Articles tagged with Breast Cancer
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Researchers found that activin B and ALK7 expressed by cancer cells form a barrier that prevents tumor formation and metastasis. The 'barrier' triggers apoptosis in cancer cells, but can be evaded by downregulating activin B or ALK7.
A study published in Developmental Cell suggests that pairing YAP/TAZ inhibitors with another drug, such as trametinib, may extend their benefit to patients. The researchers found that YAP/TAZ promotes growth by regulating glucose metabolism in cancer cells.
Researchers at the University of Chicago discover that obesity reprograms immune cells in breasts to promote tumor formation in triple-negative breast cancers. Obesity promotes inflammation through metabolically-activated macrophages, which fuel tumorigenesis and encourage tumor growth.
Johns Hopkins Medicine researchers have created a 3D image-based model of tumor behavior that captures the complexity of cancer growth. The model uses high-quality imaging data and mathematical formulas to represent blood flow, oxygenation, and structural changes within tumors.
Researchers develop nanobodies that home in on ECM proteins surrounding cancer cells, allowing for early detection and treatment of tumors. The technique has shown promise in imaging and delivering therapeutic treatments to tumors.
Researchers have identified a gene mutation in prostate cancer that is linked to poor survival and increased relapse rates. The study found that men with this mutation are more than three times as likely to die and nearly seven times as likely to relapse on standard treatments.
A study found that clinicians over-order imaging for breast pain, despite a weak correlation with breast cancer. Most respondents (72%) believe there is no strong link between breast pain and breast cancer.
Research analyzed rates of brain metastases in elderly patients with breast cancer, lung cancer, and melanoma. The study found that these cancers carry a significant risk of developing brain metastases later in life, with varying rates among primary cancer types.
A Mayo Clinic study shows that less-invasive mastectomy is a safe option for more patients, including those with locally advanced cancer or surgical complication risk factors. The procedure's complications declined significantly between 2009 and 2017, and reconstruction success rates were high at one year after surgery.
Researchers discovered that tumors subvert endothelial cells' ability to form new blood vessels, using microRNA to control gene expression. Delivering this microRNA to endothelial cells in mice slowed tumor growth and reduced blood vessel formation.
Researchers found that omitting chemotherapy in HER2 positive metastatic breast cancer can significantly shorten progression-free survival but not overall survival. The PERNETTA trial suggests that targeted therapy alone may be safe for patients with low-to-intermediate tumour burden.
A new Australian study aims to develop a framework for effective care to reduce cardiovascular disease in breast cancer survivors. The two-year project will create an integrated model of care, embedding cardiovascular risk management into breast cancer treatment.
A high intake of phenolic acids associated with a healthy diet is linked to a decreased risk of postmenopausal breast cancer. The study found that women who consumed the most hydroxycinnamic acids, particularly chlorogenic acids found in coffee and fruits, had a 62% lower risk of developing breast cancer compared to those with low intake.
A new multigene test called EndoPredict has been found to predict chemotherapy benefit in women with hormone receptor-positive, HER2-negative breast cancer. The test was successful in identifying patients who would benefit from chemotherapy and those who could opt out of the treatment.
Patients with advanced HER2-negative breast cancer treated with continuous chemotherapy showed improved survival rates and maintained quality of life compared to intermittent scheduling. The study also found that treatment holidays had a negative impact on physical quality of life scores, with a clinically meaningful decline at 24 months.
Studies presented at ESMO Breast Cancer Congress 2019 found that young women with breast cancer tend to have more aggressive tumour subtypes, including triple negative and HER2 positive types. However, proper treatment according to guidelines resulted in good survival rates and local recurrence outcomes.
The global HER2 testing survey reveals major access and affordability issues in low and middle income countries, with some upper middle income countries also affected. The study suggests that governments need better information to set planning priorities for investing in infrastructure, testing, and treatment.
The ESMO Breast Cancer Congress stresses the need for a multidisciplinary approach to patient care, including cardiovascular assessment and nutritional support. A study presented at the congress found that dietary guidelines can lead to weight loss and improved quality of life in breast cancer patients.
A combination of biological markers and genetic changes can predict radiation sensitivity, helping doctors assess patients at risk of side effects. The study found that the time of day when radiotherapy is given can also affect side effects, particularly in breast cancer patients.
Researchers found that combining tumor-selective angiotensin blockers with immune checkpoint blockers significantly improves breast cancer treatment in mouse models. The combination treatment normalizes the tumor microenvironment, inducing changes in gene expression and activating immunosupportive pathways.
