Articles tagged with Breast Cancer
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Researchers found that SHARPIN increases PRMT5 activity, boosting transcription factors that contribute to melanoma growth. SHARPIN acts as a counterbalance to reduced PRMT5 activity in tumors with deleted genes.
A study found that younger women with breast cancer who underwent axillary lymph node dissection were more likely to experience arm swelling and decreased range of motion compared to those who received sentinel lymph node biopsies. The study highlights the importance of de-escalating axillary treatment in young patients.
A study found that 3-D mammography, although more expensive upfront, is a cost-effective screening method due to its higher true negative rates and lower false positive rates compared to digital mammography. The analysis of 46,483 screening episodes showed that DBT reduced cancer diagnosis-related costs in the following year.
A Phase III trial led by MD Anderson Cancer Center found that talazoparib, a PARP inhibitor, extends progression-free survival and improves quality-of-life measures for patients with metastatic HER2-negative breast cancer and BRCA1/2 mutations. Talazoparib was associated with a 46% lower risk of progression compared to chemotherapy.
University of Illinois researchers create an oxygen-sensitive molecular beacon that emits ultrasound signals in response to light, enabling real-time imaging of hypoxic tumors and constricted arteries. This non-invasive method has the potential to guide surgical procedures and treatment plans.
A simple blood test detecting tumor cells in blood may predict high or low risk of breast cancer relapse. The study found that 5% of cancer-free women had a positive CTC test, associated with a 35% recurrence risk after two years.
A phase II trial shows that combining olaparib, a PARP inhibitor, with durvalumab, an immunotherapy drug, achieves 80% disease control at 12 weeks. The treatment is well-tolerated and produces fewer serious side effects compared to chemotherapy.
A recent study by UNC Lineberger Comprehensive Cancer Center researchers found that black women with hormone-receptor positive, HER2-negative breast cancer had a higher risk of recurrence compared to white women. The biological features of patients' tumors partially explained this difference, but not completely.
The I-SPY 2 TRIAL found that achieving pathological complete response (pCR) is a strong predictor of event-free and distant disease-free survival in high-risk breast cancer patients. pCR rates varied by breast cancer subtype, but the relationship between pCR and EFS was significant across all subtypes.
A large-scale study reveals acupuncture to be effective in alleviating joint pain experienced by breast cancer patients undergoing hormone therapy. The treatment resulted in significant pain relief for up to 24 weeks, providing a promising alternative to opioids and other medications.
African American women face significant disparities in breast cancer care, including delayed treatment and follow-up. The TRIP project aims to reduce these disparities by integrating three evidence-based strategies into a cohesive package across six hospitals.
A study published in PLOS ONE found that metformin can prevent the development of multidrug-resistant breast cancer and reverse it after its onset. The research suggests that metformin has potential as a treatment option for aggressive breast cancer, warranting further investigation.
Researchers found that contrast-enhanced digital mammography (CEDM) is comparable to breast MRI in evaluating residual breast cancer after neoadjuvant endocrine therapy or chemotherapy. CEDM may be a more accessible and cost-effective alternative to breast MRI, with fewer anxiety-provoking effects for patients.
Large racial disparities were found in the survival of patients with ovarian, colon, and breast cancers in the United States. Black women had consistently worse survival compared to white women, despite similar stage distributions. The five-year net survival for black women was lower than for white women in all three types of cancer.
Research suggests breast cancer screening in the Netherlands has a marginal effect on mortality, with improved treatments associated with a 28% reduction. Overdiagnosis has steadily increased due to extended screening and digital mammography.
A recent study by the University of Kent has identified Myosin VI as a key protein involved in the production of specific genes linked to breast cancer cell growth. This discovery may lead to new diagnostic clues and therapeutic targets for patients with oestrogen-sensitive breast cancer.
A national survey of physicians found that those with a social network member with poor breast cancer prognosis are more likely to recommend routine mammograms for younger and older patients. This suggests the need for better understanding the personal experiences that shape clinicians' practices.
Researchers from the University of Copenhagen developed a new vaccine technique that can fight HER2-positive breast cancer in mice with a 50-100% prevention rate. The vaccine works by inducing large amounts of antibodies targeted at cancer cells, preventing tumors from developing and slowing down cancer progression.
Researchers identify barriers to applying international guidelines, citing unique challenges such as younger age at presentation and lack of national breast screening programmes. The need for specific regional guidelines was agreed upon by 90.6% of survey responders.
A new study suggests that an American Cancer Society program has been effective in promoting improvements in colorectal cancer screening rates in federally qualified health centers. Funded FQHCs increased their CRC screening rates significantly more than nonfunded FQHCs, with increases of 8.7% and 12.7% over three years.
