Articles tagged with Breast Cancer
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Researchers at Mayo Clinic have discovered that a dietary supplement called cyclocreatine may block the growth of HER2 positive breast cancer. The study found that cyclocreatine effectively targets mitochondrial creatine kinase 1 enzyme and reduces cancer growth without toxicity.
A team at the Salk Institute has identified a genetic master switch, Sox10, that controls the growth and invasion of aggressive triple-negative breast cancers. This discovery may lead to new avenues for diagnosing and treating intractable cancers by targeting specific genes.
University of Toronto researchers have identified protein NUAK2, associated with poor disease prognosis in bladder cancer. Blocking NUAK2 slows down cancer cell growth and raises hopes for treating patients.
For frail nursing home residents with breast cancer, surgery often cures the cancer but worsens quality of life and daily activities. Researchers recommend individualized care with hormonal therapy or symptom management instead.
Researchers at Hong Kong Baptist University have developed a metal compound that inhibits the enzyme lysine-specific demethylase 5A (KDM5A) in TNBC tumours with less toxicity in mice. This discovery holds great promise for the development of targeted drugs for TNBC therapy, offering a new approach to treating this difficult form of bre...
Researchers identified six protein kinases that predict the evolution of triple negative breast cancer, allowing for new pharmacological targets and potential treatment combinations. The study's findings indicate a high cure rate (95%) for patients with no activated proteins, but increased relapse risk if one or more are active.
A study published in the Journal of the American Geriatrics Society found that short-term decline in physical function was common among older adults treated with chemotherapy for breast cancer. However, about half of patients were resilient and able to recover their ability to function within 12 months.
Researchers found that inflammatory response triggered by primary breast cancer prevents tumor cells from growing in distant organs. Inhibitors of interleukin-1β, such as canakinumab, are being tested in clinical trials for potential benefits in preventing metastatic growth.
Researchers discovered a previously unseen 'ecosystem' in advanced breast cancer, where primary tumors emit signals to halt secondary tumor growth. The study found that activating the immune response can freeze secondary cancers, offering new hope for living with advanced breast cancer.
A study defines mechanisms behind focused-ultrasound-assisted treatment of brain tumors, improving drug delivery across the blood-brain barrier and into abnormal tumor tissues. The approach enhances permeability of endothelial cells lining tumor blood vessels, increasing cellular uptake of anti-cancer drugs.
A new web-based calculator, CTS5, can accurately predict the long-term risk of breast cancer returning in other areas of the body. The tool helps clinicians decide whether to continue or stop hormone therapy, improving patient quality of life and reducing unnecessary treatment.
A study led by Johns Hopkins Bloomberg School of Public Health researchers found that breast cancer survivors, particularly those with lymphedema, incur significant out-of-pocket costs. The average annual cost for those with lymphedema was $2,306 excluding productivity costs and $3,325 including productivity costs.
A new study from Barcelona Institute for Global Health found that women living closer to urban green spaces had a lower risk of breast cancer. The study, which analysed data from over 3,600 women in Spain, concluded that proximity to parks or gardens was associated with reduced breast cancer risk.
Researchers identified genetic mutations associated with increased risk of breast cancer in Nigerian women. The study found that nearly half of patients were diagnosed with triple-negative breast cancer, an aggressive subtype with poor prognosis.
The EMBRACA trial shows that talazoparib provides a significant clinical benefit to patients with metastatic breast cancer and BRCA mutations. The study found that talazoparib improved progression-free survival, quality-of-life measures, and overall response rates compared to chemotherapy.
A recent study found that only 8% of disabled or older women who qualified for Medicare received BRCA1 and BRCA2 testing between 2000 and 2014. Women with these mutations are at higher risk for developing second breast cancer and ovarian cancer, making timely testing crucial for informed decision-making.
Research reveals key physical properties of giant cancer cells, including stiffness and ability to move further than standard cancer cells. This understanding may lead to the development of targeted treatments.
Researchers have identified a potential new treatment for aggressive breast cancer by targeting the communication channel between non-cancerous cells and tumour cells. The study, published in Nature Communications, shows that disrupting this connection can slow tumour growth, increase sensitivity to chemotherapy and improve survival.
A small clinical benefit was observed in reduced risk of dying from breast cancer in women with ductal carcinoma in situ (DCIS) treated with radiation plus lumpectomy. The absolute risk reduction was 0.27 percent, indicating that 370 women would need to be treated to save one life.
Researchers discovered a previously unrecognized mechanism by which arsenic trioxide and all-trans retinoic acid work together to destroy Pin1, a unique enzyme that activates over 40 cancer-driving proteins. This finding suggests novel strategies to treat common cancers, including triple-negative breast cancer.
