Articles tagged with Breast Cancer
Researchers outline a targeted therapeutic strategy to treat triple-negative breast cancer using POLR2A gene targeting. The proposed approach utilizes nanotechnology-based precision-targeting to kill TNBC cells while sparing normal cells, offering hope for improved treatment options.
A study of 872 young adults found that 14.4% borrowed over $10,000 due to illness or treatment, while 54% experienced mental task impairment. Cancer treatment with chemotherapy increased the risk of these issues significantly.
Researchers used DNA methylation to estimate biologic age and found that women with older biologic ages had higher breast cancer risks. The study suggests that biologic age may be tied to environmental exposures, potentially serving as an indicator of disease risk.
A new study using PET scans has identified a biomarker that predicts which women with HER2-positive breast cancer may benefit from standalone HER2-targeted agents without chemotherapy. Researchers found that patients with low sugar levels on PET scans at two weeks after treatment had the potential to be spared chemotherapy, indicating ...
A large-scale study validated four widely used breast cancer risk models, finding that family-history-based models outperform non-family-history based models. The study's findings suggest that all women would benefit from risk assessment involving detailed family histories.
A clinical trial found sacituzumab govitecan produced a significant treatment response in patients with difficult-to-treat metastatic triple-negative breast cancer, outperforming standard chemotherapy. The drug showed manageable side effects and improved treatment duration.
A new 'smart drug', sacituzumab govitecan, has shown significant tumor shrinkage and improved patient outcomes in a clinical trial for women with metastatic triple-negative breast cancer. The treatment resulted in better response rates and longer overall survival compared to traditional therapies.
A UC Riverside study found that spouses can help with coping by positively reframing the cancer experience and other negative experiences, associated with less stress. The researchers suggest that socially similar others, like romantic partners, can provide a roadmap for a more contented spouse.
Ralf Janknecht's research on the molecule DNPH1, overproduced in breast cancer, suggests it could serve as a new drug target for reducing cancer metastasis. The removal of DNPH1 from mouse models resulted in fewer tumors and a tenfold reduction in metastasis.
Two new forms of an older anti-cancer agent, s-DAB-IL-2 and s-DAB-IL-2(V6A), have been shown to enhance the immune system's ability to fight melanoma in mice. The agents depleted T regulatory cells and inhibited tumor growth when used individually or in combination with checkpoint blockade therapy.
A new study reveals that chronic stress promotes breast cancer growth and spread by activating a biochemical pathway involving the stress hormone epinephrine. Vitamin C has been identified as a potential therapeutic agent to target this pathway, potentially offering new hope for patients undergoing chronic stress.
A new study uses cellular barcoding to pinpoint cells responsible for breast cancer's spread, shedding light on how chemotherapy works and identifying targets for new treatments. Researchers hope to develop targeted therapies by understanding the molecular basis of cancer cell behavior.
The black-white cancer mortality gap has closed considerably over the past several decades, with faster declines among black Americans. The disparities have narrowed for lung, prostate, and colorectal cancers, and have stabilized since 2010 for breast cancer.
A study by Flinders University found that middle-aged Australian women are not aware of the link between alcohol consumption and an increased risk of breast cancer. The study suggests targeted messages addressing short-term risks caused by alcohol will be most effective in reducing current consumption levels.
Researchers developed a reversible antiplatelet therapy using deactivated platelets that can reduce the risk of blood clots and prevent cancer metastasis. By adding fresh platelets, the inhibition of normal platelet activity is rapidly reversed, allowing patients to quickly regain their ability to form blood clots.
A six-decade-long study found that all women exposed to high levels of DDT are at increased risk for breast cancer before age 54, with the timing of cancer risk depending on when they were first exposed. Women exposed in infancy and early childhood were most likely to develop premenopausal breast cancer.
A six-decade-long study found that all women exposed to high levels of DDT before age 54 are at increased breast cancer risk. The timing of first exposure matters, with early infancy and puberty linked to premenopausal cancer and later childhood and adolescence to postmenopause diagnosis.
A pilot project by Springer Nature and BCRF enables researchers to make their datasets accessible alongside published articles. Dedicated Research Data Editors will help authors draft descriptions and deposit datasets in a journal data repository.
Researchers at the University of California San Diego discovered that breast tissue stiffening triggers multiple pathways to promote cancer cell formation. The study, published in PNAS, found that a subpopulation of mammary cells do not respond to stiffening, potentially leading to fewer or smaller primary tumors.
