Articles tagged with Breast Cancer
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A study investigated the work ability of young adult cancer survivors, finding that low education, female sex, lymphoedema, fatigue, depression, and reduced physical quality of life are associated with reduced work ability. Treatment intensity was not significantly related to work ability.
A study published in Cancer Research found that serum from women with breast cancer after exercise reduces breast cancer cell viability and tumor growth via activation of the Hippo signaling pathway. The effects were most pronounced on hormone receptor-positive breast cancer cells.
A study by London School of Hygiene & Tropical Medicine found that alcohol industry organisations distort information on cancer risk, particularly for breast and colorectal cancers. The researchers call for policymakers to reconsider relationships with these bodies, which develop alcohol policy and disseminate health info.
A team of scientists at UT Austin has developed a handheld instrument that rapidly and accurately diagnoses cancerous tissue during surgery. The MasSpec Pen is over 96% accurate and can detect cancer in marginal regions, potentially improving treatment and reducing recurrence rates.
A University of Colorado study found that blood tumor markers can predict lung cancer progression, allowing for earlier adjustments to treatment plans. Markers were associated with a 10% or greater rise in 53% of patients experiencing cancer progression, but not limited brain progression cases.
A recent study found that nearly one in four small tumours were aggressive and patients benefited from chemotherapy. Researchers identified a 70-gene signature to detect aggressive tumours.
This review indicates that adipose tissue can affect cancer development through various mechanisms, including inflammation, cell metabolism, and immune clearance. The study found that different types of fat have distinct effects on cancer cells, with some types promoting tumor growth and others inhibiting it.
A new study found a significant association between opioid use and non-adherence to hormone therapy among breast cancer patients. The study highlights the challenges of managing chronic pain in cancer survivors, who often face 10 years of treatment.
Researchers at UT Health San Antonio have developed a new, first-in-class agent called ERX-11 that blocks the growth of estrogen receptor-positive (ER-positive) breast cancer in its tracks. The new drug has shown promising results in preclinical studies and is expected to begin human trials soon.
Researchers found that Z-endoxifen provided substantial drug exposure, acceptable toxicity, and promising anti-tumor activity in patients with metastatic breast cancer who had progressed on standard anti-estrogen treatments. The treatment resulted in tumor shrinkage, with some cases lasting over two years without disease progression.
A two-stage approach to risk-reducing mastectomy, involving initial breast reduction and
Researchers have found that women with a history of preeclampsia have a 90% decrease in breast cancer risk if they carry a specific common gene variant. The study, conducted in the California Teachers Study, confirms earlier findings and aims to develop new breast cancer prevention strategies for all women.
A 14-year study found that statins reduce breast cancer risk by 45% and mortality risk by 40%. Women with high cholesterol had significantly lower breast cancer rates and improved survival rates compared to those without high cholesterol.
Researchers found that concurrent administration of anti-OX40 and anti-PD1 antibodies attenuated the effect of anti-OX40, resulting in poor treatment outcomes in mice. Sequential treatment with anti-OX40 followed by anti-PD1 improved therapeutic efficacy in some cases.
A new Yale University study reveals that women undergoing IVF to become pregnant report a more intense bodily experience compared to those donating eggs for money. Researchers found a direct correlation between the intensity of bodily experiences and the motivation for harvesting eggs.
Researchers will study a nanoparticle-based therapeutic that targets the body's own cancer immunity cycle, aiming to prevent tumor progression and metastasis. The therapy shows promise in treating melanomas, ovarian, and breast tumors, with sustainable immune stimulation and prevention of relapse.
Researchers at Sanford Burnham Prebys Medical Discovery Institute have developed a proof-of-concept nanosystem that dramatically improves the visualization of tumors, achieving a five-fold increase over existing methods. The novel approach generates bright tumor signals by delivering quantum dots to cancer cells without toxic effects.
A study found that patients with one normal BRCA gene and germline mutations in breast and ovarian cancers had better survival rates when treated with chemotherapy. The research team evaluated the genetic profiles of 160 tumors and discovered a relationship between BRCA gene retention and resistance to treatment. Patients with normal B...
A comprehensive review highlights the importance of lifestyle modifications and emerging approaches to manage menopausal symptoms after breast cancer. Non-pharmacologic therapies and several promising emerging agents show promise for symptom relief with reduced breast cancer risk.
A study has identified a genetic signature linked to defects in the DNA damage repair-genes BRCA1 and BRCA2 in breast cancer. The researchers found that this signature is not exclusive to BRCA mutations but also indicates other ways of deactivating the DNA repair mechanism, offering new insights into breast cancer treatment decisions.
