Articles tagged with Breast Cancer
The global age-standardized lung cancer mortality rate among women is expected to rise by 43% from 2015 to 2030, while breast cancer mortality rates are projected to decrease by 9%. Lung cancer mortality rates will be highest in Europe and Oceania, with lower rates in America and Asia.
Researchers found that PTEN loss in normal breast tissue cells can lead to increased genetic instability and reduced response to radiation therapy. The discovery suggests that targeting stromal cells with low PTEN may help predict which patients are more likely to benefit from radiation treatment.
Scientists have found that internal mammary chain irradiation and anthracycline-based chemotherapy increase cardiovascular disease risks, while a new test may detect colorectal cancer in primary care. Researchers also discovered circulating tumor cell clusters in human glioblastoma, suggesting a new target for treatment
A study by Harvey L. Neiman Health Policy Institute found that states with legislation requiring notification of patients about breast density issues saw a significant increase in the use of ultrasound imaging after mammography, suggesting improved cancer detection rates.
A study found that a diet discouraging alcohol consumption and promoting healthy eating was associated with reduced overall and breast, prostate, and colorectal cancer risks. Adherence to the WCRF/AICR score had the strongest association with reduced risk.
Scientists at Scripps Research discovered that inhibiting Rad52 can target and kill tumors with a deficient gene, such as triple-negative breast cancers. This approach exploits synthetic lethality, where cells with both defects die, reducing side effects and toxicity.
Thyroid cancer incidence has tripled in the US over 25 years, with over 50,000 people diagnosed annually. Experts propose measures to reduce overtreatment, such as active surveillance for small papillary thyroid cancers and more conservative surgical approaches like lobectomy.
Australian researchers have discovered a team of tiny molecules, called microRNAs, that can reverse a 'switch' in cancer cells making them less aggressive. The discovery could lead to safer and more effective cancer treatments by combining the molecules with chemotherapy.
Scientists have identified a mysterious molecule called Yin Yang1 that may fuel tumour growth in breast cancer, revealing how tumours change their 'appearance' to evade treatment using epigenetics. The findings suggest doctors should take new tumour samples when a patient's cancer spreads
A new study by the University of Michigan Rogel Cancer Center found that many breast cancer patients are struggling financially due to their treatment. The study reveals that 38% of women were worried about finances, and some experienced extensive hardships, including debt and losing their home.
A new study published in the American Cancer Society journal reveals that many patients with cancer face significant financial difficulties due to treatment costs. Despite medical oncologists, surgeons, and radiation oncologists reporting some engagement with patients about financial concerns, unmet patient needs persist.
Using complementary medicine alongside conventional cancer therapy is associated with a higher risk of death from cancer. The study analyzed data from over 1.9 million patients and found that those who used complementary medicine were more likely to refuse conventional treatments.
A recent study published in the International Journal of Cancer found that women who eat high amounts of fruits and vegetables daily have a lower risk of aggressive breast tumors. Cruciferous vegetables such as broccoli were particularly associated with this reduced risk.
A new study found that eating an early supper and having a long interval between the last meal and sleep are associated with lower breast and prostate cancer risks. Participants who had supper before 9pm or slept 2 or more hours after supper had a reduced risk of developing these cancers.
Researchers at Rockefeller University have discovered the molecular means by which some cancers caused by BRCA1 mutations evade treatment by PARP inhibitors. The study challenges previous assumptions about the mechanics of these drugs and provides a foundation for advancements in PARP inhibitor therapy.
Researchers analyzed protein and RNA from routine breast cancer tests to distinguish between cancer and benign lesions, yielding 100% accurate results. This method may also aid in subtyping breast cancer, determining therapy options, and monitoring disease progression.
Researchers at Louisiana State University Health Sciences Center have identified miR-27b, a microRNA, as a potential therapeutic target for breast cancer treatment. The study found that suppressing miR-27b enhances the expression of PDHX, a protein involved in cell metabolism, which helps suppress tumor progression.
A new study has found that eating an early supper is associated with a lower risk of breast and prostate cancer. Participants who ate before 9pm had a 20% lower risk compared to those who ate late, suggesting the importance of meal timing in cancer prevention.
Mary-Claire King has been recognized by ASHG for her tireless advocacy on using genetics to help people and families worldwide. Her lab has helped reunite 130 families through mtDNA sequencing, and her work with the UN Forensic Anthropology Team has identified victims of extra-judicial execution.
A national population-based cohort study found that weight loss surgery reduced the risk of hormone-related cancers (breast, endometrial, or prostate cancer) by 77%. However, gastric bypass was associated with a greater than twofold increased risk of colorectal cancer.