Researchers from NTU and Harvard found that adding nano-sized cellulose fibers to food reduced fat absorption by up to half in laboratory and animal experiments. The discovery could aid in the global battle against obesity by reducing fat absorption, a strategy reinforced by existing knowledge on high-fibre diets.
Researchers at Salk Institute identify genetic features of human basal-like breast cancers that share similarities with embryonic mammary stem cells, which may be targeted therapeutically. The study provides insights into how cancer cells gain plasticity and become resistant to therapies.
A new study has identified specific genes, including BARD1, BRCA1, BRCA2, PALB2, and RAD51D, that are associated with an increased risk for triple-negative breast cancer. The study suggests potential revisions to guidelines for genetic testing and may lead to better prevention strategies.
Scientists at Huntsman Cancer Institute have generated a comprehensive molecular map of genes that control breast tissue formation, providing new insights into the development of breast cancer. The study identifies hundreds of potentially critical genes for further research as regulators of normal and cancerous development.
Researchers have discovered that PLK1 acts as a tumor suppressor in some breast tumors, halting development and changing prognosis. This finding was made by researchers from CNIO and DKFZ.
Researchers used a PET tracer to identify differences in ER expression across metastases and surrounding normal tissue in breast cancer patients. The study found that approximately 50% of patients had one or more estrogen-receptor negative lesions, highlighting the heterogeneity of ER expression.
A Mayo Clinic research team has identified specific genes associated with an increased risk for developing triple-negative breast cancer. Alternations in BARD1, BRCA1, BRCA2, PALB2 and RAD51D genes were linked to a high risk for this subtype of breast cancer, while mutations in BRIP1 and RAD51C genes showed a moderate risk.
A recent study found that 8.3% of trastuzumab-treated patients developed heart failure, highlighting the need for cardiac monitoring in high-risk breast cancer patients. The study also showed a consistent increase in heart failure risk with age, emphasizing the importance of prioritizing cardiac monitoring for younger patients.
Experimental studies reveal a strong interplay between liganded and non-liganded transcriptional activations of ERs. Natural estrogens can restore DNA surveillance in tumor cells via harmonized transactivation of AF1 and AF2 domains.
The global age-standardized lung cancer mortality rate among women is expected to rise by 43% from 2015 to 2030, while breast cancer mortality rates are projected to decrease by 9%. Lung cancer mortality rates will be highest in Europe and Oceania, with lower rates in America and Asia.
Researchers found that PTEN loss in normal breast tissue cells can lead to increased genetic instability and reduced response to radiation therapy. The discovery suggests that targeting stromal cells with low PTEN may help predict which patients are more likely to benefit from radiation treatment.
Scientists have found that internal mammary chain irradiation and anthracycline-based chemotherapy increase cardiovascular disease risks, while a new test may detect colorectal cancer in primary care. Researchers also discovered circulating tumor cell clusters in human glioblastoma, suggesting a new target for treatment
A study by Harvey L. Neiman Health Policy Institute found that states with legislation requiring notification of patients about breast density issues saw a significant increase in the use of ultrasound imaging after mammography, suggesting improved cancer detection rates.
A study found that a diet discouraging alcohol consumption and promoting healthy eating was associated with reduced overall and breast, prostate, and colorectal cancer risks. Adherence to the WCRF/AICR score had the strongest association with reduced risk.
Scientists at Scripps Research discovered that inhibiting Rad52 can target and kill tumors with a deficient gene, such as triple-negative breast cancers. This approach exploits synthetic lethality, where cells with both defects die, reducing side effects and toxicity.
Thyroid cancer incidence has tripled in the US over 25 years, with over 50,000 people diagnosed annually. Experts propose measures to reduce overtreatment, such as active surveillance for small papillary thyroid cancers and more conservative surgical approaches like lobectomy.
Australian researchers have discovered a team of tiny molecules, called microRNAs, that can reverse a 'switch' in cancer cells making them less aggressive. The discovery could lead to safer and more effective cancer treatments by combining the molecules with chemotherapy.
Scientists have identified a mysterious molecule called Yin Yang1 that may fuel tumour growth in breast cancer, revealing how tumours change their 'appearance' to evade treatment using epigenetics. The findings suggest doctors should take new tumour samples when a patient's cancer spreads
A new study by the University of Michigan Rogel Cancer Center found that many breast cancer patients are struggling financially due to their treatment. The study reveals that 38% of women were worried about finances, and some experienced extensive hardships, including debt and losing their home.
A new study published in the American Cancer Society journal reveals that many patients with cancer face significant financial difficulties due to treatment costs. Despite medical oncologists, surgeons, and radiation oncologists reporting some engagement with patients about financial concerns, unmet patient needs persist.