Researchers identified six factors associated with increased risk of invasive breast cancer recurrence after ductal carcinoma in situ (DCIS) diagnosis. These factors include African-American race, premenopausal status, and high histological grade. The study's findings aim to reduce overtreatment of low-risk DCIS cases.
Women with early, low-risk hormone-driven breast cancer who receive radiotherapy after surgery have a significantly lower risk of recurrence and improved disease-free survival compared to those without radiotherapy. The study found that whole breast irradiation is effective in reducing in-breast recurrences and improving overall survival.
Researchers at Case Western Reserve University have made breakthroughs in identifying who will benefit from chemotherapy using artificial intelligence and radiomics. The studies focused on markers outside the tumor that can indicate treatment response, providing hope for personalized medicine and improved patient outcomes.
A new study suggests that genetic testing, such as Oncotype DX, can help women with early-stage hormone-positive breast cancer avoid chemotherapy and save on treatment costs. The test is estimated to cost around $3,400, and its use could lead to a 8% reduction in chemotherapy costs, resulting in savings of about $338 million annually.
A new study by researchers at the University of Illinois found that combining two cancer drugs, selinexor and 4-OHT, may prevent endocrine resistance in breast tumors. The treatment protocol was more effective than either drug alone in reducing tumor cells' viability.
Researchers at Beth Israel Deaconess Medical Center discover relationship between leucine and tamoxifen resistance in ER+ breast cancer. A diet high in leucine may fuel the growth of breast cancer cells, while reducing leucine levels could be beneficial for patients with ER+ breast cancer.
NRG Oncology received $95 Million in NCI funding for six years, based on exceptional peer review scores. The organization will focus on increasing accrual, supporting young investigators, and raising awareness of clinical cancer research.
Triple negative breast cancer cells can temporarily turn on molecular pathways protecting them from chemotherapy, making them vulnerable to targeted therapy IACS-10759. This discovery offers a new treatment option for resistant TNBC patients.
Researchers at the University of Missouri have found a combination drug therapy reduces the spread of triple negative breast cancer to other locations by 50 percent. This new approach uses APR-246 and 2aG4 to target mutant p53 and prevent cancer growth, offering a promising solution for personalized medicine.
A new American Cancer Society study highlights the need to better identify patients with metastatic cancer who may not benefit from aggressive treatment. The study found wide variations in treatment patterns among patients who died within a month of diagnosis.
Researchers used mass cytometry to analyze millions of cancer and immune cells from 140 patients, discovering unique cellular compositions in each tumor. The study found that aggressive tumors are dominated by a single type of cell, while immune therapy may work for previously unsuitable breast cancer patients.
Researchers from CNIO have successfully removed advanced pancreatic ductal adenocarcinoma (PDA) in animal models through combined inhibition of EGFR and c-RAF kinase. This breakthrough has shown significant promise for developing new cancer treatments.
A new surgical guideline has been shown to decrease re-operation rates for breast cancer patients undergoing lumpectomy. According to a study by UBC medical student Alex Monaghan, women with early-stage breast cancer are now 72% less likely to require additional surgery.
A comprehensive SWOG Cancer Research Network study has identified a host of targets for new or existing cancer drugs. The research, published in the Journal for ImmunoTherapy of Cancer, found higher counts of cancer-fighting TILs in pre-treatment tissue samples of breast cancer patients who achieved complete response to chemotherapy.
Researchers at Mount Sinai have developed an innovative approach to cancer immunotherapy by injecting immune stimulants directly into a tumor. This 'in situ vaccination' teaches the immune system to destroy not only the primary tumor but also other tumor cells throughout the body, effectively turning the tumor into a vaccine factory.
The American College of Physicians (ACP) has issued a new guidance statement on breast cancer screening for average-risk women, recommending mammography every other year beginning at age 50. The guidelines take into account the potential harms of overdiagnosis and overtreatment associated with annual or biennial screening.
The American College of Physicians recommends that average-risk women between 50 and 74 years old undergo breast cancer screening with mammography every other year, as this approach balances benefits and harms. This strategy reduces false-positive findings and overtreatment, while minimizing radiation exposure and related risks.
A study found that breast cancer patients who don't respond to targeted therapy have distinct patterns of epigenetic modifications compared to those who do respond. The researchers identified 879 genes with higher methylation levels in resistant patients, suggesting potential targets for new treatments.
Scientists discovered a set of genes expressed in high levels in breast cancer tumors linked to aggressive types and shorter patient survival. The findings offer clues for diagnosis, prognosis, and potential drug discovery.
