Articles tagged with Breast Cancer
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A study of breast cancer survivors found that natural pregnancies are possible after chemotherapy, but many no longer wish to have children. The study also showed that fertility preservation measures are not widely needed among young breast cancer patients.
A French prospective study found that nearly one in six premenopausal women with early-stage breast cancer do not adequately adhere to tamoxifen therapy after one year, potentially leading to increased risk of recurrence. The study aimed to identify clinical and social characteristics associated with poor adherence to endocrine therapy.
The Case Comprehensive Cancer Center has received a $3 million NIH grant to investigate racial disparities in colorectal and breast cancer. The research program aims to identify genetic biomarkers for cancer specific to high-risk populations and promote medical and social policies that benefit communities.
A new statistical method estimates the short- and long-term risk of recurrence for hormone receptor-positive and HR-negative breast cancers in US women. The study found that while HR-positive breast cancer has a lower risk of progression to metastatic disease soon after diagnosis, the risk persists for several years.
A University of Cincinnati researcher is working on a new light therapy that uses ultraviolet light to activate light-sensitive drugs, selectively targeting cancer cells while sparing healthy stem cells. This approach has the potential to be more effective and safer than current treatments.
A deep-learning model has been successfully used on real patients to assess dense breast tissue in mammograms with high accuracy. The model outperforms traditional prediction models, achieving a kappa score of 0.85 in clinical applications, and could lead to more consistent screening procedures nationwide.
A study comparing DNA and RNA data from Nigerian breast cancer patients to those in a US database found aggressive molecular features prevalent in tumors from Nigerian women, which could explain disparities in breast cancer mortality. The study highlights the potential for targeted therapies to reduce mortality gap.
A diet high in omega-3 fatty acids from fish oil may delay the development and spread of breast cancer cells in mice. The study found that these cells took significantly longer to form tumors and grew smaller over time.
A new AI algorithm measures breast density at a high level of accuracy, comparable to experienced mammographers. The system has been successfully implemented in routine clinical practice and has the potential to standardize and automate breast density assessment.
A major clinical study in Sweden has shown that 3D mammography detects over 30% more cancers compared to traditional mammography. The method uses low-dose x-ray images from different angles, resulting in higher image quality and increased cancer detection rates.
A new blood test offers a safer approach than surgical biopsies and allows doctors to monitor treatment effectiveness even before changes are identified on scans. The study found that circulating tumor DNA in the blood or cerebrospinal fluid can reveal a driver mutation in 42 of 48 patients, indicating the tumor's genetic signature.
Researchers have developed a new method for imaging breast cancer using Cornell dots, which are smaller than 8 nanometers and can be cleared by the kidneys. The dots are equipped with antibody fragments that target HER2-positive breast cancer cells, achieving high in vivo tumor uptake rates of up to 17.2 percent.
A new report reveals a protein, deltaNp63, that directs myeloid-derived immunosuppressor cells (MDSCs) to the primary tumor and metastatic sites, promoting tumor growth and metastasis. Blocking deltaNp63 or MDSCs reduced tumor growth and metastasis in a mouse model of triple-negative breast cancer.
A recent study analyzed over 6,000 tweets about breast cancer and found that 90% of medical information was appropriate, with prevention being the most common subtheme. The study suggests that social media can be a valuable tool for providing information on cancer prevention and health education.
A study of nearly 600 women with breast cancer found that autologous fat transfer did not increase rates of cancer relapse after five years. While the study did not show significant differences, it highlights the potential benefits of this technique for correcting deformities after breast cancer surgery.
A study of 178 countries found a strong negative correlation between family size and cancer incidence, with larger families having a protective effect against various types of cancer. The protective effects are stronger for males than females, with non-reproduction-related cancers also being involved.
The Society of Breast Imaging has partnered with Oxford University Press to launch the Journal of Breast Imaging, providing a platform for high-quality, evidence-based content on breast imaging. The journal aims to advance the field of breast imaging, improving patient care and outcomes.
Three leading researchers, Ian Smith, Ann Partridge, and Zena Werb, receive top honors for their groundbreaking work on breast cancer treatment and research. Their contributions have propelled advances in breast cancer science and medicine, saving countless lives from the disease.
A study of over 6,000 patients with advanced cancer treated in community settings shows that nearly a quarter received targeted treatment based on DNA mutations. This achievement marks a significant shift towards precision medicine, allowing more patients to benefit from innovative therapies.
A new study finds that mastectomies do not completely eliminate the need for postoperative imaging and biopsy. For 10% to 15.5% of patients, subsequent imaging is required, and 6-8% undergo biopsy, with low malignancy rates.
