Articles tagged with Breast Cancer
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Researchers found a causal connection between MDMX overexpression and triple-negative breast cancer metastasis. The study suggests targeting the MDMX protein could prevent cancer spread, offering potential for new treatments.
A study published in Plastic and Reconstructive Surgery reports that autologous breast reconstruction after failed implant reconstruction is associated with significantly improved patient satisfaction and quality of life. The procedure has an acceptable complication rate, despite some additional challenges related to previous breast ca...
A recent study found nearly one-third of women under 40 underwent mammography before breast reduction surgery, despite guidelines recommending against it. The screenings can lead to unnecessary follow-up tests and treatments, wasting time and money.
Researchers found that stroke risk factors increased by tripling the likelihood of a stroke within 10 years, with hormonal treatment and racial differences also playing a role. The study calls for targeted interventions to reduce stroke risk among post-menopausal breast cancer survivors.
Drs. Silvia Formenti and Heather McArthur will collaborate on a year-long project using radiation and immunotherapy to create personalized vaccines for breast cancer patients. Their work aims to improve treatment outcomes and reduce mortality.
A new study published in HeartRhythm found that women with breast cancer have an increased risk of developing atrial fibrillation within three years following their cancer diagnosis compared to other women of the same age. The risk is higher for younger patients, with more than doubled incidence in those under sixty years old.
Research finds that plerixafor reduces fibrosis and improves response to immunotherapy in mouse models of metastatic breast cancer. Fibrosis blocks effectiveness of immunotherapies, but CXCR4 inhibition enhances immune cell infiltration and decreases formation of spontaneous metastases.
African American women with a history of keloids are more likely to be diagnosed with aggressive, late-stage breast cancers. The study found a link between ethnic variations in tumor immune response and the unique cancer risk.
Researchers at Kanazawa University have discovered a critical signaling pathway that drives the proliferation of cancer stem cells in breast cancer. The pathway, involving Semaphorin 3 and MICAL3 proteins, is targeted by inhibiting these proteins to reduce breast-cancer stem-like cells.
The debate centers on renaming ultra-low risk cancers to avoid unnecessary investigations and treatments. Experts recommend recalibrating thresholds for cancer diagnosis to categorize very low risk cancers as benign, reducing anxiety and improving patient outcomes.
Racial disparities in breast cancer survival in the US Military Health System are linked to delayed surgeries, but these delays do not explain overall survival gaps between black and white women. Researchers found that black women had greater estimated times to surgery compared to their white counterparts.
A Vanderbilt University team developed a nanoparticle to target tumor-infiltrating immune cells and activate the STING pathway, a natural mechanism to mount an immune response against cancer. The breakthrough offers hope for patients who don't respond to checkpoint blockade therapies.
Researchers identified genetic changes that may predict breast cancer relapse in women taking hormone therapy. The study found subtle differences in gene expression between tumours that relapsed and those that didn't, suggesting potential new tests to identify high-risk patients.
A new study found that acupressure significantly improved chronic pain, anxiety, depression, and poor sleep in breast cancer survivors experiencing fatigue. Researchers tested two types of acupressure and found relaxing acupressure to be more effective for depressive symptoms and sleep.
A dual COX-2/sEH inhibitor may offer a novel alternative to protect against debris-mediated inflammatory responses, which can lead to tumor survival and growth. The study used mouse models of ovarian cancer to demonstrate the anti-inflammatory compound's effectiveness in suppressing cancer growth.
A study found that breast cancers diagnosed in young women within 10 years of giving birth are more likely to metastasize than those diagnosed less recently or not at all. The risk is highest among women up to 10 years postpartum and is most pronounced in stage I or II breast cancer.
Researchers found that over 90% of purchase tickets in Brazil and Spain contained BPA, while only half did in France, due to government regulations. The study warns about the health risks associated with BPA and calls for stricter regulation and alternatives.
Researchers developed a new way to predict breast cancer risk by combining genetics, family history, weight, age at menopause, alcohol consumption, and hormone replacement therapy. The online calculator can identify different risk groups and inform tailored screening and preventative therapy.
A new study found that African-American women are less likely than white women to pursue potentially life-saving preventive care due to racial disparities in healthcare. High-risk black women were also less aware of their options and at a disadvantage when it came to getting access to information about prevention.
A new study led by Dr. Suresh Alahari found that the protein Nischarin regulates cell attachment and alters exosome properties, reducing breast cancer cell motility and adhesion. The research team's findings suggest that Nischarin-expressing exosomes may serve as an effective treatment for cancer.
