Articles tagged with Breast Cancer
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.
Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.
Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.
Practical application of scientific knowledge and engineering principles to solve real-world problems and develop innovative technologies. Encompasses all engineering disciplines, technology development, computer science, artificial intelligence, environmental sciences, agriculture, materials applications, energy systems, and industrial innovation. Bridges theoretical research with tangible solutions for infrastructure, manufacturing, computing, communications, transportation, construction, sustainable development, and emerging technologies that advance human capabilities, improve quality of life, and address societal challenges through scientific innovation and technological progress.
Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.
Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.
Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
Researchers at LSU Health found that metformin can delay mammary gland development, enhance tumor growth and metastasis, and decrease AMPK activation. The study suggests metformin's therapeutic value in treating breast cancer in patients with low Nischarin expression levels.
A landmark study found that selective mammography screening can detect male breast cancer in high-risk men at an early stage, improving survival prognosis. The cancers detected were often benign, but the study's results support targeted screening for men with elevated risk.
Researchers discovered that some cancer cells survive chemotherapy by consuming neighboring tumor cells, providing energy to stay alive. This process helps senescent cancer cells initiate tumor relapse after treatment completion.
A recent study found that men at high risk for breast cancer can benefit from mammography screening. The study involved 1,869 men who had a mammogram between 2005 and 2017, with 41 men diagnosed with breast cancer.
A substudy of the NRG Oncology clinical trial found that women rated post-lumpectomy partial breast irradiation as equivalent to whole breast irradiation in terms of cosmetic outcomes and satisfaction. The results suggest that PBI may be a viable option for patients seeking to minimize radiation time commitment and healthcare costs.
A $3 million Stand Up 2 Cancer grant supports a clinical trial evaluating a combination therapy to prevent triple-negative breast cancer recurrence. The trial will utilize a blood test to identify women at risk and harness the immune system to eliminate the cancer.
Research found that only 35% of eligible women took part in all three screening programmes, with 10% remaining unscreened. Women from areas of less deprivation and those with caring duties were more likely to take up screenings, while practices with higher proportions of unemployed patients and smokers had lower rates.
Scientists have identified distinctive characteristics of KRAS-positive lung cancers that can be targeted to inhibit growth, offering a new approach for personalized therapy. The study suggests exploring co-existing mutations as an alternative to traditional therapies.
Research reveals how breast cancer cells use exosomes to bypass the blood-brain barrier and spread to the brain. Exosomes trick endothelial cells into taking them up, allowing cancer cells to metastasize, and can also manipulate astrocytes to facilitate tumor growth.
Researchers discovered that E-cadherin promotes metastasis in invasive ductal carcinoma by allowing breast cancer cells to survive during travel and form new tumors. The study reveals that the process of metastasis is inefficient, with only 1% of cells surviving and forming new tumors.
A new clinical trial, EAZ171, is recruiting black women with breast cancer to investigate and treat taxane-induced neuropathy. The study seeks to identify the most effective chemotherapy regimen for African American women, who are disproportionately affected by this debilitating side effect.
A study supports genetic testing for all metastatic breast cancer patients to identify additional patients with increased risk of certain mutations. This strategy may also help determine response to targeted therapies such as PARP inhibitors for HER2/ERBB2 negative breast cancer.
A new study suggests that older women with chronic illnesses, such as cardiovascular disease or diabetes, may not derive significant benefits from regular screening mammograms. The research found a nearly 90-fold difference in mortality rates between breast cancer and non-breast cancer causes among women aged 75 and older.
Researchers tested immunotherapy in young and old mice with triple negative breast cancer, finding that age affects the efficacy of ICB therapy. The study found significant reduction in tumor growth and better overall survival rates in young mice compared to aged mice.
A large cohort study found that obesity is consistently associated with a greater burden of symptoms and experiences of distress among patients with breast or prostate cancer. Among patients with colon cancer, significant symptoms and distress were observed regardless of weight, suggesting alternative factors at play.
A new study published in the Journal of Nutrition found that a low-fat diet rich in fruits, vegetables, and grains reduces death following breast cancer, slows diabetes progression, and prevents coronary heart disease. The study, led by Fred Hutchinson Cancer Center researchers, followed nearly 49,000 postmenopausal women for nearly 20...
A non-coding region of the genome has been discovered to regulate the development of cancer in various types of tumors, including breast cancer and sarcomas. The RPSAP52 RNA molecule triggers cell proliferation and cancels differentiation, allowing tumor cells to multiply and spread.
The USPSTF recommends medications like tamoxifen, raloxifene, or aromatase inhibitors to reduce breast cancer risk in asymptomatic women over 35 with increased risk but low adverse effects risk. The Task Force advises against routine use for women not at high breast cancer risk.
