Articles tagged with Breast Cancer
A landmark study published in the New England Journal of Medicine found that most breast cancer patients with intermediate scores on a 21-gene test can safely avoid chemotherapy. The study's results have significant implications for doctors and patients, allowing for more personalized treatment options.
The study reveals a universal increase in lifestyle-related cancers between 2006 and 2016, with significant disparities persisting between high- and low-Socio-demographic Index countries. Breast cancer is the leading cause of cancer death in women, while lung cancer tops the list for men, accounting for nearly 20% of global cancer deaths.
The global burden of cancer has increased significantly over the past decade, with 17.2 million new cases and 8.9 million deaths reported in 2016. Cancer control planning and implementation are crucial to fulfill global commitments for cancer control and noncommunicable diseases.
Researchers found that irradiating chest lymph nodes in patients with early stage breast cancer improved overall survival by 2.4% compared to treating only the breast/thoracic wall. The study involved 4004 patients and showed no increase in non-breast cancer related mortality or serious complications.
Cancer cells use lipid molecules as fuel when blood supply is low, helping them evade antiangiogenic treatment. A new mechanism suggests that blocking lipid energy pathways could improve cancer treatment outcomes.
A recent study from the University of Pennsylvania School of Medicine found that rates of inherited mutations in genes other than BRCA1/2 are twice as high in breast cancer patients with a second primary cancer. The study also investigated polygenic risk scores, which were not strongly linked to an increased risk of cancer.
Researchers at TGen and HCI are working together to combat bone metastatic breast cancer, a leading cause of pain and death for patients. By blocking the activity of RON kinase, they aim to prevent further damage to skeletal structures and enhance anti-tumor immunity.
Plastic surgeons are crucial in managing young women at high genetic risk of breast cancer due to BRCA gene mutations. These women have a low lifetime risk of breast cancer, only 1.5-3.4% by age 30, and may benefit from mastectomy, but the decision is complex and requires careful consideration.
A lower-fat diet was linked to increased breast cancer overall survival among postmenopausal women, although the increase may be partly due to better survival from other causes. The study found modest increases in vegetable, fruit, and grain intake in the lower-fat group.
Researchers at IRB Barcelona identify p38 as a protective mechanism for tumor cells against excessive DNA accumulation, which would cause cell death. Combining p38 inhibitors with chemotherapy shows promise in shrinking tumors and killing cancer cells.
New research finds that certain cancers express high levels of the neural calcium channel TRPA1, which helps them tolerate toxic oxidative stress. Blocking TRPA1 activity in mice curbs tumor growth and makes cancer cells more sensitive to chemotherapy.
A UK analysis of 18,730 patients found that surgery reduced the risk of dying from breast cancer by 40%, compared to primary endocrine therapy. The study suggests that surgery may be a more effective treatment option for older women with oestrogen receptor-positive breast cancer.
Avoiding excess body weight and maintaining a stable weight in middle adulthood may help prevent several obesity-related cancers in women. High weight gain is associated with a significantly increased risk of pancreatic cancer, breast cancer, and endometrial cancer.
Researchers from SWOG present findings on omega-3 fatty acid supplements reducing joint pain in obese breast cancer patients. The study also explores immune microenvironment changes before and after chemotherapy in breast cancer tissue.
A new study found that gentle stretching can reduce tumor size and improve immune response in a mouse model of breast cancer. The research suggests a link between stretching, inflammation resolution, and improved immune function.
The Los Angeles Cancer Surveillance Program, managed by Keck School of Medicine and USC Norris Comprehensive Cancer Center, has improved the understanding, prevention, and control of cancer for nearly 50 years. The program is one of the largest and most comprehensive cancer registries in the US.
Researchers found that 3'UTR shortening in tumors causes tumor-suppressing genes to be turned off, promoting cancer growth. This discovery could change medical science's approach to tumor formation.
A recent study by Mayo Clinic researchers found that the FDA-approved drug decitabine may be effective in treating triple-negative breast cancer. The study identified a subset of patients who could benefit from this therapy based on the presence of certain critical proteins.
USC researchers have identified a remedy to prevent lung metastasis in triple-negative breast cancer, which is the deadliest form of breast cancer. A novel solution uses a nanoparticle to deliver a medication directly to tumors, reducing toxic side effects.
Scientists have identified a new signaling pathway essential for mammary gland development, involving the interaction between stem cells and macrophages. The discovery provides insight into breast cancer genesis and spread, potentially paving the way for early detection and targeted therapies.