The study found that urban American-Indian and Alaskan Native individuals had a higher risk of mortality from prostate and breast cancer, with AIANs facing an 87% increased risk for prostate cancer-specific mortality. The community's unique history of social and environmental injustices may be contributing to these disparities.
Researchers will evaluate a promising experimental assay and novel research into microRNAs to predict breast cancer risk. The study aims to develop personalized treatment and improve outcomes for tens of thousands of women annually.
Researchers found that abbreviated breast MRI (AB-MR) detected five additional cancers in asymptomatic women with dense breast tissue after a negative mammogram. AB-MR may be a better option than whole breast ultrasound for supplemental screening.
A new study published in The Lancet Diabetes & Endocrinology found that diabetes and being overweight or obese are responsible for nearly 800,000 new cancer cases globally. High BMI was linked to twice as many cancers as diabetes, with liver cancer and endometrial cancer being the most common types.
A new study analyzed breast cancer tumor samples over time, revealing common characteristics among treatment-resistant tumors. The research aims to understand tumor changes in real-time to adjust treatment accordingly.
A new American Cancer Society study calculates the contribution of several modifiable risk factors to cancer occurrence. The study found that more than 42% of all cancer cases and deaths in the US are associated with these major modifiable risk factors, many of which can be mitigated with prevention strategies.
A joint effort by breast cancer researchers and bioinformaticians has provided new insights into breast development, revealing previously unrecognized cell types. The study used single-cell RNA-sequencing to identify a dramatic shift in gene expression around puberty.
A new study by Einstein Medical Center found that 71% of women surveyed preferred annual mammograms, citing empowerment and education as key factors. The research challenges the USPSTF's biennial screening recommendation, highlighting the importance of women's preferences in healthcare decisions.
A new study suggests that overweight women with higher body mass index (BMI) may need shorter intervals between mammography screening exams. Women with higher BMI face an increased risk of not detecting their breast tumor until it has become large, leading to a worse prognosis.
Researchers have identified a possible way to reengage a tumor suppressor protein, Growth Differentiation Factor 11, in triple-negative breast cancer cells. This could lead to the development of novel medications that can stop the aggressive form of cancer by intervening in its progression.
A study found that only 20% of Indonesian women are aware of cervical smears, with even lower rates for mammography. Higher education, household expenditure, and health insurance were associated with increased awareness and participation. Experts call for improved education and access to resources to increase cancer screening rates.
A University of Guelph professor has identified a protein called cadherin-22 as crucial in the spread of cancer cells. The discovery could lead to new treatments by hindering the protein's function, reducing adhesion and invasion rates by up to 90%.
A new study found that only a quarter of UK adults understand the connection between weight issues and cancer, despite obesity being linked to 13 types of cancer. The study also highlighted misconceptions about cancer types linked to obesity and the impact of socio-economic background on awareness.
A protein called tyrosine kinase 6 (PTK6) has been identified as a potential therapeutic target for estrogen receptor positive (ER+) breast cancer. PTK6 promotes cancer cell survival and growth in ER+ breast cancer cells, making it a promising avenue for developing new treatments.
A study published in Journal of Cancer Survivorship found that motivation to provide samples for genetic tests depends on oncologist engagement or religion, rather than race. Women with better access to healthcare and a greater sense of well-being were more likely to participate in genetic research.
African American women with type 2 diabetes have a higher risk of developing estrogen receptor negative (ER-) breast cancer, a more aggressive form of the disease. Chronic inflammation from diabetes may contribute to this increased risk, which could help explain the higher incidence of ER- breast cancer in African American women.
African-American women with type 2 diabetes are disproportionately affected by ER-negative breast cancers. The study found a statistically significant association between type 2 diabetes and increased risk of ER-negative breast cancer in black women, particularly those with lower BMI.
A new study published in Gastroenterology found that health insurance coverage differences account for nearly half of the black-white survival disparity in colorectal cancer patients. The study analyzed data from 199,098 CRC patients aged 18-64 and found a significant impact of insurance status on treatment outcomes.
A study published in the Journal of Hepatology found that nonalcoholic fatty liver disease (NAFLD) is associated with an increased risk of liver, colorectal, and breast cancers. Patients with NAFLD were 16.73 times more likely to develop hepatocellular carcinoma and twice as likely to develop colorectal cancer.
Researchers developed a melanin-enhanced cancer immunotherapy technique using a transdermal patch that promotes the systemic immune response against melanoma. The patch is applied via a skin patch and triggers an immune response, allowing the body's immune system to remember and respond to the presence of melanoma cells.