Researchers from Osaka University have identified a gene, GREB1, as a key player in the development of hepatoblastoma. The study found that suppressing GREB1 production using antisense oligonucleotides significantly reduced tumor formation and cell proliferation in mouse liver cancer models.
A new study analyzing worldwide epidemiological evidence finds a significant association between menopausal hormone therapy and breast cancer incidence. The research indicates that the risks are greater for users of oestrogen-progestagen hormone therapy than for oestrogen-only hormone therapy.
A new study identifies PoEMs as promoting breast cancer metastasis through the loosening of lymph vessel connections. Removing these cells reduces the ability of breast cancer cells to spread. The findings suggest targeting PoEMs in cancer therapy, specifically targeting cancer-associated lymphatic vessels.
Researchers at UT Health San Antonio have identified a novel way to kill cancers caused by inherited BRCA1 mutations. Adding back microRNA 223-3p forces BRCA1-mutant cancer cells to die, offering a potential treatment for inherited breast and ovarian cancer.
Researchers found large diversity in neutrophil and macrophage frequencies, with some tumors attracting one type while others attract the other. The study highlights heterogeneity of tumor cells and immune microenvironment as important considerations for therapy.
Women with breast cancer who experience depression, anxiety, or mental health conditions are more likely to use opioids and have lower survival rates. Researchers recommend alternative pain management options like physical therapy, massage, and acupuncture to improve treatment outcomes.
Oncologists suggest using nab-paclitaxel instead of paclitaxel prior to surgery for high-risk breast cancer patients, potentially improving long-term outcomes and reducing disease recurrence. This approach may be particularly beneficial for women with hormone receptor positive, HER-2 negative breast cancer.
A new CRISPR gene editing system, encapsulated in a nanolipogel, effectively targets and knocks out the Lcn2 oncogene, curbing tumor growth in mice, providing a potential genetic treatment for triple-negative breast cancer.
Researchers compared three frontline breast cancer drugs and found significant differences in their biological activity. Abemaciclib was shown to be more effective than other drugs at high doses, affecting proteins beyond CDK4/6, suggesting it may work differently for patients who don't respond to other treatments.
Researchers at Moffitt Cancer Center have developed a model called GARD that uses genomic data to predict the risk of local tumor recurrence and optimize radiation doses for breast cancer patients. The study found that a personalized approach to radiation therapy can reduce overdosing certain patients and improve treatment outcomes.
The USPSTF recommends assessing risk in women with a history of breast, ovarian, fallopian tube, or peritoneal cancer, as well as those with an ancestry associated with BRCA1/2 mutations. Genetic counseling and testing are offered to those with a positive result after counseling.
New USPSTF recommendations for BRCA1/2 genetic testing are beneficial, increasing use of genetic counseling and testing for those with high risk. However, concerns remain about large-panel genetic tests, direct-to-consumer multi-panel tests, and racial and socioeconomic disparities in genetic testing uptake.
A new study published in the European Respiratory Journal found that women with sleep apnea are at a higher risk of developing cancer. The research, based on registry data from over 20,000 adult patients, shows a possible link between intermittent hypoxia and increased cancer prevalence among women, but not men.
Researchers have identified a combination therapy of MDM2 compounds and CDK4/6 inhibitors as a possible solution for overcoming resistance to these drugs in melanoma patients. The therapy was shown to reverse resistance mechanisms in multiple mouse models and human tumor slice culture assays.
A pan-Canadian clinical trial will investigate a new way to treat metastatic breast cancer by making it impossible for breast cancer cells to manufacture proteins needed to be aggressive. The Dream Team, led by Nahum Sonenberg and Michael Pollak, aims to find ways to overcome translational dysregulation and prevent cancer spread.
Researchers found that DNA methylation patterns can affect the impact of aspirin on mortality in women with breast cancer. Women with certain DNA characteristics who take aspirin before a breast cancer diagnosis may live longer, according to the study published in Cancer journal.
A new study suggests that aspirin use can have varying effects on breast cancer patients depending on their DNA methylation profiles. Patients with methylated tumor promoters had a higher mortality risk, while those with unmethylated promoters saw a decrease in breast cancer-specific mortality.
Researchers found that combining therapies reduced tumor relapse and side effects in mouse models of kinase mutated breast cancer. The study suggests using two therapies together, rather than one after the other, to improve treatment outcomes.
Adults aged 85 years and older account for the fastest-growing age group in the US, with higher cancer incidence rates but lower screening and treatment rates. The most common cancers among this population are lung, breast, prostate, and colorectum, but late-stage diagnosis and poorer survival outcomes are also reported.
A study analyzing published research found Nordic walking reduces swelling and improves physical fitness in breast cancer patients. However, more well-designed studies are needed to explore its full potential.
A recent study found that increasing consumption of red meat was associated with a higher risk of invasive breast cancer, while consuming poultry was linked to decreased risk. Substituting poultry for red meat may be a simple way to reduce breast cancer incidence.