A new trial shows that a shorter length of trastuzumab treatment can benefit patients with breast cancer just as much as a longer treatment, with less risk of cardiac side effects. The study found that taking trastuzumab for 6 months was non-inferior to the current standard of 12 months.
Researchers developed a pill that can detect breast cancer in mice using near-infrared light, reducing the need for mammograms and minimizing radiation exposure. The imaging agent was found to bind specifically to cancer cells with high accuracy, paving the way for potential future applications.
Scientists have discovered a new compound, metarrestin, that significantly reduces metastasis in human prostate, breast and pancreatic cancer in mice. The compound was found to blow up the complex marker PNC, which indicates cancer cells' ability to spread.
A team of researchers from Kaunas University of Technology has developed a mathematical method for classifying breast tissue images using deep learning, achieving an accuracy rate of 85%. The goal is to partially automate the diagnosis process and improve accuracy.
Researchers at the University of Colorado Cancer Center have made a breakthrough discovery that could improve immune therapy for triple-negative breast cancer. They found that a protein called Eya3 plays a key role in activating PD-L1, which helps cancer cells evade the immune system.
A new computational strategy simplifies complex cancer biomolecular data by emphasizing patient-to-patient variation in molecular signatures of cancer cells. This approach aims to provide a personalized treatment plan by analyzing the genetic makeup and impaired biological pathways of individual patients.
Researchers found a specific mutation in the PARP1 protein that prevents PARP inhibitors from working, leading to resistance. Testing for this mutation could help personalize treatment decisions and predict resistance progression.
A new quality-control test developed by TGen can detect cancer in blood with high accuracy, filtering out contaminants and evaluating cfDNA samples. This test has shown promising results in several cancer types, including melanoma and breast cancer.
Researchers at Texas A&M University have identified the Period 2 (Per2) gene as a potential contributor to breast cancer risk. Per2 suppresses a gene called BMAL or CLOCK, and its expression is lost in many mammary tumors, suggesting it may have protective effects.
Researchers at the University of Montreal have discovered a protein, AXL, that influences the occurrence of metastasis in HER2-positive breast cancers. The study found that reducing AXL levels improves survival rates, and an AXL-inhibiting drug therapy has shown promise in preventing metastases.
Researchers have discovered that an enzyme called UGT8 drives the progression of basal-like breast cancer, but found that zoledronic acid inhibits UGT8 and prevents its spread. The drug may offer a new hope for treating this aggressive form of breast cancer, which is largely untreatable.
A targeted 'click-to-release' chemotherapy approach has shown promising results in mice, demonstrating effective anticancer effects against ovarian and colon cancers. The innovative method, developed by Tagworks Pharmaceuticals, releases a large quantity of chemotherapy drug quickly, attacking the tumor cells.
Researchers have identified a novel regulatory step in autophagy, shedding light on the anti-cancer potential of PI5P4K inhibitors. Targeting these proteins could be a promising approach for cancer therapeutics.
A study of over 300,000 women found that breast cancers diagnosed after a negative screening mammogram were more likely to have poor outcomes. The small but significant rate of these cases underscores the importance of regular screenings to detect breast cancer at an early stage.
A new study suggests that shifting cancer diagnosis from emergency hospital admissions to GP referrals could save thousands of lives and £2,130 per life saved. The shift would come at a small additional cost to the NHS.
A new study found that breast cancer places a significantly greater financial burden on black women than white women, with 58% of black women experiencing negative financial impact compared to 39% of white women. Black women were more likely to experience barriers to care due to cost, lose jobs or private health insurance.
New research from UBC Okanagan shows that community-based initiatives and microgrants are effective in increasing physical activity among breast cancer survivors. The program, Project MOVE, supports community-led interventions and fosters social support and confidence
A new study has revealed that breast cancer drug lapatinib can cause breast cancer cells to grow more rapidly in some situations. The findings could lead to safer treatment decisions and improved drug design in the future. Researchers hope their results will inform how doctors select patients who may benefit most from these drugs.
Breast cancer screening should be tailored to each woman's risk, considering the benefits and harms of mammography. Experts recommend clinicians engage patients in shared decision-making to determine individualized screening plans.
Researchers at Moffitt Cancer Center used mathematical modeling to show that adaptive drug treatments based on tumor responses are more effective than maximum-tolerated dose approaches. The approach can be tailored to specific tumor types, such as melanoma and breast cancer, and may lead to better patient outcomes.