Using complementary medicine alongside conventional cancer therapy is associated with a higher risk of death from cancer. The study analyzed data from over 1.9 million patients and found that those who used complementary medicine were more likely to refuse conventional treatments.
A recent study published in the International Journal of Cancer found that women who eat high amounts of fruits and vegetables daily have a lower risk of aggressive breast tumors. Cruciferous vegetables such as broccoli were particularly associated with this reduced risk.
A new study found that eating an early supper and having a long interval between the last meal and sleep are associated with lower breast and prostate cancer risks. Participants who had supper before 9pm or slept 2 or more hours after supper had a reduced risk of developing these cancers.
Researchers at Rockefeller University have discovered the molecular means by which some cancers caused by BRCA1 mutations evade treatment by PARP inhibitors. The study challenges previous assumptions about the mechanics of these drugs and provides a foundation for advancements in PARP inhibitor therapy.
Researchers analyzed protein and RNA from routine breast cancer tests to distinguish between cancer and benign lesions, yielding 100% accurate results. This method may also aid in subtyping breast cancer, determining therapy options, and monitoring disease progression.
Researchers at Louisiana State University Health Sciences Center have identified miR-27b, a microRNA, as a potential therapeutic target for breast cancer treatment. The study found that suppressing miR-27b enhances the expression of PDHX, a protein involved in cell metabolism, which helps suppress tumor progression.
A new study has found that eating an early supper is associated with a lower risk of breast and prostate cancer. Participants who ate before 9pm had a 20% lower risk compared to those who ate late, suggesting the importance of meal timing in cancer prevention.
Mary-Claire King has been recognized by ASHG for her tireless advocacy on using genetics to help people and families worldwide. Her lab has helped reunite 130 families through mtDNA sequencing, and her work with the UN Forensic Anthropology Team has identified victims of extra-judicial execution.
A national population-based cohort study found that weight loss surgery reduced the risk of hormone-related cancers (breast, endometrial, or prostate cancer) by 77%. However, gastric bypass was associated with a greater than twofold increased risk of colorectal cancer.
The American Cancer Society and NFL have awarded $3.2 million in grant funding to address breast cancer disparities among women of color. The grants will support timely access to follow-up care and high-quality breast cancer screening for underserved women.
A new clinical trial has found that 92.9% of women with two or three sites of cancer in a single breast can undergo breast-conserving surgery, replacing mastectomy as the preferred treatment option for this condition.
A study of over 250,000 British women found no overall increased risk of invasive breast or womb cancer after assisted reproduction. However, small increased risks of non-invasive breast and ovarian tumours were detected, with the former linked to a greater number of treatment cycles.
A Phase 1b clinical trial has demonstrated that the combination of tucatinib and T-DM1 can control median 8.2 months in heavily pretreated HER2-positive breast cancer patients, with 48% response rate. The drug also shows efficacy against brain metastases, a major cause of mortality from the disease.
A randomized trial found that acupuncture twice a week for six weeks reduced joint pain in postmenopausal women with early-stage breast cancer taking an aromatase inhibitor. Women who received sham acupuncture or no treatment showed less improvement.
Deb Kelly, a Virginia Tech researcher, has received $2.1 million from the National Cancer Institute to investigate the BRCA1 protein's role in breast cancer. Her team aims to develop new tools and techniques to better detect, prevent, and repair mutations found in cancers related to BRCA1.
Extended tamoxifen therapy for 10 years increases the risk of developing endometrial cancer by two-fold compared to standard 5-year treatment. Screening for endometrial cancer may be necessary in patients receiving extended tamoxifen therapy.
A cost-effectiveness study analyzed risk-based breast cancer screening programs versus standard age-based screening, evaluating their impact on healthcare resources and patient outcomes. The study found that risk-based screening programs can be more cost-effective than traditional age-based programs for certain populations in the UK.
A new study found that surgeons have a substantial impact on genetic testing rates among breast cancer patients who need it. High-volume surgeons were more likely to refer patients for testing, while those with lower volumes saw less of a correlation between risk factors and testing rates.
Researchers develop a two-part 'punch' to re-educate macrophages and enhance their capacity to eat tumor cells, leading to complete inhibition of tumor growth. The therapy, tested in melanoma and breast cancer preclinical models, shows promise as a complementary treatment option.
Researchers found that hSATa satellite RNA directly interferes with DNA copying and damage repair in cells, leading to breast cancer. This discovery suggests targeting satellite RNAs could provide another approach for treating various cancers, including breast, ovarian, prostate, and pancreatic cancer.