.
Researchers found manmade peptides significantly reduce metastasis in a mouse model of aggressive breast cancer. These peptides directly disrupt the WASF3 gene, which helps cancer cells move and invade other tissues.
Research finds that breast-specific sensuality is better with lumpectomy, correlating with improved sexual function post-operatively. Women with breast cancer report decreased sensuality regardless of surgical modality, but lumpectomy has the best reported outcomes.
A new study found that higher levels of daily physical activity were associated with better performance on cognitive tasks, particularly attention, memory, and multitasking. Exercise was linked to reduced fatigue, which in turn improved cognitive function.
Researchers at Vanderbilt University developed a novel gene therapy delivery system that uses a human protein called albumin to target cancer cells. The approach overcomes common barriers to successful gene therapy, including drug resistance and toxicity.
A study sequenced genomic DNA of Ashkenazi Jewish women with breast cancer, revealing a higher prevalence of non-BCRA mutations in BRCA1 and BRCA2. The findings suggest that genetic testing for all breast cancer genes may benefit these patients.
The European Society for Medical Oncology has announced the recipients of its four distinguished annual awards. Miguel Martin is recognized for his work in breast cancer research, while José Baselga receives the Lifetime Achievement Award for pivotal contributions to drug development. Alberto Bardelli wins the Translational Research Aw...
The GW Cancer Center received a $100,000 grant from the Avon Foundation to fund a patient navigator and Spanish-speaking support group for breast cancer patients in the D.C. area. The program will provide resources to help 300 breast cancer patients overcome barriers in the healthcare system.
A new study offers a decision-analytic model to help women with BRCA mutations determine the optimal age for preventive surgeries that can significantly reduce lifetime breast and ovarian cancer risk. The model recommends specific ages for bilateral mastectomy (BM) and salpingo-oophorectomy (BSO) procedures.
Researchers from UT Health San Antonio found that BRCA1 mutation carriers experience higher gene expression-related stress in luminal epithelial cells, which are more prone to breast tumors. This stress is also associated with estrogen-responsive genes in the breasts and ovaries, a key site for cancer predisposition.
A study found that women with breast cancer who undergo nipple-sparing mastectomy have a low rate of recurrence within five years, comparable to standard mastectomies. The procedure leaves the natural nipple intact and has several advantages over standard mastectomy.
Researchers found that neoadjuvant radiation therapy significantly lowers the risk of developing a second primary tumor in early-stage breast cancer patients. The study also suggests that delaying surgery due to neoadjuvant radiation therapy is not detrimental to survival.
The cyclin-dependent kinase (CDK) inhibitor class of oral drugs has been found to be generally well-tolerated in treating hormone receptor-positive (HR+) metastatic breast cancer. The most common side effect is a temporary and dose-dependent decrease in white blood cells, which usually returns to normal with dosage adjustments.
Researchers from the University of Pennsylvania School of Medicine identified a process where cancer cells instruct normal cells to act like viruses, enabling tumors to spread and resist treatment. This 'virus mimic' is detected in the blood of cancer patients and could explain why some breast cancers are more aggressive than others.
Researchers have discovered that inhibiting 20-HETE, an acid metabolite overexpressed in cancer cells, reduces breast cancer tumor size and ability to spread. The study found that the drug HET0016 blocks key pathways that enable cancer cells to create a distant microenvironment.
Researchers at University of Missouri found that hormone replacement therapies can induce growth and metastasis in breast cancer by enriching specialized cancer cells like stem cells. The study suggests targeting these rare cells and immunotherapies to combat the disease.
Scientists from the University of Plymouth have discovered that cellular prion protein is over-produced in schwannoma cells, contributing to tumor growth and patient prognosis. The study identified existing drugs that could manage this protein overproduction and potentially lead to an effective therapy for neurofibromatosis 2 patients.
A team led by Gang Han has designed a human protein-based, tumor-targeting Magnetic Resonance Imaging (MRI) contrast that can be easily cleared by the body. This discovery holds promise for clinical applications, including enhanced MRI contrast for early-stage tumor detection.
The Damon Runyon Cancer Research Foundation has awarded four physician-scientists with over $1.8 million in funding to pursue cancer research. The awards provide critical support to enhance translation and clinical research, addressing the financial disincentives that often deter physicians from pursuing a research career.
A high-fat diet during pregnancy significantly increases breast cancer susceptibility in offspring for three generations, according to a Georgetown University Medical Center study. Genetic changes were observed in mammary tissue of high-fat diet progeny compared to control group's offspring.
TGen is developing 'liquid biopsies' that can help clinicians accurately treat patients with high-risk breast cancer. These non-invasive blood tests could enable continuous monitoring of a patient's progress, reducing the need for surgery, chemotherapy, and radiation.