Automated BI-RADS breast density measures have similar predictive ability to clinical assessments, but may be more reproducible and suitable for identifying women at high risk of interval cancer. Hospital readmissions within the first week are more likely preventable than those occurring later, suggesting a shift in accountability model.
A clinical trial found that women with advanced triple-negative breast cancer and BRCA gene faults have better responses to carboplatin, a less toxic alternative to standard treatment docetaxel. The study suggests that genetic testing can guide treatment for this patient group, offering new hope for those with limited treatment options.
Researchers at the University of Michigan are developing a pill that makes tumors light up when exposed to infrared light, offering a potential alternative to mammograms. The pill uses a dye that responds to infrared light to tag tumor cells, allowing physicians to better distinguish malignant from benign tumors.
A study by UCSF and Mayo Clinic found that automated breast-density evaluation is as accurate as subjective evaluation done by radiologists in predicting breast cancer risk. Women with dense breasts are more likely to be diagnosed with advanced-stage breast cancers.
Researchers from INRS published a study demonstrating the potential effects of neonicotinoids on human health by disrupting hormonal systems. The study found an increase in aromatase expression and changes in its pattern similar to those observed in certain breast cancers.
A new report by Silent Spring Institute finds that dozens of hazardous chemicals are present in hair products marketed at Black women, including hormone-disrupting chemicals and fragrance chemicals. The study highlights the need for better disclosure of ingredients and encourages manufacturers to develop safer products.
A new study published in Journal of Clinical Oncology shows a four-year overall survival rate of 96 percent for patients with stage IV Wilms tumors with lung metastases, compared to 84 percent on the predecessor study. The approach resulted in sparing initial upfront lung radiation and reducing long-term risks for nearly half of patients.
Researchers found a significant link between exposure to blue light at night and higher risks of developing breast and prostate cancer. The study used images taken by astronauts to evaluate outdoor lighting in Madrid and Barcelona.
Researchers developed a new method for early and accurate breast cancer screening using electronic nose gas sensors and GC-MS analysis, achieving 95% average accuracy in detecting breast cancer biomarkers from breath samples. Urine samples also yielded 85% average accuracy with this technology.
A study found that media coverage on cancer rarely addresses the importance of age as a risk factor, resulting in under-representation of older adults. This can lead to a lack of awareness, delayed detection, and poorer outcomes for this population.
Researchers identified age-related differences in breast tissue that contribute to increased risk of developing breast cancer in older women. The study found that accumulation of multipotent progenitor cells leads to defective luminal cells, which may be related to the increased susceptibility to breast cancer with age.
Research suggests that individuals with false-positive cancer screening test results are more likely to participate in future recommended screenings. Women with previous false-positive mammograms were at least 43% more likely to obtain future breast cancer screenings, while men with false-positive prostate cancer screenings were at lea...
Researchers found that palbociclib induces substantial changes in the proteasome, degrading proteins required for cell cycle progression and driving cells into senescence. The discovery suggests that proteasomal activity may be an additional mechanism by which palbociclib stalls proliferation.
A study found that only one in seven high-risk women take tamoxifen for breast cancer prevention, with social class, education, and ethnicity not affecting uptake. Women chose not to start taking the drug due to fears about its impact on their family and health.
Research finds that accelerated partial breast irradiation is as effective as whole breast radiotherapy in improving quality of life. Women treated with targeted therapy experienced reduced symptoms and better quality of life compared to those receiving standard treatment.
A $2 million grant from CPRIT will create a new lab focusing on breast cancer at TTUHSC El Paso, led by Shrikanth Gadad, Ph.D. The lab will conduct research on long noncoding RNAs to understand cancer growth and aggression.
Researchers discovered that pre-existing chemoresistant genotypes in tumors can adapt to become fully resistant to chemotherapy, leading to poor overall survival. The study's findings may lead to diagnostic opportunities for detecting resistant clones in TNBC patients before treatment.
Researchers at Université libre de Bruxelles identified different tumor transition states during cancer progression and metastasis. They found that cells with intermediate EMT phenotypes are the most metastatic populations.
The new technology, called Motion Model Ultrasound Localization Microscopy, allows for the tracking of individual microbubbles in real-time, enabling the reconstruction of fine vascular networks and monitoring of blood flow. This technique has potential applications in cancer treatment, particularly in sonoporation therapy.
Researchers at UT Southwestern Medical Center identified a protein strongly linked to metastatic breast cancer and its growth. High levels of ZMYND8 correlate with poor survival rates in breast cancer patients.