A clinical study demonstrated the safety and efficacy of high-dose stereotactic body radiotherapy (SBRT) for patients with centrally located non-small cell lung cancer. The treatment resulted in high tumor control rates, comparable to those seen in patients with peripheral tumors.
Researchers developed a new method to predict tumor growth rates using progression-free survival plots, reducing errors found in current methods. This improvement enables clinicians to schedule optimal screenings and set effective dosing regimens.
A retrospective cohort study found that surgery was associated with a 44% increased chance of survival for women with HER2+ stage 4 breast cancer, especially those with Medicare or private insurance. The study also revealed disparities in healthcare access and outcomes due to race and socioeconomic factors.
Professor Jonas Bergh is recognized for his work on breast cancer biology, including tailored treatments and the impact of chemotherapy. He has made significant contributions to primary breast cancer treatment through his involvement in clinical trials and research collaborations.
Salk scientists discovered a new mechanism of action for the CDK12 protein, revealing its role in regulating gene expression and cell division. This finding suggests that targeting CDK12 could be an effective way to kill cancer cells and improve treatment outcomes.
Researchers at the University of California, Riverside found that surgery is associated with a 44% increased chance of survival for patients with HER2-positive stage 4 breast cancer. The study suggests that surgery should be considered as part of treatment, particularly for women with Medicare or private insurance.
A new study found that 3D mammography improves breast cancer detection in older women, with lower false-positive rates and higher positive predictive values. The results suggest that guidelines for screening in this age group should be based on individual preferences and health status.
Scientists have found that successful removal of breast cancer tumors triggers a strong immune response, which clears disseminated tumor cells from lymph nodes and organs. In contrast, leaving behind primary tumor cells supports tumor growth and metastasis.
A prototype wearable device can continuously collect live cancer cells directly from a patient's blood, offering a biopsy alternative. This innovation could help doctors diagnose and treat cancer more effectively by providing better information for planning treatments.
The D.C. Council has passed the Breast Density Screening and Notification Act, requiring women with dense breast tissue to be informed and receive additional screenings. This legislation aims to reduce deaths from breast cancer by promoting early detection among high-risk groups.
A mesothelin-targeted CAR T-cell therapy demonstrated antitumor activity and acceptable toxicity in a phase I clinical trial for patients with malignant pleural disease. The therapy showed significant tumor regression and reduced mesothelin-related peptide levels in the blood.
Researchers found that obesity at older ages is linked to worse outcomes, with higher tumor growth in obese mice compared to lean mice. They also discovered a connection between leptin, a biological signal released by fat tissue, and increased numbers of tumor-initiating cells.
Researchers have discovered a correlation between estrogen byproducts and survival rates for women with breast cancer, with higher levels of the "good" metabolite associated with reduced mortality. The study suggests that measuring these byproducts may help predict prognosis after breast cancer diagnosis.
Researchers presented studies on the clinical utility of liquid biopsy powered by ddPCR technology to measure blood-based tumor biomarkers in a reproducible way. Studies demonstrated correlations between ctDNA mutations and response to abemaciclib in breast cancer patients and found potential as a predictor for surgery success in malig...
Scientists create vaccine that strengthens immune defences by multiplying cancer-repelling T cells, promising treatment for individualized cancer immunotherapy and potential application in autoimmune diseases. Laboratory tests conducted on tumours in mice show effectiveness of approach.
Researchers have developed an experimental combined drug therapy that dramatically shrinks tumours and prevents metastasis in mice by targeting the DNA repair capability of cancer cells. The treatment has few side-effects compared to traditional chemotherapy and is being tested in clinical trials.
Researchers from Marshall University found that consuming two ounces of walnuts daily for two weeks changes gene expression in confirmed breast cancers, slowing growth and reducing survival risk. The study involved 10 women with breast lumps, who were randomized to walnut or control groups.
Breast cancer cells are inherently changeable, morphing from one cell type to another at the molecular level. This feature may promote resistance to certain therapies. The research provides new insights into how cancer cells develop and evolve within tumours.
Researchers at UNIGE and UNIL discover clofazimine's efficacy in stopping triple negative breast cancer progression by blocking Wnt cell signaling pathway. The study highlights the need to re-examine existing drugs for potential targeted therapy.
Women with metastatic hormone receptor-positive breast cancer live longer when receiving fulvestrant and anastrozole compared to treatment with anastrozole alone. The combination therapy shows promise as a life-extending first line of treatment, particularly for women who received lower doses of fulvestrant.
A new study estimates the risk of cancer associated with moderate levels of alcohol consumption and compares it to the risk of smoking. The study found that drinking one bottle of wine per week is equivalent to smoking five cigarettes for men and ten cigarettes for women.