Articles tagged with Breast Cancer
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Researchers have identified TLK2 enzyme as a key player in several diseases, including breast cancer and intellectual disability. The study suggests that inhibiting the enzyme may be an effective therapy approach.
Breast cancer research has long neglected social factors like race and socioeconomic status, missing opportunities to understand and reduce disparities in risk and outcomes. Studies have shown that only a small percentage of clinical trials reported findings stratified by these factors.
A large international study found that high body fat in young women reduces breast cancer risk before menopause. Researchers discovered a 12-23% decrease in breast cancer risk for every five-unit increase in BMI, with strongest effects seen in the 18-24 age group.
Researchers found that resveratrol inhibits mutant p53 protein aggregation, preventing breast cancer cell migration and proliferation. This breakthrough could lead to a treatment for over half of malignant tumors, targeting novel strategic targets in cancer research.
Women with mammographically dense breast tissue have higher recall and biopsy rates, as well as increased odds of screen-detected and interval breast cancer. The study supports automated measurements as a future standard for breast density classification.
Researchers discover a protein that shields the PI3K pathway from targeted drugs, leading to improved efficacy with combination therapy. A new study reveals that blocking this protein restores cancer-killing potential in previously ineffective therapies.
A study of 5,366 US flight attendants found a higher lifetime prevalence of breast, melanoma, and non-melanoma skin cancers compared to the general population. The authors suggest that factors such as circadian rhythm disruption and exposure to cosmic ionizing radiation may contribute to these increased cancer rates.
Researchers have developed a novel approach to pretargeted radioimmunotherapy, which has shown complete responses in several solid tumor types using the beta-emitting lutetium-177 and alpha-emitting actinium-225. The new approach offers greater versatility of treatment for various solid tumors and clinical situations.
Researchers discovered that oxygen-starved tumor cells struggle to produce aspartate, a crucial amino acid. By targeting this Achilles' heel, doctors may develop new treatments to block aspartate uptake or production.
A new smart probe developed by Tel Aviv University researchers can detect and visualize individual cancer cells in real-time, allowing surgeons to target specific tumor locations. The probe uses near-infrared technology to identify overproduced enzymes in cancer cells, guiding precise removal of malignant tissue.
A new study from Harvard T.H. Chan School of Public Health found that US flight attendants have a higher prevalence of several cancers, including breast and cervical cancer, compared to the general public. The study suggests that minimizing radiation exposure and circadian rhythm disruption may help reduce the risk of cancer among cabi...
Researchers have demonstrated that combining targeted radionuclide therapy with immunotherapy can enhance treatment response and lead to a high cure rate in melanoma patients. This novel approach uses yttrium-86 (Y-86) NM600, which selectively targets tumors and delivers precise radiation doses.
Researchers at the University of Wisconsin-Madison have identified a protein called Munc13-4 that helps cancer cells secrete exosomes, stimulating tumor growth. Exosome release is dependent on calcium levels and can transfer oncogenes to neighboring cells, contributing to tumor progression.
Research suggests that higher body mass index (BMI) is associated with reduced risk of premenopausal breast cancer. The analysis found an inverse association between breast cancer risk and BMI for women between ages 18 and 54, with the strongest link in early adulthood.
A large-scale study found that higher body fat is associated with a lower risk of breast cancer in premenopausal women. The study, published in JAMA Oncology, analyzed data from over 758,000 women under the age of 55 and found that as BMI increased, breast cancer risk decreased, particularly among younger women.
Women who underwent autologous breast reconstruction reported higher satisfaction and well-being than those with implants. Two years after surgery, patients with autologous reconstruction had greater psychosocial and sexual well-being compared to those with implants.
The study identified a new class of drug-targets, called master regulators, which are rarely mutated in cancer patients. The algorithm predicted the same top drug for almost half of metastatic patients, leading to rapid FDA approval for a clinical trial.
Researchers found that women with higher vitamin D levels in their blood had a significantly reduced risk of developing breast cancer. The study, which pooled data from multiple trials and prospective studies, identified the minimum healthy level of vitamin D as 60 nanograms per milliliter.
A new laser-sonic scanner developed by Caltech researchers can detect tumors in the breast in just 15 seconds, providing higher-resolution images than traditional mammography. The technology uses near-infrared light to create detailed images of internal structures without exposing patients to X-ray radiation or discomfort.
The American Society of Clinical Oncology has endorsed guidelines from the Society for Integrative Oncology, recommending integrative therapies for anxiety, depression, and quality of life improvement. However, some treatments like ginseng and acupressure require further research due to safety concerns.