Researchers developed a targeted approach to immunotherapy by conjugating cancer drugs to peptides that bind to tumor tissues. This method showed promise in mice models, improving efficacy while minimizing treatment-related side effects.
Women with ER-positive breast cancer still face a substantial risk of cancer returning or spreading even 20 years after diagnosis, according to a new analysis. The risk is directly tied to the original cancer's size and characteristics, as well as the number of lymph nodes involved.
Researchers at Rice University and Northwestern University have developed a method to use nanoshells to deliver high doses of cancer-killing drugs inside tumors. The approach uses laser-activated gold nanoparticles to release approved drugs in laboratory cultures, demonstrating clinical applicability.
A study found circulating tumor cells (CTCs) associated with relapse in stage IV melanoma patients, suggesting a potential predictor for high-risk disease progression via liquid biopsy. CTCs were detected in approximately 40% of advanced stage melanoma patients and linked to faster relapse rates.
Zepsyre, a marine-derived anticancer drug, will be commercialized in South Korea under the deal. PharmaMar retains exclusive production rights and will sell to Boryung Pharm for commercial use.
A new study finds that a 70-year-old malaria drug can block immune cells in the liver, allowing nanoparticles to reach cancer cells. The research showed improved drug delivery to breast tumors and accumulation in mouse tumors and lungs.
A new HCI study reveals that a two-drug combination significantly reduces precancerous polyps in FAP patients, leading to near-complete blockade of cancer growth pathways. The treatment also activates immune responses aimed at destroying pre-cancerous polyps.
Researchers observed a significant association between warfarin use and reduced risk of new cancers, particularly prostate, lung, breast, and colon cancers. The findings suggest that warfarin may be protective against certain types of cancer, which could have implications for anticoagulation treatment.
Experts say pre-menopausal women with hormone-dependent advanced breast cancer should be included in clinical trials alongside older women. This could provide valuable insights into the best treatments for these patients, who make up a third of all advanced breast cancer cases globally.
Researchers found that combining targeted drugs with hormone therapy results in a significant increase in the risk of severe or life-threatening adverse events. Most of these side effects are treatable and potentially preventable.
Regular exercise can reduce fatigue and pain, and improve cardiovascular health and quality of life in women with advanced breast cancer. The study found that women who exercised had a 12.3% increase in VO2max compared to the control group, indicating improved oxygen transportation and heart function.
A large survey of breast cancer patients found that nearly one-third went against their doctor's advice and chose not to complete recommended adjuvant anti-cancer therapy. Patients with higher distrust in the healthcare system were more likely to report noncompliance, highlighting the need for strategies beyond boosting physician trust.
Patients with advanced breast cancer who experience delayed disease progression have better quality of life outcomes compared to those whose disease progresses earlier. Delaying progression could be critical in improving health-related quality of life for patients with oestrogen receptor positive, HER2 negative advanced breast cancer.
Researchers found that PARP inhibitor talazoparib caused regression of patient-derived xenografts (PDXs) of triple-negative breast cancers (TNBC) lacking BRCA mutations. The study suggests that PARP inhibitors may be effective in selected patients with other alterations in DNA damage repair genes.
Researchers mapped genetic alterations in normal mammary duct cells, identifying early changes that precede tumour development. This study provides new insights into breast cancer biology and may lead to more precision in screening and prevention.
A large study of FEA lesions found that only a small percentage (2.4%) upgraded to breast cancer at surgery, while 30% were upgraded to higher-risk but non-cancerous lesions. Surveillance over surgery is recommended for women with FEA who do not have genetic mutations or are not interested in chemoprevention.
The UA Cancer Center research team has discovered that genistein, a compound found in soy foods, can protect BRCA1, a gene crucial in thwarting tumor development in breast tissue. This finding offers new hope for treating triple-negative breast cancers, which currently have no targeted chemotherapy available.
A new open-source machine learning program at Georgia Tech predicts cancer drug effectiveness via genetic data, reducing human bias and increasing accuracy. The program aims to be widely used by researchers to improve treatment outcomes.
The South Carolina Cancer Disparities Research Center aims to understand the reasons behind racial and ethnic health disparities in cancer research. The center will increase SCSU's ability to conduct cutting-edge research, inspire new generations of researchers, and engage the general public in cancer research.
The Cleveland Clinic has developed updated guidelines for accelerated partial-breast irradiation (APBI), a technique that targets radiation to the tumor site only. The new guidelines recommend APBI for a broader range of patients, including younger individuals and those with ductal carcinoma in situ.