The American Cancer Society and NFL have awarded $3.2 million in grant funding to address breast cancer disparities among women of color. The grants will support timely access to follow-up care and high-quality breast cancer screening for underserved women.
A new clinical trial has found that 92.9% of women with two or three sites of cancer in a single breast can undergo breast-conserving surgery, replacing mastectomy as the preferred treatment option for this condition.
A study of over 250,000 British women found no overall increased risk of invasive breast or womb cancer after assisted reproduction. However, small increased risks of non-invasive breast and ovarian tumours were detected, with the former linked to a greater number of treatment cycles.
A Phase 1b clinical trial has demonstrated that the combination of tucatinib and T-DM1 can control median 8.2 months in heavily pretreated HER2-positive breast cancer patients, with 48% response rate. The drug also shows efficacy against brain metastases, a major cause of mortality from the disease.
A randomized trial found that acupuncture twice a week for six weeks reduced joint pain in postmenopausal women with early-stage breast cancer taking an aromatase inhibitor. Women who received sham acupuncture or no treatment showed less improvement.
Deb Kelly, a Virginia Tech researcher, has received $2.1 million from the National Cancer Institute to investigate the BRCA1 protein's role in breast cancer. Her team aims to develop new tools and techniques to better detect, prevent, and repair mutations found in cancers related to BRCA1.
Extended tamoxifen therapy for 10 years increases the risk of developing endometrial cancer by two-fold compared to standard 5-year treatment. Screening for endometrial cancer may be necessary in patients receiving extended tamoxifen therapy.
A cost-effectiveness study analyzed risk-based breast cancer screening programs versus standard age-based screening, evaluating their impact on healthcare resources and patient outcomes. The study found that risk-based screening programs can be more cost-effective than traditional age-based programs for certain populations in the UK.
A new study found that surgeons have a substantial impact on genetic testing rates among breast cancer patients who need it. High-volume surgeons were more likely to refer patients for testing, while those with lower volumes saw less of a correlation between risk factors and testing rates.
Researchers develop a two-part 'punch' to re-educate macrophages and enhance their capacity to eat tumor cells, leading to complete inhibition of tumor growth. The therapy, tested in melanoma and breast cancer preclinical models, shows promise as a complementary treatment option.
Researchers found that hSATa satellite RNA directly interferes with DNA copying and damage repair in cells, leading to breast cancer. This discovery suggests targeting satellite RNAs could provide another approach for treating various cancers, including breast, ovarian, prostate, and pancreatic cancer.
Researchers have identified TLK2 enzyme as a key player in several diseases, including breast cancer and intellectual disability. The study suggests that inhibiting the enzyme may be an effective therapy approach.
Breast cancer research has long neglected social factors like race and socioeconomic status, missing opportunities to understand and reduce disparities in risk and outcomes. Studies have shown that only a small percentage of clinical trials reported findings stratified by these factors.
A large international study found that high body fat in young women reduces breast cancer risk before menopause. Researchers discovered a 12-23% decrease in breast cancer risk for every five-unit increase in BMI, with strongest effects seen in the 18-24 age group.
Researchers found that resveratrol inhibits mutant p53 protein aggregation, preventing breast cancer cell migration and proliferation. This breakthrough could lead to a treatment for over half of malignant tumors, targeting novel strategic targets in cancer research.
Women with mammographically dense breast tissue have higher recall and biopsy rates, as well as increased odds of screen-detected and interval breast cancer. The study supports automated measurements as a future standard for breast density classification.
Researchers discover a protein that shields the PI3K pathway from targeted drugs, leading to improved efficacy with combination therapy. A new study reveals that blocking this protein restores cancer-killing potential in previously ineffective therapies.
A study of 5,366 US flight attendants found a higher lifetime prevalence of breast, melanoma, and non-melanoma skin cancers compared to the general population. The authors suggest that factors such as circadian rhythm disruption and exposure to cosmic ionizing radiation may contribute to these increased cancer rates.
Researchers have developed a novel approach to pretargeted radioimmunotherapy, which has shown complete responses in several solid tumor types using the beta-emitting lutetium-177 and alpha-emitting actinium-225. The new approach offers greater versatility of treatment for various solid tumors and clinical situations.
Researchers discovered that oxygen-starved tumor cells struggle to produce aspartate, a crucial amino acid. By targeting this Achilles' heel, doctors may develop new treatments to block aspartate uptake or production.
