Articles tagged with Breast Cancer
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A new model predicts the extra risk of death for breast cancer patients and survivors, taking into account improved survival rates over time. The model could lead to lower life insurance premiums and increased transparency for patients.
Two new studies show that women with 'triple negative' or HER2 positive breast cancers who respond well to chemotherapy before surgery have a very low risk of having cancer cells in their lymph nodes. Chemotherapy can safely reduce or avoid lymph node surgery for these patients, potentially reducing long-term side effects.
The average size of breast tumors decreased dramatically following the introduction of screening in the 1980s and 1990s. However, a recent study found that this trend has reversed since 2001, with a slight increase in tumor size. Women with smaller tumors at diagnosis tend to have better survival rates.
Researchers developed a new approach using biodegradable gels containing immune-stimulating drugs to deliver immunotherapy directly to the surgical site, preventing tumor recurrence and metastasis. The method showed promising results in mice with breast, lung, and melanoma tumors, offering hope for improving cancer treatment outcomes.
Researchers at the University of Illinois Chicago are developing a small drug molecule that can block JAG1, a cell surface protein found on triple-negative breast cancer cells. The new therapy aims to reduce tumor growth and metastasis, with fewer side effects than aggressive chemotherapy or radiation.
The researchers used cryo-electron microscopy to provide a high-resolution view of the NuA4/TIP60 complex. The structure reveals that Tra1/TRRAP serves as a scaffold for NuA4/TIP60 assembly and that human TRRAP mutations are largely centered on interaction surfaces mediating this assembly.
Women with BRCA1 mutations who undergo double mastectomy have lower breast cancer-specific survival, compared to those under surveillance. For BRCA2 mutation carriers, there is no difference in the chances of dying from breast cancer between mastectomy and surveillance.
A study found that patients with ductal carcinoma in situ (DCIS) who are post-menopausal or estrogen receptor positive have a low risk of recurrence. Treatment with breast-conserving surgery and radiotherapy leads to very low rates of recurrence. The research also identifies clues for tailoring treatments to individual patients.
A Brazilian study found a strong association between vitamin D insufficiency and metabolic syndrome (MetS) in postmenopausal women. The researchers detected MetS in 57.8% of the women with vitamin D insufficiency or deficiency, while only 39.8% had sufficient levels.
Researchers found that polygenic risk scores, which were originally developed to predict first breast cancer risk, can also quantify the risk of a second breast cancer in BRCA carriers. This technology has been shown to be effective in predicting the risk of a second breast cancer in women with high-risk BRCA gene mutations.
Immunotherapy has shown promising results in treating metastatic breast cancer, with a median progression-free survival of 33 months and median overall survival of 82 months. The treatment has been found to improve PFS and OS in both luminal and non-luminal subtypes, offering new hope for patients with this incurable disease.
A clinical trial found that HRD-positive triple negative breast cancer patients respond well to standard AC chemotherapy, with better disease-free survival rates. The study used preserved tissue samples from nearly two decades ago and demonstrated the value of banking tissue for future research.
New research finds a positive link between BMI and DNA damage in BRCA mutation carriers. Obesity is associated with higher levels of gamma-H2AX foci, indicating increased DNA damage.
Researchers have discovered a novel gene, EDC4, involved in familial breast cancer. The study found that mutations in EDC4 impair DNA repair mechanisms, making cells sensitive to PARP inhibitors.
Researchers at OHSU discovered the tumor microenvironment's impact on breast cancer cell growth and response to treatment. The study found that targeting resistance factors from the microenvironment could improve clinical outcomes for patients treated with HER2-targeted drugs.
Researchers found that obesity and inflammation promote resistance to anti-VEGF therapy in breast cancer. Blocking specific molecules like IL-6 or FGF-2 may overcome this resistance and improve treatment response.
A new imaging technology has been developed to grade tumour biopsies, eliminating human subjectivity and variability. The Digistain method uses mid-infrared light to map out chemical changes that signal cancer onset, providing a reliable indicator of disease progression.
Researchers at Lund University have developed a new drug that transforms aggressive breast cancer into hormone-sensitive luminal breast cancers, making them responsive to conventional hormone therapy.
Researchers have identified 110 genes linked to an increased risk of breast cancer, including 32 genes related to survival rates. The study uses a genetic technique to analyze DNA regions and identify specific genes involved in raising a woman's risk.
Researchers at Wake Forest Baptist Medical Center have developed a fluorescing nanoparticle that can find tumors and generate heat to destroy cancer cells. The nanoparticles, called Hybrid Donor-Acceptor Polymer Particles (H-DAPPs), successfully localized and killed breast cancer in mice, showing potential for future human trials.