Researchers have developed and validated a nomogram that can predict overall survival and progression-free survival for patients with oropharyngeal squamous cell carcinoma treated with radiation-based therapy. The nomograms were derived from clinical trials NRG Oncology/RTOG 0129 and 0522.
A new study found that annual screening starting at age 40 reduces breast cancer-specific deaths by nearly 40%, compared to 23-31% reductions with other recommendations. The findings suggest that women starting annual mammography at age 40 may benefit from a significant reduction in breast cancer-related deaths.
Researchers found that claudin-low triple negative breast cancers have high levels of regulatory T-cells, which suppress the immune system's defenses. They developed a strategy to deplete these cells, combining it with checkpoint inhibitors to slow tumor growth and improve outcomes.
A recent study found that tumor-infiltrating immune cells, specifically regulatory T cells (Tregs), can interfere with immune-targeting therapies in aggressive breast cancers. Depleting Tregs delayed tumor growth in mouse models, suggesting a potential strategy to improve targeted treatments.
Despite high-risk genetic mutations detectable through simple blood or saliva tests, only 15% of affected women in US have taken recommended genetic test. A new study from UCLA Fielding School of Public Health highlights a significant unmet need for genetic testing across the country.
A large long-term study found that women who live in areas with high levels of outdoor light at night may be at higher risk for breast cancer. The link was stronger among women who worked night shifts and were premenopausal or current/past smokers.
A new blood test developed by Johns Hopkins Medicine accurately identifies more than half of people with early-stage colorectal, breast, lung, and ovarian cancers. The test distinguishes between cancer-specific DNA and altered DNA that can be mistaken for biomarkers.
Researchers at Dana-Farber Cancer Institute discover that CDK4/6 inhibitors not only halt cancer cell division but also spur the immune system to attack and kill cancer cells. The findings suggest that combining these drugs with immunotherapies may lead to greater anti-cancer effects.
Researchers developed a DNA sequencing-based method to detect early stage cancers by analyzing circulating tumor DNA in blood plasma. The approach, called TEC-Seq, identified cancer driver genes in over 90% of patients with colorectal, ovarian, lung, and breast cancers.
A new study found that women with early-stage breast cancer are more likely to consider double mastectomy due to their decision-making habits and values. Researchers surveyed 2,362 women and discovered that those who were worried about making a bad decision and wanted to make their own choices were more likely to consider the aggressiv...
The Patient-Centered Outcomes Research Institute's Board approved $115 million to fund 20 comparative clinical effectiveness research (CER) studies on various conditions. These studies will investigate the most effective approaches to care planning, opioid prescribing, palliative care and more.
A new study highlights the significance of educating men to encourage women to seek medical help earlier due to cultural and religious barriers. Community nurses are found to be the most effective channel in raising breast cancer awareness in India's urban areas.
Scientists have found that breast cancer cells spread to other parts of the body relatively late in disease development. This discovery supports the importance of early diagnosis and treatment, which can increase the chances of preventing cancer cell spread and improving survival rates.
A study found that older cancer patients and their caregivers often differ in assessing the patient's physical abilities, with caregivers rating them as having poorer function. This disparity is associated with greater caregiver burden. The researchers suggest considering caregiver burden when assessing patients' needs.
Experts emphasize the importance of communicating cancer prevention messages to young adults (18-44 years) to reduce future cancer risk. The articles highlight various factors contributing to cancer risk, including health behaviors, chronic conditions, and social drivers, and propose tailored interventions to mitigate risks.
A new analysis shows that breast cancer prognoses have significantly improved for young women treated with breast conserving surgery between 1997 and 2010. The study found a dramatic reduction in breast cancer recurrences and deaths after the implementation of new diagnostic and treatment strategies in 2005.
The LSU Health New Orleans School of Public Health will receive a $15 million grant over five years to support its cancer education, early detection, and control programs. The funding will help improve cancer screening rates and reduce disparities in cancer care across the state.
A study published in Hormones & Cancer found that obese rats with sensitive androgen receptors had more aggressive tumors, even after anti-estrogen treatment. Researchers identified inflammation and cytokine interleukin 6 as key factors contributing to this sensitivity, highlighting the potential for personalized therapeutic strategies.
Researchers hope IBM's Watson will help people with cancer by providing detailed information on genetic mutations and targeted therapies. With Watson, pathologists can analyze multiple genes simultaneously, including those that are not currently tested, to provide more personalized care to patients.
Researchers found that paclitaxel, a breast cancer treatment, can fuel the spread of disease to lungs by creating an environment hospitable to cancer cells. The study identified a gene called Atf3 as key to this process, which helps distribute 'seeds' (cancer cells) and fertilize the 'soil' (lungs).