A new study found that up to one-third of primary care physicians discussed breast cancer treatment options with patients. However, many reported notable gaps in their knowledge of these topics. The research highlights the importance of educating primary care providers on cancer treatment options and supporting them in making informed ...
A large study examining phthalate exposure and postmenopausal breast cancer found no association between the two. The research, published in the Journal of the National Cancer Institute, suggests that more research is needed to investigate younger women and potential associations between phthalate exposure and breast cancer risk.
Researchers identified a new genetic cause of multi-tumor syndrome, which increases lifetime risk for patients with colorectal and breast cancers. The study found that rare NTHL1 gene mutations lead to the development of both diseases.
A recent study found that hundreds of thousands of US women's lives have been saved by mammography and improvements in breast cancer treatment since 1989. The study estimates that cumulative breast cancer deaths averted ranged from 384,000 to 614,500 over the past three decades.
Researchers have found that a new PET imaging agent, 18F-FFNP, can measure changes in progesterone receptor levels resulting from hormone therapy for breast cancer patients. This could provide an earlier indicator of therapy effectiveness and inform individualized treatment decisions.
Researchers have developed a new imaging and platelet targeting chemotherapy agent for early detection and treatment of cancers. The approach holds promise for diagnosing and treating tumors without major side effects.
Researchers at Scripps Research Institute have developed a new approach to shifting breast cancer cells into HER2-positive status using RNA-targeting precision medicines. The proof-of-concept study suggests that this technology could expand treatment options for patients with dwindling choices.
Researchers found that combining metformin with venetoclax and a PD-1-targeted antibody can efficiently kill breast tumor cells and prevent tumor growth. The treatment strategy was tested in animal models and showed promising results.
Research highlights distinct racial disparities in social support needs for breast cancer patients among White and Black women. The study found that White participants relied on other breast cancer survivors as a key source of social support, whereas Black participants did not.
A new study has identified a pair of genes that can mimic the effects of BRCA proteins, potentially making tumor cells susceptible to PARP inhibitors. The researchers found that targeting these genes could improve treatment options for people with breast or ovarian cancer caused by BRCA defects.
A Rutgers study found that hormone concentrations in early fetal development are significantly affected by maternal age, body mass index, and race. Older mothers, heavier women, and those of African descent had distinct hormone profiles, with potential implications for future health risks such as breast and ovarian cancer.
Researchers at McGill University discovered a shared genetic marker that could effectively treat rare and common types of cancer, including ovarian and lung cancers. The breakthrough is based on targeting the cyclin-dependent kinases 4/6, which are vulnerable to existing drugs used in breast cancer treatment.
Researchers found a causal connection between MDMX overexpression and triple-negative breast cancer metastasis. The study suggests targeting the MDMX protein could prevent cancer spread, offering potential for new treatments.
A study published in Plastic and Reconstructive Surgery reports that autologous breast reconstruction after failed implant reconstruction is associated with significantly improved patient satisfaction and quality of life. The procedure has an acceptable complication rate, despite some additional challenges related to previous breast ca...
A recent study found nearly one-third of women under 40 underwent mammography before breast reduction surgery, despite guidelines recommending against it. The screenings can lead to unnecessary follow-up tests and treatments, wasting time and money.
Researchers found that stroke risk factors increased by tripling the likelihood of a stroke within 10 years, with hormonal treatment and racial differences also playing a role. The study calls for targeted interventions to reduce stroke risk among post-menopausal breast cancer survivors.
Drs. Silvia Formenti and Heather McArthur will collaborate on a year-long project using radiation and immunotherapy to create personalized vaccines for breast cancer patients. Their work aims to improve treatment outcomes and reduce mortality.
A new study published in HeartRhythm found that women with breast cancer have an increased risk of developing atrial fibrillation within three years following their cancer diagnosis compared to other women of the same age. The risk is higher for younger patients, with more than doubled incidence in those under sixty years old.
Research finds that plerixafor reduces fibrosis and improves response to immunotherapy in mouse models of metastatic breast cancer. Fibrosis blocks effectiveness of immunotherapies, but CXCR4 inhibition enhances immune cell infiltration and decreases formation of spontaneous metastases.
African American women with a history of keloids are more likely to be diagnosed with aggressive, late-stage breast cancers. The study found a link between ethnic variations in tumor immune response and the unique cancer risk.
Researchers at Kanazawa University have discovered a critical signaling pathway that drives the proliferation of cancer stem cells in breast cancer. The pathway, involving Semaphorin 3 and MICAL3 proteins, is targeted by inhibiting these proteins to reduce breast-cancer stem-like cells.