A new study found that nearly half of women with breast cancer who should undergo genetic testing did not receive it. Genetic counselors were underutilized, with only half of those in the high-risk group receiving counseling before surgery.
The new guideline recommends hypofractionated whole breast irradiation (WBI) for most breast cancer patients, regardless of age or tumor stage. This accelerated treatment offers a more convenient and lower-cost option without compromising cancer control or side effects.
A multi-arm, placebo-controlled study showed that ACE inhibitors and beta blockers can significantly offset the risk of heart problems for patients with HER2-positive breast cancer. The data demonstrated a significant reduction in cardiotoxicity for patients on these medications who received doxorubicin before Herceptin.
Researchers found that nonwhite women were diagnosed at younger ages and with more advanced cancers than white women. The current guidelines may not account for racial differences, leading to delayed diagnosis and potentially harmful outcomes.
A higher proportion of nonwhite patients were diagnosed at younger than 50 years of age compared to white patients, underscoring the need for personalized screening guidelines. The study's findings challenge the use of single age-based screening guidelines that do not account for race.
Researchers identified genetic patterns in primary and matched metastatic cancers, finding that cells often break away as a collection rather than spreading as a single cell. This insight may lead to better treatments or approaches to prevent its spread at the onset.
Women living in US territories receive less comprehensive breast cancer care compared to their continental US counterparts, including delayed surgical treatments and radiation therapy. The study highlights the importance of addressing healthcare disparities in these underserved populations.
Researchers found elevated mir-24-3p in breast cancer patients destined to metastasize despite best available therapy. High expression of mir-24-3p correlated with poor survival rate and specific gene expression signature in TCGA.
A new blood test detects circulating tumour DNA to predict if the breast cancer drug palbociclib is working, allowing for earlier treatment adjustments. The test was found to be effective in identifying patients who are not responding well to the treatment.
Researchers at the University of Melbourne identified 24 previously unknown epigenetic changes that alter a woman's risk of breast cancer and can be passed down through generations. These changes, related to DNA methylation, were found in only approximately 20% of women with familial breast cancer who underwent genetic testing.
Researchers found that patients with a history of breast cancer or lymphoma are three times more likely to develop heart failure than those without cancer. Elevated risks were associated with diabetes, high doses of chemotherapy, and anthracycline drugs.
Researchers at USC Michelson Center successfully utilize a new metal detection technique for studying cancer cells. By imaging metal-tagged antibodies on biopsies from a patient with metastatic prostate cancer, scientists can identify and characterize cancer cells in a blood sample after it is placed on a slide.
A new study of 2,000 women found no association between long-term exposure to trihalomethanes (THMs) and breast cancer risk, contradicting previous links to bladder cancer. However, high levels of chloroform were linked to a moderate association with breast cancer in some cases.
A genetic variant of mutant p53 enhanced mitochondrial function, leading to increased tumor cell metabolism and poorer prognosis for breast cancer patients. The study found that this variant was associated with faster migration and higher ability to invade and metastasize in models of lung and bone metastasis.
A study found that breast cancer patients' initial negative impressions of radiation therapy were often unfounded. The majority of patients reported that short-term side effects were less than or as expected, and long-term side effects were manageable.
Researchers at UNC and NC State developed a biodegradable hydrogel scaffold system to release combination chemo-immunotherapeutic drugs, significantly inhibiting cancer recurrence after primary tumor removal. The approach could work in other tissue types and has shown promising results in animal models.
Researchers found that increased tissue stiffness leads to tumor aggressiveness and drug resistance in breast cancer cells. The study suggests that developing drugs that can prevent stiffness may stop the spread of cancer.
Researchers developed an MRI technique that eliminates contrast agents, reducing unnecessary biopsies and detecting 98% of malignant lesions. The diffusion kurtosis imaging method provides a microscopic level picture of breast tissue, helping to clarify suspicious findings.
Researchers developed a method combining diffusion-weighted MRI with intelligent image analysis to detect malignant changes in breast tissue. The new method reduced false positive findings by 70% and accurately identified malignant tumors in 98% of cases.
Researchers found that genes responsible for metastasis can also initiate primary tumour development, driven by the fly model Drosophila melanogaster. This discovery strengthens the notion that same genes can activate tumour growth and metastasis in some tumours.
