Articles tagged with Breast Cancer
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A new study from Ohio State University found that women whose family members or friends died of cancer are more likely to approach breast cancer prevention aggressively. Women with traumatic experiences perceive breast cancer as a death sentence, while those with positive experiences see it as a hardship that can be overcome.
Researchers have found that the loss of a tumor suppressor in triple-negative breast cancer provides clues for novel treatments. Drugs targeting PLK1, AURK and CHK1 may be effective for 20-30% of patients with RB-deficient tumors.
Researchers identified unique mitochondrial defects and alterations in metabolic gene expression associated with aggressive triple-negative breast cancers. The findings provide new molecular biomarkers to identify patients at risk for metastasis and offer potential therapeutic targets.
A new scientific statement highlights the interconnection between cardiovascular disease and breast cancer, emphasizing the need for research and specialized treatment. The American Heart Association emphasizes prevention and modification of cardiac risk factors during and after breast cancer treatment.
Researchers Jos Jonkers and Helen Piwnica-Worms receive a grant to investigate how the immune system recognizes breast cancer. They will use imaging mass cytometry and patient-derived models to devise new treatment combinations, accelerating promising therapies to patients.
New scientific statement highlights potential heart damage from breast cancer treatments and suggests strategies to minimize risks. Lifestyle choices, such as diet and exercise, can also help decrease the risks of developing both diseases.
A nationwide population-based study analyzed over 120,000 women diagnosed with early-stage breast cancer, finding that only 14.7% required additional biopsies during follow-up care. The study's findings will help physicians counsel patients about breast cancer recurrence rates and the need for future biopsies.
Researchers at Stanford University School of Medicine developed a cancer vaccine that eliminates tumors in mice by stimulating immune cells within the tumor site. The treatment showed promise for many types of cancers and could potentially replace or complement existing immunotherapy approaches.
A new interactive online tool helps breast cancer patients better understand their treatment options, resulting in higher knowledge and preparedness. The tool assesses patients' values and provides a customized bar graphic to guide decision-making.
Researchers at Moffitt Cancer Center have discovered a new way to stimulate the immune system to target cancer cells. The study found that activating dendritic cells with a TIM-3 antibody indirectly stimulates T cell anti-cancer activity, leading to reduced tumor growth in mice.
A study published in Plastic and Reconstructive Surgery found that direct-to-implant (DTI) breast reconstruction in women over 65 resulted in good outcomes, including similar complication rates to tissue expander implant (TEI) reconstruction. The DTI approach also showed fewer hospital readmissions and reduced total hospital stay days.
Huntsman Cancer Institute has been selected as a NCI Center for patient-derived model development, utilizing cutting-edge research to test new drugs and drug combinations for breast cancer. The goal is to provide data to prioritize clinical trials and help determine why certain drugs work for some people and others do not.
Research finds that postmenopausal women with higher body fat levels, even those with a normal BMI, have an increased risk of invasive breast cancer. Dual energy X-ray absorptiometry (DXA) measurements show that whole body fat levels are more accurately assessed than traditional BMI methods.
A University of Guelph study found that omega-3s from fish are eight times more effective at inhibiting tumour development and growth compared to plant-based options. The research suggests that marine-derived omega-3s can significantly reduce breast cancer risk, particularly in aggressive forms.
Researchers at the University of Liverpool have found that macrophages express insulin-like growth factors (IGFs) 1 and 2, which support breast cancer metastasis. The study suggests a significant reduction in tumour cell growth and lung metastasis when IGFs are blocked with paclitaxel.
Researchers at Washington University School of Medicine have developed a novel technique using nanoparticles and light to target and kill metastatic cancer cells. The technique, which harnesses the power of chemotherapy drugs and radiation, shows promise in treating multiple myeloma and aggressive breast cancer.
Researchers at Mayo Clinic developed a new test that can establish which inherited BRCA2 gene mutations increase the risk of breast or ovarian cancer. The study identified 54 pathogenic mutations and expanded the list of neutral mutations, providing better decision-making options for patients with genetic testing results.
Yale Cancer Center investigators developed a new statistical model to assess patient risk for cancer, which can result in more efficient and effective clinical trials. This approach can guarantee that the statistical power of the study is adequate to demonstrate if a new treatment is effective.
Researchers have found that blocking production of the chemical 20-HETE can control glioblastoma and breast cancer growth. The inhibitor HET0016 reduced tumor aggressiveness and invasiveness, slowing disease progression.
A team of scientists has identified the protein kinase MSK1 as a key regulator of dormant or latent metastases in estrogen-positive breast cancer. The study found that tumors expressing MSK1 have a longer period of latency with no symptoms, reducing the risk of earlier relapse.