A recent study found that palbociclib, a breast cancer drug, can effectively treat acute myeloid leukaemia (AML) with reduced toxicity compared to current chemotherapy. This breakthrough could lead to improved survival rates for patients with the serious condition.
A new study suggests targeting collagen XIII could suppress breast cancer metastasis by enhancing anoikis resistance in cancer cells. Researchers found that collagen XIII expression is significantly higher in cancerous human breast tissue and necessary for metastasis in mouse models.
A study published in CANCER found that weight loss in postmenopausal women is associated with a 12% lower risk of invasive breast cancer. Women who lost 5% of their body weight had a lower risk, while those who gained weight had an increased incidence of triple negative breast cancer.
Scientists have found that low TIP60 expression leads to uncontrolled jumping gene expression, triggering tissue inflammation that supports tumor growth. The discovery opens new avenues for cancer treatment using anti-HIV drugs.
Researchers at MUSC Hollings Cancer Center aim to find a less toxic, more effective treatment for metastatic breast cancer using a novel therapeutic antibody and innovative molecular imaging tools. The study will investigate the calcineurin/NFAT pathway's role in tumor growth and its potential inhibition by the antibody.
Researchers have identified estradiol as a potential new treatment for triple-negative breast cancer with estrogen receptor beta expression, effectively inhibiting tumor growth in studies. Estradiol stimulates the expression of cystatins, which exhibit tumor-suppressing effects on neighboring and distant cancer cells.
The ESMO 2018 Congress will feature a wide range of topics including immunotherapy, biomarkers, and prevention. The event will also host the annual congress of the European Oncology Nursing Society and a patient advocacy track emphasizing the central role of patients in securing access to optimal cancer care.
According to Dr. Holly Pederson, genetic testing can help identify patients at risk of breast cancer and reduce their chances of survival. The presentation highlights the importance of early screening and advances in cancer genetics, making it possible to save lives through preventive medications and surgical procedures.
A new computational approach has been developed to analyze large databases of clinical and splicing information for thousands of tumors. The software detects patterns of similarities between cases and identifies molecular alterations associated with patient survival and resistance to therapy.
The study, involving hundreds of breast cancer patients, found that chemotherapy and hormonal treatments do not have major adverse effects on cognitive function for most older women. A small subset of patients with the APOE4 gene showed a decline in cognitive test scores after chemotherapy.
Researchers at Stevens Institute of Technology have designed a novel molecule that uses a unique mechanism to halt or destroy breast cancer tumors. The molecule, developed by Abhishek Sharma, could potentially add to the arsenal of drugs targeting estrogen receptors in breast cancer therapy.
Scientists at University of Toronto's Leslie Dan Faculty of Pharmacy have developed a combination approach using nanoparticles to improve chemotherapy response and boost anti-tumor immunity in breast cancer. The treatment resulted in a 60% cure rate and enhanced life expectancy by five-fold compared to treating with chemotherapy alone.
Aggressive breast cancer cells exploit the natural stress protector heat shock protein 70 (HSP70) to thrive and evade cell death, says a new study. The finding highlights how cancer cells manipulate tumor necrosis factor alpha (TNFα), which normally promotes self-destruction, to aid their survival.
A Mediterranean diet increased Lactobacillus abundance in mammary glands of macaque monkeys, a nonhuman primate model of women's health. This finding suggests that diet directly influences microbiome populations outside the intestinal tract and may impact breast cancer risk.
A study published in Cell Reports found that a Mediterranean diet increased mammary gland lactobacillus and reduced breast cancer risk. The researchers also plan to investigate oral interventions and bacterial-modified compounds to protect women from breast cancer.
A large observational study found that individuals with diabetes are at a higher risk of developing certain cancers, including colorectal and breast cancer. The study also showed that people with diabetes who are diagnosed with cancer have poorer survival rates compared to those without diabetes.
A recent meta-analysis of published studies found that processed meat consumption is associated with a 9% higher breast cancer risk. However, no significant association was observed between red (unprocessed) meat intake and breast cancer risk. The study suggests cutting down processed meat may be beneficial for preventing breast cancer.
A large observational study found that adults with type 2 diabetes are at greater risk of dying from cancer, particularly obesity-related cancers. Non-obesity related cancers also pose a significant threat to individuals with type 2 diabetes.
Patients with respiratory tract infections receiving antibiotics had significantly shorter telemedicine encounters than those not receiving antibiotics. Researchers found that antibiotic prescriptions were about 33 seconds shorter, while non-antibiotic prescriptions resulted in longer encounters of approximately 1 minute and 12 seconds...
A new study from George Washington University Cancer Center found that nanoparticle-encapsulated doxorubicin is promising in treating triple-negative breast cancer. The smallest nanoparticles with slowest release of medication showed increased cell kill in resistant cancer cells, offering potential strategies to overcome drug resistance.
