Articles tagged with Breast Cancer
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A targeted 'click-to-release' chemotherapy approach has shown promising results in mice, demonstrating effective anticancer effects against ovarian and colon cancers. The innovative method, developed by Tagworks Pharmaceuticals, releases a large quantity of chemotherapy drug quickly, attacking the tumor cells.
Researchers have identified a novel regulatory step in autophagy, shedding light on the anti-cancer potential of PI5P4K inhibitors. Targeting these proteins could be a promising approach for cancer therapeutics.
A study of over 300,000 women found that breast cancers diagnosed after a negative screening mammogram were more likely to have poor outcomes. The small but significant rate of these cases underscores the importance of regular screenings to detect breast cancer at an early stage.
A new study suggests that shifting cancer diagnosis from emergency hospital admissions to GP referrals could save thousands of lives and £2,130 per life saved. The shift would come at a small additional cost to the NHS.
A new study found that breast cancer places a significantly greater financial burden on black women than white women, with 58% of black women experiencing negative financial impact compared to 39% of white women. Black women were more likely to experience barriers to care due to cost, lose jobs or private health insurance.
New research from UBC Okanagan shows that community-based initiatives and microgrants are effective in increasing physical activity among breast cancer survivors. The program, Project MOVE, supports community-led interventions and fosters social support and confidence
A new study has revealed that breast cancer drug lapatinib can cause breast cancer cells to grow more rapidly in some situations. The findings could lead to safer treatment decisions and improved drug design in the future. Researchers hope their results will inform how doctors select patients who may benefit most from these drugs.
Breast cancer screening should be tailored to each woman's risk, considering the benefits and harms of mammography. Experts recommend clinicians engage patients in shared decision-making to determine individualized screening plans.
Researchers at Moffitt Cancer Center used mathematical modeling to show that adaptive drug treatments based on tumor responses are more effective than maximum-tolerated dose approaches. The approach can be tailored to specific tumor types, such as melanoma and breast cancer, and may lead to better patient outcomes.
Automated BI-RADS breast density measures have similar predictive ability to clinical assessments, but may be more reproducible and suitable for identifying women at high risk of interval cancer. Hospital readmissions within the first week are more likely preventable than those occurring later, suggesting a shift in accountability model.
A clinical trial found that women with advanced triple-negative breast cancer and BRCA gene faults have better responses to carboplatin, a less toxic alternative to standard treatment docetaxel. The study suggests that genetic testing can guide treatment for this patient group, offering new hope for those with limited treatment options.
Researchers at the University of Michigan are developing a pill that makes tumors light up when exposed to infrared light, offering a potential alternative to mammograms. The pill uses a dye that responds to infrared light to tag tumor cells, allowing physicians to better distinguish malignant from benign tumors.
A study by UCSF and Mayo Clinic found that automated breast-density evaluation is as accurate as subjective evaluation done by radiologists in predicting breast cancer risk. Women with dense breasts are more likely to be diagnosed with advanced-stage breast cancers.
Researchers from INRS published a study demonstrating the potential effects of neonicotinoids on human health by disrupting hormonal systems. The study found an increase in aromatase expression and changes in its pattern similar to those observed in certain breast cancers.
A new report by Silent Spring Institute finds that dozens of hazardous chemicals are present in hair products marketed at Black women, including hormone-disrupting chemicals and fragrance chemicals. The study highlights the need for better disclosure of ingredients and encourages manufacturers to develop safer products.
A new study published in Journal of Clinical Oncology shows a four-year overall survival rate of 96 percent for patients with stage IV Wilms tumors with lung metastases, compared to 84 percent on the predecessor study. The approach resulted in sparing initial upfront lung radiation and reducing long-term risks for nearly half of patients.
Researchers found a significant link between exposure to blue light at night and higher risks of developing breast and prostate cancer. The study used images taken by astronauts to evaluate outdoor lighting in Madrid and Barcelona.
Researchers developed a new method for early and accurate breast cancer screening using electronic nose gas sensors and GC-MS analysis, achieving 95% average accuracy in detecting breast cancer biomarkers from breath samples. Urine samples also yielded 85% average accuracy with this technology.
A study found that media coverage on cancer rarely addresses the importance of age as a risk factor, resulting in under-representation of older adults. This can lead to a lack of awareness, delayed detection, and poorer outcomes for this population.
Researchers identified age-related differences in breast tissue that contribute to increased risk of developing breast cancer in older women. The study found that accumulation of multipotent progenitor cells leads to defective luminal cells, which may be related to the increased susceptibility to breast cancer with age.