Researchers found that black women are more likely to have aggressive breast cancer subtypes, such as basal-like and HER2-enriched tumors. The study suggests that genomic testing could help explain the disparity in survival rates between black and white women with breast cancer.
A collection of articles on hereditary cancer syndromes, including Li-Fraumeni and Lynch syndromes, has been published in JAMA Oncology. The studies focus on the effectiveness of intensive cancer surveillance programs for individuals with these rare syndromes.
A new trial has shown that targeted radiotherapy can limit the side effects of breast cancer treatment without compromising its effectiveness. The study found that women who received partial-breast radiotherapy reported fewer long-term changes to their breast appearance and feel, compared to those who underwent whole-breast radiotherapy.
Researchers have developed a new class of anti-cancer agents targeting cancer cells' 'Achilles' heel', improving outcomes for aggressive triple negative and HER2-positive breast cancers. The treatment, S63845, was found to be highly effective when combined with standard therapies.
Researchers identified a new HER2 mutation that activates tyrosine kinase, triggering tumor formation. A circulating tumor DNA analysis was developed to diagnose and monitor patients with this mutation, showing promise for treatment with neratinib.
A large cohort study found that women with periodontal disease were at increased risk of developing any type of cancer, with the strongest association seen for esophageal cancer. Certain cancers were associated with higher risks in smokers or nonsmokers with periodontal disease.
A recent University of Alberta study found that irradiation of breast fat can trigger an inflammatory response in cancer patients, enabling cancer cells to survive. The research team is developing an experimental autotaxin inhibitor to counteract this effect and improve radiotherapy's effectiveness.
A study by the Lung Cancer Mutation Consortium identified HER2 mutations in 24 lung cancer patients (3%), with median survival doubling when treated with HER2-directed therapy. This finding suggests a significant population of HER2+ lung cancer patients, highlighting the need for targeted therapies.
Researchers found manmade peptides significantly reduce metastasis in a mouse model of aggressive breast cancer. These peptides directly disrupt the WASF3 gene, which helps cancer cells move and invade other tissues.
Research finds that breast-specific sensuality is better with lumpectomy, correlating with improved sexual function post-operatively. Women with breast cancer report decreased sensuality regardless of surgical modality, but lumpectomy has the best reported outcomes.
A new study found that higher levels of daily physical activity were associated with better performance on cognitive tasks, particularly attention, memory, and multitasking. Exercise was linked to reduced fatigue, which in turn improved cognitive function.
Researchers at Vanderbilt University developed a novel gene therapy delivery system that uses a human protein called albumin to target cancer cells. The approach overcomes common barriers to successful gene therapy, including drug resistance and toxicity.
A study sequenced genomic DNA of Ashkenazi Jewish women with breast cancer, revealing a higher prevalence of non-BCRA mutations in BRCA1 and BRCA2. The findings suggest that genetic testing for all breast cancer genes may benefit these patients.
The European Society for Medical Oncology has announced the recipients of its four distinguished annual awards. Miguel Martin is recognized for his work in breast cancer research, while José Baselga receives the Lifetime Achievement Award for pivotal contributions to drug development. Alberto Bardelli wins the Translational Research Aw...
The GW Cancer Center received a $100,000 grant from the Avon Foundation to fund a patient navigator and Spanish-speaking support group for breast cancer patients in the D.C. area. The program will provide resources to help 300 breast cancer patients overcome barriers in the healthcare system.
A new study offers a decision-analytic model to help women with BRCA mutations determine the optimal age for preventive surgeries that can significantly reduce lifetime breast and ovarian cancer risk. The model recommends specific ages for bilateral mastectomy (BM) and salpingo-oophorectomy (BSO) procedures.
Researchers from UT Health San Antonio found that BRCA1 mutation carriers experience higher gene expression-related stress in luminal epithelial cells, which are more prone to breast tumors. This stress is also associated with estrogen-responsive genes in the breasts and ovaries, a key site for cancer predisposition.
A study found that women with breast cancer who undergo nipple-sparing mastectomy have a low rate of recurrence within five years, comparable to standard mastectomies. The procedure leaves the natural nipple intact and has several advantages over standard mastectomy.
Researchers found that neoadjuvant radiation therapy significantly lowers the risk of developing a second primary tumor in early-stage breast cancer patients. The study also suggests that delaying surgery due to neoadjuvant radiation therapy is not detrimental to survival.
The cyclin-dependent kinase (CDK) inhibitor class of oral drugs has been found to be generally well-tolerated in treating hormone receptor-positive (HR+) metastatic breast cancer. The most common side effect is a temporary and dose-dependent decrease in white blood cells, which usually returns to normal with dosage adjustments.