Researchers create 3D models of breast cancer tumors using stromal cells, which play a major role in cancer growth and progression. The study aims to introduce stromal cells as new therapeutic targets, offering potential treatments for triple-negative breast cancer.
Researchers at UCI will develop a new class of cancer-killing immunotherapeutics targeting abnormal glycans, which are nearly universal in cancer but limited in normal tissue. The goal is to broaden the types of cancers sensitive to immunotherapy and treat highly diverse types of cancer.
Researchers are investigating how a gene that regulates estrogen and neurotransmitter levels could be tied to cognitive decline in patients undergoing chemotherapy. The study aims to understand the underlying factors of treatment-related cognitive dysfunction, also known as chemo brain.
A study by Medical University of South Carolina found that breast cancer patients who received a second opinion at an NCI-designated center experienced a significant change in diagnosis, with 43% of cases altered. The review by a multidisciplinary tumor board led to the identification of additional cancers in 16 patients and changes in...
Researchers develop new theory to explain how tumors spread, revealing competition between forces that shape their growth. The 'active wetting' model suggests tumors behave like active drops, with cells creating forces and moving on their own.
A study published in the American Cancer Society journal found that black women and women living in poverty are less likely to report barriers to breast cancer screening due to medical distrust and social norms. Patient navigators can reduce disparities, but require training to address diverse needs.
Researchers have identified a link between inflammation and cancer growth in HER2-negative breast cancers, revealing anakinra as a potential treatment target. Anakinra, an existing anti-inflammatory drug, reduces gene expression of IL1b and other cytokines, improving symptoms and quality of life for some patients.
A new study reveals that black women are more likely to skip hormone therapy treatments for breast cancer, with barriers including cost, side effects, and difficulty adhering to treatment plans. The study highlights the need for culturally competent behavioral interventions to improve outcomes for all women with breast cancer.
Purdue University researchers have simulated how over 20 different breast tissue ratios respond to heat given off by MRIs at higher field strengths. The simulations showed that a fivefold increase in SAR could still stay within FDA limits for most breast tissue ratios, enabling the use of 7 tesla technology for safer cancer detection.
A new study by George Mason University researchers found links between chemicals used in personal care products and changes in reproductive hormones. The study, which analyzed 509 urine samples from 143 women aged 18-44, suggests that even low-level exposure to mixtures of chemicals may affect reproductive hormone levels.
A Danish-Norwegian study found that breast cancer mortality is declining due to better treatment, not screening. The study challenges the effectiveness of breast cancer screening programs, suggesting alternative methods like palpation.
Researchers have analyzed nearly 4,000 mutations in the BRCA1 gene, shedding light on its role in breast and ovarian cancer. The findings provide immediate benefits to patients with previously inconclusive genetic test results, enabling clinicians to better interpret variant of uncertain significance.
A study at the University of Chicago Medical Center and University of Washington found that twice-a-year MRI scans detected more small early stage breast cancers than annual mammograms. The research suggests that intensive surveillance can be crucial for improving outcomes in young women with high-risk genetic mutations.
A new study from the University of Missouri School of Medicine reveals that more than half of women with breast cancer are now receiving their diagnosis over the phone. The researchers found a significant shift in diagnosis delivery method since 2007, when approximately 25 percent of patients learned about their diagnosis via phone.
Researchers found that EVL protein helps contain cancer cells within the original tumor site by regulating actin cytoskeleton, which may lead to combination treatments for patients with ER-positive tumors.
Researchers at VCU Massey Cancer Center identified the enzyme cyclophilin A as a potential target for treating breast cancer. By inhibiting this enzyme, they were able to slow or halt the growth of breast cancer cells. The discovery builds on previous work and holds promise for rapid development of novel therapies.
A new imaging method targets cancer-associated fibroblasts to diagnose widespread tumors like breast, colon, and pancreas cancer with better accuracy and less inconvenience. The tracer shows high tumor uptake and image contrast, making it a promising strategy for detection and treatment of malignant tumors.
Researchers developed a new way to identify molecular markers of breast cancer tumors using machine learning. This technology can rapidly sort images of breast tumors to determine prognosis and treatment options, potentially leading to faster and more cost-effective treatments for millions of women.
A new study published in eLife suggests that the overall burden of changes in a tumor's genome can predict patient outcomes across various cancer types. Researchers found that the percentage of altered genes in a tumor, known as CNA burden, is associated with mortality and disease-free survival in multiple cancers.
A large genomic analysis has linked certain DNA mutations to a high risk of relapse in estrogen receptor positive breast cancer, while other mutations were associated with better outcomes. The study identified three genes - DDR1, PIK3R1 and NF1 - with relatively uncommon mutations that were associated with cancer recurrence and spreading.