A USC study suggests that regular exercise can lower breast cancer survivors' risk of cardiovascular disease, Type 2 diabetes, and breast cancer recurrence. Exercise helps reduce inflammation, improves heart health, and increases good cholesterol levels.
Researchers found that combining temozolomide with the enzyme inhibitor SLC-0111 significantly regressed human-derived glioblastoma, improving patient outcomes. The treatment strategy targets carbonic anhydrase 9, a membrane enzyme involved in tumor growth.
Women with MSH6 and PMS2 gene variants have a 2-fold or 3-fold increased risk of developing breast cancer. The study suggests more intensive screening for these women may be beneficial.
A study published in The Journal of the National Cancer Institute found that patients with high intra-tumour heterogeneity of the oestrogen receptor are twice as likely to die from breast cancer over a span of 25 years. This risk holds true for Luminal A breast cancer subtype, which is generally considered to have a good prognosis.
Researchers identified two new breast cancer genes MSH6 and PMS2, associated with a doubled risk of developing breast cancer by age 60. The study suggests expanding genetic screening for these genes in women with Lynch syndrome.
A new Michigan State University study finds that mice can mimic human breast cancer tissue and genes, as well as other cancers including lung, oral, and esophagus. This breakthrough could lead to more effective treatments by identifying similarities between tumors.
A study found that screening the general population for cancer genes is cost-effective, preventing more breast and ovarian cancers. This approach could lead to thousands fewer cases of these cancers, particularly among women over 30.
After the Affordable Care Act eliminated cost sharing for screening mammograms, mammogram rates increased six percentage points among older women, according to a Brown University study. The study found that eliminating copayments led to an increase in their use and was concentrated among women with more education.
Researchers found that population testing for multiple cancer genes is the most cost-effective strategy, preventing many more ovarian and breast cancers than current screening methods. This approach could save thousands of lives by reducing risk factors through enhanced screening, medical prevention, or risk-reducing surgery.
A study by Cancer Research UK found that teens who watch TV with adverts are more likely to eat unhealthy foods like crisps, biscuits, and fizzy drinks, consuming up to 500 extra snacks a year. The report suggests that reducing junk food TV marketing could help halt the obesity crisis.
A prospective cohort study found that young women diagnosed with breast cancer who carry a BRCA mutation have the same chances of survival as women without the mutation. After treatment, women with early breast cancer and BRCA mutations do not have a significant difference in overall survival compared to those without the mutation.
Researchers found that DNA repair-related biomarkers, including BRF1, BRCA1/2, and MPO, can predict outcomes in gastric cancer patients who abuse alcohol. These biomarkers were associated with disease recurrence, survival rates, and response to chemotherapy.
Researchers have identified MED1 as a key player in HER2-driven breast cancer development and spread. The study found that mutating MED1 disrupted its interaction with the estrogen receptor, significantly delaying tumor growth and cancer stem-like cell formation.
A study found that new treatments and screening methods have reduced breast cancer deaths by 49% since 2012, compared to 37% in 2000. The reduction is largely due to advances in treatment, with screening contributing 31-48% depending on the molecular subtype.
A recent study by USC researchers found that survival among adolescents and young adults with cancer has not improved over the past three decades. The study breaks down cancer survival rates by race, ethnicity, age group, socioeconomic status, and cancer stage, highlighting disparities in health outcomes.
University of Alberta researchers found that the RYBP protein prevents DNA repair in cancer cells, including breast cancer. This discovery could lead to precision medicine by tailoring treatment to individual patients' DNA.
Scientists developed a method to analyze lymph node tissue, identifying patients with higher risk of secondary cancers. The study found that analyzing architectural features of cancer-free lymph nodes can help differentiate between patients at high and low risk of metastasis.
A new study by Georgetown University Medical Center researchers found that a widely used gene expression profile test to predict breast cancer recurrence is less cost-effective in real-world practice. The test, Oncotype DX, was initially considered cost-effective but its accuracy and implementation in community settings make it less so.
Research from Anglia Ruskin University found that women dissatisfied with their breast size are less likely to perform regular self-examinations for breast cancer. Greater breast size dissatisfaction also leads to lower confidence in detecting changes and delayed medical consultations.
A new single-cell sequencing tool, TSCS, has provided a clearer understanding of how ductal carcinoma in situ (DCIS) progresses to invasive ductal carcinoma (IDC). Genome evolution occurs in the ducts before cancer clones can be disseminated, and most mutations evolve within the ducts prior to invasion.