The debate centers on renaming ultra-low risk cancers to avoid unnecessary investigations and treatments. Experts recommend recalibrating thresholds for cancer diagnosis to categorize very low risk cancers as benign, reducing anxiety and improving patient outcomes.
Racial disparities in breast cancer survival in the US Military Health System are linked to delayed surgeries, but these delays do not explain overall survival gaps between black and white women. Researchers found that black women had greater estimated times to surgery compared to their white counterparts.
A Vanderbilt University team developed a nanoparticle to target tumor-infiltrating immune cells and activate the STING pathway, a natural mechanism to mount an immune response against cancer. The breakthrough offers hope for patients who don't respond to checkpoint blockade therapies.
Researchers identified genetic changes that may predict breast cancer relapse in women taking hormone therapy. The study found subtle differences in gene expression between tumours that relapsed and those that didn't, suggesting potential new tests to identify high-risk patients.
A new study found that acupressure significantly improved chronic pain, anxiety, depression, and poor sleep in breast cancer survivors experiencing fatigue. Researchers tested two types of acupressure and found relaxing acupressure to be more effective for depressive symptoms and sleep.
A dual COX-2/sEH inhibitor may offer a novel alternative to protect against debris-mediated inflammatory responses, which can lead to tumor survival and growth. The study used mouse models of ovarian cancer to demonstrate the anti-inflammatory compound's effectiveness in suppressing cancer growth.
A study found that breast cancers diagnosed in young women within 10 years of giving birth are more likely to metastasize than those diagnosed less recently or not at all. The risk is highest among women up to 10 years postpartum and is most pronounced in stage I or II breast cancer.
Researchers found that over 90% of purchase tickets in Brazil and Spain contained BPA, while only half did in France, due to government regulations. The study warns about the health risks associated with BPA and calls for stricter regulation and alternatives.
Researchers developed a new way to predict breast cancer risk by combining genetics, family history, weight, age at menopause, alcohol consumption, and hormone replacement therapy. The online calculator can identify different risk groups and inform tailored screening and preventative therapy.
A new study found that African-American women are less likely than white women to pursue potentially life-saving preventive care due to racial disparities in healthcare. High-risk black women were also less aware of their options and at a disadvantage when it came to getting access to information about prevention.
A new study led by Dr. Suresh Alahari found that the protein Nischarin regulates cell attachment and alters exosome properties, reducing breast cancer cell motility and adhesion. The research team's findings suggest that Nischarin-expressing exosomes may serve as an effective treatment for cancer.
Researchers identified a link between BRCA2 mutations and aggressive prostate cancer in men, increasing their risk of developing other cancers. The study also found that patients with BRCA2 mutations have poorer treatment responses and outcomes.
The BRCA Exchange aggregates data on thousands of inherited variants in the BRCA1 and BRCA2 genes to improve cancer prevention, screening, and intervention. The resource includes expert classifications of variants, providing information for clinicians and researchers.
Research demonstrates how solid stress from brain tumors impacts surrounding tissue, leading to neurological dysfunction and neuronal cell death. Lithium treatment is identified as a promising strategy for preserving function in compressed brain tissue.
A new study finds that genetic testing for breast cancer does not cause excessive anxiety, even with ambiguous results. Researchers surveyed 1,063 women and found that the type of test or result did not significantly impact worry levels.
A study published in Cancer Cell found that Tinagl1, a protein-based therapy, reduced the spread of triple-negative breast cancer in mice by blocking two main pathways. The treatment is based on a naturally occurring protein and has been shown to be effective even after tumors have begun to metastasize.
A new study of over 25,000 women from the Women's Health Initiative trials found that those experiencing persistent vasomotor symptoms are more likely to be diagnosed with breast cancer. The study also identified other risk factors, including high body mass index and current alcohol use.
Researchers at Rice University and the Duke University School of Medicine have identified JAG1 as a key player in tumor mechanics. The study shows how cancer stem cells differentiate within tumors and spread through the interaction of JAG1 with a signaling pathway, enabling metastasis.
Researchers found that chemotherapy can induce tumors to release exosomes containing a protein that stimulates immune cells to attract cancerous cells, leading to metastasis. Neutralizing this protein or blocking immune cells may improve the efficacy and safety of neoadjuvant chemotherapy.
A psycho-educational team was found to have a positive impact on early breast cancer patients' coping strategies, particularly in reducing depression. The study evaluated the effects of group action on women's anxiety and body image.