Researchers found a genetic difference in people with African and European ancestry that affects inflammation response. The study suggests malaria's evolutionary pressure shaped the immune system's adaptation, which may still influence health disparities today.
A new study led by NYU Rory Meyers College of Nursing uses machine learning to detect lymphedema, a distressing side effect of breast cancer treatment. The artificial neural network achieved the best performance for detecting lymphedema, correctly classifying patients with 93.75% accuracy.
A recent BJS meta-analysis of published studies confirms that autologous fat transfer does not increase the risk of cancer recurrence in former breast cancer patients. The procedure can be performed safely to aid breast reconstruction after surgery.
Breast cancer patients aged 70 and over in England have a higher risk of mortality due to reduced surgical intervention compared to other countries. Patients with stage three breast cancer in England are also more likely to not receive surgery, which has been linked to poorer survival rates.
A combination of digital mammography and tomosynthesis detects 8.6 cancers per 1,000 cases, almost twice the rate detected by mammography alone. The technology's higher sensitivity is notable for small and medium invasive cancers, but not large ones.
Researchers found that women who underwent mammography screening were significantly more likely to utilize Pap smear, bone mass measurement, and influenza vaccine services than unscreened women. The study suggests that breast cancer screening may increase awareness of other preventive services among Medicare beneficiaries.
A new clinical trial analysis found that combining an aromatase inhibitor with ovarian function suppression yields a 10-15% improvement in freedom from distant recurrence for high-risk younger breast cancer patients. Women at low risk saw minimal benefit, while those at intermediate risk gained a 4-5% advantage.
A Phase II study found that over half of women with early-stage BRCA+ breast cancer who took talazoparib once daily prior to surgery had no evidence of disease at the time of surgery. The oral medication showed high response rates and manageable toxicities, offering an alternative to chemotherapy for this patient population.
The TAILORx trial found no benefit from chemotherapy for 70% of women with hormone receptor-positive, HER2-negative breast cancer. Treatment with hormone therapy alone after surgery was as effective as hormone therapy plus chemotherapy in reducing invasive disease-free survival and overall survival.
A landmark study published in the New England Journal of Medicine found that most breast cancer patients with intermediate scores on a 21-gene test can safely avoid chemotherapy. The study's results have significant implications for doctors and patients, allowing for more personalized treatment options.
The study reveals a universal increase in lifestyle-related cancers between 2006 and 2016, with significant disparities persisting between high- and low-Socio-demographic Index countries. Breast cancer is the leading cause of cancer death in women, while lung cancer tops the list for men, accounting for nearly 20% of global cancer deaths.
The global burden of cancer has increased significantly over the past decade, with 17.2 million new cases and 8.9 million deaths reported in 2016. Cancer control planning and implementation are crucial to fulfill global commitments for cancer control and noncommunicable diseases.
Researchers found that irradiating chest lymph nodes in patients with early stage breast cancer improved overall survival by 2.4% compared to treating only the breast/thoracic wall. The study involved 4004 patients and showed no increase in non-breast cancer related mortality or serious complications.
Cancer cells use lipid molecules as fuel when blood supply is low, helping them evade antiangiogenic treatment. A new mechanism suggests that blocking lipid energy pathways could improve cancer treatment outcomes.
A recent study from the University of Pennsylvania School of Medicine found that rates of inherited mutations in genes other than BRCA1/2 are twice as high in breast cancer patients with a second primary cancer. The study also investigated polygenic risk scores, which were not strongly linked to an increased risk of cancer.
Researchers at TGen and HCI are working together to combat bone metastatic breast cancer, a leading cause of pain and death for patients. By blocking the activity of RON kinase, they aim to prevent further damage to skeletal structures and enhance anti-tumor immunity.
Plastic surgeons are crucial in managing young women at high genetic risk of breast cancer due to BRCA gene mutations. These women have a low lifetime risk of breast cancer, only 1.5-3.4% by age 30, and may benefit from mastectomy, but the decision is complex and requires careful consideration.
A lower-fat diet was linked to increased breast cancer overall survival among postmenopausal women, although the increase may be partly due to better survival from other causes. The study found modest increases in vegetable, fruit, and grain intake in the lower-fat group.
Researchers at IRB Barcelona identify p38 as a protective mechanism for tumor cells against excessive DNA accumulation, which would cause cell death. Combining p38 inhibitors with chemotherapy shows promise in shrinking tumors and killing cancer cells.