The Society of Nuclear Medicine and Molecular Imaging has published appropriate use criteria (AUC) for somatostatin receptor PET imaging in neuroendocrine tumors. This AUC addresses several clinical scenarios for diagnosing neuroendocrine tumors (NETs).
The US cancer death rate has dropped 26% since its peak in 1991, resulting in nearly 2.4 million fewer cancer deaths. This decline is mainly due to reductions in smoking and advances in early detection and treatment.
A study led by The Ottawa Hospital and University of Ottawa suggests combining oncolytic viruses with checkpoint inhibitors could cure resistant breast cancer in mice. This combination therapy showed success in models that mimic metastatic spread after surgery, curing 60-90% of mice.
Researchers found that combining oncolytic viruses and checkpoint inhibitors cured 60-90% of triple negative breast cancer in mice, while traditional treatments failed. The combination therapy showed promising results, but further research is needed to test its efficacy in humans.
The NRG Oncology trial found that trastuzumab did not negatively affect cardiac function in patients with node-positive, HER2-positive breast cancer who survived without cancer recurrence. Both groups maintained good cardiac function at a median of 8.8 years after treatment.
Individualized risk-based lung cancer screening using calculators that account for demographic and clinical characteristics may save more lives than current USPSTF recommendations. Researchers estimate that this approach could have prevented over 5,000 more deaths in 2015 compared to the current guidelines.
Scientists at UTHealth and UT Health San Antonio are developing an innovative antibody-based drug to stem the spread of breast cancer to bone, linked to reduced survival rates. The goal is to create a less toxic treatment and reduce deaths tied to breast cancer's spread.
Researchers discovered a mechanism to regulate switching between breast cancer-associated genes, using G-quadruplex structures. The study provides new insights into alternative splicing and could lead to the development of novel therapeutic strategies for controlling cancer growth.
A team of researchers identified a crucial region in Numb that binds and inhibits Mdm2, stabilizing p53 levels. This interaction is key to understanding the regulation of p53 in breast cancers, which tend to retain a functional p53 gene.
A new DNA marker discovered by University College London researchers can detect fatal breast cancer up to a year before symptoms appear. The EFC#93 DNA methylation marker in blood serum correctly identified 43% of women who went on to be diagnosed with fatal breast cancer within three to six months.
Researchers at Hokkaido University have identified a cellular protein called STAP-2 that stabilizes the EGFR signaling pathway, leading to increased cell proliferation and tumor formation in prostate cancer. Suppressing STAP-2 with inhibitors could potentially treat Gefitinib-resistant prostate cancers.
Researchers have discovered that interferon-β can impair the migration and formation of tumors in triple-negative breast cancer cells, suggesting a potential new treatment option for patients. Elevated interferon-β levels in breast tissue correlate with extended patient survival and lower cancer recurrence rates.
Researchers identified mutational signatures characteristic of homologous recombination deficiency (HRD) as associated with improved clinical outcomes to platinum-based chemotherapy. High HRDetect scores were significantly linked to radiographic tumor shrinkage and longer overall survival in patients treated with the medication.
A recent study found that the majority of women with breast cancer report not feeling completely informed about their treatment options. The study suggests that patients often prioritize making a quick decision over thoroughly researching their options. To address this issue, researchers recommend providing consistent, reliable informa...
A new study found that inherited variation in the ADAMTSL1 gene is associated with a poorer survival rate in early-onset breast cancer patients. The research, published in Nature Communications, suggests that this genetic factor may be used to improve prognostic models and inform treatment decisions.
Researchers have developed an AI application that can detect lymph node metastases in breast cancer patients with high accuracy, similar to human pathologists. This breakthrough could improve the efficiency of surgical pathology work and provide better prognostication.
Researchers used digital pathology slide images to train computer algorithms that could detect the spread of breast cancer to lymph nodes with high accuracy. The study found that AI algorithms outperformed human pathologists in detecting cancer spread, suggesting potential improvements in diagnosis and treatment outcomes.
Breast cancer survivors who consumed more soy foods and cruciferous vegetables experienced fewer menopausal symptoms and fatigue. Phytochemicals in these foods may modulate inflammation and estrogen levels, potentially reducing treatment-related side effects.
A Stanford-led study of nearly 3,000 women with early stage breast cancer reveals a significant decline in chemotherapy use between 2013 and 2015, from 34.5% to 21.3%. This decrease reflects a growing trend towards personalized treatment approaches, with physicians increasingly considering tumor genomic testing to guide treatment choices.
Researchers found that low PUMA expression distinguishes stem-like cells in cancer patients who experienced tumor recurrence. Reducing PUMA restores metastasis in cultured cells, highlighting a possible Achilles heel in aggressive breast cancers.