Researchers developed a liquid biopsy test to profile cancer genomes from blood and predict survival outcomes for patients with metastatic triple negative breast cancer. The study found that 64% of patients had more than 10% tumor DNA, correlated with poor survival outcomes.
A new study published in JAMA Surgery found that breast cancer patients who undergo mastectomy with or without immediate reconstruction tend to be less satisfied than expected with their physical and sexual health post-surgery. Women who choose immediate reconstruction overestimated their satisfaction with appearance, while those who d...
A global survey of genetic testing labs reveals inconsistent protocols for analyzing BRCA genes, which could impact cancer susceptibility. The study calls for global best-practice guidelines to ensure consistency in test results.
A study of nearly 800 postmenopausal women found that four commonly used prognostic breast cancer tests have varying abilities to predict disease recurrence. The tests, including Oncotype Dx and Prosigna Risk of Recurrence Score, were compared for their accuracy in predicting whether the cancer will return after five years.
A large-scale study found a possible association between highly processed food intake and an increased risk of overall cancer, breast cancer, and lower risks of other types. The study suggests that rapid consumption of ultra-processed foods may drive a growing burden of cancer in the next decades.
Researchers at Dana-Farber Cancer Institute have identified a specific mechanism by which estrogen receptor-positive breast cancers become resistant to standard therapies and metastasize. DNA mutations in the estrogen receptor gene cause tumors to grow even without estrogen, leading to treatment-resistant disease.
A new optical imaging system uses red and near-infrared light to identify breast cancer patients who are likely to respond to chemotherapy. The system analyzes blood flow dynamics in response to a single breath hold and has been shown to correctly identify responders in 92.3% of patients.
A large study found that family history of breast cancer significantly increases the risk of developing invasive breast tumors in women aged 65 and older. The researchers suggest that women with a first-degree family history should consider continuing mammography screening even beyond age-based recommendations.
Researchers developed autonomous nanorobots that can selectively target and starve out cancerous tumors by blocking blood supply. The technology, using DNA origami, has shown safe and effective results in shrinking tumors and causing tissue death.
A study found that full integration of digital breast tomosynthesis (DBT) significantly reduced false positive rates in breast cancer screening exams. DBT was also associated with a higher cancer-detection rate compared to traditional digital mammography.
A study by the University of Louisville found that Medicaid expansion in Kentucky led to an increase in diagnosis rates of early-stage breast cancer and greater utilization of breast-conserving surgery. However, improvements in efficiency and timing of postsurgical therapy were less robust.
A European Organisation for Research and Treatment of Cancer trial found that combining a 'soft' chemotherapy with antiHER2 therapy is highly active and has low toxicity in older patients with HER2 positive metastatic breast cancer. The regimen resulted in a seven-month longer progression-free survival compared to targeted therapy alone.
Research from the Francis Crick Institute discovered that immune cells called Natural Killer cells accumulate in tumours and release chemicals attracting specialised dendritic cells. Genes associated with these cells correlated with cancer patient survival rates, suggesting a new basis for immunotherapies.
Researchers identified a new survival pathway in cancer stem cells that fuels the growth and spread of triple-negative breast cancer. The study suggests targeting this pathway may lead to new treatments for women with this aggressive subtype of breast cancer.
Women who underwent mastectomy without reconstruction underestimated their future quality of life, while those with immediate reconstruction overestimated it. The study highlights the importance of decision support for breast reconstruction, taking into account patients' expectations about well-being.
Researchers at UPMC Hillman Cancer Center have identified a new genetic change in the estrogen receptor that contributes to therapy resistance in ER-positive breast cancer. The presence of ESR1 fusion proteins in treatment-resistant breast cancer may lead to improved treatments for this form of the disease.
Researchers discovered that limiting an amino acid called asparagine can dramatically reduce breast cancer's ability to travel, suggesting a potential strategy to prevent its spread. Foods high in asparagine include dairy and meat products, while fruits and vegetables are low in this compound.
Researchers at Boston University School of Medicine have found that individual BET bromodomain proteins work independently, reducing the effectiveness of pan-BET inhibitors. This discovery paves the way for more fine-tuned experiments and treatments in breast cancer patients with varying levels of protein expression.
Researchers found that restricting asparagine production in mice greatly reduced breast cancer's ability to spread, suggesting a potential new treatment approach. The study also suggests that dietary changes may help stop cancer from spreading and improve outcomes for patients.
Research found that women with estrogen receptor-negative breast cancer had an increased risk of preterm birth and low birth weight compared to those with other types. The study also showed a lower birth rate among breast cancer survivors, with only about 8% having children by 10 years after diagnosis.