New research finds that certain cancers express high levels of the neural calcium channel TRPA1, which helps them tolerate toxic oxidative stress. Blocking TRPA1 activity in mice curbs tumor growth and makes cancer cells more sensitive to chemotherapy.
A UK analysis of 18,730 patients found that surgery reduced the risk of dying from breast cancer by 40%, compared to primary endocrine therapy. The study suggests that surgery may be a more effective treatment option for older women with oestrogen receptor-positive breast cancer.
Avoiding excess body weight and maintaining a stable weight in middle adulthood may help prevent several obesity-related cancers in women. High weight gain is associated with a significantly increased risk of pancreatic cancer, breast cancer, and endometrial cancer.
Researchers from SWOG present findings on omega-3 fatty acid supplements reducing joint pain in obese breast cancer patients. The study also explores immune microenvironment changes before and after chemotherapy in breast cancer tissue.
A new study found that gentle stretching can reduce tumor size and improve immune response in a mouse model of breast cancer. The research suggests a link between stretching, inflammation resolution, and improved immune function.
The Los Angeles Cancer Surveillance Program, managed by Keck School of Medicine and USC Norris Comprehensive Cancer Center, has improved the understanding, prevention, and control of cancer for nearly 50 years. The program is one of the largest and most comprehensive cancer registries in the US.
Researchers found that 3'UTR shortening in tumors causes tumor-suppressing genes to be turned off, promoting cancer growth. This discovery could change medical science's approach to tumor formation.
A recent study by Mayo Clinic researchers found that the FDA-approved drug decitabine may be effective in treating triple-negative breast cancer. The study identified a subset of patients who could benefit from this therapy based on the presence of certain critical proteins.
USC researchers have identified a remedy to prevent lung metastasis in triple-negative breast cancer, which is the deadliest form of breast cancer. A novel solution uses a nanoparticle to deliver a medication directly to tumors, reducing toxic side effects.
Scientists have identified a new signaling pathway essential for mammary gland development, involving the interaction between stem cells and macrophages. The discovery provides insight into breast cancer genesis and spread, potentially paving the way for early detection and targeted therapies.
A new trial shows that a shorter length of trastuzumab treatment can benefit patients with breast cancer just as much as a longer treatment, with less risk of cardiac side effects. The study found that taking trastuzumab for 6 months was non-inferior to the current standard of 12 months.
Researchers developed a pill that can detect breast cancer in mice using near-infrared light, reducing the need for mammograms and minimizing radiation exposure. The imaging agent was found to bind specifically to cancer cells with high accuracy, paving the way for potential future applications.
Scientists have discovered a new compound, metarrestin, that significantly reduces metastasis in human prostate, breast and pancreatic cancer in mice. The compound was found to blow up the complex marker PNC, which indicates cancer cells' ability to spread.
A team of researchers from Kaunas University of Technology has developed a mathematical method for classifying breast tissue images using deep learning, achieving an accuracy rate of 85%. The goal is to partially automate the diagnosis process and improve accuracy.
Researchers at the University of Colorado Cancer Center have made a breakthrough discovery that could improve immune therapy for triple-negative breast cancer. They found that a protein called Eya3 plays a key role in activating PD-L1, which helps cancer cells evade the immune system.
A new computational strategy simplifies complex cancer biomolecular data by emphasizing patient-to-patient variation in molecular signatures of cancer cells. This approach aims to provide a personalized treatment plan by analyzing the genetic makeup and impaired biological pathways of individual patients.
Researchers found a specific mutation in the PARP1 protein that prevents PARP inhibitors from working, leading to resistance. Testing for this mutation could help personalize treatment decisions and predict resistance progression.
A new quality-control test developed by TGen can detect cancer in blood with high accuracy, filtering out contaminants and evaluating cfDNA samples. This test has shown promising results in several cancer types, including melanoma and breast cancer.
Researchers at Texas A&M University have identified the Period 2 (Per2) gene as a potential contributor to breast cancer risk. Per2 suppresses a gene called BMAL or CLOCK, and its expression is lost in many mammary tumors, suggesting it may have protective effects.
Researchers at the University of Montreal have discovered a protein, AXL, that influences the occurrence of metastasis in HER2-positive breast cancers. The study found that reducing AXL levels improves survival rates, and an AXL-inhibiting drug therapy has shown promise in preventing metastases.
Researchers have discovered that an enzyme called UGT8 drives the progression of basal-like breast cancer, but found that zoledronic acid inhibits UGT8 and prevents its spread. The drug may offer a new hope for treating this aggressive form of breast cancer, which is largely untreatable.