Research suggests that individuals with false-positive cancer screening test results are more likely to participate in future recommended screenings. Women with previous false-positive mammograms were at least 43% more likely to obtain future breast cancer screenings, while men with false-positive prostate cancer screenings were at lea...
Researchers found that palbociclib induces substantial changes in the proteasome, degrading proteins required for cell cycle progression and driving cells into senescence. The discovery suggests that proteasomal activity may be an additional mechanism by which palbociclib stalls proliferation.
A study found that only one in seven high-risk women take tamoxifen for breast cancer prevention, with social class, education, and ethnicity not affecting uptake. Women chose not to start taking the drug due to fears about its impact on their family and health.
Research finds that accelerated partial breast irradiation is as effective as whole breast radiotherapy in improving quality of life. Women treated with targeted therapy experienced reduced symptoms and better quality of life compared to those receiving standard treatment.
A $2 million grant from CPRIT will create a new lab focusing on breast cancer at TTUHSC El Paso, led by Shrikanth Gadad, Ph.D. The lab will conduct research on long noncoding RNAs to understand cancer growth and aggression.
Researchers discovered that pre-existing chemoresistant genotypes in tumors can adapt to become fully resistant to chemotherapy, leading to poor overall survival. The study's findings may lead to diagnostic opportunities for detecting resistant clones in TNBC patients before treatment.
Researchers at Université libre de Bruxelles identified different tumor transition states during cancer progression and metastasis. They found that cells with intermediate EMT phenotypes are the most metastatic populations.
The new technology, called Motion Model Ultrasound Localization Microscopy, allows for the tracking of individual microbubbles in real-time, enabling the reconstruction of fine vascular networks and monitoring of blood flow. This technique has potential applications in cancer treatment, particularly in sonoporation therapy.
Researchers at UT Southwestern Medical Center identified a protein strongly linked to metastatic breast cancer and its growth. High levels of ZMYND8 correlate with poor survival rates in breast cancer patients.
A synthetic gene network implanted under the skin monitors blood calcium levels to detect four common types of cancer, triggering a visible mole when a threshold is exceeded. Early detection increases survival chances by up to 98%, significantly improving treatment outcomes.
Triple negative breast cancer brain metastases typically have lower numbers of immune cells, but those present are responsive to checkpoint inhibitor therapies. Researchers aim to increase immune cell presence and responsiveness to improve treatment outcomes.
A pre-clinical study has revealed that combining OX40 agonist antibody and GSK2366771 may enhance the immune system's ability to kill melanoma tumors deficient in PTEN. The combination appears to 'step on the gas', revving up T cells and providing extra power to more efficiently kill cancer cells.
A new BJS study found axillary ultrasound imaging to be less sensitive for detecting axillary metastatic lymph nodes in women with invasive lobular carcinoma compared to invasive ductal carcinoma. Women with invasive lobular carcinoma may benefit from axillary biopsies regardless of ultrasonographic appearance.
Researchers found tumors with PTEN loss are less likely to generate an immune response, suggesting PTEN levels can predict treatment outcome. The study's findings may improve personalized medicine for BRCA-deficient ovarian cancer patients.
St. Jude Children's Research Hospital investigators present research on cloud computing, exhausted T cells, breast cancer risk in childhood cancer survivors and clinical trial design for CAR-T therapy in solid tumors. The platform St. Jude Cloud provides unique analysis tools and visualizations of pediatric cancer genomics data.
Researchers identified RB1 gene mutations as a mechanism underlying acquired resistance to CDK 4/6 inhibitor treatment for HR-positive breast cancer. The study found that these mutations led to loss of RB1 function and consequently resistance to CDK 4/6 inhibitors in patients whose tumors progressed after treatment.
Researchers found that adding trastuzumab to chemotherapy regimen for women with uterine serous carcinoma significantly increased progression-free survival time, from an average of eight months to 12.6 months. The treatment showed promise in reducing tumor growth and improving overall survival.
A study by researchers at the National University of Singapore found that almost half of breast cancer patients experience cognitive decline during treatment, with symptoms persisting up to a year after. The study highlights the importance of early screening and management to improve quality of life for survivors.
Researchers have discovered a new class of drug that targets treatment-resistant cancers by inhibiting the action of enzyme CDK7. Early lab-based tests showed minimal side effects and successful suppression of tumour growth in various cancer types.
A large study of breast cancer patients found that radiotherapy and chemotherapy do not significantly increase the risk of heart disease. Good risk management in hospitals and short interval screenings may offset elevated risks. The study's findings are considered positive for treatment of breast cancer.