Researchers identified a link between BRCA2 mutations and aggressive prostate cancer in men, increasing their risk of developing other cancers. The study also found that patients with BRCA2 mutations have poorer treatment responses and outcomes.
The BRCA Exchange aggregates data on thousands of inherited variants in the BRCA1 and BRCA2 genes to improve cancer prevention, screening, and intervention. The resource includes expert classifications of variants, providing information for clinicians and researchers.
Research demonstrates how solid stress from brain tumors impacts surrounding tissue, leading to neurological dysfunction and neuronal cell death. Lithium treatment is identified as a promising strategy for preserving function in compressed brain tissue.
A new study finds that genetic testing for breast cancer does not cause excessive anxiety, even with ambiguous results. Researchers surveyed 1,063 women and found that the type of test or result did not significantly impact worry levels.
A study published in Cancer Cell found that Tinagl1, a protein-based therapy, reduced the spread of triple-negative breast cancer in mice by blocking two main pathways. The treatment is based on a naturally occurring protein and has been shown to be effective even after tumors have begun to metastasize.
A new study of over 25,000 women from the Women's Health Initiative trials found that those experiencing persistent vasomotor symptoms are more likely to be diagnosed with breast cancer. The study also identified other risk factors, including high body mass index and current alcohol use.
Researchers at Rice University and the Duke University School of Medicine have identified JAG1 as a key player in tumor mechanics. The study shows how cancer stem cells differentiate within tumors and spread through the interaction of JAG1 with a signaling pathway, enabling metastasis.
Researchers found that chemotherapy can induce tumors to release exosomes containing a protein that stimulates immune cells to attract cancerous cells, leading to metastasis. Neutralizing this protein or blocking immune cells may improve the efficacy and safety of neoadjuvant chemotherapy.
A psycho-educational team was found to have a positive impact on early breast cancer patients' coping strategies, particularly in reducing depression. The study evaluated the effects of group action on women's anxiety and body image.
Medical University of South Carolina researchers found that advanced glycation end products (AGEs) can hamper response to tamoxifen therapy for ER-positive breast cancer patients. Lifestyle interventions, such as exercise and dietary counseling, may help reduce AGE levels and improve treatment outcomes.
A study using monkeys with the breast cancer drug letrozole found significant behavioral changes and impaired brain function, including hot flashes, increased anxiety, and spatial memory issues. The research highlights the importance of studying the effects of estrogen-reducing treatments on the nervous system.
A new approach to treating tumors has been discovered by regulating vascularization through a gene that is overexpressed in the tumor vasculature. By targeting the insulin receptor, scientists hope to deliver treatments more accurately and effectively.
Researchers have developed a novel portable optical imaging system that enables real-time visualization of tumor microenvironment in human breast tissue shortly after surgery. The system provides molecular features of breast cancer tissue, allowing for more accurate diagnoses and tracking of tumor progression.
A new analysis in BJS reveals that women requiring breast-conserving surgery re-operation pay £4,511 more in hospital costs than those with clear margins. This finding emphasizes the importance of reducing re-operation rates to achieve significant cost savings.
Two new studies published in the British Journal of Cancer reveal alarming breast cancer risks for women with false-positive screening results. Women who experience a first false-positive result have a two-fold risk of developing screen-detected or interval breast cancer later in life, while those with a second false-positive result fa...
Researchers analyzed data from over 1,000 breast cancer patients and identified seven clusters of patients based on their immune evasion mechanisms. This study provides a better understanding of how breast cancer hides from the immune system, allowing oncologists to develop more personalized treatment options.
Women who have given birth experience a lower risk of breast cancer, but this protective effect may not begin until as many as 30 years after the last pregnancy. A new study found that breast cancer risk increases in the years following childbirth, with the highest risk about five years later.
Researchers identify DPYSL3 as a molecule whose expression is altered in Claudin-Low triple-negative breast cancer, a highly metastatic and aggressive subtype. The study suggests that targeting the connection between DPYSL3 and vimentin could lead to new treatments for this disease.
A new study found that combining mammography with a novel imaging technique called three-compartment breast (3CB) imaging can significantly reduce unnecessary breast biopsies. The technique uses AI algorithms to analyze tissue composition, improving the ability to predict cancer and reducing recalls by up to 36%.
A new study found that young women with hormone receptor-positive luminal A breast cancer have a lower five-year disease-free survival rate compared to older patients. The study's authors hope their findings can inform better treatment options for this age group.