A new smart probe developed by Tel Aviv University researchers can detect and visualize individual cancer cells in real-time, allowing surgeons to target specific tumor locations. The probe uses near-infrared technology to identify overproduced enzymes in cancer cells, guiding precise removal of malignant tissue.
A new study from Harvard T.H. Chan School of Public Health found that US flight attendants have a higher prevalence of several cancers, including breast and cervical cancer, compared to the general public. The study suggests that minimizing radiation exposure and circadian rhythm disruption may help reduce the risk of cancer among cabi...
Researchers have demonstrated that combining targeted radionuclide therapy with immunotherapy can enhance treatment response and lead to a high cure rate in melanoma patients. This novel approach uses yttrium-86 (Y-86) NM600, which selectively targets tumors and delivers precise radiation doses.
Researchers at the University of Wisconsin-Madison have identified a protein called Munc13-4 that helps cancer cells secrete exosomes, stimulating tumor growth. Exosome release is dependent on calcium levels and can transfer oncogenes to neighboring cells, contributing to tumor progression.
Research suggests that higher body mass index (BMI) is associated with reduced risk of premenopausal breast cancer. The analysis found an inverse association between breast cancer risk and BMI for women between ages 18 and 54, with the strongest link in early adulthood.
A large-scale study found that higher body fat is associated with a lower risk of breast cancer in premenopausal women. The study, published in JAMA Oncology, analyzed data from over 758,000 women under the age of 55 and found that as BMI increased, breast cancer risk decreased, particularly among younger women.
Women who underwent autologous breast reconstruction reported higher satisfaction and well-being than those with implants. Two years after surgery, patients with autologous reconstruction had greater psychosocial and sexual well-being compared to those with implants.
The study identified a new class of drug-targets, called master regulators, which are rarely mutated in cancer patients. The algorithm predicted the same top drug for almost half of metastatic patients, leading to rapid FDA approval for a clinical trial.
Researchers found that women with higher vitamin D levels in their blood had a significantly reduced risk of developing breast cancer. The study, which pooled data from multiple trials and prospective studies, identified the minimum healthy level of vitamin D as 60 nanograms per milliliter.
A new laser-sonic scanner developed by Caltech researchers can detect tumors in the breast in just 15 seconds, providing higher-resolution images than traditional mammography. The technology uses near-infrared light to create detailed images of internal structures without exposing patients to X-ray radiation or discomfort.
The American Society of Clinical Oncology has endorsed guidelines from the Society for Integrative Oncology, recommending integrative therapies for anxiety, depression, and quality of life improvement. However, some treatments like ginseng and acupressure require further research due to safety concerns.
Researchers found a genetic difference in people with African and European ancestry that affects inflammation response. The study suggests malaria's evolutionary pressure shaped the immune system's adaptation, which may still influence health disparities today.
A new study led by NYU Rory Meyers College of Nursing uses machine learning to detect lymphedema, a distressing side effect of breast cancer treatment. The artificial neural network achieved the best performance for detecting lymphedema, correctly classifying patients with 93.75% accuracy.
A recent BJS meta-analysis of published studies confirms that autologous fat transfer does not increase the risk of cancer recurrence in former breast cancer patients. The procedure can be performed safely to aid breast reconstruction after surgery.
Breast cancer patients aged 70 and over in England have a higher risk of mortality due to reduced surgical intervention compared to other countries. Patients with stage three breast cancer in England are also more likely to not receive surgery, which has been linked to poorer survival rates.
A combination of digital mammography and tomosynthesis detects 8.6 cancers per 1,000 cases, almost twice the rate detected by mammography alone. The technology's higher sensitivity is notable for small and medium invasive cancers, but not large ones.
Researchers found that women who underwent mammography screening were significantly more likely to utilize Pap smear, bone mass measurement, and influenza vaccine services than unscreened women. The study suggests that breast cancer screening may increase awareness of other preventive services among Medicare beneficiaries.
A new clinical trial analysis found that combining an aromatase inhibitor with ovarian function suppression yields a 10-15% improvement in freedom from distant recurrence for high-risk younger breast cancer patients. Women at low risk saw minimal benefit, while those at intermediate risk gained a 4-5% advantage.
A Phase II study found that over half of women with early-stage BRCA+ breast cancer who took talazoparib once daily prior to surgery had no evidence of disease at the time of surgery. The oral medication showed high response rates and manageable toxicities, offering an alternative to chemotherapy for this patient population.
The TAILORx trial found no benefit from chemotherapy for 70% of women with hormone receptor-positive, HER2-negative breast cancer. Treatment with hormone therapy alone after surgery was as effective as hormone therapy plus chemotherapy in reducing invasive disease-free survival and overall survival.