Researchers discovered that some cancers are genetically similar, despite originating from different organs, and grouped them into new subtypes. The study's findings support an additional cancer classification system, which could lead to improved treatment options for patients.
Researchers have discovered five previously unknown cancer subtypes among others, using a comprehensive analysis of 2,579 tumors from breast and gynecologic cancers. The study identifies shared and unique molecular features, clinically significant subtypes, and potential therapeutic targets.
A recent study analyzing breast tissue from 344 transmen found benign and malignant lesions in 48.3% of individuals. Invasive breast cancer was detected in just two samples, emphasizing the importance of thorough histopathological examination.
Researchers developed a surgical camera inspired by the morpho butterfly's eye to help surgeons detect cancerous tissue. The camera uses infrared signals to locate tumors and can be integrated with surgical goggles, making it more accessible and cost-effective than existing technologies.
A new study shows that a free web-based decision aid, BRECONDA, reduces decisional conflict and increases satisfaction with information among women considering breast reconstruction. The cost of the decision aid was estimated to be small compared to other healthcare interventions.
A recent study published in The Breast Journal found that only 1.5% of patients with microinvasive breast cancer had positive lymph nodes, suggesting that these tiny tumors rarely spread cancer to other areas. This discovery allows surgeons to select patients who may benefit from lymph node sampling, sparing others from the procedure.
The Cancer Genome Atlas project has identified 300 genes that drive tumor growth and found that just over half of tumors carry genetic mutations targetable by existing therapies. The research provides unprecedented understanding of cancer's genetic basis, enabling better-informed clinical trials and future treatments.
Researchers have developed a universal fluorescent probe that targets and stains cancer stem cells, a type of tumor-initiating cell. The probe, named TiY, demonstrates high selectivity towards these cells, which are believed to cause relapses after radiation and chemotherapy.
Researchers identify PFKFB4 enzyme as potent driver of breast cancer, offering new treatment possibilities. The study found that targeting this enzyme or SRC-3 can almost completely eliminate breast cancer recurrence and metastasis.
A new study finds that establishing a minimum recall rate for breast cancer screening programs can help balance the risk of missing invasive cancers and the cost of additional testing. The study analyzed data from the UK Breast Cancer Service Screening Program, finding that lower recall rates correlate with higher interval cancer rates.
Women with breast implants are more likely to have detectable cancers at a smaller size compared to those without implants. The study found that screening mammograms may be less effective in detecting cancers in breasts with implants.
Researchers have identified a specific sugar found on aggressive breast cancer cells that can be used as a biomarker to detect high-risk patients. This discovery aims to improve screening for early-stage breast cancer patients, reducing unnecessary treatments such as chemotherapy or radiation.
Scientists at Michigan State University have discovered a promising new drug that targets the c-Myc gene, which is linked to obesity and various cancers. The drug, I-BET-762, delays the development of existing cancers by inhibiting critical proteins involved in cancer cell growth.
The new instrument increases the sensitivity of optical mammography by up to 1000-fold, allowing for earlier detection of breast cancer. This advancement offers a safer and more gentle alternative to traditional X-ray imaging, which is often limited by patient age, weight, or other factors.
Breast cancer experts are urging men to participate in clinical trials to discover better treatment options. The research highlights the benefits of targeted treatments, such as reducing radical surgery and improving cosmetic results for men with breast cancer.
New results from IMPORT LOW trial show women treated with partial or reduced breast radiotherapy report fewer side-effects, including less change in breast appearance. The study found that over half of patients did not experience moderate or marked side-effects at any point.
A newly designed chimera could simultaneously decrease the expression of three growth factors that are over-expressed in some cancers, leading to cancer cell death. The molecule has potent anti-tumor activity and is non-toxic, simple to produce, and cost-effective compared to traditional treatment strategies.
A Cancer Research UK landmark study found that smoking remains a major preventable cause of cancer, accounting for 32,200 cases in men and 22,000 in women. Excess weight is also a significant risk factor, with over 22,800 cases attributed to being overweight or obese annually.
Researchers found that targeted drug treatment before surgery can safely treat women with aggressive tumours using breast-conserving surgery, sparing patients from extensive surgery. This approach resulted in fewer long-term side-effects and improved quality of life for a significant proportion of patients.
Women with small, low-grade tumors and a genetic profile at low risk of metastasis have only a 1.4% chance of locoregional recurrence within five years. Breast conservation surgery is as effective as mastectomy in reducing the risk of recurrence.