Researchers found that breastfeeding and family history of breast cancer had no impact on the increased risk. Risk peaked five years after childbirth, with a 80% higher risk compared to childfree women, but decreased by age 50. The study could inform screening decisions and prevention strategies.
Researchers at Tel Aviv University discovered that breast cancer tumors recruit stromal cells from bone marrow, boosting tumor cell proliferation and blood vessel formation. This finding highlights the potential for targeting these cells with novel therapies to treat the disease.
A UCLA-led research team has developed a spray gel that can awaken the immune system to stop cancer from recurring and spreading. The substance was successful half of the time in lab animals, with 50% survival rate after treatment.
Breastfeeding did not mitigate increased cancer risk, and older women are more susceptible to enhanced risks. The study analyzed data from 15 prospective studies and found that the heightened risk continued for about 24 years after childbirth.
The Canadian Task Force on Preventive Health Care updates its guideline to emphasize shared decision-making between women and their doctors. The new recommendations favor regular mammography screening for women aged 50-74, but only if they prefer it, due to uncertain benefits and harms.
The new TAILORx trial data reveals racial disparities in breast cancer outcomes, with 83.1% white women alive and cancer-free after nine years, compared to 78.9% black women. The study suggests biological factors contribute to the differences, regardless of treatment type or duration.
A study of 561 young women with breast cancer found that those who underwent mastectomy scored lower in quality of life measures, including satisfaction with appearance, psychosocial well-being, and sexual well-being. Breast-conserving surgery was associated with better outcomes, regardless of whether one or both breasts were removed.
A study found that younger breast cancer patients who underwent mastectomy reported lower breast satisfaction and poorer psychosocial and sexual well-being compared to those who had breast-conserving surgery. The researchers also found similar physical function across all groups.
Breast cancer survivors who participated in a lifestyle intervention program lost weight and had higher disease-free survival rates compared to those who received general recommendations. The study found that completion of the program was associated with a 35% higher rate of disease-free survival.
A multigene test used in breast cancer treatment helps doctors decide on chemotherapy, improving prognosis and reducing unnecessary treatments. The study found that patients with high-risk tumors had a five-fold increased risk of metastases and lower disease-free survival rates without chemotherapy.
Women who underwent supervised exercise during adjuvant breast cancer treatment experienced better cardiovascular function than those who didn't. The study found that exercise improved VO2 max and reduced decline in cardiovascular strength, particularly in patients receiving chemotherapy.
Treatment with oxybutynin significantly decreased the frequency and intensity of hot flashes in breast cancer survivors, improving their quality of life. The study found that patients on both oxybutynin doses experienced significant reductions in hot flash symptoms and improvements in overall quality of life.
Michael Hall's discovery of the TOR protein as a central controller of cell growth and metabolism has contributed to our understanding of cancer development. Rapamycin and its derivatives are now used in targeted cancer treatment, extending life expectancy for some patients with advanced cancer.
Recent studies at SABCS 2018 highlight radiation therapy's efficacy in treating breast cancer, with trials refining treatments to provide more options for patients. Accelerated partial breast irradiation has been shown to be non-inferior to traditional whole breast irradiation.
A new study published in a medical journal found that black women with early-stage breast cancer have worse outcomes than white women, even after receiving the same treatment. The study analyzed data from over 10,000 patients and found that black women had a lower survival rate and higher recurrence of invasive breast cancer.
Patients with early-stage breast cancer who had a positive sentinel lymph node biopsy showed comparable 10-year recurrence and survival rates following axillary radiotherapy or axillary lymph node dissection. The study also found that axillary radiotherapy was associated with significantly less lymphedema, a common side effect of surgery.
A phase III trial found that using circulating tumor cell count to guide treatment choice can lead to a significant gain in overall survival. Patients with estrogen receptor-positive, HER2-negative metastatic breast cancer who received chemotherapy based on high CTC counts had better progression-free and overall survival rates.
The study found that accelerated partial breast irradiation (PBI) was not statistically superior to whole breast irradiation (WBI) in preventing ipsilateral breast tumor recurrence. However, PBI showed promise as a less burdensome treatment option for some women, with smaller differences in relapse-free interval and grade 3 toxicity.
Researchers at University of Pennsylvania have developed new diagnostic tools to measure PARP-1 and glutamine levels in breast cancers. These biomarkers can help identify patients most likely to benefit from targeted therapies, offering a non-invasive way to guide treatment.
Advanced breast cancer patients with detectable PIK3CA mutations in their blood show improved progression-free survival when treated with alpelisib added to fulvestrant. Liquid biopsy analysis reveals a 45% risk reduction compared to tissue biopsy.