Nicole F. Steinmetz receives two NIH grants to develop microscopic drug-delivery systems for triple negative breast cancer patients and patients at risk of serious blood clots. The funding will enable her team to explore mechanisms behind anti-tumor effects and develop dual-pronged therapeutic approaches.
A new clinical study led by UC San Francisco has identified a molecular test that can pinpoint breast cancer patients with the lowest risk of death, even 20 years after diagnosis. The test, called MammaPrint®, can accurately identify ultralow-risk tumors, which are associated with an excellent prognosis and minimal toxic effects.
A study of nearly 4,000 women at high risk of developing breast cancer found that those who took tamoxifen were more likely to stop treatment due to symptoms like nausea or vomiting, hot flushes, and gynaecological issues. Researchers suggest better communication with patients could improve adherence to medication.
Scientists are working on more precise diagnostics for cancer using advanced imaging techniques and nano-sensors that can detect biomarkers within the body. These tools have the potential to significantly increase early detection of breast cancer with minimal risk and cost.
A new study found that nearly three-quarters of women relied on a support network to discuss their treatment options and attend appointments. Larger support networks were associated with more deliberation about treatment, suggesting patients are thinking through pros and cons.
Researchers discovered that combining palbociclib with autophagy inhibitors can significantly reduce side effects and improve treatment efficacy for ER+ breast cancer patients. The study found that Rb and cytoplasmic cyclin E biomarkers predict response to therapy, allowing for personalized treatment approaches.
A study analyzing genetic test results, family histories, and disease status of nearly 95,600 women found that eight mutations are positively associated with breast cancer, while eleven are linked to ovarian cancer. The research provides clarity on the relative risk of developing cancer for women carrying these mutations.
Researchers found a way to improve the anti-cancer effect of Smac mimetics by inhibiting MK2 protein, leading to a potent new combination therapy for acute myeloid leukemia (AML). The discovery provides hope for developing safer and more powerful treatments for cancers with few treatment options.
A new microscope can rapidly image tumor margins during surgery, reducing the need for second surgeries. It also enables pathologists to view tissue in 3D, potentially leading to improved diagnosis and treatment decisions.
Women living in lower-income areas were more likely to be diagnosed with late-stage breast cancer after a substantial rollback of Medicaid coverage, according to a new analysis. The study found a significant shift towards later stage diagnosis in low-income areas compared to higher-income areas.
A recent study found that the percentage of breast cancers diagnosed at early Stage 1 increased by 3.6 percentage points after the Affordable Care Act took effect. This increase was particularly notable among African American and Latina patients, who saw significant gains in Stage 1 diagnoses.
A multicenter study found that MRI screening added 3.8 additional cancers per 1,000 women compared to mammography alone, while ultrasonography added 2.4 additional cancers. Women treated with breast conservation surgery and radiotherapy remain at increased risk for second breast cancers.
A large-scale study of women carrying faults in cancer genes found that family history, gene position, and precise mutation type impact cancer risk. Estimates provide more confidence for counselling and clinical management.
A study of nearly 10,000 women with BRCA1 and BRCA2 mutations found age-specific breast and ovarian cancer risks that vary by mutation location and family history. The findings indicate a need for individualized counseling incorporating both family history profiles and mutation location to inform preventive strategies.
Researchers developed a new drug delivery platform that uses ultrasound waves to trigger the dispersal of chemotherapy-containing nanoparticles precisely at tumor sites. The platform resulted in a two-fold increase in targeting efficacy and a dramatic reduction in both tumor size and drug-related toxicity.
A study found that PD-L2 protein expression was associated with clinical response to pembrolizumab in patients with HNSCC, independent of PD-L1 expression. Clinical response rates were higher among patients whose tumors expressed both PD-L1 and PD-L2.
A recent study published in CANCER found that Asian women are less likely to receive timely follow-up tests after an abnormal mammogram compared to non-Hispanic White women. The study highlights disparities in breast cancer screening and outcomes among Asian ethnic groups, with Vietnamese and Filipino women facing the longest delays.
Researchers have developed new breast cancer risk prediction models to identify patients at higher risk of developing occult cancers not visible on mammography. The clinical trial, funded by the National Institutes of Health/National Cancer Institute, aims to significantly increase cancer detection rates through MRI screenings.
Scientists have identified a type of protein called Proline-Rich Homeodomain (PRH) that can help suppress the growth of breast cancer tumors. Monitoring PRH levels or activity in patients with breast cancer could be crucial for determining their prognosis.
A study has identified eight new genetic locations associated with an increased risk of testicular germ cell tumors. The findings, published in Nature Genetics, could help doctors understand which men are at the highest risk of developing the disease and signal them to screen those patients.
Researchers at Huntsman Cancer Institute discovered a new science that could provide better therapeutic options for Philadelphia chromosome-positive ALL patients. The new drug inhibits DNA repair proteins, reducing leukemia load by 50-70% in mouse models.