Scientists have developed a personalized platform called TARDIS that accurately detects circulating tumor DNA and signs of residual disease in breast cancer patients. The assay demonstrated a significant improvement in sensitivity, enabling earlier detection of tumors and monitoring patient response to chemotherapy.
A new 'liquid biopsy' blood test called TARDIS detects circulating tumor DNA in patient blood, enabling precise monitoring of disease progression and response to treatment. The test's high sensitivity could help plan surgical resection and radiation therapy after pre-operative therapy.
Researchers used artificial intelligence to identify five new types of breast cancer with distinct patterns of response to treatment, including two that are more likely to benefit from immunotherapy. The study aims to personalize treatment for women with breast cancer by selecting patients for different drugs in clinical trials.
Researchers analyzed 10,225 patient samples from 32 different cancers to better understand TP53 mutations. They found that TP53 mutations were more frequent in patients with poorer survival rates but also identified a way to predict prognosis based on four upregulated genes.
Antonio Giordano, a Hollings Cancer Center clinical scholar, is researching novel treatments for triple-negative breast cancer. He aims to develop a PLK1-inhibitor drug and explore the role of tumor-infiltrating lymphocytes in prognosis.
A novel laboratory test developed at Johns Hopkins Medicine can accurately detect malignant and benign breast tumors in a mere 5 hours, significantly reducing the wait time for diagnosis. The test exploits epigenetic alterations and has the potential to dramatically reduce wait times and improve survival rates in resource-poor settings.
A new treatment uses cellular soldiers created from the body's own defenses to track down and kill escaping cancer cells during surgeries, preventing metastasis. The innovative method has shown promise in clinical trials with triple negative breast cancer patients, increasing five-year survival rates.
Researchers at Champalimaud Centre for the Unknown discovered a cell-competition mechanism called fitness fingerprints that allows cancer cells to disguise themselves as healthy cells. By blocking this mechanism, they found that tumour growth can be slowed down, but not eliminated.
Researchers at UT Southwestern Medical Center discovered a new molecular mechanism that indicates PARP inhibitors could be effective in treating all cancers where the drugs are used, including ovarian and prostate cancers. A potential biomarker has been identified, which may indicate when patients can benefit from these drugs.
A study by University of Notre Dame researcher Siyuan Zhang and collaborators identified a gene that makes triple-negative breast cancer (TNBC) cells vulnerable to existing therapies. The discovery suggests that a targeted drug therapy may be effective for this aggressive type of breast cancer.
Researchers will investigate loss of DNA repair mechanisms and secondary mutations leading to cancer. The goal is to develop improved cancer treatment regimens and predict drug efficacy.
A new study published in Annals of Surgical Oncology suggests that delaying chemotherapy after breast cancer surgery can lead to poorer overall survival. The research found that patients who received postoperative chemotherapy within four months of diagnosis had better survival rates than those whose treatment was delayed.
Researchers at IDIBELL confirm use of PDX models for studying methylation patterns associated with breast cancer subtypes and response to docetaxel. The study validates the models' representation of human tumor samples, enabling more accurate drug preclinical studies.
A recent study published in Nutrients found that an inflammatory diet increases the risk of colorectal cancer by almost twice. The researchers suggest adopting a Mediterranean diet rich in fruits, vegetables, nuts, whole grains, and healthy oils to reduce the risk of colon cancer.
Researchers found that patients undergoing combined breast and gynecologic surgeries had significantly longer hospital stays and higher complication rates compared to those with single-site surgery. The study highlights the importance of separating these procedures for better patient outcomes.
Researchers developed a reusable device using carbon dioxide to power a cancer tissue-freezing probe, eliminating the need for expensive argon and anesthesia. The tool shows promise in reducing complications and increasing accessibility to breast cancer treatment in lower-income countries.
Research aims to reprogram immune system cells to target urothelial bladder cancer, a high-recurrence rate type with limited treatment breakthroughs. The new immunotherapy strategy could revolutionize bladder cancer treatment and increase survival rates.
Researchers have developed an AI algorithm that can analyze breast ultrasound images to detect cancer with high accuracy. The algorithm uses synthetic data to train itself, achieving nearly 100% classification rate on real-world images.
A recent study published in CANCER found significant disparities in triple-negative breast cancer diagnoses among women of color and younger women. Non-Hispanic black women had a significantly higher incidence of the disease, with over 21% diagnosed compared to under 11% for other ethnic groups.
A large French study suggests that high sugary drink consumption may contribute to an increased risk of cancer. The researchers found a strong association between daily consumption of sugary drinks and breast cancer, as well as overall cancer risk.
A recent study by Chiaki Takahashi at Kanazawa University discovered that the cancer gene RB promotes tumor growth by altering the tumor microenvironment (TME). The TME changes enable the accumulation of immunosuppressive cells, which overpower the body's natural defense system.